Jacqueline Abranches, Ph.D.

Jacqueline Abranches, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester, NY 14642

Office: (585) 273-1425
Lab: (585) 275-1433
Fax: (585) 276-0190

Research Bio

Dissemination of oral bacteria into the bloodstream has been associated with eating, oral hygiene and dental procedures; including tooth extraction, endodontic treatment, and periodontal surgery. Recently, studies identified Streptococcus mutans, the primary etiological agent of dental caries, as the most prevalent bacterial species found in clinical samples from patients who underwent heart valve and atheromatous plaque surgery. My research focuses on dissecting, at the molecular level, the interactions between S. mutans and Human Coronary Endothelial Cells.

Another field of interest is to understand the stress tolerance mechanisms employed by S. mutans to cope with the constant changes in pH, and nutrient composition and availability in the oral cavity.

Awards & Honors (Local)

Teacher of the year | Federal University of Rio de Janeiro, Brazil. 1999
Doctoral Program fellowship, Assistance Council for Post-Graduate Studies | (CAPES- Brazil). 1995 - 2000
Master's Program Fellowship, Assistance Council for Post-Graduate Studies | (CAPES- Brazil). 1993 - 1995
1990-1993 Undergraduate Research Fellowship Program, National Council of Research | (CNPq - Brazil) 1990 - Present

Recent Journal Articles

Showing the 5 most recent journal articles. 50 available »

2015 Jul 1
Kajfasz JK, Rivera-Ramos I, Scott-Anne K, Gregoire S, Abranches J, Lemos JA. "Transcription of Oxidative Stress Genes Is Directly Activated by SpxA1 and, to a Lesser Extent, by SpxA2 in Streptococcus mutans." Journal of bacteriology. 2015 Jul 1; 197(13):2160-70. Epub 2015 Apr 20.
2015 Jun 4
Baker JL, Abranches J, Faustoferri RC, Hubbard CJ, Lemos JA, Courtney MA, Quivey R. "Transcriptional profile of glucose-shocked and acid-adapted strains of Streptococcus mutans." Molecular oral microbiology. 2015 Jun 4; Epub 2015 Jun 04.
2015 May
Miller JH, Avilés-Reyes A, Scott-Anne K, Gregoire S, Watson GE, Sampson E, Progulske-Fox A, Koo H, Bowen WH, Lemos JA, Abranches J. "The collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175." Infection and immunity. 2015 May; 83(5):2001-10. Epub 2015 Mar 02.
Galvão LC, Miller JH, Kajfasz JK, Scott-Anne K, Freires IA, Franco GC, Abranches J, Rosalen PL, Lemos JA. "Transcriptional and Phenotypic Characterization of Novel Spx-Regulated Genes in Streptococcus mutans." PloS one. 2015 10(4):e0124969. Epub 2015 Apr 23.
2014 Aug
Avilés-Reyes A, Miller JH, Simpson-Haidaris PJ, Hagen FK, Abranches J, Lemos JA. "Modification of Streptococcus mutans Cnm by PgfS contributes to adhesion, endothelial cell invasion, and virulence." Journal of bacteriology. 2014 Aug; 196(15):2789-97. Epub 2014 May 16.

Current Appointments

Assistant Professor - Department of Microbiology and Immunology, Center for Oral Biology (SMD) - Primary


PhD | Microbiology (emphasis in Environmental Microbiology) | Brazil-Federal U, Rio de Janeiro2000
MS | Microbiology (emphasis in Environmental Microbiology) | Brazil-Federal U, Rio de Janeiro1995
BS | Biology | Brazil-Federal U, Rio de Janeiro1990

Post-Doctoral Training & Residency

Postdoctoral Associate, Department of Oral Biology, University of Florida, Gainesville, FL Research Advisor: Dr. Robert A. Burne 2004
Postdoctoral Fellow, Dept. Microbiology and Immunology, University of Rochester, Rochester, NY. Research Advisor: Dr. Robert E. Marquis 2001