Alan V. Smrcka, Ph.D.

Alan V. Smrcka, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Office: (585) 275-0892
Lab: (585) 275-0859
Fax: (585) 273-2652

Research Bio

G protein coupled receptors (GPCRs) form a large family of cell surface receptors responsible for triggering cellular responses to a variety of extracellular stimuli including drugs such as opiates, and hormones such as adrenaline, serotonin or acetylcholine. All GPCRs function through activation of trimeric G proteins located on the inner surface of the plasma membrane. Activated G proteins target ion channels or enzymes that produce second messengers with a variety of effects depending on the type of cell that is stimulated. Examples include regulation of synaptic transmission in the central nervous system, chemotaxis in the immune system, and vascular remodeling in the cardiovascular system. This family of receptors is an important target for pharmaceuticals and defects in GPCR systems are responsible for a number of diseases.



Our laboratory focuses on analysis of the interactions between the G proteins and their protein targets at a molecular and structural level with the goal of understanding how these interactions lead to alterations in protein and cellular activities. Another goal is to connect the biochemical information about protein interaction interfaces to specific cellular physiologies. To this end we are developing antagonists of specific G protein interactions and using these tools to probe the functions of those interactions in living cells. This approach will help to define the roles of specific G protein interactions in physiological processes and as potential targets for therapeutic intervention in cardiovascular disease or cancer.

Awards & Honors (Local)

Davey Award | URMC Cancer Center 2007

Patents

Pharmacological Manipulation of G Protein [Beta gamma] Subunit Signaling

United States Serial NO.: 11/885,981
Filed Date: March 7, 2006
Title: Compositions and Methods for Inhibiting G Protein Signaling
Invented by: Alan Smrcka, Jose Font, Tabetha Bonacci
Pharmacological Manipulation of G Protein [Beta gamma] Subunit Signaling

United States Serial NO.: 13/630,995
Filed Date: September 28, 2012
Title: Compositions and Methods for Inhibiting G Protein Signaling
Invented by: Alan Smrcka, Jose Font, Tabetha Bonacci
Small Molecule Targeting of G-Protein Beta Gamma in Cardiovascular Disease, Including Hypertension, Vascular Injury/Restenosis, and Atherosclerosis

United States Serial NO.: 12/597,509
Filed Date: April 28, 2008
Title: Compositions and Methods for Inhibiting G Protein Signaling
Invented by: Burns Blaxall, Alan Smrcka, Jean Bidlack

Recent Journal Articles

Showing the 5 most recent journal articles. 93 available »

2014 Oct 1
Le NT, Takei Y, Izawa-Ishizawa Y, Heo KS, Lee H, Smrcka AV, Miller BL, Ko KA, Ture S, Morrell C, Fujiwara K, Akaike M, Abe JI. "Identification of Activators of ERK5 Transcriptional Activity by High-Throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents." The Journal of immunology : official journal of the American Association of Immunologists. 2014 Oct 1; 193(7):3803-15. Epub 2014 Sep 03.
2014 Jun 17
Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. "Simultaneous adrenal and cardiac g-protein-coupled receptor-g?? inhibition halts heart failure progression." Journal of the American College of Cardiology. 2014 Jun 17; 63(23):2549-57. Epub 2014 Apr 02.
2014 Apr 18
Kan W, Adjobo-Hermans M, Burroughs M, Faibis G, Malik S, Tall GG, Smrcka AV. "M3 muscarinic receptor interaction with phospholipase C ?3 determines its signaling efficiency." The Journal of biological chemistry. 2014 Apr 18; 289(16):11206-18. Epub 2014 Mar 04.
2014 Feb
Ruisanchez E, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z. "Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014 Feb; 28(2):880-90. Epub 2013 Nov 18.
2013 Sep 15
Easterhoff D, Dimaio JT, Liyanage W, Lo CW, Bae W, Doran TM, Smrcka A, Nilsson BL, Dewhurst S. "Fluorescence detection of cationic amyloid fibrils in human semen." Bioorganic & medicinal chemistry letters. 2013 Sep 15; 23(18):5199-202. Epub 2013 Jul 08.

Current Appointments

Louis C. Lasagna Professorship in Experimental Therapeutics - Department of Pharmacology and Physiology (SMD)
Professor - Department of Pharmacology and Physiology (SMD) - Primary
Professor - Aab Cardiovascular Research Institute
Professor - Department of Biochemistry and Biophysics (SMD)

Education

PhD | Biochemistry | University of Arizona1990
MS | Botany | Arizona State University1984
BS | Biology | University of Connecticut1981

Post-Doctoral Training & Residency

Postdoctoral Fellow, Pharmacology Department, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, laboratory of Dr. Paul C. Sternweis 1994