Jacqueline Abranches, Ph.D.

Jacqueline Abranches, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester, NY 14642

Office: (585) 273-1425
Lab: (585) 275-1433
Fax: (585) 276-0190

Research Bio

Dissemination of oral bacteria into the bloodstream has been associated with eating, oral hygiene and dental procedures; including tooth extraction, endodontic treatment, and periodontal surgery. Recently, studies identified Streptococcus mutans, the primary etiological agent of dental caries, as the most prevalent bacterial species found in clinical samples from patients who underwent heart valve and atheromatous plaque surgery. My research focuses on dissecting, at the molecular level, the interactions between S. mutans and Human Coronary Endothelial Cells.



Another field of interest is to understand the stress tolerance mechanisms employed by S. mutans to cope with the constant changes in pH, and nutrient composition and availability in the oral cavity.

Awards & Honors (Local)

Teacher of the year | Federal University of Rio de Janeiro, Brazil. 1999
Doctoral Program fellowship, Assistance Council for Post-Graduate Studies | (CAPES- Brazil). 1995 - 2000
Master's Program Fellowship, Assistance Council for Post-Graduate Studies | (CAPES- Brazil). 1993 - 1995
1990-1993 Undergraduate Research Fellowship Program, National Council of Research | (CNPq - Brazil) 1990 - Present

Recent Journal Articles

Showing the 5 most recent journal articles. 46 available »

2014 Aug 1
Avilés-Reyes A, Miller JH, Simpson-Haidaris PJ, Hagen FK, Abranches J, Lemos JA. "Modification of Streptococcus mutans Cnm by PgfS Contributes to Adhesion, Endothelial Cell Invasion, and Virulence." Journal of bacteriology.. 2014 Aug 1; 196(15):2789-97. Epub 2014 May 16.
2014 Feb
Avilés-Reyes A, Miller JH, Simpson-Haidaris PJ, Lemos JA, Abranches J. "Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus." Molecular oral microbiology. 2014 Feb; 29(1):11-23. Epub 2013 Oct 30.
2013 Mar
Bitoun JP, Liao S, McKey BA, Yao X, Fan Y, Abranches J, Beatty WL, Wen ZT. "Psr is involved in regulation of glucan production, and double deficiency of BrpA and Psr is lethal in Streptococcus mutans." Microbiology.. 2013 Mar; 159(Pt 3):493-506. Epub 2013 Jan 03.
2013 Mar
Lemos JA, Quivey RG, Koo H, Abranches J. "Streptococcus mutans: a new Gram-positive paradigm?" Microbiology.. 2013 Mar; 159(Pt 3):436-45. Epub 2013 Feb 07.
2013
Palmer SR, Miller JH, Abranches J, Zeng L, Lefebure T, Richards VP, Lemos JA, Stanhope MJ, Burne RA. "Phenotypic heterogeneity of genomically-diverse isolates of Streptococcus mutans." PloS one. 2013 8(4):e61358. Epub 2013 Apr 16.

Current Appointments

Assistant Professor - Department of Microbiology and Immunology, Center for Oral Biology (SMD) - Primary

Education

PhD | Microbiology (emphasis in Environmental Microbiology) | Brazil-Federal U, Rio de Janeiro2000
MS | Microbiology (emphasis in Environmental Microbiology) | Brazil-Federal U, Rio de Janeiro1995
BS | Biology | Brazil-Federal U, Rio de Janeiro1990

Post-Doctoral Training & Residency

Postdoctoral Associate, Department of Oral Biology, University of Florida, Gainesville, FL Research Advisor: Dr. Robert A. Burne 2004
Postdoctoral Fellow, Dept. Microbiology and Immunology, University of Rochester, Rochester, NY. Research Advisor: Dr. Robert E. Marquis 2001