Brian Poligone, M.D., Ph.D.

Brian Poligone, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 697
Rochester, NY 14642

Office: (585) 276-4673
Administrative: (585) 275-3871
Fax: (585) 461-3509
Lab: (585) 275-0796

Research Bio

The Poligone Laboratory studies signal transduction in the skin, specifically examining the role of the transcription factor NF kappa B in skin physiology and disease. Using genetic animal models to study the function of NF kappa B, we strive to better understand the molecular mechanisms behind skin inflammation and carcinogenesis. By studying animal models of disease, we are better able to translate our findings into clinically relevant treatments for human disease. Through his past work with Drs. Albert S. Baldwin and Sankar Ghosh, Dr. Poligone has gained expertise in the study of NF kappa B and has focused his attention to the skin.

Currently we are examining how NF kappa B is involved in the formation of a type of skin cancer called a keratoacanthoma. Dr. Poligone has also examined the role of NF kappa B in psoriasis and specifically has been examining NF kappa B inhibitors in this disease.

Awards & Honors (Local)

Dermatology Foundation Career Development Award 2008, Journal of Immunology | University of North Carolina School of Medicine 2002
American Society of Hematology, Medical Student Fellowship | University of North Carolina School of Medicine 1999
National Institutes of Health Summer Research Fellowship | University of North Carolina School of Medicine 1999 - 1999
John B. Graham Research Society | University of North Carolina School of Medicine 1999
Evaluation of a Hereditary Thrombocytopenia in a Family in Coastal North Carolina | Holderness Medical Fellowship | North Carolina 1998 - 1999
Class of 1938 Scholar (Summer Study) | UNC Alumni Class | Switzerland 1994
Harrisburg Physicians Scholarship | Harrisburg, Pennsylvania 1994
Howard Hughes Undergraduate Research Grant | Wake Forest University 1993
Eta Sigma Phi (National Classical Studies Honor Society) | Wake Forest University 1992
Medical Scientist Training Program (Eight Years Scholarship) | University of North Carolina School of Medicine 1988 - 1996
Dean's List and Honors in Biology (All Semesters) | University of North Carolina

Recent Journal Articles

Showing the 5 most recent journal articles. 9 available »

2009 Feb
Zayour M, Gilmore E, Heald P, Rose M, Poligone B, Lazova R. "A distinct entity in the spectrum of the CD30+ cutaneous lymphoproliferative diseases: oligolesional nodules with pseudoepitheliomatous hyperplasia followed by spontaneous resolution." Am J Dermatopathol. 2009; 31(1): 37-43.
Poligone B, Wilson L, Subtil A, Heald P. "Primary cutaneous T-cell lymphoma localized to the lower leg. A distinct locally aggressive cutaneous T-cell lymphoma." Archives of Dermatology. 2009; 145: 6.
2007 Feb
Poligone, B, S. Christensen, R. Lazova, P. Heald. "Bazex Syndrome (Acrokeratosis Paraneoplastica)." The Lancet. 2007; 369: 530.
Sen P, Bhattacharyya S, Wallet M, Wong CP, Poligone B, Sen M, Baldwin AS Jr, Tisch R. "NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages." J Immunol. 2003; 170: 1770-80.
Poligone, B., D.J. Weaver, Jr., P. Sen, A.S. Baldwin, Jr., and R. Tisch. "Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells Results in enhanced APC function." J Immunology. 2002; 168: 188-96.


Dermatology - American Board of Dermatology


MD, | Medicine | University of North Carolina School of Medicine2003
Ph.D., | Genetics | University of North Carolina School of Medicine2001
B.S., | Biology | University of North Carolina Chapel Hill1995

Post-Doctoral Training & Residency

Fellowship in Dermatology at Yale New Haven Hospital07/11/2006 - 04/29/2008
Residency in Dermatology at Yale New Haven Hospital07/01/2004 - 06/30/2007
Internship in Internal Medicine at Stanford University Medical Center06/25/2003 - 06/24/2004