Wen-Jye Lin, Ph.D.

Wen-Jye Lin, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Lab: (585) 275-4468

Journal Articles

Showing all 26 journal articles available.

2013 Apr 6
Izumi K, Mizokami A, Lin WJ, Lai KP, Chang C. "Androgen Receptor Roles in the Development of Benign Prostate Hyperplasia (BPH)." The American journal of pathology. 2013 Apr 6; Epub 2013 Apr 06.
2012 Oct
Lu T, Lin WJ, Izumi K, Wang X, Xu D, Fang LY, Li L, Jiang Q, Jin J, Chang C. "Targeting androgen receptor to suppress macrophage-induced EMT and benign prostatic hyperplasia (BPH) development." Molecular endocrinology (Baltimore, Md.). 2012 Oct 0; 26(10):1707-15. Epub 2012 Aug 21.
2012 May 25
Wang X, Lin WJ, Izumi K, Jiang Q, Lai KP, Xu D, Fang LY, Lu T, Li L, Xia S, Chang C. "Increased infiltrated macrophages in benign prostatic hyperplasia (BPH): role of stromal androgen receptor in macrophage-induced prostate stromal cell proliferation." The Journal of biological chemistry. 2012 May 25; 287(22):18376-85. Epub 2012 Apr 02.
2012
Fang LY; Izumi K; Li L; Lai KP; Liang L; Miyamoto H; Lin WJ*; and Chang C*. "A Critical Role for AR/CCL4 axis in promotion of prostate tumorigenesis. Paper in revision to Cancer Research. co-corresponding author." 2012; .
2012
Izumi K, Fang LY, Mizokami A, Namiki M, Li L, Lin WJ*, and Chang C*. "Targeting Androgen Receptor-induced CCL2 Expression by STAT3 Activation Contributes to Prostate Cancer Metastasis. Paper in submission to EMBO Mol Medicine. co-corresponding author." EMBO Mol Medicine. 2012; .
2011 Nov 8
Lin WJ, Su YW, Lu YC, Hao Z, Chio II, Chen NJ, Brüstle A, Li WY, Mak TW. "Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NF?B2 signaling that contributes to autoimmunity." Proceedings of the National Academy of Sciences of the United States of America. 2011 Nov 8; 108(45):18354-9. Epub 2011 Oct 31.
2011 Jul
Lee YF, Liu S, Liu NC, Wang RS, Chen LM, Lin WJ, Ting HJ, Ho HC, Li G, Puzas EJ, Wu Q, Chang C. "Premature aging with impaired oxidative stress defense in mice lacking TR4." American journal of physiology. Endocrinology and metabolism. 2011 Jul 0; 301(1):E91-8. Epub 2011 Apr 26.
2011 Jan 25
Su YW, Hao Z, Hirao A, Yamamoto K, Lin WJ, Young A, Duncan GS, Yoshida H, Wakeham A, Lang PA, Murakami K, Hermeking H, Vogelstein B, Ohashi P, Mak TW. "14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1." Proceedings of the National Academy of Sciences of the United States of America. 2011 Jan 25; 108(4):1555-60. Epub 2011 Jan 04.
2011
Collins LL, Lee YF, Ting HJ, Lin WJ, Liu NC, Meshul CK, Uno H, Bao BY, Chen YT, Chang C. "The roles of testicular nuclear receptor 4 (TR4) in male fertility-priapism and sexual behavior defects in TR4 knockout mice." Reproductive biology and endocrinology : RB&E. 2011 9:138. Epub 2011 Oct 13.
2009 Oct
Liu NC, Lin WJ, Yu IC, Lin HY, Liu S, Lee YF, Chang C. "Activation of TR4 orphan nuclear receptor gene promoter by cAMP/PKA and C/EBP signaling." Endocrine. 2009 Oct 0; 36(2):211-7. Epub 2009 Jul 18.
2009
Lai JJ, Lai KP, Chuang KH, Chang P, Yu IC, Lin WJ, Chang C. "Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression." The Journal of clinical investigation. 2009 119(12):3739-51. Epub 2009 Nov 09.
2008 Aug 26
Chen NJ, Chio II, Lin WJ, Duncan G, Chau H, Katz D, Huang HL, Pike KA, Hao Z, Su YW, Yamamoto K, de Pooter RF, Zúñiga-Pflücker JC, Wakeham A, Yeh WC, Mak TW. "Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors." Proceedings of the National Academy of Sciences of the United States of America. 2008 Aug 26; 105(34):12429-34. Epub 2008 Aug 21.
2007
Chen NJ; Mirtsos C; Suh D; Lu YC; Lin W.J; McKerlie C; Lee T; Baribault H; Tian H; Yeh WC. "C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a." Nature 446(7132): 203-207.. 2007; 446(7132): 203-207.
2007
Liu NC, Lin WJ, Kim E, Collins LL, Lin HY, Yu IC, Sparks JD, Chen LM, Lee YF, Chang C. "Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis." Diabetes. 2007 56(12):2901-9. Epub 2007 Sep 07.
2005 Sep
Lin WJ, Yeh WC. "Implication of Toll-like receptor and tumor necrosis factor alpha signaling in septic shock." Shock (Augusta, Ga.). 2005 Sep 0; 24(3):206-9.
2005 Aug 1
Chau H, Wong V, Chen NJ, Huang HL, Lin WJ, Mirtsos C, Elford AR, Bonnard M, Wakeham A, You-Ten AI, Lemmers B, Salmena L, Pellegrini M, Hakem R, Mak TW, Ohashi P, Yeh WC. "Cellular FLICE-inhibitory protein is required for T cell survival and cycling." The Journal of experimental medicine. 2005 Aug 1; 202(3):405-13. Epub 2005 Jul 25.
2005 May
Chuang KH, Lee YF, Lin WJ, Chu CY, Altuwaijri S, Wan YJ, Chang C. "9-cis-retinoic acid inhibits androgen receptor activity through activation of retinoid X receptor." Molecular endocrinology (Baltimore, Md.). 2005 May 0; 19(5):1200-12. Epub 2005 Jan 13.
2005 Feb
Hsu CL, Chen YL, Ting HJ, Lin WJ, Yang Z, Zhang Y, Wang L, Wu CT, Chang HC, Yeh S, Pimplikar SW, Chang C. "Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth." Molecular endocrinology (Baltimore, Md.). 2005 Feb 0; 19(2):350-61. Epub 2004 Oct 28.
2003 Nov 1
Altuwaijri S, Lin HK, Chuang KH, Lin WJ, Yeh S, Hanchett LA, Rahman MM, Kang HY, Tsai MY, Zhang Y, Yang L, Chang C. "Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells." Cancer research. 2003 Nov 1; 63(21):7106-12.
2003 Mar 14
Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C. "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4." The Journal of biological chemistry. 2003 Mar 14; 278(11):9353-60. Epub 2003 Jan 08.
2003 Feb 28
Yang Y, Wang X, Dong T, Kim E, Lin WJ, Chang C. "Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation." The Journal of biological chemistry. 2003 Feb 28; 278(9):7709-17. Epub 2002 Dec 16.
2002 Nov 15
Kang HY, Huang KE, Chang SY, Ma WL, Lin WJ, Chang C. "Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4." The Journal of biological chemistry. 2002 Nov 15; 277(46):43749-56. Epub 2002 Sep 10.
2002 Nov 1
Lee YF, Lin WJ, Huang J, Messing EM, Chan FL, Wilding G, Chang C. "Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells." Cancer research. 2002 Nov 1; 62(21):6039-44.
2002 Sep 27
Lin HK, Altuwaijri S, Lin WJ, Kan PY, Collins LL, Chang C. "Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells." The Journal of biological chemistry. 2002 Sep 27; 277(39):36570-6. Epub 2002 Jul 15.
1999 Jun 4
Lee YF, Young WJ, Lin WJ, Shyr CR, Chang C. "Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor." The Journal of biological chemistry. 1999 Jun 4; 274(23):16198-205.
1999
Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C. "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily." Proceedings of the National Academy of Sciences of the United States of America. 1999 96(26):14724-9.