Edward M. Messing, M.D.

Edward M. Messing, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 656
Rochester, NY 14642

Office: (585) 275-0998
Fax: (585) 273-1068
Administrative: (585) 275-3345

Professional Bio

Dr. Messing received his MD degree from New York University in 1972, did his surgery training at NYU-Bellevue Hospital in New York 1972-1974, and his Urology Residency at Stanford University 1974-1978. After 2 years on the faculty at Tulane University, he completed a fellowship in Urologic Oncology at UCLA in 1982. He was on the faculty of the Division of Urology at the University of Wisconsin from 1982-1995, being Director of their Urologic Oncology Program for the last 10 years. He assumed his current
position at the University of Rochester School of Medicine and Dentistry in September 1995. Dr. Messing is a renowned expert in the diagnosis and treatment of cancers of the prostate, bladder, kidney, testicle, penis and other genitourinary organs, carries on extensive research in the basic biology of bladder and prostate cancers, and has been the principal investigator on numerous clinical studies for the detection, prevention and

treatment of genitourinary cancers.

Research Bio

Dr. Messing is an internationally renowned expert in all facets of urologic oncology, both as a clinician/surgeon, and as a clinical, translational and basic researcher.



His research contributions have ranged from enhancing our knowledge about the basic molecular biology and genetics of development and progression of cancers of the bladder, prostate and kidney, and bringing these studies to fruition for the detection, prevention and treatment of these diseases. He has also designed and conducted landmark phase III clinical trials for each of these cancers and has carried out the first
screening trial for bladder cancer in a general population. Important work has included defining the roles of epidermal growth factor (EGF) and its cell surface receptor in urothelial carcinogenesis and progression, investigating polyamine synthesis inhibition as a means to prevent bladder and prostate cancers, in large phase III clinical trials studying DFMO's ability to prevent bladder cancer's recurrence, the timing of androgen deprivation therapy (ADT) in treating regionally advanced completely resected prostate cancer, and the effectiveness of adjuvant alpha interferon for completely resected,
locally extensive, renal cell carcinoma. He has also contributed importantly to trials testing various forms of intravesical therapy for high risk, non-muscle invading bladder cancer, and the value of radiation therapy after prostatectomy for stage pT3 prostate cancer. He has demonstrated the feasibility of screening for bladder cancer (using hematuria reagent strips) and has worked on the development and testing of several molecular markers for the detection of bladder cancer.

Much of the above mentioned work continues, but currently he is also investigating gender disparities in bladder cancer's incidence and outcome. These efforts have ranged from investigations using large, national data bases, to molecular studies in cells and transgenic animal models. Additionally, he along with his basic science collaborators are investigating the preventative and therapeutic roles of nuclear transcription factors, vitamins and related molecules in prevention and treatment of prostate and bladder cancer. Furthermore, his clinical trial work
continues as the study coordinator (PI) of a large phase III clinical trial of immediate post TURBT intravesical instillation therapy for prevention of recurrence of low risk bladder cancer.

Awards & Honors (National)

Presidential Citation Award | American Urological Association | San Diego, California 2013
2013 Best of Posters Award - AUA - 2013 Annual Meeting | American Urological Association | San Diego, California 2013
2012 Best of Posters Award – AUA – 2012 Annual Meeting | American Urological Association | Atlanta, Georgia 2012
2010 Best of Posters Award - AUA - 2010 Annual Meeting | American Urological Association | San Francisco, California 2010 - Present
Fellow | American College of Surgeons 1986 - Present
Sigma Xi | The Scientific Research Society 1985 - Present
Junior Faculty Clinical Fellow | American Cancer Society 1984 - 1986
Alpha Omega Alpha | New York University - School of Medicine 1972 - Present
Phil Beta Kappa | University of Chicago 1968 - Present

Awards & Honors (Local)

Davey Award | James P. WIlmot Cancer Center | University of Rochester Medical Center 2009
CaP Cure Award | Best Clinical Research on Prostate Cancer 1999 - 1999
First Prize for Clinical Research and the Bill Smart Award for Best Clinical Paper (Interstitial Cystitis) | Northern California Urology Residents Seminar - Stanford, CA 1977 - 1977
Second Prize for Case Reports (Renal Arteriovenous Fistulas) | Northern California Urology Residents Seminar - Davis, CA 1975 - 1975
The Samuel Soifer Memorial Award for Outstanding Work in Urology - 1972 | New York University - School of Medicine 1972 - 1972

Patents

Indocyanine Green Near Infrared Fluorescence Intraoperative Imaging of Renal Cortical Tumors Facilitates Radical And Partial Nephrectomy Procedures

United States Serial NO.: 11/836,737
Filed Date: August 9, 2007
Title: Intraoperative Imaging of Renal Cortical Tumors and Cysts
Invented by: Dragan Golijanin, Ronald Wood, Edward Messing
Indocyanine Green Near Infrared Fluorescence Intraoperative Imaging of Renal Cortical Tumors Facilitates Radical And Partial Nephrectomy Procedures

United States Serial NO.:
Filed Date: January 1, 1899
Title: Intraoperative Imaging of Renal Cortical Tumors and Cysts
Invented by: Dragan Golijanin, Ronald Wood, Edward Messing
0Intraopertive Sentinel Lymph Node (SLN) Detection Using Near Infrared Fluorescense (NIRF) after Intravesical Indocyanine Green (ICG) Administration in Patients with Bladder Cancer

United States Serial NO.: 11/775,037
Filed Date: July 9, 2007
Title: Pre- and Intra-Operative Imaging of Bladder Cancer
Invented by: Dragan Golijanin, Edward Messing, Aimee Johnson Henry, Jay Reeder, Ronald Wood

Recent Journal Articles

Showing the 5 most recent journal articles. 236 available »

2013 Jul
Scosyrev E, Wu G, Golijanin D, Messing E. "Non-bladder cancer mortality in patients with urothelial cancer of the bladder." Urologic oncology. 2013 Jul; 31(5):656-63. Epub 2011 May 07.
2013 Jun
Larré S, Catto JW, Cookson MS, Messing EM, Shariat SF, Soloway MS, Svatek RS, Lotan Y, Zlotta AR, Grossman HB. "Screening for bladder cancer: rationale, limitations, whom to target, and perspectives." European urology. 2013 Jun; 63(6):1049-58. Epub 2013 Jan 08.
2013 May
Yang DR, Lin SJ, Ding XF, Miyamoto H, Messing E, Li LQ, Wang N, Chang C. "Higher expression of peroxisome proliferator-activated receptor ? or its activation by agonist thiazolidinedione-rosiglitazone promotes bladder cancer cell migration and invasion." Urology. 2013 May; 81(5):1109.e1-6. Epub 2013 Mar 19.
2013 Apr
Weight CJ, Miller DC, Campbell SC, Derweesh IH, Lane BR, Messing EM. "The management of a clinical t1b renal tumor in the presence of a normal contralateral kidney." The Journal of urology. 2013 Apr; 189(4):1198-202. Epub 2013 Jan 18.
2013 Mar 1
Scosyrev E, Messing EM. "Reply to prostate-specific antigen screening for prostate cancer and the risk of overt metastatic disease at presentation : analysis of trends over time." Cancer. 2013 Mar 1; 119(5):1113-4. Epub 2012 Oct 23.

Current Appointments

Chair - Department of Urology (SMD) - Primary Administrative
Winfield W. Scott Chair in Urology - Department of Urology (SMD)
Professor - Department of Urology (SMD) - Primary
Professor - Cancer Center
Professor - Department of Pathology and Laboratory Medicine (SMD)

Specialties

Urology - American Board of Urology

Education

MD | Medicine | New York Univ Sch Medicine1972
AB | Biology | University of Chicago1968

Post-Doctoral Training & Residency

Residency in Urology at Stanford University School of Medicine09/01/1974 - 06/30/1978
Residency in Surgery at Bellevue Hospital Center09/01/1973 - 06/30/1974
Internship in Surgery at Bellevue Hospital Center09/01/1972 - 06/30/1973