Jeffrey J. Hayes, Ph.D.

Jeffrey J. Hayes, Ph.D.

Contact Information

Jeffrey_Hayes@urmc.rochester.edu
Rochester, NY 14642

Office: (585) 273-4887
Fax: (585) 275-6007
Lab: (585) 275-1706

Research Bio

Each eukaryotic cell must execute a complex program of specific gene expression. The DNA of the genome is intimately complexed with proteins into an assembly known as chromatin. Compaction and storage of genomic DNA has long been viewed as the main function of this assembly; however, recent work has demonstrated that in some instances, chromatin structure play an important role in bringing about this pattern of specific expression, and it is likely that the structural elements of chromatin have been integrated into many transcriptional control mechanisms.



The goal of the research in this laboratory is to provide detailed structure information on the protein-DNA interactions and DNA organization within chromatin, and to correlate this information with simple functional assays of the consequences of this organization. Model chromatin complexes will be prepared in vitro and structurally analyzed with chemical approaches. In addition, cloning expression of histone proteins with specific mutations will be useful in the determination of relevant domains within these proteins while facilitating the creation of site-specific probes of protein and DNA structure with chromatin.

Recent Journal Articles

Showing the 5 most recent journal articles. 112 available »

2014 Sep 26
Pepenella S, Murphy KJ, Hayes JJ. "A distinct switch in interactions of the histone H4 tail domain upon salt-dependent folding of nucleosome arrays." The Journal of biological chemistry. 2014 Sep 26; 289(39):27342-51. Epub 2014 Aug 13.
2014 Mar
Pepenella S, Murphy KJ, Hayes JJ. "Intra- and inter-nucleosome interactions of the core histone tail domains in higher-order chromatin structure." Chromosoma. 2014 Mar; 123(1-2):3-13. Epub 2013 Aug 31.
2013 Oct 14
Raghuram N, Strickfaden H, McDonald D, Williams K, Fang H, Mizzen C, Hayes JJ, Th'ng J, Hendzel MJ. "Pin1 promotes histone H1 dephosphorylation and stabilizes its binding to chromatin." The Journal of cell biology. 2013 Oct 14; 203(1):57-71. Epub 2013 Oct 07.
2013 Feb 1
Elliott GO, Murphy KJ, Hayes JJ, Thiriet C. "Replication-independent nucleosome exchange is enhanced by local and specific acetylation of histone H4." Nucleic acids research. 2013 Feb 1; 41(4):2228-38. Epub 2013 Jan 08.
2012 Nov
Masoudi FA, Go AS, Magid DJ, Cassidy-Bushrow AE, Doris JM, Fiocchi F, Garcia-Montilla R, Glenn KA, Goldberg RJ, Gupta N, Gurwitz JH, Hammill SC, Hayes JJ, Jackson N, Kadish A, Lauer M, Miller AW, Multerer D, Peterson PN, Reifler LM, Reynolds K, Saczynski JS, Schuger C, Sharma PP, Smith DH, Suits M, Sung SH, Varosy PD, Vidaillet HJ, Greenlee RT. "Longitudinal study of implantable cardioverter-defibrillators: methods and clinical characteristics of patients receiving implantable cardioverter-defibrillators for primary prevention in contemporary practice." Circulation. Cardiovascular quality and outcomes. 2012 Nov; 5(6):e78-85.

Current Appointments

Chair - Department of Biochemistry and Biophysics (SMD) - Primary Administrative
Shohei Koide Professor in Biochemistry and Biophysics - Department of Biochemistry and Biophysics (SMD)
Professor - Department of Biochemistry and Biophysics (SMD) - Primary

Education

PhD | Chemistry | Johns Hopkins University1990
MS | Chemistry | Bowling Green University1986
BS | Chemistry | Bowling Green University1983