Mark P. Sowden, Ph.D.

Mark P. Sowden, Ph.D.

Contact Information

Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta, NY 14586

Office: (585) 276-3014
Fax: (585) 276-2272

Research Bio

Dr. Sowden received the University of Rochester Deans Institutional Award in 2002-04 to study the role of activation induced deaminase as an RNA editing enzyme in human B-cell function. Since then, he has received support from the UR Environmental Health Sciences Center and the Philip Morris External Research Program for related studies of smoking-associated carcinogenesis and teh APOBEC family of deaminases.



He is currently working with Dr. Peter Sims and Dr. Therese Wiedmer in studies of phospholipid scramblases.

Recent Journal Articles

Showing the 5 most recent journal articles. 35 available »

2007 Mar
Lehmann DM, Galloway CA, MacElrevey C, Sowden MP, Wedekind JE, Smith HC. "Functional characterization of APOBEC-1 complementation factor phosphorylation sites." Biochimica et biophysica acta. 2007 Mar; 1773(3):408-18. Epub 2006 Dec 08.
2006 Nov 10
Bennett RP, Diner E, Sowden MP, Lees JA, Wedekind JE, Smith HC. "APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic." Biochemical and biophysical research communications. 2006 Nov 10; 350(1):214-9. Epub 2006 Sep 18.
2006 Jul 1
Ichikawa HT, Sowden MP, Torelli AT, Bachl J, Huang P, Dance GS, Marr SH, Robert J, Wedekind JE, Smith HC, Bottaro A. "Structural phylogenetic analysis of activation-induced deaminase function." The Journal of immunology : official journal of the American Association of Immunologists. 2006 Jul 1; 177(1):355-61.
2006 Apr 15
Sparks JD, Collins HL, Chirieac DV, Cianci J, Jokinen J, Sowden MP, Galloway CA, Sparks CE. "Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase." The Biochemical journal. 2006 Apr 15; 395(2):363-71.
2006
Lehmann DM, Galloway CA, Sowden MP, Smith HC. "Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor." Nucleic acids research. 2006 34(11):3299-308. Epub 2006 Jul 04.

Current Appointments

Research Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD) - Primary

Education

Post-Doc | RNA Editing | University of Rochester Medical Center1995
Post-Doc | HPV Biology | University of Rochester Medical Center1992
PhD | Arts & Sciences | University of Oxford - Non-Medical School1990
BS | Microbiology | University of Warwick - Non-Medical School1987