John P. Leddy, M.D.

John P. Leddy, M.D.

Contact Information

8 Charleston Drive
Mendon, NY 14506

Office: (585) 273-3213

Journal Articles

Showing all 65 journal articles available.

1996 Jan
Popescu NA, Sheehan MG, Kouides PA, Loughner JE, Condemi JJ, Looney RJ, Leddy JP. "Allergic reactions to cyclophosphamide: delayed clinical expression associated with positive immediate skin tests to drug metabolites in five patients." The Journal of allergy and clinical immunology.. 1996 Jan; 97(1 Pt 1):26-33.
1995 May 15
Wang X, Fleischer DT, Whitehead WT, Haviland DL, Rosenfeld SI, Leddy JP, Snyderman R, Wetsel RA. "Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families." The Journal of immunology : official journal of the American Association of Immunologists.. 1995 May 15; 154(10):5464-71.
1994 Jul 15
Leddy JP, Wilkinson SL, Kissel GE, Passador ST, Falany JL, Rosenfeld SI. "Erythrocyte membrane proteins reactive with IgG (warm-reacting) anti-red blood cell autoantibodies: II. Antibodies coprecipitating band 3 and glycophorin A." Blood.. 1994 Jul 15; 84(2):650-6.
1994
Kafka, S.P.; Condemi, J.J.; Marsh, D.O.; Leddy, J.P. "Mononeuritis multiplex and vasculitis: Association with antineutrophil cytoplasmic antibody". Archives of Neurology. 1994; 51: 565-569.
1993 Apr
Leddy JP, Falany JL, Kissel GE, Passador ST, Rosenfeld SI. "Erythrocyte membrane proteins reactive with human (warm-reacting) anti-red cell autoantibodies." The Journal of clinical investigation.. 1993 Apr; 91(4):1672-80.
1991
Francis, C.W.; Brenner, B.; Leddy, J.P.; Marder, V.J. "Angioedema during therapy with recombinant tissue plasminogen activator". British Journal of Haematology. 1991; 77: 562-563.
1989 Mar
Houle JJ, Leddy JP, Rosenfeld SI. "Secretion of the terminal complement proteins, C5-C9, by human platelets." Clinical immunology and immunopathology. 1989 Mar; 50(3):385-93.
1987 May 1
Rosenfeld SI, Ryan DH, Looney RJ, Anderson CL, Abraham GN, Leddy JP. "Human Fc gamma receptors: stable inter-donor variation in quantitative expression on platelets correlates with functional responses." The Journal of immunology : official journal of the American Association of Immunologists.. 1987 May 1; 138(9):2869-73.
1986 Oct 1
Rosenfeld SI, Jenkins DE, Leddy JP. "Enhanced reactive lysis of paroxysmal nocturnal hemoglobinuria erythrocytes. Studies on C9 binding and incorporation into high molecular weight complexes." The Journal of experimental medicine.. 1986 Oct 1; 164(4):981-97.
1985 Jan 10
Packman CH, Rosenfeld SI, Leddy JP. "High-density lipoprotein and its apolipoproteins inhibit cytolytic activity of complement. Studies on the nature of inhibitory moiety." Biochimica et biophysica acta.. 1985 Jan 10; 812(1):107-15.
1985 Jan
Rosenfeld SI, Jenkins DE, Leddy JP. "Enhanced reactive lysis of paroxysmal nocturnal hemoglobinuria erythrocytes by C5b-9 does not involve increased C7 binding or cell-bound C3b." The Journal of immunology : official journal of the American Association of Immunologists.. 1985 Jan; 134(1):506-11.
1985
Rosenfeld SI, Looney RJ, Leddy JP, Phipps DC, Abraham GN, Anderson CL. "Human platelet Fc receptor for immunoglobulin G. Identification as a 40,000-molecular-weight membrane protein shared by monocytes." The Journal of clinical investigation.. 1985 76(6):2317-22.
1984
Hall, C.B.; Hall, W.J.; Gala, C.; Magill, F.B.; Leddy, J.P. "A long-term prospective study of children following respiratory syncytial virus infection". Journal of Pediatrics. 1984; 105: 358-364.
1983 Jul 1
Marinetti GV, Rosenfeld SI, Thiem PA, Condemi JJ, Leddy JP. "Beta-adrenergic receptors of human leukocytes. Studies with intact mononuclear and polymorphonuclear cells and membranes comparing two radioligands in the presence and absence of chloroquine." Biochemical pharmacology.. 1983 Jul 1; 32(13):2033-43.
1983 Apr
Rosenfeld SI, Packman CH, Leddy JP. "Inhibition of the lytic action of cell-bound terminal complement components by human high density lipoproteins and apoproteins." The Journal of clinical investigation.. 1983 Apr; 71(4):795-808.
1983
Heal, J.M.; Bailey, G.; Helphingstine, C.; Theim, P.A.; Leddy, J.P.; Buchholz, D.H.; Nusbacher, J. "Non-centifugal plasma collection using cross-flow membrane plasmapheresis". Vox Sang. 1983; 44(3): 156-166.
1980 Nov
Rosenfeld SI, Packman CH, Jenkins DE, Countryman JK, Leddy JP. "Complement lysis of human erythrocytes. III. Differing effectiveness of human and guinea pig C9 on normal and paroxysmal nocturnal hemoglobinuria cells." The Journal of immunology : official journal of the American Association of Immunologists.. 1980 Nov; 125(5):2063-8.
1980 Jun
Packman CH, Rosenfeld SI, Jenkins DE, Leddy JP. "Complement lysis of human erythrocytes. II. A unique interaction of human C8 and C9 with paroxysmal nocturnal hemoglobinuria erythrocytes." The Journal of immunology : official journal of the American Association of Immunologists.. 1980 Jun; 124(6):2818-23.
1979 Aug
Packman CH, Rosenfeld SI, Jenkins DE, Thiem PA, Leddy JP. "Complement lysis of human erythrocytes. Differeing susceptibility of two types of paroxysmal nocturnal hemoglobinuria cells to C5b-9." The Journal of clinical investigation.. 1979 Aug; 64(2):428-33.
1979
Nusbacher J, Rosenfeld SI, Leddy JP, Klemperer MR, MacPherson JL. "The leukokinetic changes and complement activation associated with filtration leukapheresis." Experimental hematology.. 1979 7(4 Suppl):24-30.
1978 Feb
Nusbacher J, Rosenfeld SI, MacPherson JL, Thiem PA, Leddy JP. "Nylon fiber leukapheresis: associated complement component changes and cranulocytopenia." Blood.. 1978 Feb; 51(2):359-65.
1978 Jan
Martin SE, Breckenridge RT, Rosenfeld SI, Leddy JP. "Responses of human platelets to immunologic stimuli: independent roles for complement and IgG in zymosan activation." The Journal of immunology : official journal of the American Association of Immunologists.. 1978 Jan; 120(1):9-14.
1977 Jan
Breckenridge RT, Rosenfeld SI, Graff KS, Leddy JP. "Hereditary C5 deficiency in man. III. Studies of hemostasis and platelet responses to zymosan." The Journal of immunology : official journal of the American Association of Immunologists.. 1977 Jan; 118(1):12-6.
1977
Staples, P.J.; Boujak, J.; Douglas, R.G.Jr.; Leddy, J.P. "Disseminated Candidiasis in a previously healthy girl: Implication of a leukocyte Candidacidal defect". Clinical Immunology and Immunopathology. 1977; 7: 157.
1977
Leddy, J.P.; Simons, R.L.; Douglas, R.G.Jr. "Effect of selective complement deficiency on the rate of neutralization of enveloped viruses by human sera". Journal of Immunology. 1977; 118: 23.
1977
Schaller JG, Gilliland BG, Ochs HD, Leddy JP, Agodoa LC, Rosenfeld SI. "Severe systemic lupus erythematosus with nephritis in a boy with deficiency of the fourth component of complement." Arthritis and rheumatism.. 1977 20(8):1519-25.
1976 Nov
Packman CH, Rosenfeld SI, Weed RI, Leddy JP. "Complement-induced ultrastructural membrane lesions: requirement for terminal components." The Journal of immunology : official journal of the American Association of Immunologists.. 1976 Nov; 117(5 Pt.2):1883-9.
1976 Jun
Rosenfeld SI, Baum J, Steigbigel RT, Leddy JP. "Hereditary deficiency of the fifth component of complement in man. II. Biological properties of C5-deficient human serum." The Journal of clinical investigation.. 1976 Jun; 57(6):1635-43.
1976 Jun
Rosenfeld SI, Kelly ME, Leddy JP. "Hereditary deficiency of the fifth component of complement in man. I. Clinical, immunochemical, and family studies." The Journal of clinical investigation.. 1976 Jun; 57(6):1626-34.
1975
Leddy, J.P.; Griggs, R.C.; Klemperer, J.R.; Frank, M.M. "Hereditary complement (C2) deficiency with dermatomyositis". American Journal of Medicine. 1975; 58: 83.
1975
Bell, D.A.; Thierm P. A.; Vaughan, J.H.; Leddy, J.P. "Studies with human leukocyte lysosomes: Evidence for anti-lysosome antibodies in systemic lupus erythematosus and for the presence of lysosomal antigen in inflammatory diseases". Journal of Clinical Investigation. 1975; 55: 256.
1975
Krieger, H.; Leddy, J.P.; Breckenridge, R.T. "Studies on a circulating anticoagulant in systemic lupus erythematousus: Evidence for inhibition of the function of activated plasma thromboplastin antecedent (factor XIa)". Blood. 1975; 46(189).
1974
Leddy, J.P.; Frank, M.M.; Gaither, T.; Baum, J.; Klemperer, M.R. "Hereditary defciency of the sixth component of complement (C6) in man. I. Immunochemical, biologic and family studies". Journal of Clinical Investigation. 1974; 53: 544.
1974
Heusinkveld, R.S.; Leddy, J.P.; Kemperer, M.R.; Breckenridge, R.T. "Hereditary deficiency of the sixth component of complement (C6) in man. II. Studies of homeostasis". Journal of Clinical Investigation. 1974; 53: 554.
1973
Taft, E.G.; Grossman, J.; Abraham, G.N.; Leddy, J.P.; Lichtman, M.A. "Psuedo leukocytosis due to cryoprotein crystals". American Journal of Clincal Pathology. 1973; 60: 669.
1972
Bell, D.A.; Leblond, P.F.; Leddy, J.P.; Lauf, P.F.; LaCelle, P.L.; Weed, R.I. "Immune hemolysis. I. Differing susceptibility of three genetic types of sheep red cells". Journal of Immunology. 1972; 108: 467.
1972
Leddy, J.P.; Thiem, P.A.; Leblond, P.F.; Weed, R.I.; Lauf, P.K. "Immune hemolysis II. Studies of the mechanisms of enhanced lysis of sheep red cells in high potassium medium". Journal of Immunology. 1972; 108: 475.
1972
Abraham, G.N.; Leddy, J.P.; Grossman, JH.; Condemi, J.J. "Properties of crystalline IgG3 globulin". Biochemistry, Biophysics Research Communications. 1972; 46: 162.
1972
Grossman, J.; Bbraham, G.N.; Leddy, J.P.; Condemi, J.J. "Crystalglobulinemia". Annals of Internal Medicine. 1972; 77: 395.
1971
Mathison, D.A.; Condemi, J.J.; Leddy, J.P.; Callerame, M.L.; Panner, B.J.; Vaughan, J.H. "Purpura, arthralgia, and IgM-IgG cryoglobulinemia with rheumatoid factor activity". Annal of Internal Medicine. 1971; 74: 467.
1970
Gilliland, B.C.; Leddy, J.P.; Vaughan, J.H. "Measurement of previously undetected IgG autoantibodies on complement-coated human red cells". Journal of Clinical Investigation. 1970; 49: 1898.
1970
Leddy, J.P.; Peterson, P.; Yeaw, M.A.; Bakemeier, R.F. "Pattterns of serologic specificity of human IgG erythrocyte autoantibodies. Correlation of antibody specificity with complement fixing behavior". Journal of Immunology. 1970; 195: 677.
1970
Leddy, J.P.; Whittemore, N.B.; Weed, R.I. "Human erythrocyte membranes: Effect of lipid extraction on binding of IgG ("warm") autoantibodies on the Rh isoantibodies". Vox Sang. 1970; 19: 444.
1969
Leddy, J.P. "reactivity of human IgG erythrocyte autoantibodies with fetal, autologous and amternal red cells". Vox Sang. 1969; 17: 525.
1969
May, A.G.; Bauer, S.; Panner, B.; Leddy, J.P.; Vaughan, J.H.; Russel, P.S. "Survival of allografts after hepatic portal venous administration of specific transplantation antigen". Annals of Surgery. 1969; 170: 822.
1968
Bakemeier, R.F.; Leddy, J.P. "Erythrocyte autoantibody associated with alphamethylodpa: Heterogeneity of structure and specificity". Blood. 1968; 32: 1.
1968
Croft, J.D.; Swisher, S.N.; Gilliland, B.C.; Bakemeier, R.F.; Leddy, J.P.; Weed, R.I. "Coombs-test positivity induced by drugs. Mechanisms of immunologic reactions and red cell destruction". Annals of Internal Medicine. 1968; 68: 176.
1968
Dubilier, L.D.; Chadwick, J.A.; Leddy, J.P. "Thymic alymphoplasia: Typical postmortem findings in an infant presenting with "hemolytic-uremic syndrome" and normal levels of lymphocytes and immunoglobulins". Journal of Pediatrics. 1968; 68: 176.
1967
Simpson, J.F.; Leddy, J.P.; Hare, J.D. "Listeriosis complicating lymphoma: report of four cases and analysis of pathogenetic factors". American Journal of Medicine. 1967; 125: 808.
1967
Leddy, J.P.; Bakemeier, R.F. "A relationship of direct Coombs test pattern to autoantibody specificity in acquired hemolytic anemia". Proceedings of the Society for Experimental Biology and Medicine. 1967; 10: 502.
1966
Leddy. J.P. "Immunological aspects of red cell injury in man". Seminars in Hematology. 1966; : 48.
1966
Vaughan, J.H.; Barnett, E.V.; Leddy, J.P. "Autosensitivity diseases". New England Journal of Medicine. 1966; 275: 1426,1486.
1965
Leddy, J.P.; Bakemeier, R.F. "Structural aspects of human erythrocyte autoantibodies: Light chain types and electrophoretic dispersion". Journal of Experimental Medicine. 1965; 121: 1.
1965
Swisher, S.N.; Trabold, N.; Leddy, J.P.; Vaughan, J.H. "Clinical correlations of the direct antiglobulin reaction In: Conference on Autoimmunity-Experimental and Clinical Aspects". Annals of the New York Academy of Science. 1965; 124: 441.
1965
Barnett, E.V.; Leddy, J.P.; Condemi, J.J.; Vaughan, J.H. "Antinuclear factors in rheumatoid arthritis In: Conference on Autoimmunity-Experimental and Clinical Aspects". Annals of the New York Academy of Science. 1965; 124: 896.
1965
Barnett, E.V.; Bakemeier, R.F.; Leddy, J.P.; Vaughan, J.H. "Heterogeneity of antinuclear factors in lupus erythematosus and rheumatoid arthritis". Proceedings of the Society for Biology and Medicine. 1965; 118(803).
1964
Jacox, R.F.; Mongan, E.S.; Hanshaw, J.B.; Leddy, J.P. "Hypogammaglobulinemia with thymoma and probable pulmonary infection with cytomegalovirus". New England Journal of Medicine. 1964; 271: 1901.
1964
Leddy, J.P.; Vaughan, J.H. "Auto-sensitization of trypsin treated human red cells by complement". Proceedings of the Society for Experimental Biology and Medicine. 1964; 117: 734.
1964
Barnett, E.V.; Condemi, J.J.; Leddy, J.P.; Vaughan, J.H. "g2, g1A, and g1M antinuclear factors in human sera". Journal of Clinical Investigation. 1964; 43: 1104.
1963
Kagen, L.J.; Leddy, J.P.; Becker, E.L. "Isolation of two permeability globulins from human serum". Nature. 1963; 197: 693.
1963
Kagen, L.J.; Leddy, J.P.; Becher, E.L. "The presence of two permeability globulins in human serum". Journal of Clinical Investigation. 1963; 42: 1353.
1963
Allison, R.B.; Rodriquez, F.L.; Higgins, E.A.; Leddy, J.P.; Abelmann, W.H., Ellis, L.B.; Robbins, S.L. "Clinicopathologic correlation in coronary atherosclerosis: 430 patients studied with postmortem coronary angiography". Circulation. 1963; 27: 170.
1962
Leddy, J.P.; Trabold, N.C., Baughan, J.H.; Swisher, S.N. "The unitary nature of "complete" and "incomplete" pathologic cold hemagglutinins". Blood. 1962; 19: 379.
1962
Leddy, J.P.; Freeman, G.L.; Luz, A.; Todd, R.H.;. "Inactivation of the skin-sensitizing antibodies of human allergy by thiols". Proceedings of the Society for Experimental Biology and Medicine. 1962; 111: 7.
1960
Tashijian, A.H.; Leddy, J.P. "Agranulocytosis associated with phenindione". Archives of Internal Medicine. 1960; 105: 121.

Books

1995
JP Leddy. "Electophoretic and immunochemical analysis of human immunoglobulins". Hematology - Basic Principles and Practice. R Hoffman, et al. New York: Churchill-Livingstone, 1995. 2265-2274
1995
JP Leddy. "Immune Hemolytic Anemia". Clinical Immunology: Principles and Practice. R Rich et al. St Louis: Mosby-Year Book, Inc, 1995. 1273-1288
1995
CH Packman, JP Leddy. "Acquired hemolytic anemia due to warm-reacting autoantibodies". Hematology. WJ Williams, et al. New York: McGraw-Hill, 1995. 677-685
1995
CH Packman, JP Leddy. "Cryopathic hemolytic syndromes". Op Cit. : not given, 1995. 685-691
1995
CH Packman, JP Leddy. "Drug-related immunologic injury of erythrocytes". Op Cit. : not given, 1995. 691-697
1991
JP Leddy. "Electrophoretic and immunochemical analysis of human immunoglobulins". Hematology - Basic Principles and Practice. R Hoffman et al. New York: Churchill-Livingstone, 1991. 1827-1835
1990
CH Packman, JP Leddy. "Acquired hemolytic anemia due to wrm-reaching autoantibodies". Hematology. WJ Williams, et al. New York: McGraw-Hill, 1990. 666-674
1990
CH Packman, JP Leddy. "Cryopathic hemolytic syndromes". Op Cit. : not given, 1990. 675-680
1990
Ch Packman, JP Leddy. "Drug-related immunologic injury of erythrocytes". Op Cit. : not given, 1990.
1986
JP Leddy, SI Rosenfeld. "Role of Complement in Hemolytic Anemia and Thrombocytopenia". Immunology of the Complement System. GD Ross. : not given, 1986.
1983
J.P. Leddy, C.H. Packman. "Acquired Hemolytic Anemia Due to Warm-Reacting Autoantibodies". Hematology. WJ Williams, E Beutler, AJ Erslev, MA Lichtman. New York: McGraw-Hill Book Company, 1983. 632-641
1983
J.P. Leddy, C.H. Packman. "Cryopathic Hemolytic Syndromes". Hematology. WJ Williams, E Beutler, AJ Erslev, MA Lichtman. New York: McGraw-Hill Book Company, 1983. 642-647
1983
J.P. Leddy, C.H. Packman. "Drug-Related Immunologic Injury of Erythroctes". Hematology. WJ Williams, E Beutler, AJ erslev, MA Lichtman. New York: McGraw-Hill Book Company, 1983. 647-652
1981
J.P. Leddy; S.I. Rosenfeld. "Complement and its Alteration in Diseases". Principles Diagnosis in Medicine. Milgrom, Abeyounis and Kano. : Lea and Febiger, 1981.
1978
J.P. Leddy, C.H. Packman. "hypergammaglobulinemia: Monoclonal and Polyclonal States". Hematology for Practitioners. M.A. Lichtman. : Little, Brown and Company, 1978.
1978
J.P. Leddy; S.N. Swisher. "Acquired Immune Hemolytic Disorders (Including Drug-Induced Immune Hemolytic Anemia)". Immunological Diseases. M Samer et al. : Little, Brown and Company, 1978.
1978
J.P. Leddy; J. Nusbacher. "Immune Hemolytic Anemia and Immune Thrombocytopenic Purpura". Principles of Immunological Diagosis in Medicine. Milgrom. Abeyounis and Kano. : Lea and Febiger, 1978.
1978
J.P. Leddy, J. Baum, S. Rosenfeld. "Genetic Deficiencies of Complement-Derived Chemotactic Factors". Leukocyte Chemotaxis: Methods, Physiology and Clinical Implications. J.I. Gallin and P.G. Quie. New York: Raven Press, 1978.
1971
J.P. Leddy; S.N. Swisher. "Acquired Immune Hemolytic Disease". Immunological Diseases. M. Samter, et al. : Little, Brown and Company, 1971.
1971
J.P. Leddy; R.F. Bakemeier. "Autoimmune Hemolytic Anemia". Hematology for Internists. R.I. Weed, et al. : Little, Brown and Company, 1971.
1965
J.P. Leddy. "Aspermatogensis, orchitis and infertility". Immunological Diseases. M. Samter, et al. : Little, Brown and Company, 1965.
1965
J.P. Leddy, R.F. Bakemeier. "Sjogren's Syndrome". Immunological Diseases. M. Samter, et al. : Little, Brown and Company, 1965.
1963
J.P. Leddy, R.W. Hills; S.N. Swisher; J.H. Vaughn. "Observations on the Immunochemical Nature of Red Cell Autosensitization". Immunopathology, Third International Symposium. Basel. : Schwabe and Company, 1963. 318