Berislav V. Zlokovic, M.D., Ph.D.

Berislav V. Zlokovic, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 670
Rochester, NY 14642

Office: (585) 273-3131
Fax: (585) 273-3133
Administrative: (585) 276-4171

Research Bio

PRINCIPAL RESEARCH INTERESTS



• Alzheimer's Disease and Neurodegenerative Disorders
• Brain Ischemia and Stroke
• Activated Protein C System in Brain
• Blood-Brain Barrier

HONORS AND AWARDS

• British Council Award for Medical Research 1988
• James Zumberg Innovation Award, University of So. California 1991
• Shannon Carreer Development Award, NIH 1991
• Herbert Jr Hoover Award for Medical Research, Los Angeles 1993
• Serbian National Academy of Sciences & Arts, Foreign Member 1997
• MERIT Award from the National Institute on Aging "in recognition of sustained contribution to aging and leadership and commitment to the field" 2004
• Dean's Professor – Distinguished Faculty University of Rochester 2005
• ISOA/Elan Award for "novel approaches to drug discovery for Alzheimer's disease" 2006
• MetLife Award for Medical Research for "significant contributions to our understanding of Alzheimer's disease and for brining us closer to a cure" 2006
• Javits Award National Institute on Neurological Disorders and Stroke for "distinguished record of substantial contributions in a field of neurological sciences" 2007
• Potamkin Prize from the American Academy of Neurology "in recognition of outstanding achievements in research on Alzheimer's and related neurodegenerative diseases" 2009
• McCune Award from the Alzheimer's Association Dallas Texas "which is given to a researcher who has made a difference in Alzheimer's disease" 2009
• Presidential Citation (University of Rochester) for "pioneering approach to Alzheimer's disease" 2009

NATIONAL LEADERSHIP POSITIONS, SOCIETIES AND BOARDS

• NIH Neuroscience Study Section NLS3/BDCN3, regular member 1995- 2000
• Chair NIH Study Section: Brain Disorders BDCN-3 2003
• Chair NIH Study Section: Cell Death and Injury in Chronic Neurodegeneration 2004-2005
• Chair NIH Study Section: Brain Injury and Neurovascular Pathologies 2005-2007
• NIH Distingusihed Neuroscience Editor for Challenging Grants 2009
• Editorial Board: Neurosurgery 1996-present
• Editorial Board: Neurobiology of Aging 2000-2005
• Ediotorial Board: Molecular Neurodegeneration, Associate Editor 2005-present
• Editor, Advanced Drug Delivery Reviews 2002
• Chair Keystone Meeting "Neuronal & Vascular Injury in Alzheimer's Disease" 2001
• Member, Society for Neurosciences (SFN) 1989- present
Chair SFN 2009 Symposium "The role of blood-brain barrier and non-neuronal cells in neurodegeneration"

PRINCIPAL PERVIOUS EMPLOYMENT

• Professor and Chief Division of Neurovascular Biology, Center for Aging and Developmental Biology, URMC, New York 2000-2004
• Professor of Neurological Surgery, Physiology & Biophysics, University of Southern California (USC) School of Medicine, Los Angeles, California (CA)1992-2000
• Associate Professor of Neurological Surgery, Physiology and Biophysics, USC School of Medicine, Los Anegles, CA 1989-1991
• Director, Laboratory for Neurological Surgery, USC School of Medicine, Los Angeles, CA 1989-2000

CURRENT BIOTECHNOLOGY POSITIONS

• Scientific Director and Founder, Socratech L.L.C. (biotechnology company), 2000-present
• Scientific Director and Founder, ZZ Biotech L.L.C., 2007-present
Scientific Director and Founder, ZZ Alztech L.L.C., 2008-present

HOBBIES/SPARE TIME

In his spare time, Zlokovic (Betza) enjoys swimming, tennis, reading and making breakfasts. He is trained as an opera bel canto singer (tenor) and continues to sing from a repertoire of opera classics; and loves relaxing with his wife Zora, an internationally acclaimed concert pianist, and daughter Anna.

Awards & Honors (National)

Potamkin Prize for Research in Pick's, Alzheimer's and Related Diseases | American Academy of neurology | St Paul, MN 2009
The Javits Investigator Award | National Institute of Neurological Disorders and Stroke | Washington, DC 2007
MetLife Award for Medical Research (Alzheimer's Disease) | MetLife 2006
ELAN Award | Institute for the Study of Aging and Elan Pharmaceuticals 2006
Shannon Award | National Institutes of Health 1991

Awards & Honors (Local)

British Council Award for Medicine 1988
Serbian Medical Society National Award - Best Graduated M.D. in the country 1975

Patents

Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System

United States Serial NO.: 10/537,545
Filed Date: December 5, 2003
Title: Neuroprotective Activity of Activated Protein C is Independent of Its Anticoagulant Activity
Invented by: Berislav Zlokovic, John Griffin
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System

United States Serial NO.: DK03790377.0
Filed Date: December 5, 2003
Title: Neuroprotective Activity of Activated Protein C is Independent of Its Anticoagulant Activity
Invented by: Berislav Zlokovic, John Griffin
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System

United States Serial NO.: FR03790377.0
Filed Date: December 5, 2003
Title: Neuroprotective Activity of Activated Protein C is Independent of Its Anticoagulant Activity
Invented by: Berislav Zlokovic, John Griffin
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System

United States Serial NO.: DE03790377.0
Filed Date: December 5, 2003
Title: Neuroprotective Activity of Activated Protein C is Independent of Its Anticoagulant Activity
Invented by: Berislav Zlokovic, John Griffin
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System

United States Serial NO.: IT03790377.0
Filed Date: December 5, 2003
Title: Neuroprotective Activity of Activated Protein C is Independent of Its Anticoagulant Activity
Invented by: Berislav Zlokovic, John Griffin
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System

United States Serial NO.: NL03790377.0
Filed Date: December 5, 2003
Title: Neuroprotective Activity of Activated Protein C is Independent of Its Anticoagulant Activity
Invented by: Berislav Zlokovic, John Griffin
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System

United States Serial NO.: ES03790377.0
Filed Date: December 5, 2003
Title: Neuroprotective Activity of Activated Protein C is Independent of Its Anticoagulant Activity
Invented by: Berislav Zlokovic, John Griffin
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System

United States Serial NO.: SE03790377.0
Filed Date: December 5, 2003
Title: Neuroprotective Activity of Activated Protein C is Independent of Its Anticoagulant Activity
Invented by: Berislav Zlokovic, John Griffin
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System

United States Serial NO.: GB03790377.0
Filed Date: December 5, 2003
Title: Neuroprotective Activity of Activated Protein C is Independent of Its Anticoagulant Activity
Invented by: Berislav Zlokovic, John Griffin
Neuroprotective Anti-Thrombotic and Anti-Inflammatory Activities of Protein S and Use for Cerebral Vascular Ischemia

United States Serial NO.: 10/529,748
Filed Date: September 30, 2003
Title: Protein S Protects the Nervous System From Injury
Invented by: Berislav Zlokovic, John Griffin
Small Molecules which Disrupt RAGE/ Amyloid-Beta Peptide Interaction

United States Serial NO.: 12/223,276
Filed Date: January 26, 2007
Title: Inhibiting Amyloid-Beta Peptide/RAGE Interaction at the Blood-Brain Barrier
Invented by: Berislav Zlokovic, Rashid Deane, Benjamin Miller

Recent Journal Articles

Showing the 5 most recent journal articles. 164 available »

2010 Sep
Vates GE, Takano T, Zlokovic B, Nedergaard M. "Pericyte constriction after stroke: the jury is still out." Nature medicine.. 2010 Sep; 16(9):959; author reply 960.
2010 Mar 4
Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. "Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice." Brain research.. 2010 Mar 4; 1317:218-26. Epub 2010 Jan 04.
2010 Jan
Petraglia AL, Marky AH, Walker C, Thiyagarajan M, Zlokovic BV. "Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact." Neurosurgery.. 2010 Jan; 66(1):165-71; discussion 171-2.
2009 Nov
Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. "Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells." The Journal of clinical investigation.. 2009 Nov; 119(11):3437-49. Epub 2009 Oct 19.
2009 Jul
Bell RD, Zlokovic BV. "Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease." Acta neuropathologica.. 2009 Jul; 118(1):103-13. Epub 2009 Mar 25.

Education

Ph.D. | Membrane Transport | University of Belgrade1983
Transport Biology | Queen Elizabeth College1982
MS | Endocrinology | University of Belgrade, School of Medicine1978
MD | Medicine | University of Belgrade, School of Medicine1975
BS | Applied Science | University of Belgrade, School of Medicine1970

Post-Doctoral Training & Residency

Resident in Clinical Physiology (Neurology and Intensive Care), School of Medicine, University of Belgrade 1989
Post-Doctoral Fellow; Neurobiology; St. Thomas' Hospital; London, England 1986
Post-Doctoral Fellow; Neurobiology; King's College; London, England 1984
Res. Fellow in Transport Biology, Queen Elizabeth College, London 1981