Lin Gan, Ph.D.

Lin Gan, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 659
Rochester, NY 14642

Office: (585) 273-1510
Lab: (585) 273-1513
Fax: (585) 276-2432

Research Bio

The mammalian retina and inner ear are two of the most common places of genetic diseases that cause blindness and deafness due to the degeneration of retinal and inner ear neurons. In order to understand the disease processes, it is very crucial to elucidate the fundamental mechanisms regulating the normal development and maintenance of these neurons at the molecular level. My research is centered on identifying genes required for neuron differentiation and survival, investigating the genetic pathways involved in these processes, and developing therapies for blindness and deafness via gene therapy and stem cell replacement.

I am currently investigating the roles of three classes of transcription factors (TFs), the basic helix-loop-helix (bHLH), POU-homeodomain (POU-HD), and LIM-domain TFs, in the formation and maintenance of mouse retina and inner ear. Using homologous recombination in mouse embryonic stem (ES) cells to mutate these TF genes, I have shown that these TFs function in a cascade to regulate the differentiation of neuronal progenitor cells into specific types of neurons and to regulate the maturation and survival of post-differentiation neurons.

Awards & Honors (National)

Research to Prevent Blindness Senior Scientific Investigator Award | Research to Prevent Blindness 2011 - 2011
Rosanne H. Silbermann Fellow | Silbermann Foundation 1999 - 2003
CUSBEA (China-United States Biochemistry and Molecular Biology Examination and Administration) Program Scholarship | Ministry of Education | China 1985

Recent Journal Articles

Showing the 5 most recent journal articles. 82 available »

2014 Nov
Luo X, Huang L, Han L, Luo Z, Hu F, Tieu R, Gan L. "Systematic prioritization and integrative analysis of copy number variations in schizophrenia reveal key schizophrenia susceptibility genes." Schizophrenia bulletin. 2014 Nov; 40(6):1285-99. Epub 2014 Mar 24.
2014 Sep 1
Balasubramanian R, Gan L. "Development of Retinal Amacrine Cells and Their Dendritic Stratification." Current ophthalmology reports. 2014 Sep 1; 2(3):100-106.
2014 Sep
Balasubramanian R, Bui A, Xie X, Deng M, Gan L. "Generation and characterization of Lhx9-GFPCreER(T2) knock-in mouse line." Genesis : the journal of genetics and development. 2014 Sep; 52(9):827-32. Epub 2014 Aug 12.
2014 May
Deng M, Yang H, Xie X, Liang G, Gan L. "Comparative expression analysis of POU4F1, POU4F2 and ISL1 in developing mouse cochleovestibular ganglion neurons." Gene expression patterns : GEP. 2014 May; 15(1):31-7. Epub 2014 Apr 04.
2014 Apr
Li M, Luo XJ, Rietschel M, Lewis CM, Mattheisen M, Müller-Myhsok B, Jamain S, Leboyer M, Landén M, Thompson PM, Cichon S, Nöthen MM, Schulze TG, Sullivan PF, Bergen SE, Donohoe G, Morris DW, Hargreaves A, Gill M, Corvin A, Hultman C, Toga AW, Shi L, Lin Q, Shi H, Gan L, Meyer-Lindenberg A, Czamara D, Henry C, Etain B, Bis JC, Ikram MA, Fornage M, Debette S, Launer LJ, Seshadri S, Erk S, Walter H, Heinz A, Bellivier F, Stein JL, Medland SE, Arias Vasquez A, Hibar DP, Franke B, Martin NG, Wright MJ, , Strohmaier J, Breuer R, Meier S, Mühleisen TW, Degenhardt FA, Hoffmann P, Herms S, Schwarz M, Vedder H, Kammerer-Ciernioch J, Reif A, Sasse J, Bauer M, Zwick S, Hautzinger M, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Martin NG, Czerski PM, Hauser J, Schumacher J, Maier W, Propping P, , Backlund L, Frisén L, Lavebratt C, Schalling M, Osby U, , , , Su B. "Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility." Molecular psychiatry. 2014 Apr; 19(4):452-61. Epub 2013 Apr 09.

Current Appointments

Dean's Professorship - Department of Ophthalmology (SMD)
Professor - Department of Ophthalmology (SMD) - Primary
Professor - Center for Visual Science A&S (RC)
Professor - Department of Neurobiology and Anatomy (SMD)


PhD | Biochemistry, All Other | U Tex-Houstn Grad Sch Biomd Sc1992
BS | Biochemistry, All Other | China - Non-Medical School1985

Post-Doctoral Training & Residency

Postdoctoral Fellow (with William Klein, Ph.D.), Dept. of Biochemistry and Molecular Biology, Univ. of Texas M.D. Anderson Cancer Center 1994