Bradford C. Berk, M.D., Ph.D.

Bradford C. Berk, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 706
Rochester, NY 14642

Office: (585) 275-3647
Lab: (585) 276-9840
Administrative: (585) 275-3647

Lab Information

1) Vascular biology; 2) ischemic injury; 3) electrophysiology and ion channels, 4) pharmacology and signal transduction; 5) genetics of cardiovascular disease

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Professional Bio

Dr. Berk is Professor of Medicine, Cardiology, and Pharmacology and the Senior Vice President for Health Sciences at the University of Rochester. Dr. Berk received his M.D. and Ph.D. degrees from the University of Rochester. He has served on the faculties of Harvard Medical School, Emory University, and the University of Washington. Dr. Berk was previously Chairman of Medicine (1999-2006) and Chief of the Cardiology Unit (1998-2003) at the University of Rochester. In addition he was Director of the Aab Cardiovascular Research Institute. Dr. Berk is a fellow of the American Heart Association and the American College of Cardiology, and a member of the Association of American Physicians. Dr. Berk is past-president of the North American Vascular Biology Organization (NAVBO). He is Consulting Editor for Circulation and Circulation Research and is on the editorial boards of ATVB and the Journal of Clinical Investigation. He serves on the Empire State Stem Cell Board Funding Committee and the National Heart, Lung and Blood Institute (NHLBI), Stem Cell Clinical Trial Network and Gene and Cell-Based Therapies Data and Safety Monitoring Board (DSMB).



His research interests include: molecular biology of renin-angiotensin-aldosterone
system; regulation of endothelial cell function especially by shear stress; the role of oxidative stress in vascular biology and the genetic mechanisms of vascular remodeling. Dr. Berk has published widely – more than 250 articles, chapters, and books.

Listed below is Dr. Berk's affiliation:

Bradford C. Berk, M.D., Ph.D.
Professor of Medicine, Cardiology, and Pharmacology
Senior Vice President for Health Sciences
University of Rochester Medical Center
Rochester, New York

US Postal mail should be sent to:
Bradford C. Berk, M.D., Ph.D.
University of Rochester Medical Center
Office of Vice President for Health Sciences
601 Elmwood Avenue, Box 706
Rochester, New York 14642

FEDEX
Bradford C. Berk, M.D, Ph.D.
University of Rochester Medical Center
Office of Vice President for Health Sciences
601 Elmwood Avenue, Box 706, Rm. 1-4337
Rochester, NY 14642

Research Bio

Dr. Berk's laboratory is known for studying signal transduction mechanisms in the vasculature, focusing specifically on defining the mechanisms by which cells in the vascular wall respond to hemodynamic and hormonal stimuli. The four major research areas ongoing in the laboratory include 1) Mechanisms by which blood vessels sense changes in blood flow using protein kinases as targets for signal events. Using cultured endothelial cells and animal models of altered blood flow two projects are underway. The first project investigates the mechanisms by which flow activates the Big MAP kinase (or ERK5) and inhibits inflammation and atherosclerosis.

In the second project, the redox-dependent mechanisms that maintain an antioxidant environment are being studied using the apoptosis signal kinase-1 (ASK1) and thioredoxin as targets. The goal of these projects is to identify signal transduction events that confer atheroprotection in the setting of steady laminar flow as opposed to the pro-atherosclerotic effects of disturbed and turbulent flow. 2) The cellular mechanisms that cause hypertension are being investigated by analysis of the role of the renin angiotensin system and the kinases that regulate intracellular sodium. The regulation of smooth muscle cell growth by angiotensin II is focused on the activation of intracellular kinases and phosphatases by the angiotensin II receptor. 3) The mechanisms by which changes in cellular redox state alter blood vessel function are being studied to provide insight into the ways that reactive oxygen species regulate vessel function. Specifically the role of the chaperone molecule cyclophilin A as a mediator of vascular pathology is being studied with several different transgenic models. 4) A genetic model of vascular remodeling in the mouse has been established. A carotid flow reduction model has been characterized and is being used to identify genes responsible for impaired flow-dependent remodeling by positional cloning in inbred strains of mice.

Awards & Honors (National)

National Science Foundation Undergraduate Research Program (Molecular Biology) | California Institute of Technology | Pasadena, CA 1973

Awards & Honors (Local)

Vice-chair | Vascular Cell Biology Gordon Conference 2004 - 2005
Russell Ross Memorial Lectureship in Vascular Biology | Council for Arteriosclerosis, Thrombosis, Vascular Biology 2003
Theo Tsagaris Memorial Lecture | University of Utah | Salt Lake City, Utah 2002
Indiana Vascular Society/ICVBM Conference | University of Indiana | Indianapolis, Indiana 2002
Pfizer Visiting Professor | University of Iowa | Iowa City, Iowa 2002
Borun Visiting Professor in Cardiology | UCLA Medical Center | Los Angeles, CA 1999
Annual Pulsifer Lecture, Guest Speaker | Rochester Academy of Medicine 1999
Pfizer Visiting Professor of Cardiovascular Disease | Wayne State University School of Medicine 1995
Marion Young Scholar Award | American Society for Hypertension 1992
Katz Prize Finalist | American Heart Association 1986
Young Investigator's Award | American College of Cardiology 1985
Robert Kates Memorial Prize in Research, Doran J. Stephens Prize in Medicine | Alpha Omega Alpha 1981
Phi Beta Kappa, John Albree Jr. Class of 1981 Memorial Fund Award for History | John Woodruff Simpson Postgraduate Scholarship in Medicine 1975
Medical Scientist Training Program (Pharmacology) | University of Rochester | Rochester, NY 1975 - 1981
Woods Hole Oceanographic Institution Fellowship (Microbiology) | Woods Hole Oceanographic Institute | Woods Hole, MA 1974

Patents

Thioredoxin Interacting Protein (TXNIP or VDUP1) as a Regulator of Vascular Function

United States Serial NO.: 11/814,442
Filed Date: January 20, 2006
Title: Thioredoxin Interacting Protein (TXNIP) as a Regulator of Vascular Function
Invented by: Bradford Berk
Thioredoxin Interacting Protein (TXNIP or VDUP1) as a Regulator of Vascular Function

United States Serial NO.: 2006206376
Filed Date: January 20, 2006
Title: Thioredoxin Interacting Protein (TXNIP as Regulator of Vascular Function
Invented by: Bradford Berk

Recent Journal Articles

Showing the 5 most recent journal articles. 293 available »

2014 May 5
Wang L, Soe NN, Sowden M, Xu Y, Modjeski K, Baskaran P, Kim Y, Smolock EM, Morrell C, Berk BC. "Cyclophilin A is an important mediator of platelet function by regulating integrin ?IIb?3 bidirectional signalling." Thrombosis and haemostasis.. 2014 May 5; 111(5):873-82. Epub 2014 Jan 16.
2014 Mar 28
Spindel ON, Burke RM, Yan C, Berk BC. "Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation." Circulation research.. 2014 Mar 28; 114(7):1125-32. Epub 2014 Feb 10.
2014 Mar 1
Soe NN, Sowden M, Baskaran P, Kim Y, Nigro P, Smolock EM, Berk BC. "Acetylation of cyclophilin A is required for its secretion and vascular cell activation." Cardiovascular research.. 2014 Mar 1; 101(3):444-53. Epub 2013 Nov 29.
2014 Feb
Majumder S, Sowden MP, Gerber SA, Thomas T, Christie CK, Mohan A, Yin G, Lord EM, Berk BC, Pang J. "G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation." Arteriosclerosis, thrombosis, and vascular biology.. 2014 Feb; 34(2):419-26. Epub 2013 Nov 21.
2013 Sep
Soe NN, Sowden M, Baskaran P, Smolock EM, Kim Y, Nigro P, Berk BC. "Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells." Arteriosclerosis, thrombosis, and vascular biology.. 2013 Sep; 33(9):2147-53. Epub 2013 Jul 11.

Current Appointments

CEO, University of Rochester Medical Center - Department of Office of VP for Health Sciences (URMC)
Senior Vice President for Health Sciences - Department of Office of VP for Health Sciences (URMC) - Primary Administrative
Professor - Department of Medicine, Cardiology (SMD) - Primary

Specialties

Internal Medicine - American Board of Internal Medicine
Cardiovascular Disease - American Board of Internal Medicine

Education

PhD | Pharmacology | University of Rochester School of Medicine and Dentistry1981
MD | Medicine | University of Rochester School of Medicine and Dentistry1981
BA | Pre-Medical | Amherst College1975

Post-Doctoral Training & Residency

Fellowship in Cardiology at Brigham and Women's Hospital07/01/1984 - 06/30/1987
Fellowship in Research Fellow in Medicine at Harvard Medical School07/01/1984 - 06/30/1987
Residency in Cardiology at Brigham and Women's Hospital07/01/1982 - 06/30/1984
Residency in Internal Medicine at West Roxbury Veteran s Hospital07/01/1982 - 06/30/1984
Internship in Internal Medicine at Brigham and Women's Hospital07/01/1981 - 6/30/1982