David J. Topham, Ph.D.

David J. Topham, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 609
Rochester, NY 14642

Office: (585) 273-1403
Administrative: (585) 273-1400
Lab: (585) 273-1408
Fax: (585) 273-2452

Professional Bio

David Topham joined the faculty at the University of Rochester Medical Center in 1999 and was appointed in 2009 as Vice Provost and Executive Director of the Health Science Center for Computational Innovation (HSCCI), a partnership between the University and IBM. As Executive Director of the HSCCI, Dr. Topham's responsibility is to support collaboration in biomedical research using High Performance Computational Resources. He will bring together academic biomedical and health-related Research Investigators, High Performance Computational Biologists, and HP Research Computing resources. Dr. Topham provides strategic direction to the HSCCI and facilitates the development of research projects between UR scientists and its corporate partners, as well as support from state and federal agencies.



Dr. Topham is an Associate Professor of Microbiology and Immunology, a member of the David H. Smith Center for Vaccine Biology and Immunology, and co-directs the New York Influenza Center of Excellence--one of the six national Centers of Excellence in Influenza Research and Surveillance supported by the National Institutes of Health. He has also served on IBM's Global Pandemic Steering Committee. His research interests are in the area of immune responses to influenza and experimental vaccines, and include computational modeling of the immune system.

Research Bio

Virus infections of the respiratory tract are responsible for a great deal of illness and even death among the world's human population. Influenza, in particular, has a history of causing deadly pandemics and the continuing emergence of highly pathogenic H5 influenzas around the world is reason for concern. It is essential to understand how the immune system clears a virus infection and provides long term immunity if we are to design more rational vaccination and treatment strategies. The lab has a combined program in basic research using animal models of influenza infection and immunity, as well as a translational research program to study human immune responses to influenza infection and vaccination.

Within these programs we are investigating the mechanisms that provide optimal immune protection against influenza virus. One particular focus is to understand how T cells are regulated in the environment of the lung tissue and airways. We believe this is the key to generating long-lived protective immunity against diverse influenza viruses, including potential pandemic strains. The concepts and information we gather from the animal models are being directly translated into the human situation. To this end, we have established the New York Influenza Center of Excellence, a robust, collaborative program for basic and translational investigation of influenza virology, pathogenesis, immunology, and vaccines.

Awards & Honors (Local)

Scholar | Nathan Shock Center for the Study of Aging and Development | University of Rochester 2001

Patents

Enhancing Immune Memory by Blocking Intrahepatic T Cell Deletion via TLR-4 Inhibition

United States Serial NO.: 11/917,866
Filed Date: June 19, 2006
Title: Methods and Compositions for Enhancing Immune Memory by Blocking Intrahepatic Activated T Cell Deletion
Invented by: Ian Nicholas Crispe, David Topham, Beena John, Ingo Klein

Recent Journal Articles

Showing the 5 most recent journal articles. 82 available »

2014 Oct 15
Guo H, Baker S, Martínez-Sobrido L, Topham DJ. "Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus." Journal of virology. 2014 Oct 15; 88(20):12006-16. Epub 2014 Aug 06.
2014 Sep
Nogales A, Baker SF, Ortiz-Riaño E, Dewhurst S, Topham DJ, Martínez-Sobrido L. "Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development." Journal of virology. 2014 Sep; 88(18):10525-40. Epub 2014 Jun 25.
2014 Sep
Baker SF, Nogales A, Finch C, Tuffy KM, Domm W, Perez DR, Topham DJ, Martínez-Sobrido L. "Influenza A and B virus intertypic reassortment through compatible viral packaging signals." Journal of virology. 2014 Sep; 88(18):10778-91. Epub 2014 Jul 09.
2014
Miao H, Sangster MY, Livingstone AM, Hilchey SP, Zhang L, Topham DJ, Mosmann TR, Holden-Wiltse J, Perelson AS, Wu H, Zand MS. "Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection." PloS one. 2014 9(8):e104781. Epub 2014 Aug 29.
2013 Nov
Chen J, Pompano RR, Santiago FW, Maillat L, Sciammas R, Sun T, Han H, Topham DJ, Chong AS, Collier JH. "The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation." Biomaterials. 2013 Nov; 34(34):8776-85. Epub 2013 Aug 13.

Current Appointments

Professor - Department of Microbiology and Immunology, Center for Vaccine Biology and Immunology (SMD) - Primary

Education

PhD | Cellular/Molecular Biology | University of Vermont1994
MS | Pathology | University of Vermont1992
BS | Biology | University of Vermont1986

Post-Doctoral Training & Residency

St. Jude Children's Research Hospital, Memphis, TN, Department of Immunology (Mentor, Peter C. Doherty) 1999