Alan V. Smrcka, Ph.D.

Alan V. Smrcka, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Office: (585) 275-0892
Lab: (585) 275-0859
Fax: (585) 273-2652

Journal Articles

Showing all 92 journal articles available.

2014 Jun 17
Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. "Simultaneous adrenal and cardiac g-protein-coupled receptor-g?? inhibition halts heart failure progression." Journal of the American College of Cardiology.. 2014 Jun 17; 63(23):2549-57. Epub 2014 Apr 02.
2014 Apr 18
Kan W, Adjobo-Hermans M, Burroughs M, Faibis G, Malik S, Tall GG, Smrcka AV. "M3 muscarinic receptor interaction with phospholipase C ?3 determines its signaling efficiency." The Journal of biological chemistry.. 2014 Apr 18; 289(16):11206-18. Epub 2014 Mar 04.
2014 Feb
Ruisanchez E, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z. "Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2014 Feb; 28(2):880-90. Epub 2013 Nov 18.
2013 Sep 15
Easterhoff D, Dimaio JT, Liyanage W, Lo CW, Bae W, Doran TM, Smrcka A, Nilsson BL, Dewhurst S. "Fluorescence detection of cationic amyloid fibrils in human semen." Bioorganic & medicinal chemistry letters.. 2013 Sep 15; 23(18):5199-202. Epub 2013 Jul 08.
2013 Jun 7
"WDR26 functions as a scaffolding protein to promote G??-mediated phospholipase C ?2 (PLC?2) activation in leukocytes." The Journal of biological chemistry.. 2013 Jun 7; 288(23):16715-25. Epub 2013 Apr 26.
2013 May
Smrcka AV. "Molecular targeting of G? and G?? subunits: a potential approach for cancer therapeutics." Trends in pharmacological sciences. 2013 May; 34(5):290-8. Epub 2013 Apr 01.
2013 Mar 28
Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV. "Phospholipase C? hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy." Cell.. 2013 Mar 28; 153(1):216-27.
2013 Feb 26
Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, Brown JH. "Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses." Proceedings of the National Academy of Sciences of the United States of America.. 2013 Feb 26; 110(9):3609-14. Epub 2013 Feb 11.
2012 Jun
Smrcka AV, Brown JH, Holz GG. "Role of phospholipase C? in physiological phosphoinositide signaling networks." Cellular signalling. 2012 Jun; 24(6):1333-43. Epub 2012 Jan 20.
2012 Jun
McCoy KL, Gyoneva S, Vellano CP, Smrcka AV, Traynelis SF, Hepler JR. "Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop." Cellular signalling. 2012 Jun; 24(6):1351-60. Epub 2012 Jan 28.
2012 Mar 15
Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG. "Corrigenda." The Journal of physiology.. 2012 Mar 15; 590(Pt 6):1511. Epub 2012 Jan 23.
2012
Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM. "G protein-coupled receptor-mediated activation of p110? by G?? is required for cellular transformation and invasiveness." Science signaling. 2012 5(253):ra89. Epub 2012 Dec 04.
2011 Oct
Kamal FA, Smrcka AV, Blaxall BC. "Taking the heart failure battle inside the cell: small molecule targeting of G?? subunits." Journal of molecular and cellular cardiology.. 2011 Oct; 51(4):462-7. Epub 2011 Jan 21.
2011 Oct
Lin Y, Smrcka AV. "Understanding molecular recognition by G protein ?? subunits on the path to pharmacological targeting." Molecular pharmacology.. 2011 Oct; 80(4):551-7. Epub 2011 Jul 07.
2011 Sep
Seneviratne AM, Burroughs M, Giralt E, Smrcka AV. "Direct-reversible binding of small molecules to G protein ?? subunits." Biochimica et biophysica acta.. 2011 Sep; 1814(9):1210-8. Epub 2011 May 18.
2011 Jul 1
Zhang L, Malik S, Kelley GG, Kapiloff MS, Smrcka AV. "Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes." The Journal of biological chemistry.. 2011 Jul 1; 286(26):23012-21. Epub 2011 May 05.
2011 Feb
Park MS, Smrcka AV, Stern HA. "Conformational flexibility and binding interactions of the G protein ?? heterodimer." Proteins.. 2011 Feb; 79(2):518-27.
2011 Jan 28
Chan P, Gabay M, Wright FA, Kan W, Oner SS, Lanier SM, Smrcka AV, Blumer JB, Tall GG. "Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf)." The Journal of biological chemistry.. 2011 Jan 28; 286(4):2625-35. Epub 2010 Nov 29.
2011 Jan
Dessal AL, Prades R, Giralt E, Smrcka AV. "Rational design of a selective covalent modifier of G protein ?? subunits." Molecular pharmacology.. 2011 Jan; 79(1):24-33. Epub 2010 Sep 29.
2011
Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG. "Phospholipase C-? links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans." Islets. 2011 3(3):121-8. Epub 2011 May 01.
2010 Aug 20
Casey LM, Pistner AR, Belmonte SL, Migdalovich D, Stolpnik O, Nwakanma FE, Vorobiof G, Dunaevsky O, Matavel A, Lopes CM, Smrcka AV, Blaxall BC. "Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure." Circulation research.. 2010 Aug 20; 107(4):532-9. Epub 2010 Jun 24.
2010 Jan 12
Smrcka AV, Kichik N, Tarragó T, Burroughs M, Park MS, Itoga NK, Stern HA, Willardson BM, Giralt E. "NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes." Proceedings of the National Academy of Sciences of the United States of America.. 2010 Jan 12; 107(2):639-44. Epub 2009 Dec 16.
2010 Jan 1
Serasinghe MN, Seneviratne AM, Smrcka AV, Yoon Y. "Identification and characterization of unique proline-rich peptides binding to the mitochondrial fission protein hFis1." The Journal of biological chemistry.. 2010 Jan 1; 285(1):620-30. Epub 2009 Oct 28.
2010
Gaudy AM, Clementi AH, Campbell JS, Smrcka AV, Mooney RA. "Suppressor of cytokine signaling-3 is a glucagon-inducible inhibitor of PKA activity and gluconeogenic gene expression in hepatocytes." The Journal of biological chemistry.. 2010 285(53):41356-65. Epub 2010 Oct 26.
2010
Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG. "Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in ?-cells of phospholipase C-? knockout mice." The Journal of physiology.. 2010 588(Pt 24):4871-89. Epub 2010 Nov 01.
2009 Oct 16
Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D. "Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5." The Journal of biological chemistry.. 2009 Oct 16; 284(42):28599-606. Epub 2009 Aug 27.
2009 Oct
Bianchi E, Norcini M, Smrcka A, Ghelardini C. "Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia." Journal of neurochemistry. 2009 Oct; 111(1):171-80. Epub 2009 Jul 27.
2009 Feb
Park MS, Dessal AL, Smrcka AV, Stern HA. "Evaluating docking methods for prediction of binding affinities of small molecules to the G protein betagamma subunits." Journal of chemical information and modeling.. 2009 Feb; 49(2):437-43.
2009 Jan 16
Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. "Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II." The Journal of biological chemistry.. 2009 Jan 16; 284(3):1514-22. Epub 2008 Oct 27.
2008 Nov 19
Mathews JL, Smrcka AV, Bidlack JM. "A novel Gbetagamma-subunit inhibitor selectively modulates mu-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 Nov 19; 28(47):12183-9.
2008 Jul
Smrcka AV. "G protein ?? subunits: central mediators of G protein-coupled receptor signaling." Cellular and molecular life sciences : CMLS.. 2008 Jul; 65(14):2191-214.
2008 Jun
Smrcka AV, Lehmann DM, Dessal AL. "G protein betagamma subunits as targets for small molecule therapeutic development." Combinatorial chemistry & high throughput screening. 2008 Jun; 11(5):382-95.
2008 Feb
Lehmann DM, Seneviratne AM, Smrcka AV. "Small molecule disruption of G protein beta gamma subunit signaling inhibits neutrophil chemotaxis and inflammation." Molecular pharmacology.. 2008 Feb; 73(2):410-8. Epub 2007 Nov 15.
2007 Nov 1
Smrcka AV, Oestreich EA, Blaxall BC, Dirksen RT. "EPAC regulation of cardiac EC coupling." The Journal of physiology.. 2007 Nov 1; 584(Pt 3):1029-31. Epub 2007 Sep 20.
2007 Sep 25
Citro S, Malik S, Oestreich EA, Radeff-Huang J, Kelley GG, Smrcka AV, Brown JH. "Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation." Proceedings of the National Academy of Sciences of the United States of America.. 2007 Sep 25; 104(39):15543-8. Epub 2007 Sep 18.
2007 Jul 6
Yuan C, Sato M, Lanier SM, Smrcka AV. "Signaling by a non-dissociated complex of G protein ?? and ? subunits stimulated by a receptor-independent activator of G protein signaling, AGS8." The Journal of biological chemistry.. 2007 Jul 6; 282(27):19938-47. Epub 2007 Apr 19.
2007 May 16
Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ. "Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2007 May 16; 27(20):5484-94.
2007 Mar
Blumer JB, Smrcka AV, Lanier SM. "Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling." Pharmacology & therapeutics. 2007 Mar; 113(3):488-506. Epub 2006 Nov 28.
2007 Feb 23
Oestreich EA, Wang H, Malik S, Kaproth-Joslin KA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. "Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes." The Journal of biological chemistry.. 2007 Feb 23; 282(8):5488-95. Epub 2006 Dec 17.
2007
Lehmann DM, Yuan C, Smrcka AV. "Analysis and pharmacological targeting of phospholipase C beta interactions with G proteins." Methods in enzymology. 2007 434:29-48.
2006 Apr 21
Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, Smrcka AV. "Differential targeting of Gbetagamma-subunit signaling with small molecules." Science.. 2006 Apr 21; 312(5772):443-6.
2006 Feb 3
Kelley GG, Kaproth-Joslin KA, Reks SE, Smrcka AV, Wojcikiewicz RJ. "G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner." The Journal of biological chemistry.. 2006 Feb 3; 281(5):2639-48. Epub 2005 Nov 28.
2006 Jan 17
Sato M, Cismowski MJ, Toyota E, Smrcka AV, Lucchesi PA, Chilian WM, Lanier SM. "Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma." Proceedings of the National Academy of Sciences of the United States of America.. 2006 Jan 17; 103(3):797-802. Epub 2006 Jan 09.
2006 Jan
Mahon MJ, Bonacci TM, Divieti P, Smrcka AV. "A docking site for G protein ?? subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways." Molecular endocrinology.. 2006 Jan; 20(1):136-46. Epub 2005 Aug 11.
2006
Oestreich,Emily A.; Wang,Huan; Malik,Sundeep; Kaproth-Joslin,Katherine A.; Blaxall,Burns C.; Kelley,Grant G.; Dirksen,Robert T.; Smrcka,Alan V.;. "EPAC-mediated activation of phospholipase Cepsilon plays a critical role in beta -adrenergic receptor dependent enhancement of Ca2+ mobilization in cardiac myocytes". Journal of Biological Chemistry. 2006; : M608495200. Link
2006
Hinkes B, Wiggins RC, Gbadegesin R, Vlangos CN, Seelow D, Nürnberg G, Garg P, Verma R, Chaib H, Hoskins BE, Ashraf S, Becker C, Hennies HC, Goyal M, Wharram BL, Schachter AD, Mudumana S, Drummond I, Kerjaschki D, Waldherr R, Dietrich A, Ozaltin F, Bakkaloglu A, Cleper R, Basel-Vanagaite L, Pohl M, Griebel M, Tsygin AN, Soylu A, Müller D, Sorli CS, Bunney TD, Katan M, Liu J, Attanasio M, O'toole JF, Hasselbacher K, Mucha B, Otto EA, Airik R, Kispert A, Kelley GG, Smrcka AV, Gudermann T, Holzman LB, Nürnberg P, Hildebrandt F. "Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible." Nature genetics.. 2006 38(12):1397-405. Epub 2006 Nov 05.
2005 Aug 9
Davis TL, Bonacci TM, Sprang SR, Smrcka AV. "Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits." Biochemistry.. 2005 Aug 9; 44(31):10593-604.
2005 Jul
Malik S, Ghosh M, Bonacci TM, Tall GG, Smrcka AV. "Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells." Molecular pharmacology.. 2005 Jul; 68(1):129-36. Epub 2005 Mar 31.
2005 Mar 18
Bonacci TM, Ghosh M, Malik S, Smrcka AV. "Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2." The Journal of biological chemistry.. 2005 Mar 18; 280(11):10174-81. Epub 2004 Dec 16.
2005
Wang H, Oestreich EA, Maekawa N, Bullard TA, Vikstrom KL, Dirksen RT, Kelley GG, Blaxall BC, Smrcka AV. "Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy." Circulation research.. 2005 97(12):1305-13. Epub 2005 Nov 17.
2004 Nov 12
Shajahan AN, Tiruppathi C, Smrcka AV, Malik AB, Minshall RD. "Gbetagamma activation of Src induces caveolae-mediated endocytosis in endothelial cells." The Journal of biological chemistry.. 2004 Nov 12; 279(46):48055-62. Epub 2004 Sep 02.
2004 Feb 15
Kelley GG, Reks SE, Smrcka AV. "Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins." The Biochemical journal.. 2004 Feb 15; 378(Pt 1):129-39.
2004
Ghosh M, Wang H, Kelley GG, Smrcka AV. "Purification of phospholipase C beta and phospholipase C epsilon from Sf9 cells." Methods in molecular biology.. 2004 237:55-64.
2004
Ghosh M, Smrcka AV. "Assay for G protein-dependent activation of phospholipase C beta using purified protein components." Methods in molecular biology.. 2004 237:67-75.
2003 Sep 12
Ghosh M, Peterson YK, Lanier SM, Smrcka AV. "Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation." The Journal of biological chemistry.. 2003 Sep 12; 278(37):34747-50. Epub 2003 Jul 24.
2003 Jul 25
Li Z, Hannigan M, Mo Z, Liu B, Lu W, Wu Y, Smrcka AV, Wu G, Li L, Liu M, Huang CK, Wu D. "Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42." Cell.. 2003 Jul 25; 114(2):215-27.
2003 May 30
Goubaeva F, Ghosh M, Malik S, Yang J, Hinkle PM, Griendling KK, Neubig RR, Smrcka AV. "Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides." The Journal of biological chemistry.. 2003 May 30; 278(22):19634-41. Epub 2003 Mar 20.
2002
Smrcka AV, Scott JK. "Discovery of ligands for beta gamma subunits from phage-displayed peptide libraries." Methods in enzymology. 2002 344:557-76.
2001 Nov 9
Fogg VC, Azpiazu I, Linder ME, Smrcka A, Scarlata S, Gautam N. "Role of the gamma subunit prenyl moiety in G protein beta gamma complex interaction with phospholipase Cbeta." The Journal of biological chemistry.. 2001 Nov 9; 276(45):41797-802. Epub 2001 Sep 06.
2001 Apr 6
Yoshikawa DM, Bresciano K, Hatwar M, Smrcka AV. "Characterization of a phospholipase C beta 2-binding site near the amino-terminal coiled-coil of G protein beta gamma subunits." The Journal of biological chemistry.. 2001 Apr 6; 276(14):11246-51. Epub 2001 Jan 05.
2001 Feb 15
Kelley GG, Reks SE, Ondrako JM, Smrcka AV. "Phospholipase C(epsilon): a novel Ras effector." The EMBO journal. 2001 Feb 15; 20(4):743-54.
2001 Feb 15
Scott JK, Huang SF, Gangadhar BP, Samoriski GM, Clapp P, Gross RA, Taussig R, Smrcka AV. "Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors." The EMBO journal. 2001 Feb 15; 20(4):767-76.
2000 Sep 19
Yoshikawa DM, Hatwar M, Smrcka AV. "G protein beta 5 subunit interactions with alpha subunits and effectors." Biochemistry.. 2000 Sep 19; 39(37):11340-7.
2000 Feb 22
Barr AJ, Ali H, Haribabu B, Snyderman R, Smrcka AV. "Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits." Biochemistry.. 2000 Feb 22; 39(7):1800-6.
2000 Feb 11
Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, Wu D. "Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction." Science.. 2000 Feb 11; 287(5455):1046-9.
2000
Hou Y, Azpiazu I, Smrcka A, Gautam N. "Selective role of G protein gamma subunits in receptor interaction." The Journal of biological chemistry.. 2000 275(50):38961-4.
1999 Aug 31
Xie W, Samoriski GM, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D. "Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids." Proceedings of the National Academy of Sciences of the United States of America.. 1999 Aug 31; 96(18):10385-90.
1998 Mar 20
Sankaran B, Osterhout J, Wu D, Smrcka AV. "Identification of a structural element in phospholipase C beta2 that interacts with G protein betagamma subunits." The Journal of biological chemistry.. 1998 Mar 20; 273(12):7148-54.
1997 Apr 4
Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F, Coadwell J, Smrcka AS, Thelen M, Cadwallader K, Tempst P, Hawkins PT. "The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101." Cell.. 1997 Apr 4; 89(1):105-14.
1996 Oct 11
Romoser V, Ball R, Smrcka AV. "Phospholipase C beta2 association with phospholipid interfaces assessed by fluorescence resonance energy transfer. G protein betagamma subunit-mediated translocation is not required for enzyme activation." The Journal of biological chemistry.. 1996 Oct 11; 271(41):25071-8.
1996 Oct 11
Ptasznik A, Prossnitz ER, Yoshikawa D, Smrcka A, Traynor-Kaplan AE, Bokoch GM. "A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils." The Journal of biological chemistry.. 1996 Oct 11; 271(41):25204-7.
1996 Jun 11
Parish CA, Smrcka AV, Rando RR. "The role of G protein methylation in the function of a geranylgeranylated beta gamma isoform." Biochemistry.. 1996 Jun 11; 35(23):7499-505.
1996 Jun 7
Jiang H, Kuang Y, Wu Y, Smrcka A, Simon MI, Wu D. "Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors." The Journal of biological chemistry.. 1996 Jun 7; 271(23):13430-4.
1996 Apr 2
Kuang Y, Wu Y, Smrcka A, Jiang H, Wu D. "Identification of a phospholipase C beta2 region that interacts with Gbeta-gamma." Proceedings of the National Academy of Sciences of the United States of America.. 1996 Apr 2; 93(7):2964-8.
1995 Jun 13
Parish CA, Smrcka AV, Rando RR. "Functional significance of beta gamma-subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3-kinase." Biochemistry.. 1995 Jun 13; 34(23):7722-7.
1994 Apr 8
Stephens L, Smrcka A, Cooke FT, Jackson TR, Sternweis PC, Hawkins PT. "A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits." Cell.. 1994 Apr 8; 77(1):83-93.
1994 Feb 11
Ueda N, Iñiguez-Lluhi JA, Lee E, Smrcka AV, Robishaw JD, Gilman AG. "G protein beta gamma subunits. Simplified purification and properties of novel isoforms." The Journal of biological chemistry.. 1994 Feb 11; 269(6):4388-95.
1994
Pang IH, Smrcka AV, Sternweis PC. "Synthesis and applications of affinity matrix containing immobilized beta gamma subunits of G proteins." Methods in enzymology. 1994 237:164-74.
1993 Oct 1
Kozasa T, Hepler JR, Smrcka AV, Simon MI, Rhee SG, Sternweis PC, Gilman AG. "Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits." Proceedings of the National Academy of Sciences of the United States of America.. 1993 Oct 1; 90(19):9176-80.
1993 Jul 5
Hepler JR, Kozasa T, Smrcka AV, Simon MI, Rhee SG, Sternweis PC, Gilman AG. "Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits." The Journal of biological chemistry.. 1993 Jul 5; 268(19):14367-75.
1993 May 5
Smrcka AV, Sternweis PC. "Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits." The Journal of biological chemistry.. 1993 May 5; 268(13):9667-74.
1993
Sternweis PC, Smrcka AV. "G proteins in signal transduction: the regulation of phospholipase C." Ciba Foundation symposium.. 1993 176:96-106; discussion 106-11.
1992 Apr 29
Sternweis PC, Smrcka AV, Gutowski S. "Hormone signalling via G-protein: regulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by Gq." Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 1992 Apr 29; 336(1276):35-41; discussion 41-2.
1992 Apr 25
Berstein G, Blank JL, Smrcka AV, Higashijima T, Sternweis PC, Exton JH, Ross EM. "Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1." The Journal of biological chemistry.. 1992 Apr 25; 267(12):8081-8.
1992
Sternweis PC, Smrcka AV. "Regulation of phospholipase C by G proteins." Trends in biochemical sciences.. 1992 17(12):502-6.
1991 Oct 25
Gutowski S, Smrcka A, Nowak L, Wu DG, Simon M, Sternweis PC. "Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones." The Journal of biological chemistry.. 1991 Oct 25; 266(30):20519-24.
1991 Jun 25
Wange RL, Smrcka AV, Sternweis PC, Exton JH. "Photoaffinity labeling of two rat liver plasma membrane proteins with [32P]gamma-azidoanilido GTP in response to vasopressin. Immunologic identification as alpha subunits of the Gq class of G proteins." The Journal of biological chemistry.. 1991 Jun 25; 266(18):11409-12.
1991 Apr
Smrcka AV, Bohnert HJ, Jensen RG. "Modulation of the tight binding of carboxyarabinitol 1,5-bisphosphate to the large subunit of ribulose 1,5-bisphosphate carboxylase/oxygenase." Archives of biochemistry and biophysics.. 1991 Apr; 286(1):14-9.
1991 Apr
Smrcka AV, Ramage RT, Bohnert HJ, Jensen RG. "Purification and characterization of large and small subunits of ribulose 1,5-bisphosphate carboxylase expressed separately in Escherichia coli." Archives of biochemistry and biophysics.. 1991 Apr; 286(1):6-13.
1991 Feb 15
Smrcka AV, Hepler JR, Brown KO, Sternweis PC. "Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq." Science.. 1991 Feb 15; 251(4995):804-7.
1988 Feb
Smrcka AV, Jensen RG. "HPLC separation and indirect ultraviolet detection of phosphorylated sugars." Plant physiology. 1988 Feb; 86(2):615-8.
1986 Jan
Smrcka AV, Szarek SR. "Phenotypical temperature adaptation of protein turnover in desert annuals." Plant physiology. 1986 Jan; 80(1):206-10.

Books

2004
Alan V. Smrcka editor. G Protein signaling: Methods and Protocols. Alan V. Smrcka. Totowa, NJ: Humana Press, 2004.
2004
Ghosh, M. and Smrcka, A.V.. "Assay for G Protein Dependent Activation of Phospholipase C beta Using Purified Protein Components". G Protein signaling: Methods and Protocols. Alan V. Smrcka. Totowa, NJ: Humana Press, 2004. 67-75
2004
Ghosh, M., Wang, H., Kelley, G.G., and Smrcka, A.V.. "Purification of Phospholipase C beta and Phospholipase C epsilon from Sf9 cells". G Protein signaling: Methods and Protocols. Alan V. Smrcka. Totowa, NJ: Humana Press, 2004. 55-64