Sherry L. Spinelli, Ph.D.

Sherry L. Spinelli, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Office: (585) 273-3762

Research Bio

Platelets are anucleate cells released from megakaryocytes that circulate in the vascular system. Their importance and function in hemostasis is well known. Our (Drs. Neil Blumberg, Richard Phipps and myself) research interests lie in the emerging concept that platelets have a significant role in the mediation of inflammation and immunoregulation. Of particular interest is the nuclear hormone receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), part of a superfamily of ligand-activated receptors involved in transcriptional regulation of genes in energy metabolism and adipocyte differentiation. Several cell types including lymphocytes, fibroblasts, and endothelial cells express PPARgamma. Interestingly, our laboratory has recently demonstrated that human platelets also express PPARgamma and receptor binding of PPARgamma by PPARgamma agonists reduces platelet release of proinflammatory mediators. This is of major significance as platelet activation is linked to several diseases including atherosclerosis, insulin resistance in type II diabetes, and cancer. My goal is to understand the role of platelet PPARgamma in inflammation. This research is conducted in collaboration with the laboratory of Dr. Richard Phipps.



Platelet transfusion can cause a life-threatening inflammatory response. Upon activation, platelets undergo rapid morphological changes, and release bioactive mediators including chemokines, prostaglandins and growth factors that elicit a variety of responses. We will investigate the role of platelet-released proinflammatory mediators in transfusion-associated inflammation and multi-organ failure. Our goal is to develop a therapeutic strategy to reduce the risk of inflammatory responses in patients transfused with platelets.

Awards & Honors (Local)

Regional Trio Achiever Award 2004
Walter S. Bloor Award 1999
Elon Huntington Hooker Graduate Research Fellowship 1998 - 1999
Stotz Fellowship 1994 - 1996
Sigma Xi Award for Research 1994
EMSA Undergraduate Scholarship 1994
Ronald E. McNair Program 1993 - 1994

Recent Journal Articles

Showing the 5 most recent journal articles. 35 available »

2014 Jun
Spinelli SL, Lannan KL, Casey AE, Croasdell A, Curran TM, Henrichs KF, Pollock SJ, Milne GA, Refaai MA, Francis CW, Phipps RP, Blumberg N. "Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro." Transfusion.. 2014 Jun; 54(6):1569-79. Epub 2013 Nov 05.
2013 Jun 1
McMillan DH, Woeller CF, Thatcher TH, Spinelli SL, Maggirwar SB, Sime PJ, Phipps RP. "Attenuation of inflammatory mediator production by the NF-?B member RelB is mediated by microRNA-146a in lung fibroblasts." American journal of physiology. Lung cellular and molecular physiology.. 2013 Jun 1; 304(11):L774-81. Epub 2013 Apr 05.
2013 Feb
Refaai MA, Carter J, Henrichs KF, Davidson DC, Pollock SJ, Casey AE, Spinelli SL, Phipps RP, Francis CW, Blumberg N. "Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B." Transfusion.. 2013 Feb; 53(2):382-93. Epub 2012 May 25.
2013 Jan
Lannan KL, Sahler J, Spinelli SL, Phipps RP, Blumberg N. "Transfusion immunomodulation--the case for leukoreduced and (perhaps) washed transfusions." Blood cells, molecules & diseases.. 2013 Jan; 50(1):61-8. Epub 2012 Sep 13.
2012 Jun
Sahler J., Spinelli S., Phipps R., Blumberg N. "CD40 ligand (CD154) involvement in platelet transfusion reactions." Transfus Clin Biol.. 2012; 19(3): 98-103.

Current Appointments

Research Associate Professor - Department of Pathology and Laboratory Medicine (SMD) - Primary

Education

PhD | Biochemistry | Univ Rochester Sch Med/Dent1999
MS | Biochemistry | Univ Rochester Sch Med/Dent1997
BS | Biology | SUNY Coll at Brockport1994

Post-Doctoral Training & Residency

Postdoctoral Fellow Douglas Turner, PhD University of Rochester Rochester, New York 14627-0011 2003
Postdoctoral Fellow Eric Phizicky, PhD University of Rochester School of Medicine and Dentistry Rochester, NY 14642 2000