Research Bio
My primary research interest is energy generation in the heart, both physiologically and pathologically. Energy in form of ATP is made by mitochondria and necessary to keep the heart working and even apoptotic cell death requires energy. My special research interest is the mitochondrial permeability transition pore. Although a variety of mitochondrial proteins have been hypothesized to constitute the pore, the structural components are still not identified. It is well established that opening of the permeability transition pore will lead to apoptotic cell death. However, the physiological role of this pore is much less understood.
My research will focus on the identification of the components of the permeability transition pore and how this pore is regulated during cardiac development. Experimental models of my research will include isolate mitochondria from the heart, primary cultured cardiac myocytes and in vivo models like transgenic mice.
2011 Jun 17
Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS. "Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts." The Journal of biological chemistry. 2011 Jun 17; 286(24):21324-9. Epub 2011 Apr 27. |
2010 May 17
Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS. "Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels." FEBS letters. 2010 May 17; 584(10):1948-55. Epub 2010 Jan 21. |
2009 Oct 2
Kalifa L, Beutner G, Phadnis N, Sheu SS, Sia EA. "Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity." DNA repair. 2009 Oct 2; 8(10):1242-9. Epub 2009 Aug 21. |
2007 Jul
Altschafl BA, Beutner G, Sharma VK, Sheu SS, Valdivia HH. "The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile." Biochimica et biophysica acta. 2007 Jul 0; 1768(7):1784-95. Epub 2007 Apr 19. |
2005 Nov 10
Beutner G, Sharma VK, Lin L, Ryu SY, Dirksen RT, Sheu SS. "Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling." Biochimica et biophysica acta. 2005 Nov 10; 1717(1):1-10. Epub 2005 Oct 11. |
