Research Bio
My laboratory research interests are focused on understanding the phenotypic and functional diversity of human B cells. In addition, we are specially interested in the regulation of human autoreactive B cells and the subversion of tolerance in autoimmunity. Our studies employ a combination of multiparameter flow cytometry and in vitro studies (including antibody and cytokine production, proliferation assays and transcriptional profiling) to understand the function of finely discriminated B cell subsets and their homeostasis in healthy subjects and in a number of autoimmune diseases including SLE, RA, Sjögren's syndrome and more recently type 1 diabetes.
Over the years we have put together a comprehensive toolbox that enables us to ask these important questions, including: multi-color (>12) flow cytometry with multidimensional analysis and single cell PCR generation of monoclonal antibodies. Our current goals include the generation of monoclonal antibodies from autoreactive B cells that infiltrate the target tissues in SLE and Sjogren's syndrome (kidneys and salivary glands).
2012 Mar
Barr PM, Wei C, Roger J, Schaefer-Cutillo J, Kelly JL, Rosenberg AF, Jung J, Sanz I, Friedberg JW. "Syk inhibition with fostamatinib leads to transitional B lymphocyte depletion." Clinical immunology (Orlando, Fla.). 2012 Mar 0; 142(3):237-42. Epub 2012 Jan 05. |
2011 Nov
Wei C, Jung J, Sanz I. "OMIP-003: phenotypic analysis of human memory B cells." Cytometry. Part A : the journal of the International Society for
Analytical Cytology. 2011 Nov 0; 79(11):894-6. Epub 2011 Jul 27. |
2011 Sep 29
Hilchey SP, Rosenberg AF, Hyrien O, Secor-Socha S, Cochran MR, Brady MT, Wang JC, Sanz I, Burack WR, Quataert SA, Bernstein SH. "Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation." Blood. 2011 Sep 29; 118(13):3591-602. Epub 2011 Aug 05. |
2011 May 1
Lee FE, Halliley JL, Walsh EE, Moscatiello AP, Kmush BL, Falsey AR, Randall TD, Kaminiski DA, Miller RK, Sanz I. "Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect." Journal of immunology (Baltimore, Md. : 1950). 2011 May 1; 186(9):5514-21. Epub 2011 Mar 25. |
2011 May
Sanz I, Yasothan U, Kirkpatrick P. "Belimumab." Nature reviews. Drug discovery. 2011 May 0; 10(5):335-6. |
