Zheng-Gen Jin, Ph.D.

Zheng-Gen Jin, Ph.D.

Contact Information

Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta, NY 14586

Office: (585) 276-9783
Fax: (585) 276-9829
Lab: (585) 276-9836
Administrative: (585) 276-9800

Lab Information

Molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that regulate vasomotor tone, but&.

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Research Bio

Research



* Molecular regulation of vascular endothelial function.

Dr. Jin's research has been focused on molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that not only physiologically regulate vasomotor tone and vascular homeostasis, but also mediate the recruitment and activity of inflammatory cells and the propensity towards atherosclerotic lesion formation and thrombosis in the pathological condition. Normal laminar shear stress, a fractional force generated by blood flow, regulates the activity of endothelial nitric oxide synthase (eNOS) and promotes the expression of genes in endothelial cells that may protect against atherosclerosis. In contrast, oxidant stress caused by over-production of reactive oxygen species plays a major role in impairing vascular functions, by reducing the bioavailability of nitric oxide and stimulating proinflammatory pathways. By understanding the nature of molecular regulation of endothelial function and dysfunction by shear stress and oxidative stress as well as growth factors and cytokines, Dr. Jin's research will help to develop novel therapeutic strategies for preventing atherosclerotic vascular diseases.

The specific ongoing projects in the lab are: 1) to characterize the signaling pathways involved in flow-mediated eNOS activation and anti-inflammatory effect; 2) to identify specific intracellular signaling molecules essential for oxidative stress-induced endothelial dysfunction; 3) to define the molecular mechanisms of endothelial proinflammatory and angiogenetic responses to growth factors and cytokines.

Recent Journal Articles

2008 Aug
Xu X, Jhun BS, Ha CH, Jin ZG. "Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation." Endocrinology. 2008 Aug; 149(8):4183-92. Epub 2008 May 01.
2008 May 23
Ha CH, Wang W, Jhun BS, Wong C, Hausser A, Pfizenmaier K, McKinsey TA, Olson EN, Jin ZG. "Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis." The Journal of biological chemistry.. 2008 May 23; 283(21):14590-9. Epub 2008 Mar 10.
2008 Mar 14
Ha CH, Bennett AM, Jin ZG. "A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor." The Journal of biological chemistry.. 2008 Mar 14; 283(11):7261-70. Epub 2008 Jan 07.
2008
Ha, C.H., Jhun, B.S., Kao, H.Y., Jin, Z.G. ""VEGF Stimulates HDAC7 Phosphorylation and Cytoplasmic Accumulation Modulating Matrix Metalloproteinase Expression and Angiongenesis."". Arterioscler Thromb Vasc Biol.. 2008; . Link
2007 Nov
Xu X, Ha CH, Wong C, Wang W, Hausser A, Pfizenmaier K, Olson EN, McKinsey TA, Jin ZG. "Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy." Arteriosclerosis, thrombosis, and vascular biology.. 2007 Nov; 27(11):2355-62. Epub 2007 Sep 06.

Current Appointments

Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD) - Primary

Education

PhD | Physiology | China - Non-Medical School1991
BS | Physics | China - Non-Medical School1987