Carrie Dykes, Ph.D.

Carrie Dykes, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 689
Rochester, NY 14642

Office: (585) 273-4104
Fax: (585) 442-9328
Lab: (585) 275-0384

Journal Articles

Showing all 29 journal articles available.

2013 Jul
Wang J, Li D, Bambara RA, Yang H, Dykes C. "L74V increases the reverse transcriptase content of HIV-1 virions with non-nucleoside reverse transcriptase drug-resistant mutations L100I+K103N and K101E+G190S, which results in increased fitness." The Journal of general virology. 2013 Jul; 94(Pt 7):1597-607. Epub 2013 Mar 27.
2013 Apr
Zhang X, Tierney C, Albrecht M, Demeter LM, Morse G, DiFrancesco R, Dykes C, Jiang H, Haas DW. "Discordant associations between SLCO1B1 521T?C and plasma levels of ritonavir-boosted protease inhibitors in AIDS clinical trials group study A5146." Therapeutic drug monitoring.. 2013 Apr; 35(2):209-16.
2012 Jun
Block O, Mitra A, Novotny L, Dykes C. "A rapid label-free method for quantitation of human immunodeficiency virus type-1 particles by nanospectroscopy." Journal of virological methods.. 2012 Jun; 182(1-2):70-5. Epub 2012 Mar 20.
2011 Oct
Wang J, Zhang G, Bambara RA, Li D, Liang H, Wu H, Smith HM, Lowe NR, Demeter LM, Dykes C. "Nonnucleoside reverse transcriptase inhibitor-resistant HIV is stimulated by efavirenz during early stages of infection." Journal of virology.. 2011 Oct; 85(20):10861-73. Epub 2011 Aug 10.
2011 Feb 20
Piekna-Przybylska D, Dykes C, Demeter LM, Bambara RA. "Sequences in the U3 region of human immunodeficiency virus 1 improve efficiency of minus strand transfer in infected cells." Virology.. 2011 Feb 20; 410(2):368-74. Epub 2010 Dec 30.
2011
Albrecht M, Mukherjee AL, Tierney C, Morse GD, Dykes C, Klingman KL, Demeter LM. "A randomized clinical trial evaluating therapeutic drug monitoring (TDM) for protease inhibitor-based regimens in antiretroviral-experienced HIV-infected individuals: week 48 results of the A5146 study." HIV clinical trials. 2011 12(4):201-14.
2010 Nov
Dykes C, Wu H, Sims M, Holden-Wiltse J, Demeter LM. "Human immunodeficiency virus type 1 protease inhibitor drug-resistant mutants give discordant results when compared in single-cycle and multiple-cycle fitness assays." Journal of clinical microbiology.. 2010 Nov; 48(11):4035-43. Epub 2010 Sep 08.
2010 Sep
Wang J, Bambara RA, Dykes C. "Reduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions." Journal of virology.. 2010 Sep; 84(18):9377-89. Epub 2010 Jun 30.
2010 Sep
Dykes C, Mukherjee AL, Bosch RJ, Connick E, Volberding PA, Demeter LM. "Prevalence of primary resistance at baseline in acutely and recently infected subjects enrolled in AIDS clinical trials group protocol 371." Journal of acquired immune deficiency syndromes : JAIDS.. 2010 Sep; 55(1):132-4.
2010 Aug
Difrancesco R, Rosenkranz S, Mukherjee AL, Demeter LM, Jiang H, Dicenzo R, Dykes C, Rinehart A, Albrecht M, Morse GD. "Quality assessment for therapeutic drug monitoring in AIDS Clinical Trials Group (ACTG 5146): a multicenter clinical trial." Therapeutic drug monitoring.. 2010 Aug; 32(4):458-66.
2010 Jul 5
Wang J, Liang H, Bacheler L, Wu H, Deriziotis K, Demeter LM, Dykes C. "The non-nucleoside reverse transcriptase inhibitor efavirenz stimulates replication of human immunodeficiency virus type 1 harboring certain non-nucleoside resistance mutations." Virology.. 2010 Jul 5; 402(2):228-37. Epub 2010 Apr 18.
2010 Mar 23
Mitra A, Deutsch B, Ignatovich F, Dykes C, Novotny L. "Nano-optofluidic detection of single viruses and nanoparticles." ACS nano.. 2010 Mar 23; 4(3):1305-12.
2010 Jan 15
Gandhi RT, Bosch RJ, Aga E, Albrecht M, Demeter LM, Dykes C, Bastow B, Para M, Lai J, Siliciano RF, Siliciano JD, Eron JJ, . "No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy." The Journal of infectious diseases.. 2010 Jan 15; 201(2):293-6.
2010
Ma J, Dykes C, Wu T, Huang Y, Demeter L, Wu H. "vFitness: a web-based computing tool for improving estimation of in vitro HIV-1 fitness experiments." BMC bioinformatics. 2010 11:261. Epub 2010 May 18.
2009 Mar
Miao H, Dykes C, Demeter LM, Wu H. "Differential equation modeling of HIV viral fitness experiments: model identification, model selection, and multimodel inference." Biometrics.. 2009 Mar; 65(1):292-300. Epub 2008 May 28.
2009 Jan 28
Demeter LM, Jiang H, Mukherjee AL, Morse GD, DiFrancesco R, DiCenzo R, Dykes C, Sista P, Bacheler L, Klingman K, Rinehart A, Albrecht M. "A randomized trial of therapeutic drug monitoring of protease inhibitors in antiretroviral-experienced, HIV-1-infected patients." AIDS.. 2009 Jan 28; 23(3):357-68.
2008 Aug
Miao H, Dykes C, Demeter LM, Cavenaugh J, Park SY, Perelson AS, Wu H. "Modeling and estimation of kinetic parameters and replicative fitness of HIV-1 from flow-cytometry-based growth competition experiments." Bulletin of mathematical biology. 2008 Aug; 70(6):1749-71. Epub 2008 Jul 22.
2006 Sep 15
Koval CE, Dykes C, Wang J, Demeter LM. "Relative replication fitness of efavirenz-resistant mutants of HIV-1: correlation with frequency during clinical therapy and evidence of compensation for the reduced fitness of K103N + L100I by the nucleoside resistance mutation L74V." Virology.. 2006 Sep 15; 353(1):184-92. Epub 2006 Jun 21.
2006 Jun
Dykes C, Wang J, Jin X, Planelles V, An DS, Tallo A, Huang Y, Wu H, Demeter LM. "Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture." Journal of clinical microbiology.. 2006 Jun; 44(6):1930-43.
2006 May 10
Wang J, Dykes C, Domaoal RA, Koval CE, Bambara RA, Demeter LM. "The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in replication efficiency." Virology.. 2006 May 10; 348(2):462-74. Epub 2006 Feb 28.
2006 Mar
Wu H, Huang Y, Dykes C, Liu D, Ma J, Perelson AS, Demeter LM. "Modeling and estimation of replication fitness of human immunodeficiency virus type 1 in vitro experiments by using a growth competition assay." Journal of virology.. 2006 Mar; 80(5):2380-9.
2004 Sep 1
Dykes C, Balakrishnan M, Planelles V, Zhu Y, Bambara RA, Demeter LM. "Identification of a preferred region for recombination and mutation in HIV-1 gag." Virology.. 2004 Sep 1; 326(2):262-79.
2004 Mar 15
Dykes C, Najjar J, Bosch RJ, Wantman M, Furtado M, Hart S, Hammer SM, Demeter LM. "Detection of drug-resistant minority variants of HIV-1 during virologic failure of indinavir, lamivudine, and zidovudine." The Journal of infectious diseases.. 2004 Mar 15; 189(6):1091-6. Epub 2004 Mar 01.
2001 Jul 5
Dykes C, Fox K, Lloyd A, Chiulli M, Morse E, Demeter LM. "Impact of clinical reverse transcriptase sequences on the replication capacity of HIV-1 drug-resistant mutants." Virology.. 2001 Jul 5; 285(2):193-203.
2000 Sep
Archer RH, Dykes C, Gerondelis P, Lloyd A, Fay P, Reichman RC, Bambara RA, Demeter LM. "Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture." Journal of virology.. 2000 Sep; 74(18):8390-401.
2000 Jul
Dykes C, Mootsikapun P, Dexter A, Berrios L, Chiulli M, Reichman RC, Demeter LM. "Analysis of env sequence evolution in human immunodeficiency virus-infected patients receiving therapy with nonnucleoside reverse-transcriptase inhibitors." The Journal of infectious diseases.. 2000 Jul; 182(1):316-20. Epub 2000 Jul 06.
1997 May
Dykes C, Chan H, Krenitsky DM, Dewhurst S. "Stringent structural and sequence requirements of the human herpesvirus 6B lytic-phase origin of DNA replication." The Journal of general virology. 1997 May; 78 ( Pt 5):1125-9.
1997 Apr
van Loon N, Dykes C, Deng H, Dominguez G, Nicholas J, Dewhurst S. "Identification and analysis of a lytic-phase origin of DNA replication in human herpesvirus 7." Journal of virology.. 1997 Apr; 71(4):3279-84.
1994 Oct
Dewhurst S, Krenitsky DM, Dykes C. "Human herpesvirus 6B origin: sequence diversity, requirement for two binding sites for origin-binding protein, and enhanced replication from origin multimers." Journal of virology.. 1994 Oct; 68(10):6799-803.

Books