Ignacio Sanz, M.D.

Ignacio Sanz, M.D.

Contact Information

Emory University School of Medicine
Mail Stop: 1941-001-1AN
Whitehead Research Bldg 247
Atlanta, GA 30322

Office: (585) 275-2891
Lab: (585) 275-3561
Administrative: (585) 275-2891
Fax: (585) 442-3214

Journal Articles

Showing all 82 journal articles available.

2012 Mar
Barr PM, Wei C, Roger J, Schaefer-Cutillo J, Kelly JL, Rosenberg AF, Jung J, Sanz I, Friedberg JW. "Syk inhibition with fostamatinib leads to transitional B lymphocyte depletion." Clinical immunology : the official journal of the Clinical Immunology Society.. 2012 Mar; 142(3):237-42. Epub 2012 Jan 05.
2011 Nov
Wei C, Jung J, Sanz I. "OMIP-003: phenotypic analysis of human memory B cells." Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2011 Nov; 79(11):894-6. Epub 2011 Jul 27.
2011 Sep 29
Hilchey SP, Rosenberg AF, Hyrien O, Secor-Socha S, Cochran MR, Brady MT, Wang JC, Sanz I, Burack WR, Quataert SA, Bernstein SH. "Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation." Blood.. 2011 Sep 29; 118(13):3591-602. Epub 2011 Aug 05.
2011 May 1
Lee FE, Halliley JL, Walsh EE, Moscatiello AP, Kmush BL, Falsey AR, Randall TD, Kaminiski DA, Miller RK, Sanz I. "Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect." The Journal of immunology : official journal of the American Association of Immunologists.. 2011 May 1; 186(9):5514-21. Epub 2011 Mar 25.
2011 May
Sanz I, Yasothan U, Kirkpatrick P. "Belimumab." Nature reviews. Drug discovery.. 2011 May; 10(5):335-6.
2011 May
Sanz I. "Connective tissue diseases: targeting B cells in SLE: good news at last!" Nature reviews. Rheumatology.. 2011 May; 7(5):255-6.
2011 Apr 15
Quách TD, Manjarrez-Orduño N, Adlowitz DG, Silver L, Yang H, Wei C, Milner EC, Sanz I. "Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM." The Journal of immunology : official journal of the American Association of Immunologists.. 2011 Apr 15; 186(8):4640-8. Epub 2011 Mar 11.
2011
Kobie JJ, Zheng B, Bryk P, Barnes M, Ritchlin CT, Tabechian DA, Anandarajah AP, Looney RJ, Thiele RG, Anolik JH, Coca A, Wei C, Rosenberg AF, Feng C, Treanor JJ, Lee FE, Sanz I. "Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor." Arthritis research & therapy. 2011 13(6):R209. Epub 2011 Dec 16.
2010 Nov
Calero I, Sanz I. "Targeting B cells for the treatment of SLE: the beginning of the end or the end of the beginning?" Discovery medicine. 2010 Nov; 10(54):416-24.
2010 Jun 1
Li J, Kuzin I, Moshkani S, Proulx ST, Xing L, Skrombolas D, Dunn R, Sanz I, Schwarz EM, Bottaro A. "Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Jun 1; 184(11):6142-50. Epub 2010 Apr 30.
2010 Jun
Sanz I, Lee FE, . "B cells as therapeutic targets in SLE." Nature reviews. Rheumatology.. 2010 Jun; 6(6):326-37.
2010 Apr 30
Halliley JL, Kyu S, Kobie JJ, Walsh EE, Falsey AR, Randall TD, Treanor J, Feng C, Sanz I, Lee FE. "Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization." Vaccine.. 2010 Apr 30; 28(20):3582-7. Epub 2010 Mar 16.
2010 Feb
John Looney R, Anolik J, Sanz I. "A perspective on B-cell-targeting therapy for SLE." Modern rheumatology / the Japan Rheumatism Association. 2010 Feb; 20(1):1-10. Epub 2009 Aug 08.
2010
Lee FE, Falsey AR, Halliley JL, Sanz I, Walsh EE. "Circulating antibody-secreting cells during acute respiratory syncytial virus infection in adults." The Journal of infectious diseases.. 2010 202(11):1659-66. Epub 2010 Oct 27.
2009 Sep
Coca A, Sanz I. "B cell depletion in lupus and Sjögren's syndrome: an update." Current opinion in rheumatology. 2009 Sep; 21(5):483-8.
2009 Jun
Sanz I. "Connective tissue diseases: The conundrum of B cell depletion in SLE." Nature reviews. Rheumatology.. 2009 Jun; 5(6):304-5.
2009 May 15
Palanichamy A, Barnard J, Zheng B, Owen T, Quach T, Wei C, Looney RJ, Sanz I, Anolik JH. "Novel human transitional B cell populations revealed by B cell depletion therapy." The Journal of immunology : official journal of the American Association of Immunologists.. 2009 May 15; 182(10):5982-93.
2009 Feb
Manjarrez-Orduño N, Quách TD, Sanz I. "B cells and immunological tolerance." The Journal of investigative dermatology.. 2009 Feb; 129(2):278-88.
2009 Jan
Jenks SA, Sanz I. "Altered B cell receptor signaling in human systemic lupus erythematosus." Autoimmunity reviews. 2009 Jan; 8(3):209-13. Epub 2008 Aug 22.
2009
Kyu. S.; Kobie, J.; Zand, M.; Topham, D.; Quataert, S.; Sanz, I.; Lee, F. E-H. "Similar Human Influenza-specific Antibody Secreting Cells or Plasmablasts Frequencies post Vaccination from Fresh and Frozen PBMC". Journal of Immunological Methods. 2009; 340: 42-47.
2009
Crompton, P.D.; Micetic, M.; Weiss, G.; Baughman, A.; Huang, C.; Topham, D.J.; Treanor, J.J.; Sanz, I.; Durbin, A.P.; Miura, K.; Narum, D.L.; Ellis, R.D.; Malkin, E,; Mullen, G.D.; Miller, L.H.; Martin, L. A.; Pierce, S.K. "The TLR9 ligand CpG promotes the acquitition of plasmodium falciparum-specific memory B cells in malaria-naive individuals". Journal of Immunology. 2009; 182: 3318-3326.
2009
Anolik, J.; Looney, R.; Lund, R.; Randall, T. Sanz, I. "Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: Extension of a phase II, double-blind, placeo-controlled, dose-ranging study." Immunologic Research. 2009; .
2009
Anolik JH, Looney RJ, Lund FE, Randall TD, Sanz I. "Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets." Immunologic research. 2009 45(2-3):144-58. Epub 2009 Apr 07.
2008 Feb 1
Kim SW, Oleksyn DW, Rossi RM, Jordan CT, Sanz I, Chen L, Zhao J. "Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells." Blood.. 2008 Feb 1; 111(3):1644-53. Epub 2007 Nov 19.
2008 Feb
Sanz I, Wei C, Lee FE, Anolik J. "Phenotypic and functional heterogeneity of human memory B cells." Seminars in immunology. 2008 Feb; 20(1):67-82. Epub 2008 Feb 06.
2008 Jan 15
Anolik JH, Ravikumar R, Barnard J, Owen T, Almudevar A, Milner EC, Miller CH, Dutcher PO, Hadley JA, Sanz I. "Cutting edge: anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid germinal centers and follicular dendritic cell networks." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 Jan 15; 180(2):688-92.
2008
Anolik, J.; Barnard, J.; Zheng, B.; Owen, T.; Quach, T.; Wei, C.W.; Miyake, B.; Milner, E.C.B.,;Looney, R.J.; Sanz, I. "Novel human transitional B cell populations revealed by B cell depletion therapy". 2008; .
2007 Sep
Anolik JH, Barnard J, Owen T, Zheng B, Kemshetti S, Looney RJ, Sanz I. "Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy." Arthritis and rheumatism.. 2007 Sep; 56(9):3044-56.
2007 May 15
Wei C, Anolik J, Cappione A, Zheng B, Pugh-Bernard A, Brooks J, Lee EH, Milner EC, Sanz I. "A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus." The Journal of immunology : official journal of the American Association of Immunologists.. 2007 May 15; 178(10):6624-33.
2007 Feb 15
Huggins J, Pellegrin T, Felgar RE, Wei C, Brown M, Zheng B, Milner EC, Bernstein SH, Sanz I, Zand MS. "CpG DNA activation and plasma-cell differentiation of CD27- naive human B cells." Blood.. 2007 Feb 15; 109(4):1611-9. Epub 2006 Oct 10.
2007 Feb
Anolik JH, Friedberg JW, Zheng B, Barnard J, Owen T, Cushing E, Kelly J, Milner EC, Fisher RI, Sanz I. "B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny." Clinical immunology : the official journal of the Clinical Immunology Society.. 2007 Feb; 122(2):139-45. Epub 2006 Sep 27.
2007
Nicholas, M.W.; Dooley, M.A.; Hogan, S.; Anolik, J.; Looney, R.J.; Sanz, I.; Clarke, S.H. "A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE". Clinical Immunology. 2007; 126: 189-201.
2007
Sanz I, Anolik JH, Looney RJ. "B cell depletion therapy in autoimmune diseases." Frontiers in bioscience : a journal and virtual library. 2007 12:2546-67. Epub 2007 Jan 01.
2006 Apr 1
Zand MS, Vo T, Pellegrin T, Felgar R, Liesveld JL, Ifthikharuddin JJ, Abboud CN, Sanz I, Huggins J. "Apoptosis and complement-mediated lysis of myeloma cells by polyclonal rabbit antithymocyte globulin." Blood.. 2006 Apr 1; 107(7):2895-903. Epub 2005 Dec 20.
2006 Feb
Looney RJ, Anolik J, Sanz I. "New therapies for systemic lupus erythematosus: cellular targets." Rheumatic diseases clinics of North America.. 2006 Feb; 32(1):201-15, xi.
2005 Nov
Cappione A, Anolik JH, Pugh-Bernard A, Barnard J, Dutcher P, Silverman G, Sanz I. "Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus." The Journal of clinical investigation.. 2005 Nov; 115(11):3205-16. Epub 2005 Oct 06.
2005 Jun 15
Zand MS, Vo T, Huggins J, Felgar R, Liesveld J, Pellegrin T, Bozorgzadeh A, Sanz I, Briggs BJ. "Polyclonal rabbit antithymocyte globulin triggers B-cell and plasma cell apoptosis by multiple pathways." Transplantation.. 2005 Jun 15; 79(11):1507-15.
2005 Mar
Milner EC, Anolik J, Cappione A, Sanz I. "Human innate B cells: a link between host defense and autoimmunity?" Springer seminars in immunopathology. 2005 Mar; 26(4):433-52. Epub 2005 Jan 05.
2005
Looney RJ, Anolik J, Sanz I. "Treatment of SLE with anti-CD20 monoclonal antibody." Current directions in autoimmunity. 2005 8:193-205.
2005
Sanz I, Anolik J. "Reconstitution of the adult B cell repertoire after treatment with rituximab." Arthritis research & therapy. 2005 7(5):175-6. Epub 2005 Jul 22.
2004 Nov
Anolik JH, Barnard J, Cappione A, Pugh-Bernard AE, Felgar RE, Looney RJ, Sanz I. "Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus." Arthritis and rheumatism.. 2004 Nov; 50(11):3580-90.
2004 Aug
Looney RJ, Anolik JH, Campbell D, Felgar RE, Young F, Arend LJ, Sloand JA, Rosenblatt J, Sanz I. "B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab." Arthritis and rheumatism.. 2004 Aug; 50(8):2580-9.
2004 May
Looney RJ, Anolik J, Sanz I. "B cells as therapeutic targets for rheumatic diseases." Current opinion in rheumatology. 2004 May; 16(3):180-5.
2004 Apr 1
Cappione AJ, Pugh-Bernard AE, Anolik JH, Sanz I. "Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes." The Journal of immunology : official journal of the American Association of Immunologists.. 2004 Apr 1; 172(7):4298-307.
2004
Looney RJ, Anolik J, Sanz I. "B lymphocytes in systemic lupus erythematosus: lessons from therapy targeting B cells." Lupus.. 2004 13(5):381-90.
2003 Oct
Anolik J, Sanz I, Looney RJ. "B cell depletion therapy in systemic lupus erythematosus." Current rheumatology reports. 2003 Oct; 5(5):350-6.
2003 Sep
Anolik J, Looney RJ, Bottaro A, Sanz I, Young F. "Down-regulation of CD20 on B cells upon CD40 activation." European journal of immunology.. 2003 Sep; 33(9):2398-409.
2003 Feb
Anolik JH, Campbell D, Felgar RE, Young F, Sanz I, Rosenblatt J, Looney RJ. "The relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus." Arthritis and rheumatism.. 2003 Feb; 48(2):455-9.
2001 Oct
Pugh-Bernard AE, Silverman GJ, Cappione AJ, Villano ME, Ryan DH, Insel RA, Sanz I. "Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance." The Journal of clinical investigation.. 2001 Oct; 108(7):1061-70.
2000 Sep 12
Bili A, Moss AJ, Francis CW, Zareba W, Watelet LF, Sanz I. "Anticardiolipin antibodies and recurrent coronary events: a prospective study of 1150 patients. Thrombogenic Factors, and Recurrent Coronary Events Investigators." Circulation.. 2000 Sep 12; 102(11):1258-63.
2000 Sep
Rey E, Zeidel M, Rhine C, Tami J, Krolick K, Fischbach M, Sanz I. "Characterization of human anti-acetylcholine receptor monoclonal autoantibodies from the peripheral blood of a myasthenia gravis patient using combinatorial libraries." Clinical immunology : the official journal of the Clinical Immunology Society.. 2000 Sep; 96(3):269-79.
2000 Jun 1
Li P, Sanz I, O'Keefe RJ, Schwarz EM. "NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Jun 1; 164(11):5990-7.
2000 May
Pryhuber GS, O'Brien DP, Baggs R, Phipps R, Huyck H, Sanz I, Nahm MH. "Ablation of tumor necrosis factor receptor type I (p55) alters oxygen-induced lung injury." American journal of physiology. Lung cellular and molecular physiology.. 2000 May; 278(5):L1082-90.
2000 Apr
Deng SX, Hanson E, Sanz I. "In vivo cell penetration and intracellular transport of anti-Sm and anti-La autoantibodies." International immunology. 2000 Apr; 12(4):415-23.
2000 Apr
Goater J, Müller R, Kollias G, Firestein GS, Sanz I, O'Keefe RJ, Schwarz EM. "Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis." The Journal of rheumatology.. 2000 Apr; 27(4):983-9.
2000
del Rincon, I.; Ziedel, M.; Rey, E.; Harley, J.B.; James, J.A.; Fischbach, M.; Sanz, I. "Delineation of the human systemic lupus erythematosus anti-Smith Antibody response using phage-display combinatorial libraries". Journal of Immunology. 2000; 165(12): 7011-7015.
1999 Feb
O'Brien DP, Briles DE, Szalai AJ, Tu AH, Sanz I, Nahm MH. "Tumor necrosis factor alpha receptor I is important for survival from Streptococcus pneumoniae infections." Infection and immunity.. 1999 Feb; 67(2):595-601.
1997
Raaphorst, F,M.; Raman, C.S.; Tami, J.; Fischbach, M.; Sanz, I. "Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: Evidence for structural selection of D-H amino acid sequences". International Immunology. 1997; 10: 1503-1515.
1996
Raaphorst, F.M.; Sanz, I. "A powerful technique for the global study of heavy chain CDR3 profiles in cell development". Biotechniques. 1996; 20: 78.
1994
Sanz, I.; Wang, S-S.; Meneses, G.; Fischbach, M. "Molecular characterization of human immunoglobulin heavy chain DIR genes". Journal of Immunology. 1994; 152: 3958-3969.
1993
Barbas, C.F.; Collet, T.A.; Roben, P.; Binley, J.; Amberg, W.; Hoekstra, D.; Cababa, D.; Jones, T.M.; Williamson, R.A.; Haigwood, N.L.; Satterhwait, A.; Sanz, I.; Burton, D.R. "Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries". Journal of Molecular Biology. 1993; 230: 812.
1993
Dang, H.; Lazaridis, K.; Talal, N.; Fischbach, M.; Sanz, I. "Cloning of a human IgM autoantibody bearing a cross-reactive idiotype in a lambda expression vector: A new approach to studying autoantibodies". Clinical Immunopathology. 1993; 67: 249.
1992
Weng, N.P.; Yu-Lee, L-Y.; Sanz, I.; Patten, .BM.; Marcus, D.M. "Structure and specificities of anti-ganglioside autoantibodies associated with motor neuropathies". Journal of Immunology. 1992; 149: 2518-2529.
1992
Braun, J.; Berberian, L.; King, L.; Sanz, I.; Govan III, H.L.; Saxon, A. "Restricted use of "fetal" VH3 genes by post-antigenic B cells in the human adult. Predominance of the 56P1/1.9 III VH gene in common variable immunodeficiency". Journal of Clinical Investigation. 1992; 89: 1395-1402.
1991
Bangs, L.A.; Sanz, I.; Teale, J.M. "Comparison of D, JH and junctional diversity in the fetal, adult and aged B cell repertoires". Journal of Immunology. 1991; 146: 1996-2004.
1991
Sanz, I. "Multiple mechanisms participate in the generation of diversity of human heavy chain CDR3 regions". Journal of Immunology. 1991; 147: 1720.
1991
Kim, S.O.; Sanz, I.; Williams, C.; Capra, J.D.; Gottlieb, P.D. "Polymorphism in VK 10 genes encoding L chains of antibodies bearing the ARS-A and A48 cross-reactive idiotypes". Immunogenetics. 1991; 34: 231-241.
1990
McCauliffe, D.P.; Lux, F.A.; Lieu, T-S.; Sanz, I.; Hanke, J.; Newkirk, M.; Bachinski, L.L.; Siciliano, M.J.; Sontheimer, R.D.; Capra, J.D. "Molecular cloning expression and chromosome 19 localization of a human Ro/SS-A autoantigen". Journal of Clininal Investigtion. 1990; 85: 1379-1381.
1990
Meek, K.; Dang, H.; Sanz, I.; Takei, M.; Dauphinee, M.J.; Capra, J.D.; Talal, N. "An idiotype shared by human and mouse anti-Sm antibodies maps to heavy chain CDR2". Journal of Immunology. 1990; 144: 1375-1381.
1990
Victor-Kobrin, C.; Barak, Z.; Bonilla, F.A.; Cobrin, B.; Sanz, I.; French, D.; Rothe, J.; Bona, C. "A molecular and structural analysis of the VH and VK regions of monoclonal autobodies bearing the A48 regulatory idiotype". Journal of Immunology. 1990; 144: 614-624.
1989
Sanz, I.; Kelly, P.; Williams, C.; Scholl, S.; Tucker, P.W.; Capra, J.D. "The smaller human VH gene families display remarkable little polymorphism". Embo J. 1989; 8: 3741-3749.
1989
Sanz, I.; Dang, H.; Takei, M.; Talal, N.; Capra, J.D. "VH sequence of a human anti-Sm autoantibody. Evidence that autoantibodies can be unmutated copies of germline genes". Journal of Immunology. 1989; 142: 883-887.
1988
Sanz, I.; Casali, P.; Thomas, J.W.; Notkins, A.L.; Capra, J.D. "Nucleotide sequences of eight human natural autoantibodies VH regions reveals apparent restricted use of VH families". Journal of Immunology. 1988; 142: 4954-4061.
1988
Rathbun, G.; Sanz, I.; Meek, K.; Tucker, P.W.; Capra, J.D. "The molecular genetics of the arsenate idiotypic system of A/J mice". Advances in Immunology. 1988; 42: 95-164.
1987
Sanz, I.; Capra, J.D. "VK and JK gene segments of A/J ARS/A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions". Proceedings of the Natational Academy of Science USA. 1987; 84: 1085.
1987
Meek, K.; Sanz, I.; Rathbun, G.; Nisonoff, A.; Capra, J.D. "Identity of the VK10 ARS-A gene segments of the A/J and BALB/C strains". Proceedinds of the National Academy of Science (USA). 1987; 84: 6244.
0
Palanichamy, A.; Zheng, B.; Owen; Wei, C.W.; Looney, R.J.; Anolik, J.; Sanz, I. "Spontaneous expansion of transitional T3 B cells in patients with active SLE". .
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Wei, C.W.; Jenks, S.; Sanz, I. "Differentiation of human B cell subsets with central and effector phenotypes using multi-color flow cytometry". .
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Quach, T.; Jenks, S.; Sanz, I. "Characterization of anergic IgMlow human naïve B cells and their disregulation in SLE.".
0
Richardson, C.; Kim, D.; Marin, E.; Silver, L.; Roberts, M.; Sanz, I. "Role of receptor editing and positive selection in the regulation of autoreactive 9G4 B cells.".
0
Lee, F. H-Y.; Kyu, S.; Kobie, J.; Halley, J.; Lumb, M.; Walsh, E.; Liesveld, J.; Sanz, I. "Kinetic analysis of influenza vaccine-specific antibody secreting cells in human blood and bone marrow.".
0
Lee, F. H-Y.; Hellerstein; Wu, H.; Sanz, I. "Homeostatic studies of human B cells in healthy subjects and SLE patients by in vivo labeling with deuterated glucose.".

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