Carl J. Johnston, Ph.D.

Carl J. Johnston, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-5948

Books

1998
Oberdörster G, Gelein R, Johnston C, Mercer P, Corson N, Finkelstein J.. "Ambient ultrafine particles: Inducers of acute injury?". Relationships between respiratory disease and exposure to air pollution. Dungworth et al, U Mohr. Washington, DC: ILSI Monographs, ILSI press, 1998. 216-229
1998
Reynolds PR, Romano PR, Chi H, Wang J, Reynolds SD, Johnston C, Leboy PS, Tiller GE, Dasouk MJ, O'Keefe RJ, Puzas E, Rosier RN. "Identification and characterization of a novel phosphatase with a role in the growth plate chondrocyte maturation". Skeletal growth and development. JA Buckwalter, MG Ehrlich, LJ Sandell, SB Tripped. Rosemont, IL: American Academy of Orthopaedic Surgeons, 1998. 359-370

Journal Articles

Showing all 61 journal articles available.

2013
Allen JA, Conrad K, Oberdörster G, Johnston CJ, Sleezer B, Cory-Slecta DA. "Developmental exposure to concentrated ambient particles and preference for immediate reward in mice". Env Health Perspect. 2013; 121(1): 32-38. Link
2013
Manning CM, Johnston CJ, Reed CK, Lawrence BP, Williams JP, Finkelstein JN. "Lung Irradiation Increases Mortality Following Influenza A Virus Challenge Occurring Late After Exposure". International Journal of Radiation Oncology*Biology*Physics. 2013; 86(1): 128-135. Link
2013
Johnston CJ, Manning CM, Rangel-Moreno J, Randall TD, Hernady E, Finkelstein JN, Williams JP. "Neonatal Irradiation Sensitizes Mice to Delayed Pulmonary Challenge". Radiation Research. 2013; 179(4): 475-484. Link
2013
Manning CM, Johnston CJ, Hernady E, Miller JH, Reed CK, Lawrence BP, Williams JP, Finkelstein JN. "Exacerbation of lung radiation injury by viral infection: The role of Clara cells and Clara cell secretory protein". Radiation Research. 2013; Accepted. Link
2011 Aug
Johnston CJ, Manning C, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP. "Effect of Low Total Body Irradiation on Late Lung Effects: Hidden Danger". Int J Radiat Biol. 2011; 82(8): 902-13. Link
2010
Chess P; Benson R; Maniscalco W; Wright T; O'Reilly M; Johnston C. "Murine Mechanical Ventilation Stimulates Alveolar Epithelial Cell Proliferation." Exp Lung Res. 2010; 36: 331-341. Link
2010
Johnston CJ; Hernady E; Reed C; Thurston SW; Finkelstein JN; Williams JP. "Early Alterations in Cytokine Expression: Surrogate Markers in Adult vs Developing Lung in Mice Following Radiation Exposure." Radiation Research. 2010; 173: 522-535. Link
2010
Williams JP, Johnston CJ and Finkelstein JN. "Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?". Curr Drug Targets. 2010; 11(11): 1386-94. Link
2009
Saperstein S; Huyck H; Kimball E; Johnston CJ; Finkelstein JN; Pryhuber G. "The Effects of Interleukin-1 beta in tumor Necrosis Factor-alpha-induced Acute Pulmonary Inflammation in Mice." Mediators of Inflammation. 2009; : [Epub 958658]. Link
2006 Oct
Johnston CJ, Holm BA, Gelein R, Finkelstein JN. "Postnatal lung development: immediate-early gene responses post ozone and LPS exposure." Inhalation toxicology. 2006 Oct; 18(11):875-83.
2006 Jun
Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA. "p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth." The American journal of pathology.. 2006 Jun; 168(6):1838-47.
2005 May
Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW. "Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells." Infection and immunity.. 2005 May; 73(5):2766-77.
2005 May
Johnston CJ, Holm BA, Finkelstein JN. "Sequential exposures to ozone and lipopolysaccharide in postnatal lung enhance or inhibit cytokine responses." Experimental lung research. 2005 May; 31(4):431-47.
2005
Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G. "Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate." Experimental lung research. 2005 31(6):527-46.
2004 May
Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN. "Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model." Radiation research.. 2004 May; 161(5):560-7.
2004 Apr
Finkelstein JN, Johnston CJ. "Enhanced sensitivity of the postnatal lung to environmental insults and oxidant stress." Pediatrics.. 2004 Apr; 113(4 Suppl):1092-6.
2004 Jan
D'Angio CT, LoMonaco MB, Johnston CJ, Reed CK, Finkelstein JN. "Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage." American journal of physiology. Lung cellular and molecular physiology.. 2004 Jan; 286(1):L30-6. Epub 2003 Aug 08.
2004
Johnston CJ; Holm BA; Finkelstein JN. "Differential proinflammatory cytokine responses of the lung to ozone and lipopolysaccharide exposure during postnatal development." Exp Lung Res. 2004; 30(7): 599-614. Link
2004
Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN. "Inflammatory cell recruitment following thoracic irradiation." Experimental lung research. 2004 30(5):369-82.
2003 Jun
Hjort MR, Brenyo AJ, Finkelstein JN, Frampton MW, LoMonaco MB, Stewart JC, Johnston CJ, D'Angio CT. "Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release." Inflammation. 2003 Jun; 27(3):137-45.
2002 Sep
Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN. "Endotoxin potentiates ozone-induced pulmonary chemokine and inflammatory responses." Experimental lung research. 2002 Sep; 28(6):419-33.
2002 Mar
Johnston CJ, Williams JP, Okunieff P, Finkelstein JN. "Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families." Radiation research.. 2002 Mar; 157(3):256-65.
2001 Aug
Johnston CJ, Oberdörster G, Finkelstein JN. "Recovery from oxidant-mediated lung injury: response of metallothionein, MIP-2, and MCP-1 to nitrogen dioxide, oxygen, and ozone exposures." Inhalation toxicology. 2001 Aug; 13(8):689-702.
2000 Nov 1
Johnston CJ, Finkelstein JN, Mercer P, Corson N, Gelein R, Oberdörster G. "Pulmonary effects induced by ultrafine PTFE particles." Toxicology and applied pharmacology.. 2000 Nov 1; 168(3):208-15.
2000 Aug
Johnston CJ, Driscoll KE, Finkelstein JN, Baggs R, O'Reilly MA, Carter J, Gelein R, Oberdörster G. "Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica." Toxicological sciences : an official journal of the Society of Toxicology.. 2000 Aug; 56(2):405-13.
2000 Mar
Johnston CJ, Reed CK, Avissar NE, Gelein R, Finkelstein JN. "Antioxidant and inflammatory response after acute nitrogen dioxide and ozone exposures in C57Bl/6 mice." Inhalation toxicology. 2000 Mar; 12(3):187-203.
2000 Mar
Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN. "Newborn mice differ from adult mice in chemokine and cytokine expression to ozone, but not to endotoxin." Inhalation toxicology. 2000 Mar; 12(3):205-24.
2000 Mar
Elder AC, Finkelstein J, Johnston C, Gelein R, Oberdörster G. "Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice." Inhalation toxicology. 2000 Mar; 12(3):225-43.
2000
Oberdörster G, Finkelstein J, Johnston C, Gelein R, Cox C, Baggs R, Elder A. "Ultrafine particles as inducers of acute lung injury: Mechanisms and correlation with age and disease". Health Effects Institute. 2000; Report # 96: 1-88. Link
1999 Jul
Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN. "Chemokine gene expression during Pneumocystis carinii-driven pulmonary inflammation." Infection and immunity.. 1999 Jul; 67(7):3452-60.
1999 Jun
Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. "Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha-induced oxidant stress." The American journal of physiology.. 1999 Jun; 276(6 Pt 1):L979-88.
1999
Barrett EG, Johnston C, Finkelstein JN, Oberdöerster G. "Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure". Toxicol Appl Pharm. 1999; 158(3): 211-220. Link
1999
Barrett EG, Johnston C, Finkelstein JN, Oberdöerster G. "Silica selectively binds apolipoprotein-A1 resulting in a shift of the dose-response for silica-induced chemokine expression in alveolar type II cells". Toxicol Appl Pharm. 1999; 161(2): 111-122. Link
1999
Johnston CJ, Finkelstein JN, Oberdörster G, Reynolds SD, Stripp BR. "Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin." Experimental lung research. 1999 25(1):7-21.
1999
Johnston CJ, Stripp BR, Reynolds SD, Avissar NE, Reed CK, Finkelstein JN. "Inflammatory and antioxidant gene expression in C57BL/6J mice after lethal and sublethal ozone exposures." Experimental lung research. 1999 25(1):81-97.
1998 Aug
Mango GW, Johnston CJ, Reynolds SD, Finkelstein JN, Plopper CG, Stripp BR. "Clara cell secretory protein deficiency increases oxidant stress response in conducting airways." The American journal of physiology.. 1998 Aug; 275(2 Pt 1):L348-56.
1998 Jun
Piedboeuf B, Horowitz S, Johnston CJ, Gamache M, Bélanger S, Poubelle PE, Welty SE, Watkins RH. "Interleukin-1 expression during hyperoxic lung injury in the mouse." Free radical biology & medicine.. 1998 Jun; 24(9):1446-54.
1998
Johnston CJ, Finkelstein JN,Gelein R, Oberdörster G. "Pulmonary inflammatory responses and cytokine and antioxidant mRNA levels in the lungs of young and old C57Bl/6 mice after exposure to teflon fumes". Inh Tox. 1998; 10(10): 931-953. Link
1998
Johnston CJ, Stripp BR, Piedbeouf B, Wright TW, Mango GW, Reed CK, Finkelstein JN. "Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury." Experimental lung research. 1998 24(2):189-202.
1998
Johnston CJ, Wright TW, Rubin P, Finkelstein JN. "Alterations in the expression of chemokine mRNA levels in fibrosis-resistant and -sensitive mice after thoracic irradiation." Experimental lung research. 1998 24(3):321-37.
1998
D'Angio CT, Johnston CJ, Wright TW, Reed CK, Finkelstein JN. "Chemokine mRNA alterations in newborn and adult mouse lung during acute hyperoxia." Experimental lung research. 1998 24(5):685-702.
1998
Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. "Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha." The American journal of physiology.. 1998 275(6 Pt 1):L1110-9.
1998
Johnston CJ, Finkelstein JN, Gelein R, Oberdörster G. "Pulmonary cytokine and chemokine mRNA levels after inhalation of lipopolysaccharide in C57BL/6 mice." Toxicological sciences : an official journal of the Society of Toxicology.. 1998 46(2):300-7.
1997 Jan
O'Reilly MA, Staversky RJ, Flanders KC, Johnston CJ, Finkelstein JN. "Temporal changes in expression of TGF-beta isoforms in mouse lung exposed to oxygen." The American journal of physiology.. 1997 Jan; 272(1 Pt 1):L60-7.
1997
Johnston CJ, Mango GW, Finkelstein JN, Stripp BR. "Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice". American Journal of Respiratory Cell and Molecular Biology : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 1997; 17(2): 147-155. Link
1997
Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN. "Analysis of cytokine mRNA profiles in the lungs of Pneumocystis carinii-infected mice". American Journal of Respiratory Cell and Molecular Biology: An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 1997; 17(4): 491-500. Link
1997
Finkelstein JN, Johnston C, Barrett T, Oberdöerster G. "Particle-cell interactions in pulmonary epithelial gene expression". Env Health Perspect. 1997; 105(suppl 5): 1179-1182. Link
1997
Johnston CJ, Wright TW, Reed CK, Finkelstein JN. "Comparison of adult and newborn pulmonary cytokine mRNA expression after hyperoxia." Experimental lung research. 1997 23(6):537-52.
1996 Nov
Driscoll KE, Howard BW, Carter JM, Asquith T, Johnston C, Detilleux P, Kunkel SL, Isfort RJ. "Alpha-quartz-induced chemokine expression by rat lung epithelial cells: effects of in vivo and in vitro particle exposure." The American journal of pathology.. 1996 Nov; 149(5):1627-37.
1996 Oct
Stripp BR, Lund J, Mango GW, Doyen KC, Johnston C, Hultenby K, Nord M, Whitsett JA. "Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals." The American journal of physiology.. 1996 Oct; 271(4 Pt 1):L656-64.
1996 Sep
Johnston CJ, Finkelstein JN, Gelein R, Baggs R, Oberdörster G. "Characterization of the early pulmonary inflammatory response associated with PTFE fume exposure." Toxicology and applied pharmacology.. 1996 Sep; 140(1):154-63.
1996 Jul 10
Reynolds SD, Johnston C, Leboy PS, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. "Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy." Experimental cell research.. 1996 Jul 10; 226(1):197-207.
1996 Jun
Johnston CJ, Piedboeuf B, Rubin P, Williams JP, Baggs R, Finkelstein JN. "Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation." Radiation research.. 1996 Jun; 145(6):762-7.
1996 Mar
Oberdörster G, Finkelstein J, Ferin J, Godleski J, Chang LY, Gelein R, Johnston C, Crapo JD. "Ultrafine particles as a potential environmental health hazard. Studies with model particles." Chest. 1996 Mar; 109(3 Suppl):68S-69S.
1995 Aug 30
Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. "A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis." International journal of radiation oncology, biology, physics.. 1995 Aug 30; 33(1):99-109.
1995 May
Johnston CJ, Piedboeuf B, Baggs R, Rubin P, Finkelstein JN. "Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis." Radiation research.. 1995 May; 142(2):197-203.
1994 Feb 1
Finkelstein JN, Johnston CJ, Baggs R, Rubin P. "Early alterations in extracellular matrix and transforming growth factor beta gene expression in mouse lung indicative of late radiation fibrosis." International journal of radiation oncology, biology, physics.. 1994 Feb 1; 28(3):621-31.
1994
Piedboeuf B, Johnston CJ, Watkins RH, Hudak BB, Lazo JS, Cherian MG, Horowitz S. "Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure". American Journal of Respiratory Cell and Molecular Biology: An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 1994; 10(2): 123-132. Link
1991
Veness-Meehan KA, Cheng ER, Mercier CE, Blixt SL, Johnston CJ, Watkins RH, Horowitz S. "Cell-specific alterations in expression of hyperoxia-induced mRNAs of lung". American Journal of Respiratory Cell and Molecular Biology: An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 1991; 5(6): 516-521. Link
1990 Feb
Horowitz S, Shapiro DL, Finkelstein JN, Notter RH, Johnston CJ, Quible DJ. "Changes in gene expression in hyperoxia-induced neonatal lung injury." The American journal of physiology.. 1990 Feb; 258(2 Pt 1):L107-11.
1988
Black JJ, Maccubin AE, Johnston CJ. "Carcinogenicity of benzo(a) pyrene in the rainbow trout as the result of ovo exposure by egg microinjection." Aquatic Toxicology. 1988; 13(4): 297-308. Link