Research projects in the Advanced Physiological Optics Laboratory have been focusing on optics of the eye. The goals of the projects are to objectively understand optical quality of the eye and to improve visual performance by correcting the optical defects in the eye with various correction methods. We have successfully developed the large dynamic range wavefront sensor with high measurement sensitivity that allows us to measure highly aberrated eyes such as advanced keratoconus. We have also developed the customized correction methods. These include customized optical components such as phase plate and soft contact lenses, and laser refractive surgery.
We recently implemented the large stroke adaptive optics system for vision testing that has sufficient deformable mirror stroke to correct the highly aberrated eyes such as advanced keratoconus. This powerful tool is being used to understand interaction between optics of the eye and adaptation effects of the human visual system. We are currently expanding our research scope to presbyopia, accommodation and dry eye with advanced intraocular imaging system such as Fourier domain optical coherence tomography and high-resolution magnetic resonance imaging. We have also been very active in collaborating with PIs in intramural and extramural research laboratories and industry.