Deborah J. Fowell, Ph.D.

Deborah J. Fowell, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 609
Rochester, NY 14642

Office: (585) 273-3680
Lab: (585) 273-2902
Administrative: (585) 273-1400
Fax: (585) 273-2452

Journal Articles

Showing all 51 journal articles available.

2014 Feb 3
Shi G, Field DJ, Ko KA, Ture S, Srivastava K, Levy S, Kowalska MA, Poncz M, Fowell DJ, Morrell CN. "Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection." The Journal of clinical investigation. 2014 Feb 3; 124(2):543-52. Epub 2014 Jan 27.
2013 Sep
Overstreet MG, Gaylo A, Angermann BR, Hughson A, Hyun YM, Lambert K, Acharya M, Billroth-Maclurg AC, Rosenberg AF, Topham DJ, Yagita H, Kim M, Lacy-Hulbert A, Meier-Schellersheim M, Fowell DJ. "Inflammation-induced interstitial migration of effector CD4? T cells is dependent on integrin ?V." Nature immunology. 2013 Sep; 14(9):949-58. Epub 2013 Aug 11.
2013 Aug
Batchu SN, Hughson A, Gerloff J, Fowell DJ, Korshunov VA. "Role of Axl in early kidney inflammation and progression of salt-dependent hypertension." Hypertension. 2013 Aug; 62(2):302-9. Epub 2013 Jun 17.
2013
Lazarski CA, Ford J, Katzman SD, Rosenberg AF, Fowell DJ. "IL-4 attenuates Th1-associated chemokine expression and Th1 trafficking to inflamed tissues and limits pathogen clearance." PloS one. 2013 8(8):e71949. Epub 2013 Aug 26.
2012 Jul 2
Hyun YM, Sumagin R, Sarangi PP, Lomakina E, Overstreet MG, Baker CM, Fowell DJ, Waugh RE, Sarelius IH, Kim M. "Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels." The Journal of experimental medicine. 2012 Jul 2; 209(7):1349-62. Epub 2012 Jun 18.
2012 Feb 1
Huang YH, Sojka DK, Fowell DJ. "Cutting edge: Regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NF-?B nuclear accumulation in CD4 T cells." The Journal of immunology : official journal of the American Association of Immunologists. 2012 Feb 1; 188(3):947-51. Epub 2012 Jan 06.
2012
Mock DJ, Hollenbaugh JA, Daddacha W, Overstreet MG, Lazarski CA, Fowell DJ, Kim B. "Leishmania induces survival, proliferation and elevated cellular dNTP levels in human monocytes promoting acceleration of HIV co-infection." PLoS pathogens. 2012 8(4):e1002635. Epub 2012 Apr 05.
2011 Nov 8
Sojka DK, Fowell DJ. "Regulatory T cells inhibit acute IFN-? synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10." Proceedings of the National Academy of Sciences of the United States of America. 2011 Nov 8; 108(45):18336-41. Epub 2011 Oct 24.
2011 Oct 4
Singleton KL, Gosh M, Dandekar RD, Au-Yeung BB, Ksionda O, Tybulewicz VL, Altman A, Fowell DJ, Wülfing C. "Itk controls the spatiotemporal organization of T cell activation." Science signaling. 2011 Oct 4; 4(193):ra66.
2011 Aug
Hughson A, Bromberg I, Johnson B, Quataert S, Jospe N, Fowell DJ. "Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes." Diabetes. 2011 Aug; 60(8):2125-33. Epub 2011 Jun 29.
2010 Apr 29
Morales-Tirado V, Sojka DK, Katzman SD, Lazarski CA, Finkelman FD, Urban JF, Fowell DJ. "Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function." Blood. 2010 Apr 29; 115(17):3498-507. Epub 2009 Dec 23.
2010
Sahu N, Morales JL, Fowell D, August A. "Modeling susceptibility versus resistance in allergic airway disease reveals regulation by Tec kinase Itk." PloS one. 2010 5(6):e11348. Epub 2010 Jun 28.
2009 Jun
Sojka DK, Hughson A, Fowell DJ. "CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation." European journal of immunology. 2009 Jun; 39(6):1544-51.
2009 Apr
Fowell DJ. "Signals for the execution of Th2 effector function." Cytokine. 2009 Apr; 46(1):1-6. Epub 2009 Feb 23.
2009
Sojka DK, Lazarski CA, Huang YH, Bromberg I, Hughson A, Fowell DJ. "Regulation of immunity at tissue sites of inflammation." Immunologic research. 2009 45(2-3):239-50. Epub 2009 Jan 31.
2008 Oct 17
Lazarski CA, Hughson A, Sojka DK, Fowell DJ. "Regulating Treg cells at sites of inflammation." Immunity. 2008 Oct 17; 29(4):511; author reply 512.
2008 May
Sojka DK, Huang YH, Fowell DJ. "Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target." Immunology. 2008 May; 124(1):13-22. Epub 2008 Mar 14.
2008 Feb
Katzman SD, Fowell DJ. "Pathogen-imposed skewing of mouse chemokine and cytokine expression at the infected tissue site." The Journal of clinical investigation. 2008 Feb; 118(2):801-11.
2007 Jul 1
Au-Yeung BB, Fowell DJ. "A key role for Itk in both IFN gamma and IL-4 production by NKT cells." The Journal of immunology : official journal of the American Association of Immunologists. 2007 Jul 1; 179(1):111-9.
2007
Zhao X, Zheng B, Huang Y, Yang D, Katzman S, Chang C, Fowell D, Zeng WP. "Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses." The Journal of immunology : official journal of the American Association of Immunologists. 2007 179(12):8297-304.
2006 Nov 15
Kobie JJ, Shah PR, Yang L, Rebhahn JA, Fowell DJ, Mosmann TR. "T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine." The Journal of immunology : official journal of the American Association of Immunologists. 2006 Nov 15; 177(10):6780-6.
2006 Nov 15
Sukiennicki TL, Fowell DJ. "Distinct molecular program imposed on CD4+ T cell targets by CD4+CD25+ regulatory T cells." The Journal of immunology : official journal of the American Association of Immunologists. 2006 Nov 15; 177(10):6952-61.
2006 Apr 1
Au-Yeung BB, Katzman SD, Fowell DJ. "Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function." The Journal of immunology : official journal of the American Association of Immunologists. 2006 Apr 1; 176(7):3895-9.
2005
Sojka DK, Hughson A, Sukiennicki TL, Fowell DJ. "Early kinetic window of target T cell susceptibility to CD25+ regulatory T cell activity." The Journal of immunology : official journal of the American Association of Immunologists. 2005 175(11):7274-80.
2004 Jul 15
Morales-Tirado V, Johannson S, Hanson E, Howell A, Zhang J, Siminovitch KA, Fowell DJ. "Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells." The Journal of immunology : official journal of the American Association of Immunologists. 2004 Jul 15; 173(2):726-30.
2000 Jul 15
Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA. "Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells." The Journal of immunology : official journal of the American Association of Immunologists. 2000 Jul 15; 165(2):915-24.
1999 Nov
Heath VL, Hutchings P, Fowell DJ, Cooke A, Mason DW. "Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: evidence against a common environmental cross-reactivity in the pathogenicity of type 1 diabetes." Diabetes. 1999 Nov; 48(11):2157-65.
1999 Oct
Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, Locksley RM. "Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells." Immunity. 1999 Oct; 11(4):399-409.
1999 Jun
Fowell DJ, Locksley RM. "Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases." BioEssays : news and reviews in molecular, cellular and developmental biology. 1999 Jun; 21(6):510-8.
1999 Apr 5
Pingel S, Launois P, Fowell DJ, Turck CW, Southwood S, Sette A, Glaichenhaus N, Louis JA, Locksley RM. "Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope." The Journal of experimental medicine. 1999 Apr 5; 189(7):1111-20.
1999 Mar
Locksley RM, Pingel S, Lacy D, Wakil AE, Bix M, Fowell DJ. "Susceptibility to infectious diseases: Leishmania as a paradigm." The Journal of infectious diseases. 1999 Mar; 179 Suppl 2:S305-8.
1999
Pippig SD, Peña-Rossi C, Long J, Godfrey WR, Fowell DJ, Reiner SL, Birkeland ML, Locksley RM, Barclay AN, Killeen N. "Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)." The Journal of immunology : official journal of the American Association of Immunologists. 1999 163(12):6520-9.
1998 Nov 2
Wakil AE, Wang ZE, Ryan JC, Fowell DJ, Locksley RM. "Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development." The Journal of experimental medicine. 1998 Nov 2; 188(9):1651-6.
1998 Sep
Fowell DJ, Bix M, Shinkai K, Lacy D, Locksley RM. "Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model." European cytokine network. 1998 Sep; 9(3 Suppl):102-6.
1998 Jan 15
Reiner SL, Fowell DJ, Moskowitz NH, Swier K, Brown DR, Brown CR, Turck CW, Scott PA, Killeen N, Locksley RM. "Control of Leishmania major by a monoclonal alpha beta T cell repertoire." The Journal of immunology : official journal of the American Association of Immunologists. 1998 Jan 15; 160(2):884-9.
1998
Locksley RM, Fowell DJ, Shinkai K, Wakil AE, Lacy D, Bix M. "Development of CD4+ effector T cells and susceptibility to infectious diseases." Advances in experimental medicine and biology. 1998 452:45-52.
1997 Jun 16
Hagenbaugh A, Sharma S, Dubinett SM, Wei SH, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M. "Altered immune responses in interleukin 10 transgenic mice." The Journal of experimental medicine. 1997 Jun 16; 185(12):2101-10.
1997 May
Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM. "Impaired Th2 subset development in the absence of CD4." Immunity. 1997 May; 6(5):559-69.
1996 Oct 1
Brown DR, Fowell DJ, Corry DB, Wynn TA, Moskowitz NH, Cheever AW, Locksley RM, Reiner SL. "Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses." The Journal of experimental medicine. 1996 Oct 1; 184(4):1295-304.
1996 Apr 1
Ramírez F, Fowell DJ, Puklavec M, Simmonds S, Mason D. "Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro." The Journal of immunology : official journal of the American Association of Immunologists. 1996 Apr 1; 156(7):2406-12.
1996 Apr
Heath VL, Saoudi A, Seddon BP, Moore NC, Fowell DJ, Mason DW. "The role of the thymus in the control of autoimmunity." Journal of autoimmunity. 1996 Apr; 9(2):241-6.
1996 Feb
Saoudi A, Seddon B, Heath V, Fowell D, Mason D. "The physiological role of regulatory T cells in the prevention of autoimmunity: the function of the thymus in the generation of the regulatory T cell subset." Immunological reviews. 1996 Feb; 149:195-216.
1996
Saoudi A, Seddon B, Fowell D, Mason D. "The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients." The Journal of experimental medicine. 1996 184(6):2393-8.
1995
Locksley RM, Wakil AE, Corry DB, Pingel S, Bix M, Fowell DJ. "The development of effector T cell subsets in murine Leishmania major infection." Ciba Foundation symposium. 1995 195:110-7; discussion 117-22.
1995
Fowell D, Powrie F, Saoudi A, Seddon B, Heath V, Mason D. "The role of subsets of CD4+ T cells in autoimmunity." Ciba Foundation symposium. 1995 195:173-82; discussion 182-8.
1995
Fowell DJ, Wakil AE, Locksley RM. "Interleukin-12 in murine leishmaniasis--match, flame or fuel?" Research in immunology. 1995 146(7-8):566-75.
1994
Cyster JG, Fowell D, Barclay AN. "Antigenic determinants encoded by alternatively spliced exons of CD45 are determined by the polypeptide but influenced by glycosylation." International immunology. 1994 6(12):1875-81.
1993 Mar 1
Fowell D, Mason D. "Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential." The Journal of experimental medicine. 1993 Mar 1; 177(3):627-36.
1992
Mason D, Fowell D. "T-cell subsets in autoimmunity." Current opinion in immunology. 1992 4(6):728-32.
1991 Oct
Fowell D, McKnight AJ, Powrie F, Dyke R, Mason D. "Subsets of CD4+ T cells and their roles in the induction and prevention of autoimmunity." Immunological reviews. 1991 Oct; 123:37-64.
1991 Jan
Powrie F, Fowell D, McKnight AJ, Mason D. "Lineage relationships and functions of CD4+ T-cell subsets in the rat." Research in immunology. 1991 Jan; 142(1):54-8.

Books

2001
Mosmann, T. & Fowell, DJ. "The Th1/Th2 Paradigm in infections". Immunology of Infectious Disease. Kaufmann, Sher & Ahmed. : ASM press, 2001.