Mark D. Platt, Ph.D.

Mark D. Platt, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester, NY 14642

Office: (585) 276-6804

Research Bio

"Elucidating protein structure and function is an important first step towards understanding every cellular process as well as the molecular basis of many diseases. My research into the field of proteomics, which is defined as the "attempt to identify all of the proteins expressed by a given genome," seeks to not only identify proteins through determination of their primary amino acid sequence, but to also characterize protein post-translational modifications (PTMs) and to quantitate their relative expression levels between different cell types and/or growth states. To this end, our laboratory has demonstrated expertise in the enrichment and preparation of samples from bacteria, plants, and mammalian systems (including human tissues and biological fluids) and we have developed several novel proteomic approaches for biomarker discovery and detection of potential drug targets.

The instrumentation installed, maintained and operated within the laboratory includes a number of high-end mass spectrometers (Thermo LTQ, Thermo TSQ, Bruker micrOTOF and Bruker 9.4T Apex FTMS) and associated data analysis software (SEQUEST, Mascot, Proteome Discoverer). This equipment and expertise has permitted us to successfully establish joint research collaborations and integrate proteomic workflows into wider research efforts at the URMC."

Recent Journal Articles

Showing the 5 most recent journal articles. 9 available »

2013 Jan 16
Tang X, Platt MD, Lagnese CM, Leslie JR, Hamada FN. "Temperature integration at the AC thermosensory neurons in Drosophila." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Jan 16; 33(3):894-901.
2012 Oct
Porambo JR, Salicioni AM, Visconti PE, Platt MD. "Sperm phosphoproteomics: historical perspectives and current methodologies." Expert review of proteomics. 2012 Oct; 9(5):533-48.
2009 Mar
Platt MD, Salicioni AM, Hunt DF, Visconti PE. "Use of differential isotopic labeling and mass spectrometry to analyze capacitation-associated changes in the phosphorylation status of mouse sperm proteins." Journal of proteome research. 2009 Mar; 8(3):1431-40.
2008 Apr
Platt MD, Schurr MJ, Sauer K, Vazquez G, Kukavica-Ibrulj I, Potvin E, Levesque RC, Fedynak A, Brinkman FS, Schurr J, Hwang SH, Lau GW, Limbach PA, Rowe JJ, Lieberman MA, Barraud N, Webb J, Kjelleberg S, Hunt DF, Hassett DJ. "Proteomic, microarray, and signature-tagged mutagenesis analyses of anaerobic Pseudomonas aeruginosa at pH 6.5, likely representing chronic, late-stage cystic fibrosis airway conditions." Journal of bacteriology. 2008 Apr; 190(8):2739-58. Epub 2008 Jan 18.
2007 May
Lin CH, Platt MD, Ficarro SB, Hoofnagle MH, Shabanowitz J, Comai L, Hunt DF, Owens GK. "Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor." American journal of physiology. Cell physiology. 2007 May; 292(5):C1617-24. Epub 2006 Dec 20.