Michael John Zuscik, Ph.D.

Michael John Zuscik, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Books

2006
Zuscik MJ, Drissi H, Chen D and Rosier RN. "Cell and molecular biology in orthopaedics.". Orthopaedic Basic Science: Biology and Biomechanics of the Musculoskeletal. Buckwalter JA, Einhorn TA and Simon SR, eds.. Rosemont, IL: AAOS Press,, 2006.
2005
Drissi H, Zuscik MJ, Rosier RN and O'Keefe RJ. "Transcriptional regulation of chondrocyte maturation: Potential involvement of transcription factors in OA pathogenesis.". Molecular Aspects of Medicine. Amsterdam, Netherlands: MAM is Elsevier, 2005.
2003
Zuscik MJ, Rosier RN and Schwarz EM. "Altered negative regulation of transforming growth factor-b signaling in scleroderma: Potential involvement of Smurf2 in disease. 48:1779-1780.". Athritis and Rheumatism. Hoboken, NJ: A&R is John Wiley and Sons, Inc., 2003.
2003
O'Keefe RJ, Schwarz EM, Ionescu AI, Zuscik MJ, Zhang X, Puzas JE and Rosier RN. "Transforming growth factor-b and chondrocyte differentiation.". In: Molecular Biology in Orthopaedics. Rosier RN and Evans CH, eds.. Rosemont, IL.: AAOS Press, 2003.
2002
Perez DM, Zuscik MJ, Ross SA and Waugh DJJ. "Point mutations and chimeric receptors in studies of ligand binding domains and second messenger activation of a1-adrenoceptors.". In: Receptors: New Objectives, New Techniques. Stanford SC, Horton RW, eds. New York, NY: Oxford University Press, 2002.
2000
Perez DM, Zuscik MJ. "Polymerase chain reaction screening of genomic libraries for adrenergic receptor genes.". Methods in Molecular Biology. CA Machida. Totowa, NJ: Humana Press, 2000.
2000
Perez DM, Zuscik MJ. "Solution-phase library screening for identification of rare adrenergic receptor clones.". Methods in Molecular Biology. CA Machida. Totowa, NJ: Humana Press, 2000.

Journal Articles

Showing all 57 journal articles available.

2008 Jun 5
Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH. "Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis." Oncogene. 2008 Jun 5; 27(25):3605-14. Epub 2008 Jan 28.
2008 May
Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN. "Regulation of embryonic endochondral ossification by Smurf2." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 May; 26(5):704-12.
2008 Mar
Usui M, Xing L, Drissi H, Zuscik M, O'Keefe R, Chen D, Boyce BF. "Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2008 Mar; 23(3):314-25.
2008 Mar
Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y, Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA. "Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery." Molecular therapy : the journal of the American Society of Gene Therapy. 2008 Mar; 16(3):466-73. Epub 2008 Jan 08.
2008 Feb
Zuscik MJ, Hilton MJ, Zhang X, Chen D, O'Keefe RJ. "Regulation of chondrogenesis and chondrocyte differentiation by stress." The Journal of clinical investigation.. 2008 Feb; 118(2):429-38.
2008
Wu,Q.; Wang,M.; Zuscik,M. J.; Chen,D.; O'Keefe,R. J.; Rosier,R. N.;. "Regulation of embryonic endochondral ossification by Smurf2". J.Orthop.Res.. 2008; . Link
2007 Nov
Dao DY, Yang X, Chen D, Zuscik M, O'Keefe RJ. "Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways." Annals of the New York Academy of Sciences.. 2007 Nov; 1116:82-99.
2007 Aug
Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. "Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2007 Aug; 22(8):1260-70.
2007 Aug
Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM. "Recent advances in gene delivery for structural bone allografts." Tissue engineering. 2007 Aug; 13(8):1973-85.
2007 Mar
Holz JD, Sheu TJ, Drissi H, Matsuzawa M, Zuscik MJ, Puzas JE. "Environmental agents affect skeletal growth and development." Birth defects research. Part C, Embryo today : reviews. 2007 Mar; 81(1):41-50.
2007 Jan
Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O'Keefe RJ, Chen D. "Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase." Genesis (New York, N.Y. : 2000). 2007 Jan; 45(1):44-50.
2007
Bärnighausen T, Liu Y, Zhang X, Sauerborn R. "Willingness to pay for social health insurance among informal sector workers in Wuhan, China: a contingent valuation study." BMC health services research. 2007 7:114. Epub 2007 Jul 20.
2006 Jul 28
Li TF, Chen D, Wu Q, Chen M, Sheu TJ, Schwarz EM, Drissi H, Zuscik M, O'Keefe RJ. "Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes." The Journal of biological chemistry.. 2006 Jul 28; 281(30):21296-304. Epub 2006 May 10.
2006 Apr
Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT. "Autoimmunity and bone." Annals of the New York Academy of Sciences.. 2006 Apr; 1068:275-83.
2006 Apr
O'Keefe RJ, Tiyapatanaputi P, Xie C, Li TF, Clark C, Zuscik MJ, Chen D, Drissi H, Schwarz E, Zhang X. "COX-2 has a critical role during incorporation of structural bone allografts." Annals of the New York Academy of Sciences.. 2006 Apr; 1068:532-42.
2006 Feb 10
Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'keefe RJ, Chen D. "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." The Journal of biological chemistry.. 2006 Feb 10; 281(6):3569-76. Epub 2005 Nov 18.
2006 Jan 1
Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN. "Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB." Experimental cell research.. 2006 Jan 1; 312(1):40-50. Epub 2005 Nov 02.
2006 Jan
Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ. "Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2006 Jan; 21(1):4-16. Epub 2005 Sep 19.
2005 Aug 1
Dong Y, Drissi H, Chen M, Chen D, Zuscik MJ, Schwarz EM, O'Keefe RJ. "Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta." Journal of cellular biochemistry. 2005 Aug 1; 95(5):1057-68.
2005 Jul
Wei X, Zhang X, Zuscik MJ, Drissi MH, Schwarz EM, O'Keefe RJ. "Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 Jul; 20(7):1136-48. Epub 2005 Feb 14.
2005 Jun
Drissi H, Zuscik M, Rosier R, O'Keefe R. "Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis." Molecular aspects of medicine. 2005 Jun; 26(3):169-79.
2005 Jun
Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. "Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency." Environmental health perspectives.. 2005 Jun; 113(6):749-55.
2005 Mar 18
Clark CA, Schwarz EM, Zhang X, Ziran NM, Drissi H, O'Keefe RJ, Zuscik MJ. "Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation." Biochemical and biophysical research communications.. 2005 Mar 18; 328(3):764-76.
2005
Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN. "Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase." Journal of cellular biochemistry. 2005 96(6):1262-73.
2004 Oct 15
Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ. "PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling." Experimental cell research.. 2004 Oct 15; 300(1):159-69.
2004 Sep 10
Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. "Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway." Experimental cell research.. 2004 Sep 10; 299(1):128-36.
2004 Jul
Ferguson CM, Schwarz EM, Puzas JE, Zuscik MJ, Drissi H, O'Keefe RJ. "Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jul; 22(4):687-96.
2004 May 15
Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN. "5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes." Journal of cellular biochemistry. 2004 May 15; 92(2):316-31.
2004 May
Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. "Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation." Bone.. 2004 May; 34(5):809-17.
2004 Mar
Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ. "CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter." Journal of cellular physiology. 2004 Mar; 198(3):428-40.
2003 Sep
Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ. "Smad6 is induced by BMP-2 and modulates chondrocyte differentiation." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Sep; 21(5):908-13.
2003 Sep
Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ. "ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2003 Sep; 18(9):1593-604.
2003 Aug 1
Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, O'Keefe RJ. "ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation." Experimental cell research.. 2003 Aug 1; 288(1):198-207.
2003 Jul
Zuscik MJ, Rosier RN, Schwarz EM. "Altered negative regulation of transforming growth factor beta signaling in scleroderma: potential involvement of SMURF2 in disease." Arthritis and rheumatism. 2003 Jul; 48(7):1779-80.
2003 Jun
Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ. "Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5." Endocrinology. 2003 Jun; 144(6):2514-23.
2003 Feb
Yun J, Zuscik MJ, Gonzalez-Cabrera P, McCune DF, Ross SA, Gaivin R, Piascik MT, Perez DM. "Gene expression profiling of alpha(1b)-adrenergic receptor-induced cardiac hypertrophy by oligonucleotide arrays." Cardiovascular research. 2003 Feb; 57(2):443-55.
2003 Jan 3
Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE. "A phage display technique identifies a novel regulator of cell differentiation." The Journal of biological chemistry.. 2003 Jan 3; 278(1):438-43. Epub 2002 Oct 25.
2003
Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. "Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes." Journal of cellular biochemistry. 2003 90(6):1287-98.
2002 Nov
Papay R, Zuscik MJ, Ross SA, Yun J, McCune DF, Gonzalez-Cabrera P, Gaivin R, Drazba J, Perez DM. "Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation." Journal of neurochemistry. 2002 Nov; 83(3):623-34.
2002 Nov
Kunieda T, Zuscik MJ, Boongird A, Perez DM, Lüders HO, Najm IM. "Systemic overexpression of the alpha 1B-adrenergic receptor in mice: an animal model of epilepsy." Epilepsia. 2002 Nov; 43(11):1324-9.
2002 Sep
Zuscik MJ, O'Keefe RJ, Gunter TE, Puzas JE, Schwarz EM, Rosier RN. "Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Sep; 20(5):1079-90.
2002 Jul
Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ. "Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jul; 20(4):811-8.
2002 Jun 10
Zuscik MJ, D'Souza M, Ionescu AM, Gunter KK, Gunter TE, O'Keefe RJ, Schwarz EM, Puzas JE, Rosier RN. "Growth plate chondrocyte maturation is regulated by basal intracellular calcium." Experimental cell research.. 2002 Jun 10; 276(2):310-9.
2001 Jul 6
Waugh DJ, Gaivin RJ, Zuscik MJ, Gonzalez-Cabrera P, Ross SA, Yun J, Perez DM. "Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists." The Journal of biological chemistry.. 2001 Jul 6; 276(27):25366-71. Epub 2001 Apr 30.
2001 Apr 27
Zuscik MJ, Chalothorn D, Hellard D, Deighan C, McGee A, Daly CJ, Waugh DJ, Ross SA, Gaivin RJ, Morehead AJ, Thomas JD, Plow EF, McGrath JC, Piascik MT, Perez DM. "Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1B-adrenergic receptor." The Journal of biological chemistry.. 2001 Apr 27; 276(17):13738-43. Epub 2001 Feb 01.
2000 Apr 21
Waugh DJ, Zhao MM, Zuscik MJ, Perez DM. "Novel aromatic residues in transmembrane domains IV and V involved in agonist binding at alpha(1a)-adrenergic receptors." The Journal of biological chemistry.. 2000 Apr 21; 275(16):11698-705.
2000
Perez DM, Zuscik MJ. "Polymerase chain reaction screening of genomic libraries for adrenergic receptor genes." Methods in molecular biology.. 2000 126:73-89.
2000
Perez DM, Zuscik MJ. "Solution-phase library screening for identification of rare adrenergic receptor clones." Methods in molecular biology.. 2000 126:91-116.
2000
Zuscik MJ, Sands S, Ross SA, Waugh DJ, Gaivin RJ, Morilak D, Perez DM. "Overexpression of the alpha1B-adrenergic receptor causes apoptotic neurodegeneration: multiple system atrophy." Nature medicine.. 2000 6(12):1388-94.
1999
Zuscik MJ, Piascik MT, Perez DM. "Cloning, cell-type specificity, and regulatory function of the mouse alpha(1B)-adrenergic receptor promoter." Molecular pharmacology.. 1999 56(6):1288-97.
1998 Feb 6
Zuscik MJ, Porter JE, Gaivin R, Perez DM. "Identification of a conserved switch residue responsible for selective constitutive activation of the beta2-adrenergic receptor." The Journal of biological chemistry.. 1998 Feb 6; 273(6):3401-7.
1997 May 19
Zuscik MJ, Gunter TE, Puzas JE, Rosier RN. "Characterization of voltage-sensitive calcium channels in growth plate chondrocytes." Biochemical and biophysical research communications.. 1997 May 19; 234(2):432-8.
1995 Oct
Martinez DA, Zuscik MJ, Ishibe M, Rosier RN, Romano PR, Cushing JE, Puzas JE. "Identification of functional insulin-like growth factor-II/mannose-6-phosphate receptors in isolated bone cells." Journal of cellular biochemistry. 1995 Oct; 59(2):246-57.
1994 Aug
Zuscik MJ, Gunter TE, Rosier RN, Gunter KK, Puzas JE. "Activation of phosphoinositide metabolism by parathyroid hormone in growth plate chondrocytes." Cell calcium. 1994 Aug; 16(2):112-22.
1994
Zuscik MJ, Puzas JE, Rosier RN, Gunter KK, Gunter TE. "Cyclic-AMP-dependent protein kinase activity is not required by parathyroid hormone to stimulate phosphoinositide signaling in chondrocytes but is required to transduce the hormone's proliferative effect." Archives of biochemistry and biophysics.. 1994 315(2):352-61.
1991 Nov 15
Gunter KK, Zuscik MJ, Gunter TE. "The Na(+)-independent Ca2+ efflux mechanism of liver mitochondria is not a passive Ca2+/2H+ exchanger." The Journal of biological chemistry.. 1991 Nov 15; 266(32):21640-8.
1990 Aug
Gunter TE, Zuscik MJ, Puzas JE, Gunter KK, Rosier RN. "Cytosolic free calcium concentrations in avian growth plate chondrocytes." Cell calcium. 1990 Aug; 11(7):445-57.