Lin Gan, Ph.D.

Lin Gan, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 659
Rochester, NY 14642

Office: (585) 273-1510
Lab: (585) 273-1513
Fax: (585) 276-2432

Research Bio

The mammalian retina and inner ear are two of the most common places of genetic diseases that cause blindness and deafness due to the degeneration of retinal and inner ear neurons. In order to understand the disease processes, it is very crucial to elucidate the fundamental mechanisms regulating the normal development and maintenance of these neurons at the molecular level. My research is centered on identifying genes required for neuron differentiation and survival, investigating the genetic pathways involved in these processes, and developing therapies for blindness and deafness via gene therapy and stem cell replacement.

I am currently investigating the roles of three classes of transcription factors (TFs), the basic helix-loop-helix (bHLH), POU-homeodomain (POU-HD), and LIM-domain TFs, in the formation and maintenance of mouse retina and inner ear. Using homologous recombination in mouse embryonic stem (ES) cells to mutate these TF genes, I have shown that these TFs function in a cascade to regulate the differentiation of neuronal progenitor cells into specific types of neurons and to regulate the maturation and survival of post-differentiation neurons.

Awards & Honors (National)

Research to Prevent Blindness Senior Scientific Investigator Award | Research to Prevent Blindness 2011 - 2011
Rosanne H. Silbermann Fellow | Silbermann Foundation 1999 - 2003
CUSBEA (China-United States Biochemistry and Molecular Biology Examination and Administration) Program Scholarship | Ministry of Education | China 1985

Recent Journal Articles

Showing the 5 most recent journal articles. 86 available »

2015 Nov
Luo XJ, Mattheisen M, Li M, Huang L, Rietschel M, Børglum AD, Als TD, van den Oord EJ, Aberg KA, Mors O, Mortensen PB, Luo Z, Degenhardt F, Cichon S, Schulze TG, Nöthen MM, , , Su B, Zhao Z, Gan L, Yao YG. "Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function." Schizophrenia bulletin. 2015 Nov; 41(6):1294-308. Epub 2015 Mar 10.
2015 May
Luo XJ, Huang L, Oord EJ, Aberg KA, Gan L, Zhao Z, Yao YG. "Common variants in the MKL1 gene confer risk of schizophrenia." Schizophrenia bulletin. 2015 May; 41(3):715-27. Epub 2014 Nov 07.
2015 Mar 15
Eblimit A, Nguyen TM, Chen Y, Esteve-Rudd J, Zhong H, Letteboer S, van Reeuwijk J, Simons DL, Ding Q, Wu KM, Li Y, van Beersum S, Moayedi Y, Xu H, Pickard P, Wang K, Gan L, Wu SM, Williams DS, Mardon G, Roepman R, Chen R. "Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina." Human molecular genetics. 2015 Mar 15; 24(6):1584-601. Epub 2014 Nov 14.
2014 Nov
Luo X, Huang L, Han L, Luo Z, Hu F, Tieu R, Gan L. "Systematic prioritization and integrative analysis of copy number variations in schizophrenia reveal key schizophrenia susceptibility genes." Schizophrenia bulletin. 2014 Nov; 40(6):1285-99. Epub 2014 Mar 24.
2014 Sep 1
Balasubramanian R, Gan L. "Development of Retinal Amacrine Cells and Their Dendritic Stratification." Current ophthalmology reports. 2014 Sep 1; 2(3):100-106.

Current Appointments

Professor - Department of Ophthalmology (SMD) - Primary
Professor - Department of Neurobiology and Anatomy (SMD)
Professor - Center for Visual Science A&S (RC)


PhD | Biochemistry, All Other | U Tex-Houstn Grad Sch Biomd Sc1992
BS | Biochemistry, All Other | China - Non-Medical School1985

Post-Doctoral Training & Residency

Postdoctoral Fellow (with William Klein, Ph.D.), Dept. of Biochemistry and Molecular Biology, Univ. of Texas M.D. Anderson Cancer Center 1994