William J. Bowers, Ph.D.

William J. Bowers, Ph.D.

Contact Information

Vaccinex, Inc.
1895 Mt. Hope Avenue
Rochester, NY 14620

Office: (585) 271-2700 x199

Journal Articles

Showing all 92 journal articles available.

2013 Jun
Montgomery SL, Narrow WC, Mastrangelo MA, Olschowka JA, O'Banion MK, Bowers WJ. "Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies." The American journal of pathology.. 2013 Jun; 182(6):2285-97. Epub 2013 Apr 06.
2012 Mar
Montgomery SL, Bowers WJ. "Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2012 Mar; 7(1):42-59. Epub 2011 Jul 05.
2011 Oct
de Silva S, Bowers WJ. "Targeting the central nervous system with herpes simplex virus / Sleeping Beauty hybrid amplicon vectors." Current gene therapy. 2011 Oct; 11(5):332-40.
2011 Oct
Montgomery SL, Mastrangelo MA, Habib D, Narrow WC, Burrell SA, Wright TW, Bowers WJ. "Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-? suppressive therapeutic strategies in the brain." The American journal of pathology.. 2011 Oct; 179(4):2053-70. Epub 2011 Aug 09.
2011 Oct
Schnell L, Hunanyan AS, Bowers WJ, Horner PJ, Federoff HJ, Gullo M, Schwab ME, Mendell LM, Arvanian VL. "Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord." The European journal of neuroscience. 2011 Oct; 34(8):1256-67. Epub 2011 Oct 13.
2011 Sep 16
Domm W, Brooks L, Chung HL, Feng C, Bowers WJ, Watson G, McGrath JL, Dewhurst S. "Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier." Vaccine.. 2011 Sep 16; 29(40):7080-9. Epub 2011 Jul 27.
2011 Apr 15
Bowers WJ, Breakefield XO, Sena-Esteves M. "Genetic therapy for the nervous system." Human molecular genetics.. 2011 Apr 15; 20(R1):R28-41. Epub 2011 Mar 23.
2011 Apr
Desai MK, Guercio BJ, Narrow WC, Bowers WJ. "An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction." Glia.. 2011 Apr; 59(4):627-40. Epub 2011 Feb 03.
2011 Jan 11
Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S. "Trk retrograde signaling requires persistent, Pincher-directed endosomes." Proceedings of the National Academy of Sciences of the United States of America.. 2011 Jan 11; 108(2):852-7. Epub 2010 Dec 27.
2011
García-Alías G, Petrosyan HA, Schnell L, Horner PJ, Bowers WJ, Mendell LM, Fawcett JW, Arvanian VL. "Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2011 31(49):17788-99.
2011
Azadniv M, Bowers WJ, Topham DJ, Crispe IN. "CD4+ T cell effects on CD8+ T cell location defined using bioluminescence." PloS one. 2011 6(1):e16222. Epub 2011 Jan 20.
2011
Hunter JM, Bowers WJ, Maarouf CL, Mastrangelo MA, Daugs ID, Kokjohn TA, Kalback WM, Luehrs DC, Valla J, Beach TG, Roher AE. "Biochemical and morphological characterization of the A?PP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease." Journal of Alzheimer's disease : JAD.. 2011 27(2):361-76.
2010 Nov
de Silva S, Mastrangelo MA, Lotta Jr LT, Burris CA, Izsvák Z, Ivics Z, Bowers WJ. "Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo." Human gene therapy. 2010 Nov; 21(11):1603-13. Epub 2010 Oct 22.
2010 Nov
de Silva S, Lotta Jr LT, Burris CA, Bowers WJ. "Virion-associated cofactor high-mobility group DNA-binding protein-1 facilitates transposition from the herpes simplex virus/Sleeping Beauty amplicon vector platform." Human gene therapy. 2010 Nov; 21(11):1615-22. Epub 2010 Oct 07.
2010 Sep
Desai MK, Mastrangelo MA, Ryan DA, Sudol KL, Narrow WC, Bowers WJ. "Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target." The American journal of pathology.. 2010 Sep; 177(3):1422-35. Epub 2010 Aug 09.
2010 Sep
Lee BD, Shin JH, Vankampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. "Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease." Nature medicine.. 2010 Sep; 16(9):998-1000. Epub 2010 Aug 22.
2010 Aug
Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. "Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice." Molecular therapy : the journal of the American Society of Gene Therapy.. 2010 Aug; 18(8):1471-81. Epub 2010 Jun 15.
2010 Jul 15
Ryan DA, Narrow WC, Federoff HJ, Bowers WJ. "An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies." Journal of neuroscience methods.. 2010 Jul 15; 190(2):171-9. Epub 2010 May 07.
2010 Jul 14
Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. "Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2010 Jul 14; 30(28):9567-77.
2010 Jul
Park KM, Bowers WJ. "Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction." Cellular signalling. 2010 Jul; 22(7):977-83. Epub 2010 Jan 21.
2010 Apr
Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ. "GTPase activity plays a key role in the pathobiology of LRRK2." PLoS genetics.. 2010 Apr; 6(4):e1000902. Epub 2010 Apr 08.
2010 Mar
de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Federoff HJ, Bowers WJ. "Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform." Gene therapy.. 2010 Mar; 17(3):424-31. Epub 2009 Oct 29.
2010 Mar
Park KM, Yule DI, Bowers WJ. "Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons." Cellular signalling. 2010 Mar; 22(3):519-26.
2010 Feb
Fong S, Chan MK, Fong A, Bowers WJ, Kelly KJ. "Viral vector-induced expression of bone morphogenetic protein 2 produces inhibition of tumor growth and bone differentiation of stem cells." Cancer gene therapy.. 2010 Feb; 17(2):80-5. Epub 2009 Oct 16.
2009 Nov
Mastrangelo MA, Sudol KL, Narrow WC, Bowers WJ. "Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice." The American journal of pathology.. 2009 Nov; 175(5):2076-88. Epub 2009 Oct 01.
2009 Oct 2
Park KM, Yule DI, Bowers WJ. "Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter." The Journal of biological chemistry.. 2009 Oct 2; 284(40):27557-66. Epub 2009 Aug 07.
2009 Aug
Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. "Real-time MR imaging of adeno-associated viral vector delivery to the primate brain." NeuroImage. 2009 Aug; 47 Suppl 2:T27-35. Epub 2008 Nov 27.
2009 May
Federoff HJ, Chiu YG, Bowers WJ, Lim ST, Ryan DA. "Effects of herpes simplex virus amplicon transduction on murine dendritic cells." Human gene therapy. 2009 May; 20(5):442-52.
2009 Apr 2
Daubeuf S, Singh D, Tan Y, Liu H, Federoff HJ, Bowers WJ, Tolba K. "HSV ICP0 recruits USP7 to modulate TLR-mediated innate response." Blood.. 2009 Apr 2; 113(14):3264-75. Epub 2008 Oct 24.
2009 Jan 1
Desai MK, Sudol KL, Janelsins MC, Mastrangelo MA, Frazer ME, Bowers WJ. "Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology." Glia.. 2009 Jan 1; 57(1):54-65.
2009
de Silva S, Bowers WJ. "Herpes Virus Amplicon Vectors." Viruses. 2009 1(3):594-629.
2009
Bancos S, Cao Q, Bowers WJ, Crispe IN. "Dysfunctional memory CD8+ T cells after priming in the absence of the cell cycle regulator E2F4." Cellular immunology.. 2009 257(1-2):44-54.
2009
Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. "Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease." Molecular therapy : the journal of the American Society of Gene Therapy.. 2009 17(12):2031-40. Epub 2009 Jul 28.
2008 Nov 28
Park KM, Yule DI, Bowers WJ. "Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor." The Journal of biological chemistry.. 2008 Nov 28; 283(48):33069-79. Epub 2008 Oct 06.
2008 May
Nechushtan H, Pham D, Zhang Y, Morgensztern D, Yi KH, Shin SU, Federoff HJ, Bowers WJ, Tolba KA, Rosenblatt JD. "Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction." Cancer immunology, immunotherapy : CII.. 2008 May; 57(5):663-75. Epub 2007 Oct 19.
2008 May
Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. "Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4." Molecular therapy : the journal of the American Society of Gene Therapy.. 2008 May; 16(5):845-53. Epub 2008 Mar 11.
2008 Feb
Burris CA, de Silva S, Narrow WC, Casey AE, Lotta LT, Federoff HJ, Bowers WJ. "Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0." The journal of gene medicine.. 2008 Feb; 10(2):152-64.
2008
Mastrangelo MA, Bowers WJ. "Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice." BMC neuroscience. 2008 9:81. Epub 2008 Aug 12.
2008
Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. "Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice." The American journal of pathology.. 2008 173(6):1768-82. Epub 2008 Oct 30.
2007 Oct 16
Duke CM, Maguire CA, Keefer MC, Federoff HJ, Bowers WJ, Dewhurst S. "HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime." Vaccine.. 2007 Oct 16; 25(42):7410-21. Epub 2007 Aug 30.
2007 Oct 15
Yi KH, Nechushtan H, Bowers WJ, Walker GR, Zhang Y, Pham DG, Podack ER, Federoff HJ, Tolba KA, Rosenblatt JD. "Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo." Cancer research.. 2007 Oct 15; 67(20):10027-37.
2007 Oct
Peterson EB, Mastrangelo MA, Federoff HJ, Bowers WJ. "Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition." Molecular therapy : the journal of the American Society of Gene Therapy.. 2007 Oct; 15(10):1848-55. Epub 2007 Jul 24.
2007 Oct
Azadniv M, Dugger K, Bowers WJ, Weaver C, Crispe IN. "Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporter." International immunology. 2007 Oct; 19(10):1165-73. Epub 2007 Aug 14.
2007 Feb 23
Sortwell CE, Bowers WJ, Counts SE, Pitzer MR, Fleming MF, McGuire SO, Maguire-Zeiss KA, Federoff HJ, Collier TJ. "Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival." Brain research.. 2007 Feb 23; 1134(1):33-44. Epub 2006 Dec 28.
2007 Feb 19
Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff HJ, Frelinger JG, Bowers WJ, Dewhurst S. "Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag." Vaccine.. 2007 Feb 19; 25(9):1634-46. Epub 2006 Nov 15.
2007
Santos, K.; Sanfilippo, C.M.; Narrow, W.C.; Casey, A.E.; McDermott, M.; Federoff, H.J.; Bowers, W.J.; Dewhurst, S. "Infectivity of Herpes Simplex Virus Type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging". J Virol Meth. 2007; 145: 37-46.
2006 Nov
Halterman MW, Giuliano RE, Bowers WJ, Federoff HJ. "Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity." The journal of gene medicine.. 2006 Nov; 8(11):1320-8.
2006 Jun
Tyler CM, Wuertzer CA, Bowers WJ, Federoff HJ. "HSV amplicons: neuro applications." Current gene therapy. 2006 Jun; 6(3):337-50.
2006 Mar
Bowers WJ, Mastrangelo MA, Howard DF, Southerland HA, Maguire-Zeiss KA, Federoff HJ. "Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector." Molecular therapy : the journal of the American Society of Gene Therapy.. 2006 Mar; 13(3):580-8. Epub 2006 Jan 18.
2006 Feb
Arvanian VL, Bowers WJ, Anderson A, Horner PJ, Federoff HJ, Mendell LM. "Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat." Experimental neurology.. 2006 Feb; 197(2):347-52. Epub 2005 Nov 11.
2005 Nov 16
Federoff HJ, Bowers WJ. "Immune shaping and the development of Alzheimer's disease vaccines." Science of aging knowledge environment : SAGE KE. 2005 Nov 16; 2005(46):pe35. Epub 2005 Nov 16.
2005 Oct 18
Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. "Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice." Journal of neuroinflammation. 2005 Oct 18; 2:23. Epub 2005 Oct 18.
2005 Aug
Corso TD, Torres G, Goulah C, Roy I, Gambino AS, Nayda J, Buckley T, Stachowiak EK, Bergey EJ, Pudavar H, Dutta P, Bloom DC, Bowers WJ, Stachowiak MK. "Assessment of viral and non-viral gene transfer into adult rat brains using HSV-1, calcium phosphate and PEI-based methods." Folia morphologica. 2005 Aug; 64(3):130-44.
2005 Apr
Bowers WJ, Mastrangelo MA, Stanley HA, Casey AE, Milo LJ, Federoff HJ. "HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses." Neurobiology of aging.. 2005 Apr; 26(4):393-407.
2005 Feb
Gorantla S, Santos K, Meyer V, Dewhurst S, Bowers WJ, Federoff HJ, Gendelman HE, Poluektova L. "Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge." Journal of virology.. 2005 Feb; 79(4):2124-32.
2005
Reinblatt M, Pin RH, Bowers WJ, Federoff HJ, Fong Y. "Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma." Annals of surgical oncology.. 2005 12(12):1025-36. Epub 2005 Oct 25.
2004 Nov
Pin RH, Reinblatt M, Bowers WJ, Federoff HJ, Fong Y. "Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2004 Nov; 8(7):812-22; discussion 822-3.
2004
Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. "Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2004 24(48):10963-73.
2004
Arvanian, V.L.; Bowers, W.J.; Petruska, J.C.; Motin, V.; Manuzon, H.; Narrow, W.C.; Federoff, H.J.; Mendell, L.M. "Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons." J. Neurophys.. 2004; 92: 2394-2404. Link
2003 Nov
Kyrkanides S, Miller JH, Bowers WJ, Federoff HJ. "Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system." Molecular therapy : the journal of the American Society of Gene Therapy.. 2003 Nov; 8(5):790-5.
2003 Sep
Harvey BK, Chang CF, Chiang YH, Bowers WJ, Morales M, Hoffer BJ, Wang Y, Federoff HJ. "HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury." Experimental neurology.. 2003 Sep; 183(1):47-55.
2003 Aug 13
Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, Vereker E, Bowers WJ, Federoff HJ, Goodyer CG, LeBlanc A. "p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 Aug 13; 23(19):7385-94.
2003 Jun 2
Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff HJ, Dewhurst S. "Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming." Vaccine.. 2003 Jun 2; 21(19-20):2288-97.
2003 Jun
Bowers WJ, Olschowka JA, Federoff HJ. "Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy." Gene therapy.. 2003 Jun; 10(11):941-5.
2003 Feb
Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR. "Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing." Nature medicine.. 2003 Feb; 9(2):231-5. Epub 2003 Jan 21.
2003 Feb
Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff HJ. "Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS." Molecular therapy : the journal of the American Society of Gene Therapy.. 2003 Feb; 7(2):218-27.
2002 Nov 15
Tolba KA, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD. "Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity." Cancer research.. 2002 Nov 15; 62(22):6545-51.
2002 Oct
Tolba KA, Bowers WJ, Eling DJ, Casey AE, Kipps TJ, Federoff HJ, Rosenblatt JD. "HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia." Molecular therapy : the journal of the American Society of Gene Therapy.. 2002 Oct; 6(4):455-63.
2002 Jul 12
Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. "Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor." Science.. 2002 Jul 12; 297(5579):259-63.
2002 Jul
Mankodi A, Takahashi MP, Jiang H, Beck CL, Bowers WJ, Moxley RT, Cannon SC, Thornton CA. "Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy." Molecular cell. 2002 Jul; 10(1):35-44.
2002 Jun
Hocknell PK, Wiley RD, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst S. "Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses." Journal of virology.. 2002 Jun; 76(11):5565-80.
2002 Jun
Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK. "Reporter gene transfer induces apoptosis in primary cortical neurons." Molecular therapy : the journal of the American Society of Gene Therapy.. 2002 Jun; 5(6):723-30.
2002 Mar
Halaby IA, Lyden SP, Davies MG, Roztocil E, Salamone LJ, Brooks AI, Green RM, Federoff HJ, Bowers WJ. "Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle." Molecular therapy : the journal of the American Society of Gene Therapy.. 2002 Mar; 5(3):300-6.
2002 Jan
Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. "Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth." Development.. 2002 Jan; 129(2):467-77.
2002
Bowers, W.J.; Chen, X.; Guo, H.; Frisina, D.R.; Federoff, H.J.; Frisina, R.D.;. "Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea". Mol Ther. 2002; 6(1): Ganglion/drug effects/*physiopathology. Link
2002
Bowers WJ, Federoff HJ. "Amyloid immunotherapy-engendered CNS inflammation." Neurobiology of aging.. 2002 23(5):675-6; discussion 683-4.
2002
Maguire-Zeiss KA, Bowers WJ, Federoff HJ. "Somatic mosaic approaches and the aging brain." Neurobiology of aging.. 2002 23(5):977-84.
2002
Wang SW, Mu X, Bowers WJ, Klein WH. "Retinal ganglion cell differentiation in cultured mouse retinal explants." Methods (San Diego, Calif.). 2002 28(4):448-56.
2001 Oct 10
Willis RA, Bowers WJ, Turner MJ, Fisher TL, Abdul-Alim CS, Howard DF, Federoff HJ, Lord EM, Frelinger JG. "Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice." Human gene therapy. 2001 Oct 10; 12(15):1867-79.
2001 Oct
Maguire-Zeiss KA, Bowers WJ, Federoff HJ. "HSV vector-mediated gene delivery to the central nervous system." Current opinion in molecular therapeutics. 2001 Oct; 3(5):482-90.
2001 Aug 16
Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G. "Regulation of neuronal traits by a novel transcriptional complex." Neuron.. 2001 Aug 16; 31(3):353-65.
2001 Jul 15
Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff HJ, Rosenblatt JD. "Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia." Blood.. 2001 Jul 15; 98(2):287-95.
2001 Jun
Chen X, Frisina RD, Bowers WJ, Frisina DR, Federoff HJ. "HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage." Molecular therapy : the journal of the American Society of Gene Therapy.. 2001 Jun; 3(6):958-63.
2001 Mar 1
Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins." Nature.. 2001 Mar 1; 410(6824):89-93.
2001 Jan
Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff HJ. "Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers." Gene therapy.. 2001 Jan; 8(2):111-20.
2000 Nov 20
Brooks AI, Cory-Slechta DA, Bowers WJ, Murg SL, Federoff HJ. "Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus." Human gene therapy. 2000 Nov 20; 11(17):2341-52.
2000 Mar
Bowers WJ, Howard DF, Federoff HJ. "Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration." Molecular therapy : the journal of the American Society of Gene Therapy.. 2000 Mar; 1(3):294-9.
1997 May 6
Baglia LA, Bowers WJ, Ruddell A. "The avian C/EBPgamma gene encodes a highly conserved leucine zipper transcription factor." Gene.. 1997 May 6; 190(2):297-302.
1997 Mar
Bowers WJ, Howard DF, Federoff HJ. "Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease." Experimental neurology.. 1997 Mar; 144(1):58-68.
1996 May
Bowers WJ, Baglia LA, Ruddel A. "Regulation of avian leukosis virus long terminal repeat-enhanced transcription by C/EBP-Rel interactions." Journal of virology.. 1996 May; 70(5):3051-9.
1994 Apr
Bowers WJ, Petrosino JF, Smith CD, Ruddell A. "Transcriptional regulation of ALV bursal lymphomagenesis." Leukemia.. 1994 Apr; 8 Suppl 1:S211-3.
1992 Nov
Bowers WJ, Ruddell A. "a1/EBP: a leucine zipper protein that binds CCAAT/enhancer elements in the avian leukosis virus long terminal repeat enhancer." Journal of virology.. 1992 Nov; 66(11):6578-86.

Books

2007
Bowers, W.J.; Janelsins, M.C.; Federoff, H.J.. "Application to gene therapy and vaccination.". Neuroimmune Pharmacology. Ikezu, T.; Gendelman, H.. New York, NY: Springer, 2007.
2006
Bowers, W.J.; Federoff, H.J.. "Immunotherapeutic approaches for Alzheimer's disease". Gene Therapy for Neurological Disorders. Lowenstein, P.; Castro, M.. New York, NY: Taylor and Francis, 2006. 197-227
2006
Bowers, W.J.; Federoff, H.J.. "Herpes Simplex Virus Type-1-derived Amplicon Vectors". Gene Transfer: Delivery and Expression of DNA and RNA. Friedmann, T.; Rossi, J.. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2006. 227-254
2004
Bowers, W.J.; Federoff, H.J.. "Gene therapy for neurological diseases.". Gene Therapy: Therapeutic Mechanisms and Strategies. Templeton, N.S.. New York, NY: Marcel Dekker, 2004. 601-627
2002
Maguire-Zeiss, K.A.; Bowers, W.J.; Federoff, H.J.. "HSV amplicon vectors in neuronal apoptosis studies.". Neuromethods. LeBlanc, A.. Totowa, NJ: Humana Press, 2002. 61-82