Ignacio Sanz, M.D.

Ignacio Sanz, M.D.

Contact Information

Emory University School of Medicine
Mail Stop: 1941-001-1AN
Whitehead Research Bldg 247
Atlanta, GA 30322

Office: (585) 275-2891
Lab: (585) 275-3561
Administrative: (585) 275-2891
Fax: (585) 442-3214

Lab Information

The focus is on B cell development, function and tolerance and B cell depletion in the treatment. The lab is a Center for the Biodefense of Immunocomprimised Populations and a NIH ACE.

Visit Lab Website »


Research Bio

My laboratory research interests are focused on understanding the phenotypic and functional diversity of human B cells. In addition, we are specially interested in the regulation of human autoreactive B cells and the subversion of tolerance in autoimmunity. Our studies employ a combination of multiparameter flow cytometry and in vitro studies (including antibody and cytokine production, proliferation assays and transcriptional profiling) to understand the function of finely discriminated B cell subsets and their homeostasis in healthy subjects and in a number of autoimmune diseases including SLE, RA, Sjögren's syndrome and more recently type 1 diabetes.

Over the years we have put together a comprehensive toolbox that enables us to ask these important questions, including: multi-color (>12) flow cytometry with multidimensional analysis and single cell PCR generation of monoclonal antibodies. Our current goals include the generation of monoclonal antibodies from autoreactive B cells that infiltrate the target tissues in SLE and Sjogren's syndrome (kidneys and salivary glands).

Awards & Honors (National)

Virginia P. Engelischoff Research Award | National Arthritis Foundation 1991

Recent Journal Articles

Showing the 5 most recent journal articles. 82 available »

2012 Mar
Barr PM, Wei C, Roger J, Schaefer-Cutillo J, Kelly JL, Rosenberg AF, Jung J, Sanz I, Friedberg JW. "Syk inhibition with fostamatinib leads to transitional B lymphocyte depletion." Clinical immunology : the official journal of the Clinical Immunology Society. 2012 Mar; 142(3):237-42. Epub 2012 Jan 05.
2011 Nov
Wei C, Jung J, Sanz I. "OMIP-003: phenotypic analysis of human memory B cells." Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2011 Nov; 79(11):894-6. Epub 2011 Jul 27.
2011 Sep 29
Hilchey SP, Rosenberg AF, Hyrien O, Secor-Socha S, Cochran MR, Brady MT, Wang JC, Sanz I, Burack WR, Quataert SA, Bernstein SH. "Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation." Blood. 2011 Sep 29; 118(13):3591-602. Epub 2011 Aug 05.
2011 May 1
Lee FE, Halliley JL, Walsh EE, Moscatiello AP, Kmush BL, Falsey AR, Randall TD, Kaminiski DA, Miller RK, Sanz I. "Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect." The Journal of immunology : official journal of the American Association of Immunologists. 2011 May 1; 186(9):5514-21. Epub 2011 Mar 25.
2011 May
Sanz I, Yasothan U, Kirkpatrick P. "Belimumab." Nature reviews. Drug discovery. 2011 May; 10(5):335-6.

Specialties

Internal Medicine - American Board of Internal Medicine
Rheumatology - American Board of Internal Medicine

Education

MD | Medicine | University of Santander Medical School1978
BS | Biology | Colegio San Agustin1973

Post-Doctoral Training & Residency

Univ. of Texas Health Science Center San Antonio, Tx Postdoctoral fellowship in Rheumatology 1991
Clinica Puerta de Hierro Madrid, Spain Residency in Internal Medicine 0
Southwestern Medical School Dallas, Tx Postdoctoral fellowship in Immunology 1988