Janet L. Dehoff-Sparks, Ph.D.

Janet L. Dehoff-Sparks, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Bpx 626
Rochester, NY 14642

Office: (585) 275-7755
Fax: (585) 756-5337

Journal Articles

Showing all 69 journal articles available.

2014 Oct
Yu IC, Lin HY, Sparks JD, Yeh S, Chang C. "Androgen Receptor Roles in Insulin Resistance and Obesity in Males: The Linkage of Androgen-Deprivation Therapy to Metabolic Syndrome." Diabetes. 2014 Oct; 63(10):3180-3188.
2014 Jun
Huang CK, Pang H, Wang L, Niu Y, Luo J, Chang E, Sparks JD, Lee SO, Chang C. "New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis." Hypertension. 2014 Jun; 63(6):1345-53. Epub 2014 Mar 31.
2014 Jun
Sparks CE, Corsetti JP, Sparks JD. "High-density lipoproteins: taking the good with the bad." Current opinion in lipidology. 2014 Jun; 25(3):230-2.
2014
Greene MW, Burrington CM, Lynch DT, Davenport SK, Johnson AK, Horsman MJ, Chowdhry S, Zhang J, Sparks JD, Tirrell PC. "Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis." PloS one. 2014 9(1):e85848. Epub 2014 Jan 15.
2013 Oct
Sparks CE, Sparks JD. "Hepatic postprandial transition and very low-density lipoprotein biogenesis." Current opinion in lipidology. 2013 Oct; 24(5):450-2.
2013 Jun 14
Sparks JD, O'Dell C, Chamberlain JM, Sparks CE. "Insulin-dependent apolipoprotein B degradation is mediated by autophagy and involves class I and class III phosphatidylinositide 3-kinases." Biochemical and biophysical research communications. 2013 Jun 14; 435(4):616-20. Epub 2013 May 15.
2013 Feb
Yu IC, Lin HY, Liu NC, Sparks JD, Yeh S, Fang LY, Chen L, Chang C. "Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-?B-mediated PTP1B expression." Diabetes. 2013 Feb; 62(2):411-23. Epub 2012 Nov 08.
2012 Sep
Sparks JD, Sparks CE, Adeli K. "Selective hepatic insulin resistance, VLDL overproduction, and hypertriglyceridemia." Arteriosclerosis, thrombosis, and vascular biology. 2012 Sep; 32(9):2104-12. Epub 2012 Jul 12.
2011 May
Kim E, Liu NC, Yu IC, Lin HY, Lee YF, Sparks JD, Chen LM, Chang C. "Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity." Diabetes. 2011 May; 60(5):1493-503. Epub 2011 Apr 08.
2011 Mar 11
Sparks JD, Chamberlain J, O'Dell C, Khatun I, Hussain MM, Sparks CE. "Acute suppression of apo B secretion by insulin occurs independently of MTP." Biochemical and biophysical research communications. 2011 Mar 11; 406(2):252-6. Epub 2011 Feb 18.
2011 Jan 17
Nigro P, Satoh K, O'Dell MR, Soe NN, Cui Z, Mohan A, Abe JI, Alexis JD, Sparks JD, Berk BC. "Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice." The Journal of experimental medicine. 2011 Jan 17; 208(1):53-66. Epub 2010 Dec 20.
2010 Nov
Galloway CA, Ashton J, Sparks JD, Mooney RA, Smith HC. "Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes." Biochimica et biophysica acta. 2010 Nov; 1802(11):976-85. Epub 2010 Jun 09.
2010 Oct
Sparks JD, Cianci J, Jokinen J, Chen LS, Sparks CE. "Interleukin-6 mediates hepatic hypersecretion of apolipoprotein B." American journal of physiology. Gastrointestinal and liver physiology. 2010 Oct; 299(4):G980-9. Epub 2010 Jul 22.
2009 Jun
Sparks JD, Dong HH. "FoxO1 and hepatic lipid metabolism." Current opinion in lipidology. 2009 Jun; 20(3):217-226.
2009
Caviglia, J. M.; Sparks, J. D.; Toraskar, N.; Brinker, A. M.; Yin, T. C.; Dixon, J. L.; Brasaemle, D. L.;. "ABHD5/CGI-58 facilitates the assembly and secretion of apolipoprotein B lipoproteins by McA RH7777 rat hepatoma cells". Biochim Biophys Acta. 2009; 1791(3): 198-205. Link
2008 Jun
Lin HY, Yu IC, Wang RS, Chen YT, Liu NC, Altuwaijri S, Hsu CL, Ma WL, Jokinen J, Sparks JD, Yeh S, Chang C. "Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor." Hepatology : official journal of the American Association for the Study of Liver Diseases. 2008 Jun; 47(6):1924-35.
2008 Jun
Sparks JD, Sparks CE. "Overindulgence and metabolic syndrome: is FoxO1 a missing link?" The Journal of clinical investigation. 2008 Jun; 118(6):2012-5.
2008 May
Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S, Chang C. "Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue." Endocrinology. 2008 May; 149(5):2361-8. Epub 2008 Feb 14.
2007
Liu NC, Lin WJ, Kim E, Collins LL, Lin HY, Yu IC, Sparks JD, Chen LM, Lee YF, Chang C. "Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis." Diabetes. 2007 56(12):2901-9. Epub 2007 Sep 07.
2006 Sep
Chirieac DV, Davidson NO, Sparks CE, Sparks JD. "PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice." American journal of physiology. Gastrointestinal and liver physiology. 2006 Sep; 291(3):G382-8. Epub 2006 Jun 22.
2006 Apr 15
Sparks JD, Collins HL, Chirieac DV, Cianci J, Jokinen J, Sowden MP, Galloway CA, Sparks CE. "Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase." The Biochemical journal. 2006 Apr 15; 395(2):363-71.
2006
Nieman, K. M.; Hartz, C. S.; Szegedi, S. S.; Garrow, T. A.; Sparks, J. D.; Schalinske, K. L.;. "Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats". Am J Physiol Endocrinol Metab. 2006; 291(6): E1235-42. Link
2005 Jun
Lin HY, Xu Q, Yeh S, Wang RS, Sparks JD, Chang C. "Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor." Diabetes. 2005 Jun; 54(6):1717-25.
2004 Jul
Chirieac DV, Collins HL, Cianci J, Sparks JD, Sparks CE. "Altered triglyceride-rich lipoprotein production in Zucker diabetic fatty rats." American journal of physiology. Endocrinology and metabolism. 2004 Jul; 287(1):E42-9. Epub 2004 Feb 17.
2004
Au, C. S.; Wagner, A.; Chong, T.; Qiu, W.; Sparks, J. D.; Adeli, K.;. "Insulin regulates hepatic apolipoprotein B production independent of the mass or activity of Akt1/PKBalpha". Metabolism. 2004; 53(2): 228-35. Link
2002 Sep 13
Chirieac DV, Cianci J, Collins HL, Sparks JD, Sparks CE. "Insulin suppression of VLDL apo B secretion is not mediated by the LDL receptor." Biochemical and biophysical research communications. 2002 Sep 13; 297(1):134-7.
2001
Fisher, E. A.; Pan, M.; Chen, X.; Wu, X.; Wang, H.; Jamil, H.; Sparks, J. D.; Williams, K. J.;. "The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways". J Biol Chem. 2001; 276(30): 27855-63. Link
2000 Nov
Chirieac DV, Chirieac LR, Corsetti JP, Cianci J, Sparks CE, Sparks JD. "Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production." American journal of physiology. Endocrinology and metabolism. 2000 Nov; 279(5):E1003-11.
2000 Nov
Sparks JD, Shaw WN, Corsetti JP, Bolognino M, Pesek JF, Sparks CE. "Insulin-treated Zucker diabetic fatty rats retain the hypertriglyceridemia associated with obesity." Metabolism: clinical and experimental. 2000 Nov; 49(11):1424-30.
2000 Jul 14
Collins HL, Sparks CE, Sparks JD. "B48 is preferentially translated over B100 in cells with increased endogenous apo B mRNA." Biochemical and biophysical research communications. 2000 Jul 14; 273(3):1156-60.
2000 Feb
Corsetti JP, Sparks JD, Peterson RG, Smith RL, Sparks CE. "Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats." Atherosclerosis. 2000 Feb; 148(2):231-41.
1999 Aug 1
Sowden MP, Collins HL, Smith HC, Garrow TA, Sparks JD, Sparks CE. "Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase." The Biochemical journal. 1999 Aug 1; 341 ( Pt 3):639-45.
1998 Nov 18
Van Mater D, Sowden MP, Cianci J, Sparks JD, Sparks CE, Ballatori N, Smith HC. "Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells." Biochemical and biophysical research communications. 1998 Nov 18; 252(2):334-9.
1998 Nov
Sparks JD, Phung TL, Bolognino M, Cianci J, Khurana R, Peterson RG, Sowden MP, Corsetti JP, Sparks CE. "Lipoprotein alterations in 10- and 20-week-old Zucker diabetic fatty rats: hyperinsulinemic versus insulinopenic hyperglycemia." Metabolism: clinical and experimental. 1998 Nov; 47(11):1315-24.
1997 Aug 18
Phung TL, Mooney RA, Kulas DT, Sparks CE, Sparks JD. "Suppression of the protein tyrosine phosphatase LAR reduces apolipoprotein B secretion by McA-RH7777 rat hepatoma cells." Biochemical and biophysical research communications. 1997 Aug 18; 237(2):367-71.
1997 Jul 12
Sparks JD, Collins HL, Sabio I, Sowden MP, Smith HC, Cianci J, Sparks CE. "Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells." Biochimica et biophysica acta. 1997 Jul 12; 1347(1):51-61.
1997
Phung TL, Roncone A, Jensen KL, Sparks CE, Sparks JD. "Phosphoinositide 3-kinase activity is necessary for insulin-dependent inhibition of apolipoprotein B secretion by rat hepatocytes and localizes to the endoplasmic reticulum." The Journal of biological chemistry. 1997 272(49):30693-702.
1996 Sep
Phung TL, Sowden MP, Sparks JD, Sparks CE, Smith HC. "Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat." Metabolism: clinical and experimental. 1996 Sep; 45(9):1056-8.
1996 Feb 6
Schock D, Kuo SR, Steinburg MF, Bolognino M, Sparks JD, Sparks CE, Smith HC. "An auxiliary factor containing a 240-kDa protein complex is involved in apolipoprotein B RNA editing." Proceedings of the National Academy of Sciences of the United States of America. 1996 Feb 6; 93(3):1097-102.
1996 Jan 15
Sparks JD, Phung TL, Bolognino M, Sparks CE. "Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and phosphatidylinositol 3-kinase activation: studies with brefeldin A and wortmannin in primary cultures of rat hepatocytes." The Biochemical journal. 1996 Jan 15; 313 ( Pt 2):567-74.
1996
Sparks JD, Sparks CE. "Chromatographic method for isolation and quantification of apolipoproteins B-100 and B-48." Methods in enzymology. 1996 263:104-20.
1994 Nov 30
Sparks JD, Sparks CE. "Obese Zucker (fa/fa) rats are resistant to insulin's inhibitory effect on hepatic apo B secretion." Biochemical and biophysical research communications. 1994 Nov 30; 205(1):417-22.
1994 Nov 17
Sparks JD, Sparks CE. "Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion." Biochimica et biophysica acta. 1994 Nov 17; 1215(1-2):9-32.
1994 Jun
Sparks JD, Corsetti JP, Sparks CE. "Liver regrowth and apolipoprotein B secretion by rat hepatocytes following partial hepatectomy." Metabolism: clinical and experimental. 1994 Jun; 43(6):681-90.
1994
Bjornsson, O. G.; Sparks, J. D.; Sparks, C. E.; Gibbons, G. F.;. "Regulation of VLDL secretion in primary culture of rat hepatocytes: involvement of cAMP and cAMP-dependent protein kinases". Eur J Clin Invest. 1994; 24(2): 137-48. Link
1993 Apr 5
Harris SG, Sabio I, Mayer E, Steinberg MF, Backus JW, Sparks JD, Sparks CE, Smith HC. "Extract-specific heterogeneity in high-order complexes containing apolipoprotein B mRNA editing activity and RNA-binding proteins." The Journal of biological chemistry. 1993 Apr 5; 268(10):7382-92.
1993 Apr
Corsetti JP, Sparks JD, Sikora B, Sparks CE. "Cellular heterogeneity in binding and uptake of low-density lipoprotein in primary rat hepatocytes." Hepatology : official journal of the American Association for the Study of Liver Diseases. 1993 Apr; 17(4):645-50.
1993
Chen, X.; Sparks, J. D.; Yao, Z.; Fisher, E. A.;. "Hepatic polysomes that contain apoprotein B mRNA have unusual physical properties". J Biol Chem. 1993; 268(28): 21007-13. Link
1992 Jun
Corsetti JP, Way BA, Sparks CE, Sparks JD. "Immunolocalization, quantitation and cellular heterogeneity of apolipoprotein B in rat hepatocytes." Hepatology : official journal of the American Association for the Study of Liver Diseases. 1992 Jun; 15(6):1117-24.
1992 May
Sparks JD, Zolfaghari R, Sparks CE, Smith HC, Fisher EA. "Impaired hepatic apolipoprotein B and E translation in streptozotocin diabetic rats." The Journal of clinical investigation. 1992 May; 89(5):1418-30.
1992
Bjornsson, O. G.; Duerden, J. M.; Bartlett, S. M.; Sparks, J. D.; Sparks, C. E.; Gibbons, G. F.;. "The role of pancreatic hormones in the regulation of lipid storage, oxidation and secretion in primary cultures of rat hepatocytes. Short- and long-term effects". Biochem J. 1992; 281 ( Pt 2): 381-6. Link
1992
Bjornsson, O. G.; Sparks, J. D.; Sparks, C. E.; Gibbons, G. F.;. "Prostaglandins suppress VLDL secretion in primary rat hepatocyte cultures: relationships to hepatic calcium metabolism". J Lipid Res. 1992; 33(7): 1017-27. Link
1992
Gibbons, G. F.; Bartlett, S. M.; Sparks, C. E.; Sparks, J. D.;. "Extracellular fatty acids are not utilized directly for the synthesis of very-low-density lipoprotein in primary cultures of rat hepatocytes". Biochem J. 1992; 287 ( Pt 3): 749-53. Link
1991 Jul
Corsetti JP, Sterry JA, Sparks JD, Sparks CE, Weintraub M. "Effect of weight loss on serum lipoprotein(a) concentrations in an obese population." Clinical chemistry. 1991 Jul; 37(7):1191-5.
1991 Feb 15
Smith HC, Kuo SR, Backus JW, Harris SG, Sparks CE, Sparks JD. "In vitro apolipoprotein B mRNA editing: identification of a 27S editing complex." Proceedings of the National Academy of Sciences of the United States of America. 1991 Feb 15; 88(4):1489-93.
1990 Jul 31
Backus JW, Eagleton MJ, Harris SG, Sparks CE, Sparks JD, Smith HC. "Quantitation of endogenous liver apolipoprotein B mRNA editing." Biochemical and biophysical research communications. 1990 Jul 31; 170(2):513-8.
1990 May 25
Sparks JD, Sparks CE. "Insulin modulation of hepatic synthesis and secretion of apolipoprotein B by rat hepatocytes." The Journal of biological chemistry. 1990 May 25; 265(15):8854-62.
1989 Oct 15
Kwong TC, Sparks JD, Pryce DJ, Cianci JF, Sparks CE. "Inhibition of apolipoprotein B net synthesis and secretion from cultured rat hepatocytes by the calcium-channel blocker diltiazem." The Biochemical journal. 1989 Oct 15; 263(2):411-5.
1989 Jul 1
Sparks JD, Sparks CE, Miller LL. "Insulin effects on apolipoprotein B production by normal, diabetic and treated-diabetic rat liver and cultured rat hepatocytes." The Biochemical journal. 1989 Jul 1; 261(1):83-8.
1988 Sep
Jackson TK, Salhanick AI, Sparks JD, Sparks CE, Bolognino M, Amatruda JM. "Insulin-mimetic effects of vanadate in primary cultures of rat hepatocytes." Diabetes. 1988 Sep; 37(9):1234-40.
1988 Jul
Sparks JD, Sparks CE, Bolognino M, Roncone AM, Jackson TK, Amatruda JM. "Effects of nonketotic streptozotocin diabetes on apolipoprotein B synthesis and secretion by primary cultures of rat hepatocytes." The Journal of clinical investigation. 1988 Jul; 82(1):37-43.
1988 Apr 15
Sparks JD, Sparks CE, Roncone AM, Amatruda JM. "Secretion of high and low molecular weight phosphorylated apolipoprotein B by hepatocytes from control and diabetic rats. Phosphorylation of APO BH and APO BL." The Journal of biological chemistry. 1988 Apr 15; 263(11):5001-4.
1986
Sparks, C. E.; Sparks, J. D.; Bolognino, M.; Salhanick, A.; Strumph, P. S.; Amatruda, J. M.;. "Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes". Metabolism. 1986; 35(12): 1128-36. Link
1986
Sparks, J. D.; Bolognino, M.; Trax, P. A.; Sparks, C. E.;. "The production and utility of monoclonal antibodies to rat apolipoprotein B lipoproteins". Atherosclerosis. 1986; 61(3): 205-11. Link
1986
Sparks, J. D.; Sparks, C. E.; Kritchevsky, D.;. "Hypercholesterolemia and aortic glycosaminoglycans of rabbits fed semi-purified diets containing sucrose and lactose". Atherosclerosis. 1986; 60(2): 183-96. Link
1985
Kwong, T. C.; Sparks, J. D.; Sparks, C. E.;. "Lipoprotein and protein binding of the calcium channel blocker diltiazem". Proc Soc Exp Biol Med. 1985; 178(2): 313-6. Link
1985
Sparks, J. D.; Sparks, C. E.;. "Apolipoprotein B and lipoprotein metabolism". Adv Lipid Res. 1985; 21: 1-46. Link
1979
Capuzzi, D. M.; Sparks, C. E.; DeHoff, J. L.;. "Effect of residual enzymes on degradation of radioiodinated VLDL by collagenase-dispersed hepatocytes". Biochem Biophys Res Commun. 1979; 90(2): 587-95. Link
1978
Sparks, C. E.; Dehoff, J. L.; Capuzzi, D. M.; Pietra, G.; Marsh, J. B.;. "Proteolysis of very low density lipoprotein in perfused lung". Biochim Biophys Acta. 1978; 529(1): 123-30. Link

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