Terry W. Wright, Ph.D.

Terry W. Wright, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-4246
Lab: (585) 275-2234

Research Bio

Dr. Wright's research interests are:



1) Pneumocystis carinii biology
2) Pathogenesis of lung injury during Pneumocystis carinii pneumonia.

The rapid clearance of bacterial and fungal pathogens is essential to preserve the delicate structure and critical function of the lung. The opportunistic pathogen, Pneumocystis carinii, colonizes the alveolar epithelium of patients suffering from a variety of immunodeficiencies, including AIDS. Dr. Wright's laboratory uses an immunologically-reconstituted scid mouse model of Pneumocystis carinii pneumonia (PCP) to study the host response to infection. Scid mice lack functional lymphocytes and therefore develop active P. carinii infections. However, the adoptive transfer of congenic spleen cells, including CD4+ T lymphocytes, to P. carinii-infected scid mice results in inflammatory cell recruitment to sites of infection and organism clearance. They are now examining the earliest molecular signals (including cytokine and chemokine expression) produced at epithelial sites of P. carinii colonization, to determine which cell types and which soluble mediators are involved in targeting inflammatory cell recruitment. These studies will not only further our understanding of PCP, but may also provide insight into general mechanisms of lung defense.

In addition, they are examining the role of pulmonary inflammation in the pathology of PCP. As stated above, an intense CD4+ T lymphocyte-dependent inflammatory response is mounted at sites of infection in reconstituted scid mice. In many cases this inflammatory response is productive, and serves to resolve the infection. However, under certain circumstances the inflammatory response may actually contribute to the pulmonary injury and respiratory impairment observed in P. carinii pneumonia. They have begun studies using physiological and molecular measurements of lung injury to assess the in vivo role of P. carinii driven inflammation in PCP. They also plan to test specific anti-inflammatory agents to manipulate various aspects of the inflammatory response to determine the effect on lung injury. These studies will help define the role of inflammation in PCP, and further our understanding of pulmonary immunology.

Awards & Honors (Local)

American Society for Microbiology Sustaining Membership Travel Award 1994

Recent Journal Articles

Showing the 5 most recent journal articles. 47 available »

2014 Jan 1
Bello-Irizarry SN, Wang J, Johnston CJ, Gigliotti F, Wright TW. "MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection." The Journal of immunology : official journal of the American Association of Immunologists.. 2014 Jan 1; 192(1):282-92. Epub 2013 Nov 29.
2013 Nov 1
Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW. "Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis." The Journal of immunology : official journal of the American Association of Immunologists.. 2013 Nov 1; 191(9):4720-30. Epub 2013 Sep 27.
2013
Kulkarni AA, Thatcher TH, Hsiao HM, Olsen KC, Kottmann RM, Morrissette J, Wright TW, Phipps RP, Sime PJ. "The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis." PloS one. 2013 8(5):e63798. Epub 2013 May 31.
2012
Gigliotti F, Wright TW. "Pneumocystis: where does it live?" PLoS pathogens.. 2012 8(11):e1003025. Epub 2012 Nov 29.
2011
Wang J, Wright TW, Gigliotti F. "Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia." Interdisciplinary perspectives on infectious diseases. 2011 2011:918038. Epub 2011 Aug 29.

Current Appointments

Associate Professor - Department of Pediatrics, Infectious Diseases (SMD) - Primary

Education

PhD | Microbiology and Immunology | University of Rochester School of Medicine and Dentistry1995
MS | Microbiology and Immunology | University of Rochester School of Medicine and Dentistry1992
BS | Biotechnology | Rochester Institute of Technology1990

Post-Doctoral Training & Residency

Pediatrics Postdoctoral Training, Division of Neonatology, University of Rochester School of Medicine and Dentistry, Rochester, NY 1997