Regis J. O'Keefe, M.D., Ph.D.

Regis J. O'Keefe, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Fax: (585) 756-4721
Administrative: (585) 275-3100
Office: (585) 275-5167
Administrative: (585) 273-1261

Books

Journal Articles

Showing all 287 journal articles available.

2014
Shane E, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster DW, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Howe TS, van der Meulen MC, Weinstein RS, Whyte MP. "Atypical subtrochanteric and diaphyseal femoral fractures: Second report of a task force of the American society for bone and mineral research." Journal of Bone and Mineral Research. 2014; . Link
2013
Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM. "PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis." Journal of Bone and Mineral Research. 2013; 28(3): 586-97. Link
2013
Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ. "RBP-J?-Dependent Notch Signaling Is Required for Murine Articular Cartilage and Joint Maintenance." Arthritis Rheumatology. 2013; 65(10): 2623-33. Link
2013
Bonewald LF, Kiel DP, Clemens TL, Esser K, Orwoll ES, O'Keefe RJ, Fielding RA. "Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop." Journal of Bone and Mineral Research. 2013; 28(9): 1857-65. Link
2013
Shah K, Majeed Z, Jonason J, O'Keefe RJ. "The role of muscle in bone repair: the cells, signals, and tissue responses to injury." Current Osteoporosis Reports. 2013; 11(2): 130-5. Link
2013
Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. "Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis." Connective Tissue Research. 2013; 54(3): 218-26. Link
2013
Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH. "TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages." Journal of Cell Science. 2013; 126: 5704-13. Link
2013
Giang AH, Raymond T, Brookes P, de Mesy Bentley K, Schwarz E, O'Keefe R, Eliseev R. "Mitochondrial dysfunction and permeability transition in osteosarcoma cells showing the Warburg effect." The Journal of Biological Chemistry. 2013; 288(46): 33303-11. Link
2013
Shen J, Li J, Wang B, Jin H, Wang M, Zhang Y, Yang Y, Im HJ, O'Keefe R, Chen D. "Deletion of the transforming growth factor ? receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice." Arthritis and Rheumatism. 2013; 65(12): 3107-19. Link
2012
Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. "Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression." Journal of Orthopaedic Research. 2012; 30(2): 325-33. Link
2012
Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ. "Cartilage-specific RBPj?-dependent and -independent Notch signals regulate cartilage and bone development." Development. 2012; 139(6): 1198-212. Link
2012
Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ. "Cartilage-specific ß-CATENIN signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development." Journal of Bone and Mineral Research. 2012; . Link
2012
Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ. "Ski inhibits TGF-?/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes." Journal of Cellular Biochemistry. 2012; 113(6): 2156-66. Link
2012
Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, Chen D. "Conditional activation of ?-catenin signaling leads to severe defects in intervertebral disc tissue." Arthritis and Rheumatism. 2012; . Link
2012
Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe R, Eliseev RA. "Targeting radioresistant osteosarcoma cells with parthenolide." Journal of Cellular Biochemistry. 2012; 113(4): 1282-91. Link
2012
Kung MH, Yukata K, O'Keefe RJ, Zuscik MJ. "Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene." Journal of Cellular Physiology. 2012; 227(3): 1062-70. Link
2012
Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ. "Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury". PLoS One. 2012; 7(7). Link
2012
Farhat YM, Al-Maliki AA, Chen T, Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. "Gene expression analysis of the pleiotropic effects of TGF-?1 in an in vitro model of flexor tendon healing." PLoS One. 2012; 7(12). Link
2011 May
Takahata M, Awad HA, O'Keefe RJ, Bukata SV, Schwarz EM. "Endogenous tissue engineering: PTH therapy for skeletal repair." Cell Tissue Research. 2011; . Link
2011 May
Kung MH, Yukata K, O'Keefe RJ, Zuscik MJ. "Aryl Hydrocarbon Receptor-Mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene." J Cell Physiology. 2011; 10.1002/jcp: 22819. Link
2011 May
Katzel EB, Wolenski M, Loiselle AE, Basile P, Flick LM, Langstein HN, Hilton MJ, Awad HA, Hammert WC, O'Keefe RJ. "Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing." Journal of Orthopaedic Research. 2011; 29(5): 684-93. Link
2011
Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'keefe RJ, Langstein HN. "The Impact of Smad3 Loss of Function on TGF-? Signaling and Radiation-Induced Capsular Contracture." Plastic Reconstructive Surgery. 2011; 127(6): 2263-9. Link
2011
Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ. "Establishment of an index with increased sensitivity for assessing murine arthritis." Journal of Orthopaedic Research. 2011; 8(29). Link
2011
Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O'Keefe RJ, Rosier RN. "The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model." J Bone Miner Research (6):1283-94. doi: 10.1002/jbmr.336.. 2011; (6): 1283-94 (6):1283-94(doi: 10.1002/jbmr.336.). Link
2011
Bukata SV, Kates SL, O'Keefe RJ. "Short-term and Long-term Orthopaedic Issues in Patients With Fragility Fractures." Clinical Orthopaedic Related Research. 2011; . Link
2011
Yazici C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O'Keefe RJ, Awad HA, Schwarz EM. "Self-complementary AAV2.5-BMP2-coated Femoral Allografts Mediated Superior Bone Healing Versus Live Autografts in Mice With Equivalent Biomechanics to Unfractured Femur." Molecular Therapy. 2011; . Link
2011
Sampson ER, Amin V, Schwarz EM, O'Keefe RJ, Rosier RN. "The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy." Journal of Orthopaedic Research. 2011; 29(4): 623-32. Link
2011
Reynolds DG, Takahata M, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. "Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model." Bone. 2011; 48(3): 562-70. Link
2011
Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ. "EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair." Journal of Bone and Mineral Research. 2011; 26(4): 792-802. Link
2011
Dhakal S, Chen J, McCance S, Rosier R, O'Keefe R, Constine LS. "Bone density changes after radiation for extremity sarcomas: exploring the etiology of pathologic fractures." International Journal of Radiation Oncology, Biology, Physics. 2011; 80(4): 1158-63. Link
2011
Jacobson JA, Yanoso-Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas EJ, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz EM, Awad HA. "Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects." Tissue Engineering: Part A. 2011; 17(3-4): 389-98. Link
2011
Katzel EB, Koltz, PF, Tierney R, Williams JP, Awad HA, O'Keefe RJ, Langstein HN. "The impact of Smad3 loss of function on TGF-B Signaling and Radiation-Induced Capsular Contracture." Plastic Reconstructive Surgery. 2011; 27(6): 2263-9.. Link
2011
Hu CT, Offley SC, Yaseen Z, O'keefe RJ, Humphrey CA. "Murine model of oligotrophic tibial nonunion." Journal of Orthopaedic Trauma. 2011; 25(8): 500-5. Link
2011
Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. "Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression." Journal of Orthopaedic Research. 2011; . Link
2011
O'Keefe RJ, Mao J. "Bone Tissue Engineering and Regeneration: From Discovery to the Clinic An Overview." Tissue Engineering. 2011; . Link
2011
Bukata SV, Kates SL, O'Keefe RJ. "Short-term and long-term orthopaedic issues in patients with fragility fractures." Clinical Orthopaedics and Related Research. 2011; 469(8): 2225-36. Link
2011
Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ. "Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis." Science Translational Medicine. 2011; 101(3). Link
2011
Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe R, Eliseev RA. "Targeting radioresistant osteosarcoma cells with parthenolide." Journal of cellular biochemistry. 2011; . Link
2011
Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D. "BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development." Journal of cell science. 2011; 124: 3428-40. Link
2011
Takahata M, Schwarz EM, Chen T, O'Keefe RJ, Awad HA. "Delayed short course treatment with teriparatide (PTH(1-34) ) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction." Journal of bone and mineral research. 2011; . Link
2011
O'Keefe RJ, Mao J. "Bone tissue engineering and regeneration: from discovery to the clinic--an overview." Tissue Engineering. 2011; 17(6): 389-92. Link
2010 Jan
Dao, DY; Yang, X; Flick, LM; Chen, D; Hilton, MJ; O'Keefe, RJ. "Axin2 regulates chondrocyte maturatin and axial skeletal development". J Orthop Res. 2010; 1: 89-95. Link
2010
Dong Y, Jesse AM, Kohn A, Gunnell LM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ. "RBP Jk - dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development." Development. 2010; 137(9): 1461-71. Link
2010
Gunnell, LM, Jonason, JH, Loiselle, AE, Kohn, A, Schwarz, EM, Hilton, M J. O'Keefe. "RJ. TAK1 regulates cartilage and joint Development via the MAPK and BMP Signaling pathways." J Bone Miner Res.. 2010; 25(8): 1784-97. Link
2010
Dao D, Gunnell L, Hsu W, Chen D, O'Keefe RJ and Hilton MJ. "Cartilage specific B-catenin signaling regulates chrondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development." 2010; . Link
2010
Kohn A, Dong Y, Mirando A, Jesse AM, Honjo T, O'Keefe RJ, and Hilton MJ. "RBPJk-dependent and-independent Notch signaling regulates chondrocyte proliferation and maturation while coordination osteoblast differentiation during cartilage development." 2010; . Link
2010
Mirando A, Moore T, Lang A, Jesse A, Kohn A, Zuscik MJ, O'Keefe RJ, and Hilton MJ. "RBP-Jk-dependent Notch signaling is required for articular cartilage and joint maintenance." 2010; . Link
2010
Dong Y, O'Keefe RJ, and Hilton MJ. "The Notch pathway as a tool to select, maintain and expand a human mesenchymal stem cell population ex vivo. (in preparation)". 2010; . Link
2010
Wu Q, Zhu M, Rosier RN, Zuscik MJ, O'Keefe RJ, Chen D. "Beta-catenin, cartilage, and osteoarthritis". Ann NY Academy Science. 2010; 1192-1: 344-50. Link
2010
Katzel EB, Wolenski M, Loiselle AE, Basile P, Flick LM, Langstein HN, Hilton MJ, Awad HA, Hammert WC, O'Keefe RJ. "Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing. ." J Orthop Res., 2010. 2010; . Link
2010
Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Soballe K, O'Keefe RJ, Awad HA, Xing L, Schwarz EM. "Effects of anti-resorptive agents on osteomyelitis: Novel insights on osteonec". Anal NY Acad Sci. 2010; 1192 (1): 84-95. Link
2010
Jacobson JA, Yanoso Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas JE, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz E, Awad H. "Teriparatide Therapy and beta-TCP Enhance Scaffold Reconstruction of Mouse Femoral Defects". Tissue Eng Part A. 2010; . Link
2010
Yanoso-Scholl L, Jacobson JA, Bradica G, Lerner AL, O'Keefe RJ, Schwarz EM, Zuscik MJ, Awad HA. "Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering." J Biomed Mater Res A. 2010; . Link
2010
Li TF, Gao L, Sheu RJ, Sampson ER, Flick LM, Konttinnen YR, Chen D. Schwarz EM, Zuscik MJ, Jonason JH, O'Keefe RJ. "Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis". Arthritis Reheum. 2010; 62((8)): 2359-69. Link
2010
Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'Keefe RJ, Langstein HN. "A novel animal model for studying silicone gel-related capsular contracture." Plastic and Reconstructive Surgery. 2010; 126(5): 1483-91. Link
2010
Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster D, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Sen HT, van der Meulen MC, Weinstein RS, Whyte M; American Society for Bone and Mineral Research. "Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research." Journal of Bone and Mineral Research. 2010; 25(11): 2267-94. Link
2010
Reynolds DG, Takata M. Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. "Terparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model." Bone. 2010; . Link
2010
Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ. "EP1-/- mice have enhanced osteoblast differentiation and accelerated fracture repair." Journal of Bone and Mineral Research. 2010; . Link
2009 Oct
Tsutsumi, R; Xie, C; Wei, X; Zhang, M; Zhang, X; Flick, LM; Schwarz, EM; O'Keefe, RJ. "PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis". J Bone Miner Res. 2009; 24(10): 1753-62. Link
2009 Oct
Darowish, M; Rahman, R; Li, P; Bukata, SV; Gelina, J; Huang, W; Flick, LM; Schwarz, EM; O'Keefe, RJ. "Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentitation". Bone. 2009; 45(4): 661-8. Link
2009 Aug
Wei, X; Zhang, X; Flick, LM; Drissi, H; Schwarz, EM; O'Keefe, RJ. "Titanium particles stimulate COX-2 expression in synolvial fibroblasts through an oxidative stress-induced, calpain-depedent, NF-Kappa B pathway". Am J Physiol Cell Physiol. 2009; 297 (2): C310-20. Link
2009 Aug
Wu, W; Huang, JH; Sampson, ER; Kim, KO; Zuscik, MJ; O'Keefe, RJ; Chen, D; Rosier, RN. "Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage". Exp Cell Res. 2009; 315(14): 2386-98. Link
2009 Aug
Xie, C; Liang, B; Xue, M; Lin, AS; Loiselle, A; Schwarz, EM; Guildberg, RE, O'Keefe, RJ; Zhang, X. "Rescue of impaired fracture healing in COX-2-/-mice via activation of prostaglandin E2 receptor subtype 4". Am J. Pathol.. 2009; 175(2): 772-85. Link
2009 Aug
Crane DP, Gromov K, Li D, Søballe K, Wahnes C, Büchner H, Hilton MJ, O'Keefe RJ, Murray CK, Schwarz EM. "Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 Aug; 27(8):1008-15.
2009 Jun
Clark CA, Li TF, Kim KO, Drissi H, Zuscik MJ, Zhang X, O'Keefe RJ. "Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 Jun; 27(6):785-92.
2009 Jun
Loiselle AE, Bragdon GA, Jacobson JA, Hasslund S, Cortes ZE, Schwarz EM, Mitten DJ, Awad HA, O'Keefe RJ. "Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 Jun; 27(6):833-40.
2009 Jun
Taylor DK, Meganck JA, Terkhorn S, Rajani R, Naik A, O'Keefe RJ, Goldstein SA, Hankenson KD. "Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 Jun; 24(6):1043-54.
2009 May
Reynolds DG, Shaikh S, Papuga MO, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. "muCT-based measurement of cortical bone graft-to-host union." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 May; 24(5):899-907.
2009 Feb
Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ. "Reduced COX-2 expression in aged mice is associated with impaired fracture healing." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 Feb; 24(2):251-64.
2009 Jan
Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D. "Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 Jan; 24(1):12-21.
2009
Frish, BJ; Porter, RL; Gigliotti, BJ; Olm-Shipman, AJ; Weber, JM; O'Keefe, RJ; Jordan, CT; Calvi, LM. "In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells". Blood. 2009; 114-19: 4054-63. Link
2009
Yan, Y; Tang, D; Chen, M; Huang, J; Xie, R; Jonason, JH; Tax, X; Hou, W; Reynolds, D; Hsu, W; Harris, SE; Puzas, JE; Awad, H; O'Keefe, RJ; Boyce, BF; Chen, D. "Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice". J Cell Sci. 2009; 122-Pt 19: 3566-78. Link
2009
Guise, TA, O'Keefe, RJ, Randall, RL, Terek, RM. "Molecular biology and therapeutics in musculoskeletal oncology." J Bone Joint Surg Am. 2009; 91: 724-32. Link
2008 Oct
Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN. "Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice." Arthritis and rheumatism. 2008 Oct; 58(10):3132-44.
2008 Jun 5
Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH. "Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis." Oncogene. 2008 Jun 5; 27(25):3605-14. Epub 2008 Jan 28.
2008 May 1
Chen M, Zhu M, Awad H, Li TF, Sheu TJ, Boyce BF, Chen D, O'Keefe RJ. "Inhibition of beta-catenin signaling causes defects in postnatal cartilage development." Journal of cell science.. 2008 May 1; 121(Pt 9):1455-65. Epub 2008 Apr 08.
2008 May
Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN. "Regulation of embryonic endochondral ossification by Smurf2." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 May; 26(5):704-12.
2008 Mar
Usui M, Xing L, Drissi H, Zuscik M, O'Keefe R, Chen D, Boyce BF. "Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2008 Mar; 23(3):314-25.
2008 Mar
Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y, Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA. "Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery." Molecular therapy : the journal of the American Society of Gene Therapy. 2008 Mar; 16(3):466-73. Epub 2008 Jan 08.
2008 Feb
McGrail JC, O'Keefe RT. "The U1, U2 and U5 snRNAs crosslink to the 5' exon during yeast pre-mRNA splicing." Nucleic acids research.. 2008 Feb; 36(3):814-25. Epub 2007 Dec 15.
2008 Feb
Zuscik MJ, Hilton MJ, Zhang X, Chen D, O'Keefe RJ. "Regulation of chondrogenesis and chondrocyte differentiation by stress." The Journal of clinical investigation.. 2008 Feb; 118(2):429-38.
2008 Feb
Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X. "Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation." The Journal of bone and joint surgery. American volume.. 2008 Feb; 90 Suppl 1:9-13.
2008 Jan
Kaback LA, Soung do Y, Naik A, Smith N, Schwarz EM, O'Keefe RJ, Drissi H. "Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification." Journal of cellular physiology. 2008 Jan; 214(1):173-82.
2008 Jan
Li D, Gromov K, Søballe K, Puzas JE, O'Keefe RJ, Awad H, Drissi H, Schwarz EM. "Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 Jan; 26(1):96-105.
2008 Jan
Zhu M, Chen M, Lichtler AC, O'Keefe RJ, Chen D. "Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice." Osteoarthritis and cartilage. 2008 Jan; 16(1):129-30. Epub 2007 Sep 20.
2008
Hasslund,S.; Jacobson,J. A.; Dadali,T.; Basile,P.; Ulrich-Vinther,M.; Soballe,K.; Schwarz,E. M.; O'Keefe,R. J.; Mitten,D. J.; Awad,H. A.;. "Adhesions in a murine flexor tendon graft model: Autograft versus allograft reconstruction". J.Orthop.Res.. 2008; . Link
2008
Tsutsumi,R.; Hock,C.; Bechtold,C. D.; Proulx,S. T.; Bukata,S. V.; Ito,H.; A Awad,H.; Nakamura,T.; O'Keefe,R. J.; Schwarz,E. M.;. "Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT". J.Orthop.Res.. 2008; . Link
2008
Bostrom M, O'Keefe RJ. "What experimental approaches (eg, in vivo, in vitro, tissue retrieval) are effective in investigating the biologic effects of particles?". Journal of American Academy of Orthopaedic Surgery. 2008; : S63-67. Link
2008
Zhang X, Awad, HA, O'Keefe, RJ, Guldberg, RE, Schwarz, EM. "A perspective: engineering periosteum for structural bone graft healing." Clinical Orthopaedic Related Research. 2008; 466: 1777-87. Link
2008
Kaback, LA, Soung DY, Naik A, Geneau G, Schwarz EM, Rosier RN, O'Keefe, RJ, Drissi, H. "Teriparatide (1-34 human PTH) regulation of osterix during fracture repair." Journal of Cell Biochemistry. 2008; 1:105(1): 219-26. Link
2008
Wu Q, Chen D, Zuscik MJ, O'Keefe RJ, Rosier RN. "Overexpression of Smurf2 Stimulates Endochondral Ossification Through Upregulation of beta-Catenin." Journal of Bone and Mineral Research. 2008; 26(5): 704-712. Link
2008
Xie C, Ming X, Wang Q, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. "COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing." Bone.. 2008 43(6):1075-83. Epub 2008 Aug 16.
2007 Nov
Dong YF, Soung do Y, Chang Y, Enomoto-Iwamoto M, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. "Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner." Molecular endocrinology.. 2007 Nov; 21(11):2805-20. Epub 2007 Aug 07.
2007 Nov
Dao DY, Yang X, Chen D, Zuscik M, O'Keefe RJ. "Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways." Annals of the New York Academy of Sciences.. 2007 Nov; 1116:82-99.
2007 Sep 20
Zhang X, Sun B. "Organic crystal fibers aligned into oriented bundles with polarized emission." The journal of physical chemistry. B. 2007 Sep 20; 111(37):10881-5. Epub 2007 Aug 28.
2007 Sep 7
Dobbyn HC, McEwan PA, Krause A, Novak-Frazer L, Bella J, O'Keefe RT. "Analysis of pre-mRNA and pre-rRNA processing factor Snu13p structure and mutants." Biochemical and biophysical research communications.. 2007 Sep 7; 360(4):857-62. Epub 2007 Jul 09.
2007 Sep
Frazer LN, O'Keefe RT. "A new series of yeast shuttle vectors for the recovery and identification of multiple plasmids from Saccharomyces cerevisiae." Yeast (Chichester, England). 2007 Sep; 24(9):777-89.
2007 Aug
Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. "Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2007 Aug; 22(8):1260-70.
2007 Aug
Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM. "Recent advances in gene delivery for structural bone allografts." Tissue engineering. 2007 Aug; 13(8):1973-85.
2007 May
Wang YJ, Zhou CJ, Shi Q, Smith N, Li TF. "Aging delays the regeneration process following sciatic nerve injury in rats." Journal of neurotrauma. 2007 May; 24(5):885-94.
2007 Apr 6
Wang Q, Wei X, Zhu T, Zhang M, Shen R, Xing L, O'Keefe RJ, Chen D. "Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2." The Journal of biological chemistry.. 2007 Apr 6; 282(14):10742-8. Epub 2007 Jan 10.
2007 Jan
Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O'Keefe RJ, Chen D. "Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase." Genesis (New York, N.Y. : 2000). 2007 Jan; 45(1):44-50.
2007
Zuscik MJ, Ma L, Buckley T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ. "Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations." Environment Health Perspective. 2007; 115(9): 1276-82. Link
2007
Xie, C, Reynolds, D, Awad, H, Rubery, PT, Pelled, G., Gazit, D., Guldberg, RE, Schwarz, E.M., O'Keefe, RJ, Zhang, X. "Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering." Tissue Engineering. 2007; 13(3): 435-45. Link
2007
Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'keefe RJ, Lerner AL, Schwarz EM, Awad HA. "Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts." Journal of biomechanics. 2007 40(14):3178-86. Epub 2007 May 23.
2007
Bärnighausen T, Liu Y, Zhang X, Sauerborn R. "Willingness to pay for social health insurance among informal sector workers in Wuhan, China: a contingent valuation study." BMC health services research. 2007 7:114. Epub 2007 Jul 20.
2006 Oct
Robertson G, Xie C, Chen D, Awad H, Schwarz EM, O'Keefe RJ, Guldberg RE, Zhang X. "Alteration of femoral bone morphology and density in COX-2-/- mice." Bone.. 2006 Oct; 39(4):767-72. Epub 2006 May 30.
2006 Oct
Baumhauer JF, O'Keefe RJ, Schon LC, Pinzur MS. "Cytokine-induced osteoclastic bone resorption in charcot arthropathy: an immunohistochemical study." Foot & ankle international.. 2006 Oct; 27(10):797-800.
2006 Jul 28
Li TF, Chen D, Wu Q, Chen M, Sheu TJ, Schwarz EM, Drissi H, Zuscik M, O'Keefe RJ. "Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes." The Journal of biological chemistry.. 2006 Jul 28; 281(30):21296-304. Epub 2006 May 10.
2006 Jul
Dong YF, Soung do Y, Schwarz EM, O'Keefe RJ, Drissi H. "Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor." Journal of cellular physiology. 2006 Jul; 208(1):77-86.
2006 Jun 16
Shen R, Wang X, Drissi H, Liu F, O'Keefe RJ, Chen D. "Cyclin D1-cdk4 induce runx2 ubiquitination and degradation." The Journal of biological chemistry.. 2006 Jun 16; 281(24):16347-53. Epub 2006 Apr 13.
2006 Jun 15
Wang YJ, Shi Q, Lu WW, Cheung KC, Darowish M, Li TF, Dong YF, Zhou CJ, Zhou Q, Hu ZJ, Liu M, Bian Q, Li CG, Luk KD, Leong JC. "Cervical intervertebral disc degeneration induced by unbalanced dynamic and static forces: a novel in vivo rat model." Spine. 2006 Jun 15; 31(14):1532-8.
2006 Jun
Mandelin J, Hukkanen M, Li TF, Korhonen M, Liljeström M, Sillat T, Hanemaaijer R, Salo J, Santavirta S, Konttinen YT. "Human osteoblasts produce cathepsin K." Bone.. 2006 Jun; 38(6):769-77. Epub 2005 Dec 05.
2006 May 10
Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. "Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene." Gene. 2006 May 10; 372:62-70. Epub 2006 Mar 29.
2006 Apr
Maloney MD, Goater JJ, Parsons R, Ito H, O'Keefe RJ, Rubery PT, Drissi MH, Schwarz EM. "Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects." The Journal of bone and joint surgery. American volume.. 2006 Apr; 88(4):753-61.
2006 Apr
Zhang X, Sun B, Friend RH, Guo H, Nau D, Giessen H. "Metallic photonic crystals based on solution-processible gold nanoparticles." Nano letters. 2006 Apr; 6(4):651-5.
2006 Apr
Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT. "Autoimmunity and bone." Annals of the New York Academy of Sciences.. 2006 Apr; 1068:275-83.
2006 Apr
O'Keefe RJ, Tiyapatanaputi P, Xie C, Li TF, Clark C, Zuscik MJ, Chen D, Drissi H, Schwarz E, Zhang X. "COX-2 has a critical role during incorporation of structural bone allografts." Annals of the New York Academy of Sciences.. 2006 Apr; 1068:532-42.
2006 Feb 10
Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'keefe RJ, Chen D. "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." The Journal of biological chemistry.. 2006 Feb 10; 281(6):3569-76. Epub 2005 Nov 18.
2006 Jan 1
Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN. "Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB." Experimental cell research.. 2006 Jan 1; 312(1):40-50. Epub 2005 Nov 02.
2006 Jan
Looney RJ, Schwarz EM, Boyd A, O'Keefe RJ. "Periprosthetic osteolysis: an immunologist's update." Current opinion in rheumatology. 2006 Jan; 18(1):80-7.
2006 Jan
Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ. "Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2006 Jan; 21(1):4-16. Epub 2005 Sep 19.
2006
Xie,C.; Reynolds,D.; Awad,H.; Rubery,P. T.; Pelled,G.; Gazit,D.; Guldberg,R. E.; Schwarz,E. M.; O'Keefe,R. J.; Zhang,X.;. "Structural Bone Allograft Combined with Genetically Engineered Mesenchymal Stem Cells As a Novel Platform for Bone Tissue Engineering". Tissue Eng.. 2006; . Link
2006
O'Keefe, RJ, Leach, JK, McDevitt, CA. "On the horizon from the ORS." Journal of American Academy Orthpaedic Surgery. 2006; 14(10): 629-31. Link
2006
Robertson, G, Xie, C, Chen, D, Awad, H, Schwarz, EM, O'Keefe, RJ, Guldberg, R.E. and Zhang, X. "Alteration of femoral bone morphology and density in COX-2-/- mice." Bone. 2006; 39: 767-72. Link
2006
Xing L, Thorndyke B, Schreibmann E, Yang Y, Li TF, Kim GY, Luxton G, Koong A. "Overview of image-guided radiation therapy." Medical dosimetry : official journal of the American Association of Medical Dosimetrists. 2006 31(2):91-112.
2005 Nov
Soloviev A, Schwarz EM, Darowish M, O'Keefe RJ. "Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: a role for free radicals, NFkappaB, and TNFalpha." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2005 Nov; 23(6):1258-65. Epub 2005 Jun 09.
2005 Sep
Wang Y, Belflower RM, Dong YF, Schwarz EM, O'Keefe RJ, Drissi H. "Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 Sep; 20(9):1624-36. Epub 2005 May 23.
2005 Sep
Voloshin I, Gelinas J, Maloney MD, O'Keefe RJ, Bigliani LU, Blaine TA. "Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa in patients with rotator cuff disease." Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 2005 Sep; 21(9):1076.e1-1076.e9.
2005 Sep
Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, O'Keefe RJ, Xing L. "TNF-alpha and pathologic bone resorption." The Keio journal of medicine. 2005 Sep; 54(3):127-31.
2005 Aug 1
Dong Y, Drissi H, Chen M, Chen D, Zuscik MJ, Schwarz EM, O'Keefe RJ. "Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta." Journal of cellular biochemistry. 2005 Aug 1; 95(5):1057-68.
2005 Aug
Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM. "Biological effects of rAAV-caAlk2 coating on structural allograft healing." Molecular therapy : the journal of the American Society of Gene Therapy. 2005 Aug; 12(2):212-8.
2005 Jul
Mandelin J, Liljeström M, Li TF, Ainola M, Hukkanen M, Salo J, Santavirta S, Konttinen YT. "Pseudosynovial fluid from loosened total hip prosthesis induces osteoclast formation." Journal of biomedical materials research. Part B, Applied biomaterials. 2005 Jul; 74(1):582-8.
2005 Jul
Wei X, Zhang X, Zuscik MJ, Drissi MH, Schwarz EM, O'Keefe RJ. "Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 Jul; 20(7):1136-48. Epub 2005 Feb 14.
2005 Jun
Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. "Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency." Environmental health perspectives.. 2005 Jun; 113(6):749-55.
2005 Apr 15
Gordon AH, O'Keefe RJ, Schwarz EM, Rosier RN, Puzas JE. "Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone." Cancer research.. 2005 Apr 15; 65(8):3209-17.
2005 Apr
Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH. "Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development." Journal of cellular physiology. 2005 Apr; 203(1):133-43.
2005 Apr
Mandelin J, Li TF, Hukkanen M, Liljeström M, Salo J, Santavirta S, Konttinen YT. "Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K." The Journal of rheumatology. 2005 Apr; 32(4):713-20.
2005 Mar 18
Clark CA, Schwarz EM, Zhang X, Ziran NM, Drissi H, O'Keefe RJ, Zuscik MJ. "Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation." Biochemical and biophysical research communications.. 2005 Mar 18; 328(3):764-76.
2005 Mar
Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM. "Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy." Nature medicine.. 2005 Mar; 11(3):291-7. Epub 2005 Feb 13.
2005 Feb
Yu S, Zhang X, He Z, Liu Y. "[Corrosiveness of Ti-Fe-Mo-Mn-Nb-Zr alloys in various pH lactic acids]." Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. 2005 Feb; 22(1):91-4.
2005 Jan 1
Li TF, O'Keefe RJ, Chen D. "TGF-beta signaling in chondrocytes." Frontiers in bioscience : a journal and virtual library. 2005 Jan 1; 10:681-8. Epub 2005 Jan 01.
2005
Andela VB, Schwarz EM, O'Keefe RJ, Puzas EJ, Rosenblatt JD, Rosier RN. "A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival." FEBS letters.. 2005 579(30):6814-20. Epub 2005 Nov 28.
2005
Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN. "Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase." Journal of cellular biochemistry. 2005 96(6):1262-73.
2005
Zhang, X, Naik, A, Xie, C, Reynolds, D, Palmer, J, Lin, A, Awad, H, Guldberg, R, Schwarz, EM, and O'Keefe, RJ. "Periosteal stem cells are essential for bone revitalization and repair." Journal of Musculoskeletal Neuronal Interact. 2005; 5(4): 360-2. Link
2005
Schwarz, EM, O'Keefe, RJ, Zing, L, Looney, RJ, Ritchlin, CT. "Receptor activator of nuclear ? ß ligand and osteoprotegerin: Where are we now and what about future treatment uses?". Current Opinion in Orthopaedics. 2005; 16: 370-375. Link
2005
Drissi, H, Zuscik, M, Rosier, R, and O'Keefe, RJ. "Transcriptional regulation of chondrocyte maturation: Potential involvement of transcription factors in OA pathogenesis." Molecular Aspects of Medicine. 2005; 26: 169-179. Link
2005
O'Keefe, RJ, and Rubery, PT. "Point of View." Spine. 2005; 30(1): 31-32. Link
2005
Blaine TA, Kim YS, Voloshin I, Chen D, Murakami K, Chang SS, Winchester R, Lee FY, O'keefe RJ, Bigliani LU. "The molecular pathophysiology of subacromial bursitis in rotator cuff disease." Journal of shoulder and elbow surgery. 2005 14(1 Suppl S):84S-89S.
2005
Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE. "Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 20(12):2124-37. Epub 2005 Aug 08.
2005
O'Keefe RJ. "Summary--Cell therapies for orthopedic applications." Journal of musculoskeletal & neuronal interactions. 2005 5(4):367-8.
2005
Gu X, Feng Y, Shi C, Li M, Fu Z, Zhang X. "Antiapoptotic mechanism of insulin in reoxygenation-induced injury in cultured cardiomyocytes of neonatal rats." Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2005 25(6):632-5.
2004 Nov
Tiyapatanaputi P, Rubery PT, Carmouche J, Schwarz EM, O'keefe RJ, Zhang X. "A novel murine segmental femoral graft model." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Nov; 22(6):1254-60.
2004 Oct 15
Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ. "PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling." Experimental cell research.. 2004 Oct 15; 300(1):159-69.
2004 Sep 10
Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. "Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway." Experimental cell research.. 2004 Sep 10; 299(1):128-36.
2004 Sep
Ritchlin CT, Schwarz EM, O'Keefe RJ, Looney RJ. "RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis." Journal of musculoskeletal & neuronal interactions. 2004 Sep; 4(3):276-84.
2004 Jul
Ferguson CM, Schwarz EM, Puzas JE, Zuscik MJ, Drissi H, O'Keefe RJ. "Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jul; 22(4):687-96.
2004 Jul
Ulrich-Vinther M, Duch MR, Søballe K, O'Keefe RJ, Schwarz EM, Pedersen FS. "In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jul; 22(4):726-34.
2004 May 15
Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN. "5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes." Journal of cellular biochemistry. 2004 May 15; 92(2):316-31.
2004 May
Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. "Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation." Bone.. 2004 May; 34(5):809-17.
2004 Mar
Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ. "CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter." Journal of cellular physiology. 2004 Mar; 198(3):428-40.
2004 Feb
Li P, Schwarz EM, O'Keefe RJ, Ma L, Boyce BF, Xing L. "RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2004 Feb; 19(2):207-13.
2004 Feb
Yu S, Zhang X, He Z, Gao Z, Wang C. "[The influence of Ce on microstructures and mechanics performances of Ti-Fe-Mo-Mn-Nb-Zr alloys]." Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. 2004 Feb; 21(1):102-6.
2004 Jan
Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ. "PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jan; 22(1):6-12.
2004 Jan
Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O'Keefe RJ, Schwarz EM. "Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells." Gene therapy. 2004 Jan; 11(1):34-41.
2004 Jan
Li P, Schwarz EM, O'Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L. "Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice." Arthritis and rheumatism. 2004 Jan; 50(1):265-76.
2004
Guldberg, RE, Oest, M, Lin, ASP, Ito, H, Chao, S, Gromov, K, Goater, JJ, Koefoed, M, Schwarz, EM, O'Keefe, RJ, and Zhang, X. "Functional integration of tissue- engineered bone constructs." Journal of Muscular Neuronal Interact. 2004; 4(4): 399-400. Link
2004
Zhang X, Wang T. "Quantitative analysis on economic contribution of community health service in China." Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2004 24(1):103-6.
2004
Schwarz EM, O'Keefe RJ, Looney RJ. "Bone implant interface, osteolysis and potential therapies." Journal of musculoskeletal & neuronal interactions. 2004 4(4):390-2.
2003 Nov
Schwarz EM, Campbell D, Totterman S, Boyd A, O'Keefe RJ, Looney RJ. "Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Nov; 21(6):1049-55.
2003 Oct
Andela VB, Pirri M, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosenblatt JD, Rosier RN. "The mevalonate synthesis pathway as a therapeutic target in cancer." Clinical orthopaedics and related research.. 2003 Oct; (415 Suppl):S59-66.
2003 Oct
Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ. "NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone." Clinical orthopaedics and related research.. 2003 Oct; (415 Suppl):S75-85.
2003 Oct
O'Keefe RJ, Guise TA. "Molecular mechanisms of bone metastasis and therapeutic implications." Clinical orthopaedics and related research.. 2003 Oct; (415 Suppl):S100-4.
2003 Sep
Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ. "Smad6 is induced by BMP-2 and modulates chondrocyte differentiation." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Sep; 21(5):908-13.
2003 Sep
Mandelin J, Li TF, Hukkanen MV, Liljeström M, Chen ZK, Santavirta S, Kitti U, Konttinen YT. "Increased expression of a novel osteoclast-stimulating factor, ADAM8, in interface tissue around loosened hip prostheses." The Journal of rheumatology. 2003 Sep; 30(9):2033-8.
2003 Sep
Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ. "ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2003 Sep; 18(9):1593-604.
2003 Aug 1
Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, O'Keefe RJ. "ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation." Experimental cell research.. 2003 Aug 1; 288(1):198-207.
2003 Jul
Flick LM, Weaver JM, Ulrich-Vinther M, Abuzzahab F, Zhang X, Dougall WC, Anderson D, O'Keefe RJ, Schwarz EM. "Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Jul; 21(4):676-84.
2003 Jun
Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ. "Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5." Endocrinology. 2003 Jun; 144(6):2514-23.
2003 May 8
Andela VB, Gingold BI, Souza MD, O'Keefe RJ, Puzas EJ, Schwarz EM, Rosier RN. "Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB." Cancer letters. 2003 May 8; 194(1):37-43.
2003 May
Ballock RT, O'Keefe RJ. "Physiology and pathophysiology of the growth plate." Birth defects research. Part C, Embryo today : reviews. 2003 May; 69(2):123-43.
2003 Apr
Ballock RT, O'Keefe RJ. "The biology of the growth plate." The Journal of bone and joint surgery. American volume.. 2003 Apr; 85-A(4):715-26.
2003 Jan 3
Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE. "A phage display technique identifies a novel regulator of cell differentiation." The Journal of biological chemistry.. 2003 Jan 3; 278(1):438-43. Epub 2002 Oct 25.
2003
Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. "Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes." Journal of cellular biochemistry. 2003 90(6):1287-98.
2003
Bukata, SV, Gelinas, J, Wei, X, Rosier, RN, Puzas, JE, Zhang, X, Schwarz, EM, Song, XR, Griswold, DE, and O'Keefe, RJ. "PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway." Journal of Orthopaedic Research. 2003; 22(1): 6-12. Link
2003
Huang W, O'Keefe RJ, Schwarz EM. "Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation." Arthritis research & therapy. 2003 5(1):R49-59. Epub 2002 Nov 12.
2003
Huang W, Drissi MH, O'Keefe RJ, Schwarz EM. "A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis." Calcified tissue international.. 2003 73(6):584-93. Epub 2003 Oct 02.
2003
Ulrich-Vinther M, Maloney MD, Schwarz EM, Rosier R, O'Keefe RJ. "Articular cartilage biology." The Journal of the American Academy of Orthopaedic Surgeons.. 2003 11(6):421-30.
2003
Puzas JE, O'Keefe RJ, Schwarz EM, Zhang X. "Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition." Journal of musculoskeletal & neuronal interactions. 2003 3(4):308-12; discussion 320-1.
2002 Oct
Pateder DB, Gish MW, O'Keefe RJ, Hicks DG, Teot LA, Rosier RN. "Parathyroid hormone-related Peptide expression in cartilaginous tumors." Clinical orthopaedics and related research.. 2002 Oct; (403):198-204.
2002 Sep 20
Andela VB, Sheu TJ, Puzas EJ, Schwarz EM, O'Keefe RJ, Rosier RN. "Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB." Biochemical and biophysical research communications.. 2002 Sep 20; 297(2):237-41.
2002 Sep
Zuscik MJ, O'Keefe RJ, Gunter TE, Puzas JE, Schwarz EM, Rosier RN. "Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Sep; 20(5):1079-90.
2002 Aug
Ulrich-Vinther M, Carmody EE, Goater JJ, S balle K, O'Keefe RJ, Schwarz EM. "Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis." The Journal of bone and joint surgery. American volume.. 2002 Aug; 84-A(8):1405-12.
2002 Aug
Ulrich-Vinther M, Maloney MD, Goater JJ, Søballe K, Goldring MB, O'Keefe RJ, Schwarz EM. "Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes." Arthritis and rheumatism. 2002 Aug; 46(8):2095-104.
2002 Jul
Soloviev A, Schwarz EM, Kuprash DV, Nedospasov SA, Puzas JE, Rosier RN, O'Keefe RJ. "The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jul; 20(4):714-22.
2002 Jul
Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ. "Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jul; 20(4):811-8.
2002 Jun 10
Zuscik MJ, D'Souza M, Ionescu AM, Gunter KK, Gunter TE, O'Keefe RJ, Schwarz EM, Puzas JE, Rosier RN. "Growth plate chondrocyte maturation is regulated by basal intracellular calcium." Experimental cell research.. 2002 Jun 10; 276(2):310-9.
2002 Jun
Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. "Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair." The Journal of clinical investigation.. 2002 Jun; 109(11):1405-15.
2002 Jun
O'Keefe RJ. "Determination of responsiveness in biological systems is dependent on highly sensitive quantitative measures." Annals of the New York Academy of Sciences.. 2002 Jun; 961:206.
2002 Jun
Guilak F, Kapur R, Sefton MV, Vandenburgh HH, Koretsky AP, Kriete A, O'Keefe RJ. "Functional assessment of engineered tissues and elements of tissue design: breakout session summary." Annals of the New York Academy of Sciences.. 2002 Jun; 961:207-9.
2002 May
Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE. "Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 May; 17(5):915-22.
2002 May
Carmody EE, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. "Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles." Arthritis and rheumatism. 2002 May; 46(5):1298-308.
2002 Apr
Andela VB, Rosenblatt JD, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosier RN. "Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis." Clinical orthopaedics and related research.. 2002 Apr; (397):228-39.
2002 Apr
Konttinen YT, Mandelin J, Li TF, Salo J, Lassus J, Liljeström M, Hukkanen M, Takagi M, Virtanen I, Santavirta S. "Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis." Arthritis and rheumatism. 2002 Apr; 46(4):953-60.
2002 Mar
Good CR, O'Keefe RJ, Puzas JE, Schwarz EM, Rosier RN. "Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors." Journal of surgical oncology. 2002 Mar; 79(3):174-9.
2002 Mar
Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. "Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Mar; 20(2):169-73.
2002 Feb
Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM. "In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 Feb; 17(2):192-9.
2002 Feb
Zhang D, Ferguson CM, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. "A role for the BMP antagonist chordin in endochondral ossification." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 Feb; 17(2):293-300.
2002 Jan
Pateder DB, Sheu TJ, O'Keefe RJ, Puzas JE, Schwarz EM, Constine LS, Okunieff P, Rosier RN. "Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes." Radiation research.. 2002 Jan; 157(1):62-8.
2002 Jan
Puzas JE, O'Keefe RJ, Lieberman JR. "The orthopaedic genome: what does the future hold and are we ready?" The Journal of bone and joint surgery. American volume.. 2002 Jan; 84-A(1):133-41.
2002 Jan
Paavonen K, Mandelin J, Partanen T, Jussila L, Li TF, Ristimaki A, Alitalo K, Konttinen YT. "Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium." The Journal of rheumatology. 2002 Jan; 29(1):39-45.
2002 Jan
Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. "COX-1 and COX-2 expression in osteoid osteomas." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jan; 20(1):159-62.
2002
Looney RJ, Boyd A, Totterman S, Seo GS, Tamez-Pena J, Campbell D, Novotny L, Olcott C, Martell J, Hayes FA, O'Keefe RJ, Schwarz EM. "Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear." Arthritis research. 2002 4(1):59-63. Epub 2001 Oct 03.
2001 Sep
Pateder DB, Ferguson CM, Ionescu AM, Schwarz EM, Rosier RN, Puzas JE, O'Keefe RJ. "PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling." Journal of cellular physiology. 2001 Sep; 188(3):343-51.
2001 Jul
Pollice PF, Rosier RN, Looney RJ, Puzas JE, Schwarz EM, O'Keefe RJ. "Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components." The Journal of bone and joint surgery. American volume.. 2001 Jul; 83-A(7):1057-61.
2001 Jun
Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN. "The role of autocrine growth factors in radiation damage to the epiphyseal growth plate." Radiation research.. 2001 Jun; 155(6):847-57.
2001 Apr 13
Ionescu AM, Schwarz EM, Vinson C, Puzas JE, Rosier R, Reynolds PR, O'Keefe RJ. "PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling." The Journal of biological chemistry.. 2001 Apr 13; 276(15):11639-47. Epub 2001 Jan 02.
2001 Apr
Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM. "Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 Apr; 16(4):660-70.
2001 Feb
Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM. "Efficacy of etanercept for wear debris-induced osteolysis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 Feb; 16(2):338-47.
2001 Jan
Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Schwarz EM, Reynolds PR, Roiser RN, O'Keefe RJ. "BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2001 Jan; 19(1):18-25.
2001
Huang, W, O'Keefe, RJ, and Schwarz, EM. "Gene polymorphisms and musculoskeletal disease." Current Opinion Orthopaedics. 2001; 12: 416-23. Link
2001
Zhang, X, Zhang, Y, Schwarz, EM, and O'Keefe, RJ. "Cyclooxygenase and bone repair." Current Opinion Orthopaedics. 2001; 12: 397-402. Link
2001
Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM. "Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis." The Journal of bone and joint surgery. American volume.. 2001 83-A(12):1789-97.
2000 Sep
Chi H, Yang X, Kingsley PD, O'Keefe RJ, Puzas JE, Rosier RN, Shears SB, Reynolds PR. "Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo." Molecular and cellular biology. 2000 Sep; 20(17):6496-507.
2000 Jun 1
Li P, Sanz I, O'Keefe RJ, Schwarz EM. "NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Jun 1; 164(11):5990-7.
2000 May 2
Reynolds SD, Zhang D, Puzas JE, O'Keefe RJ, Rosier RN, Reynolds PR. "Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues." Gene. 2000 May 2; 248(1-2):233-43.
2000 May 1
Pateder DB, Rosier RN, Schwarz EM, Reynolds PR, Puzas JE, D'Souza M, O'Keefe RJ. "PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes." Experimental cell research.. 2000 May 1; 256(2):555-62.
2000 May
Schwarz EM, Lu AP, Goater JJ, Benz EB, Kollias G, Rosier RN, Puzas JE, O'Keefe RJ. "Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2000 May; 18(3):472-80.
2000 Apr
Goater J, Müller R, Kollias G, Firestein GS, Sanz I, O'Keefe RJ, Schwarz EM. "Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis." The Journal of rheumatology. 2000 Apr; 27(4):983-9.
2000 Apr
Temple HT, Scully SP, O'Keefe RJ, Katapurum S, Mankin HJ. "Clinical outcome of 38 patients with juxtacortical osteosarcoma." Clinical orthopaedics and related research.. 2000 Apr; (373):208-17.
2000
Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN. "Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB." Cancer research.. 2000 60(23):6557-62.
2000
O'Keefe, RJ, Schwarz, EM, and Boyce, BF. "Bone metastases: An update on mechanisms of bone resorption and therapeutic strategies." Current Opinion Orthopaedics. 2000; 11(5): 353-359. Link
2000
Schwarz, EM, and O'Keefe, RJ. "Breakthrough in bone: The molecular mechanism of osteoclast/osteoblast coupling revealed." Current Opinion Orthopaedics. 2000; 11(5): 329-335,. Link
2000
Schwarz, EM, Benz, EB, Lu, AP, Goater, Mollano, AV, Rosier, RN, Puzas, JE, and O'Keefe, RJ. "A quantitative small animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis." Journal of Orthopaedic Research. 2000; 18: 849-55. Link
2000
Rosier RN, O'Keefe RJ. "Hyaluronic acid therapy." Instructional course lectures. 2000 49:495-502.
2000
Schwarz EM, Looney RJ, O'Keefe RJ. "Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis." Arthritis research. 2000 2(3):165-8. Epub 2000 Mar 27.
2000
Ferguson CM, Schwarz EM, Reynolds PR, Puzas JE, Rosier RN, O'Keefe RJ. "Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation." Endocrinology. 2000 141(12):4728-35.
1999 May
Vena VE, Hsu J, Rosier RN, O'Keefe RJ. "Pelvic reconstruction for severe periacetabular metastatic disease." Clinical orthopaedics and related research.. 1999 May; (362):171-80.
1999 Apr
Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Reynolds PR, Rosier RN, O'Keefe RJ. "BMP-6 is an autocrine stimulator of chondrocyte differentiation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1999 Apr; 14(4):475-82.
1999 Mar 15
Chi H, Tiller GE, Dasouki MJ, Romano PR, Wang J, O'keefe RJ, Puzas JE, Rosier RN, Reynolds PR. "Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19." Genomics.. 1999 Mar 15; 56(3):324-36.
1998 Nov
Pollice PF, Hsu J, Hicks DG, Bukata S, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ. "Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: evidence of an anti-inflammatory regulatory pathway." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1998 Nov; 16(6):697-704.
1998 Oct
Serletti JM, Carras AJ, O'Keefe RJ, Rosier RN. "Functional outcome after soft-tissue reconstruction for limb salvage after sarcoma surgery." Plastic and reconstructive surgery. 1998 Oct; 102(5):1576-83; discussion 1584-5.
1998 Oct
Rosier RN, O'Keefe RJ, Hicks DG. "The potential role of transforming growth factor beta in fracture healing." Clinical orthopaedics and related research.. 1998 Oct; (355 Suppl):S294-300.
1998 Sep
Guerra CE, Betts RF, O'Keefe RJ, Shilling JW. "Mycobacterium bovis osteomyelitis involving a hip arthroplasty after intravesicular bacille Calmette-Guérin for bladder cancer." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 1998 Sep; 27(3):639-40.
1998 Mar
Romano PR, Wang J, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. "HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation." Journal of cell science.. 1998 Mar; 111 ( Pt 6):803-13.
1998 Mar
Grimsrud CD, Rosier RN, Puzas JE, Reynolds PR, Reynolds SD, Hicks DG, O'Keefe RJ. "Bone morphogenetic protein-7 in growth-plate chondrocytes: regulation by retinoic acid is dependent on the stage of chondrocyte maturation." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1998 Mar; 16(2):247-55.
1998
Reynolds, SD, Zuscik, MJ, Gunter, TE, O'Keefe, RJ, Puzas, JE, Rosier, RN, and Reynolds, PR. "Parathyroid hormone and parathyroid hormone-related peptide effects on growth plate chondrocytes: an overview." Cells and Materials. 1998; 7(4): 289-300. Link
1998
Rapoport, AP, Constine, LS, Packman, CH, Rosier, RN, O'Keefe, RJ, Hicks, DG, Rubin, SJ, and Rowe, JM. "Treatment of multifocal lymphoma of bone with intensified promace-cytabom chemotherapy and involved field radiotherapy." Americal Journal of Hematology. 1998; 58: 1-7. Link
1998
Rosier RN, O'Keefe RJ. "Autocrine regulation of articular cartilage." Instructional course lectures. 1998 47:469-75.
1998
O'Keefe RJ, Rosier RN, Teot LA, Stewart JM, Hicks DG. "Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction." The Iowa orthopaedic journal. 1998 18:26-34.
1997 Oct
Blaine TA, Pollice PF, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ. "Modulation of the production of cytokines in titanium-stimulated human peripheral blood monocytes by pharmacological agents. The role of cAMP-mediated signaling mechanisms." The Journal of bone and joint surgery. American volume.. 1997 Oct; 79(10):1519-28.
1997 Jun
Rosier RN, O'Keefe RJ, Teot LA, Fox EJ, Nester TA, Puzas JE, Reynolds PR, Hicks DG. "P-glycoprotein expression in cartilaginous tumors." Journal of surgical oncology. 1997 Jun; 65(2):95-105.
1997 Apr
O'Keefe RJ, Teot LA, Singh D, Puzas JE, Rosier RN, Hicks DG. "Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study." Laboratory investigation; a journal of technical methods and pathology.. 1997 Apr; 76(4):457-65.
1997 Mar
O'Keefe RJ, Loveys LS, Hicks DG, Reynolds PR, Crabb ID, Puzas JE, Rosier RN. "Differential regulation of type-II and type-X collagen synthesis by parathyroid hormone-related protein in chick growth-plate chondrocytes." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1997 Mar; 15(2):162-74.
1997
Hicks, DG, Stroyer, BF, Teot, L.A, and O'Keefe, RJ. "In-situ hybridization in skeletal tissues utilizing non-radioactive probes." Journal of Histotechnology. 1997; 20: 215-224. Link
1996 Sep
Hicks DG, O'Keefe RJ, Reynolds KJ, Cory-Slechta DA, Puzas JE, Judkins A, Rosier RN. "Effects of lead on growth plate chondrocyte phenotype." Toxicology and applied pharmacology.. 1996 Sep; 140(1):164-72.
1996 Aug
Blaine TA, Rosier RN, Puzas JE, Looney RJ, Reynolds PR, Reynolds SD, O'Keefe RJ. "Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles." The Journal of bone and joint surgery. American volume.. 1996 Aug; 78(8):1181-92.
1996 Jul 10
Reynolds SD, Johnston C, Leboy PS, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. "Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy." Experimental cell research.. 1996 Jul 10; 226(1):197-207.
1996 Jul
Teot LA, O'Keefe RJ, Rosier RN, O'Connell JX, Fox EJ, Hicks DG. "Extraosseous primary and recurrent giant cell tumors: transforming growth factor-beta1 and -beta2 expression may explain metaplastic bone formation." Human pathology. 1996 Jul; 27(7):625-32.
1996 Jun 8
Reynolds PR, Reynolds SD, O'Keefe RJ, Puzas JE, Rosier RN. "Alternative splicing of a chondrocyte-specific gene." Annals of the New York Academy of Sciences.. 1996 Jun 8; 785:321-4.
1996 Apr
Hicks DG, Judkins AR, Sickel JZ, Rosier RN, Puzas JE, O'Keefe RJ. "Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. The presence of wear debris, cytokine production, and immunologically activated macrophages." The Journal of bone and joint surgery. American volume.. 1996 Apr; 78(4):482-96.
1996 Mar
Scully SP, Temple HT, O'Keefe RJ, Mankin HJ, Gebhardt M. "The surgical treatment of patients with osteosarcoma who sustain a pathologic fracture." Clinical orthopaedics and related research.. 1996 Mar; (324):227-32.
1996
Delsignore JL, Dvoretsky PM, Hicks DG, O'Keefe RJ, Rosier RN. "Mastocytosis presenting as a skeletal disorder." The Iowa orthopaedic journal. 1996 16:126-34.
1995 Oct
O'Keefe RJ, Scurry JP, Dennerstein G, Sfameni S, Brenan J. "Audit of 114 non-neoplastic vulvar biopsies." British journal of obstetrics and gynaecology. 1995 Oct; 102(10):780-6.
1995 Oct
O'Keefe RJ, O'Donnell RJ, Temple HT, Scully SP, Mankin HJ. "Giant cell tumor of bone in the foot and ankle." Foot & ankle international.. 1995 Oct; 16(10):617-23.
1995 Sep
Scully SP, Temple HT, O'Keefe RJ, Scarborough MT, Mankin HJ, Gebhardt MC. "Role of surgical resection in pelvic Ewing's sarcoma." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 1995 Sep; 13(9):2336-41.
1995 Sep
O'Keefe RJ, O'Connell JX, Temple HT, Scully SP, Kattapuram SV, Springfield DS, Rosenberg AE, Mankin HJ. "Calcific myonecrosis. A late sequela to compartment syndrome of the leg." Clinical orthopaedics and related research.. 1995 Sep; (318):205-13.
1995 Apr
Hughes SS, Hicks DG, O'Keefe RJ, Hurwitz SR, Crabb ID, Krasinskas AM, Loveys L, Puzas JE, Rosier RN. "Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1995 Apr; 10(4):533-44.
1995
Rosier RN, Teot LA, Hicks DG, Schwartz C, O'Keefe RJ, Puzas JE. "Multiple drug resistance in osteosarcoma." The Iowa orthopaedic journal. 1995 15:66-73.
1994 Nov
O'Keefe RJ, Puzas JE, Loveys L, Hicks DG, Rosier RN. "Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: rapid induction of type X collagen in culture." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1994 Nov; 9(11):1713-22.
1994 Nov
Dennerstein GJ, Scurry JP, Garland SM, Brenan JA, Fortune DW, Sfameni SF, O'Keefe RJ, Tabrizi SN. "Human papillomavirus vulvitis: a new disease or an unfortunate mistake?" British journal of obstetrics and gynaecology. 1994 Nov; 101(11):992-8.
1994 Oct
Fraser SH, O'Keefe RJ, Scurry JP, Watkins AM, Drew JH, Chow CW. "Hydrocephalus ex vacuo and clasp thumb deformity due to congenital cytomegalovirus infection." Journal of paediatrics and child health. 1994 Oct; 30(5):450-2.
1994 Aug
Scully SP, Mott MP, Temple HT, O'Keefe RJ, O'Donnell RJ, Mankin HJ. "Late recurrence of giant-cell tumor of bone. A report of four cases." The Journal of bone and joint surgery. American volume.. 1994 Aug; 76(8):1231-3.
1994 May
O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. "Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1994 May; 12(3):299-310.
1994 Mar
Temple HT, Scully SP, O'Keefe RJ, Rosenthal DI, Mankin HJ. "Clinical presentation of alveolar soft-part sarcoma." Clinical orthopaedics and related research.. 1994 Mar; (300):213-8.
1994 Feb
Scully SP, Temple HT, O'Keefe RJ, Gebhardt MC. "Case report 830: Aneurysmal bone cyst." Skeletal radiology. 1994 Feb; 23(2):157-60.
1994
Puzas JE, Hicks DG, Reynolds SD, O'Keefe RJ. "Regulation of osteoclastic activity in infection." Methods in enzymology. 1994 236:47-58.
1992 Nov
O'Keefe RJ, Jones JA, Hurwitz SR. "Bilateral sacroiliac joint fracture-dislocation requiring late coccygectomy: a case report." The Journal of trauma. 1992 Nov; 33(5):793-4.
1992 Apr
O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. "Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1992 Apr; 7(4):397-404.
1992 Jan
Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN. "Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes." Calcified tissue international.. 1992 Jan; 50(1):61-6.
1990 Nov
Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN. "Synergistic effect of transforming growth factor beta and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1990 Nov; 5(11):1105-12.
1990
O'Keefe RJ, Rosier RN, Puzas JE. "Differential expression of biological effects in maturationally distinct subpopulations of growth plate chondrocytes." Connective tissue research.. 1990 24(1):53-66.
1989 Apr
O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. "Countercurrent centrifugal elutriation. High-resolution method for the separation of growth-plate chondrocytes." The Journal of bone and joint surgery. American volume.. 1989 Apr; 71(4):607-20.
1989
Rosier RN, O'Keefe RJ, Crabb ID, Puzas JE. "Transforming growth factor beta: an autocrine regulator of chondrocytes." Connective tissue research.. 1989 20(1-4):295-301.
1988 Jun
O'Keefe RJ, Puzas JE, Brand JS, Rosier RN. "Effects of transforming growth factor-beta on matrix synthesis by chick growth plate chondrocytes." Endocrinology. 1988 Jun; 122(6):2953-61.
1988
O'Keefe RJ, Puzas JE, Brand JS, Rosier RN. "Effect of transforming growth factor-beta on DNA synthesis by growth plate chondrocytes: modulation by factors present in serum." Calcified tissue international.. 1988 43(6):352-8.
1987 Aug
O'Keefe RJ, Domalik-Wawrzynski L, Guerrero JL, Rosow CE, Lowenstein E, Powell WJ. "Local and neurally mediated effects of sufentanil on canine skeletal muscle vascular resistance." The Journal of pharmacology and experimental therapeutics.. 1987 Aug; 242(2):699-706.