Research Bio
The Poligone Laboratory studies signal transduction in the skin, specifically examining the role of the transcription factor NF kappa B in skin physiology and disease. Using genetic animal models to study the function of NF kappa B, we strive to better understand the molecular mechanisms behind skin inflammation and carcinogenesis. By studying animal models of disease, we are better able to translate our findings into clinically relevant treatments for human disease. Through his past work with Drs. Albert S. Baldwin and Sankar Ghosh, Dr. Poligone has gained expertise in the study of NF kappa B and has focused his attention to the skin.
Currently we are examining how NF kappa B is involved in the formation of a type of skin cancer called a keratoacanthoma. Dr. Poligone has also examined the role of NF kappa B in psoriasis and specifically has been examining NF kappa B inhibitors in this disease.
| www.facultyof1000.com, Journal of Immunology | University of North Carolina School of Medicine |
2002 |
| American Society of Hematology, Medical Student Fellowship | University of North Carolina School of Medicine |
1999 |
| National Institutes of Health Summer Research Fellowship | University of North Carolina School of Medicine |
1999 - 1999 |
| John B. Graham Research Society | University of North Carolina School of Medicine |
1999 |
| Evaluation of a Hereditary Thrombocytopenia in a Family in Coastal North Carolina | Holderness Medical Fellowship | North Carolina |
1998 - 1999 |
| Class of 1938 Scholar (Summer Study) | UNC Alumni Class | Switzerland |
1994 |
| Harrisburg Physicians Scholarship | Harrisburg, Pennsylvania |
1994 |
| Howard Hughes Undergraduate Research Grant | Wake Forest University |
1993 |
| Eta Sigma Phi (National Classical Studies Honor Society) | Wake Forest University |
1992 |
| Medical Scientist Training Program (Eight Years Scholarship) | University of North Carolina School of Medicine |
1988 - 1996 |
| Dean's List and Honors in Biology (All Semesters) | University of North Carolina |
|
| Dermatology Foundation Career Development Award |
2008 |
2009 Feb
Zayour M, Gilmore E, Heald P, Rose M, Poligone B, Lazova R. "A distinct entity in the spectrum of the CD30+ cutaneous lymphoproliferative diseases: oligolesional nodules with pseudoepitheliomatous hyperplasia followed by spontaneous resolution." Am J Dermatopathol. 2009; 31(1): 37-43. |
2009
Poligone B, Wilson L, Subtil A, Heald P. "Primary cutaneous T-cell lymphoma localized to the lower leg. A distinct locally aggressive cutaneous T-cell lymphoma." Archives of Dermatology. 2009; 145: 6. |
2007 Feb
Poligone, B, S. Christensen, R. Lazova, P. Heald. "Bazex Syndrome (Acrokeratosis Paraneoplastica)." The Lancet. 2007; 369: 530. |
2003
Sen P, Bhattacharyya S, Wallet M, Wong CP, Poligone B, Sen M, Baldwin AS Jr, Tisch R. "NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages." J Immunol. 2003; 170: 1770-80. |
2002
Poligone, B., D.J. Weaver, Jr., P. Sen, A.S. Baldwin, Jr., and R. Tisch. "Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells Results in enhanced APC function." J Immunology. 2002; 168: 188-96. |
