Yi-Tao Yu, Ph.D.

Yi-Tao Yu, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 275-1271
Fax: (585) 275-6007

Research Bio

Our long-range goal is to elucidate the underlying biological principles and functional roles of posttranscriptional RNA modifications. Currently, we are particularly interested in 2'-O-methylation and pseudouridylation in three different types of RNA, including the spliceosomal snRNA involved in pre-mRNA splicing, the telomerase RNA required for telomere length maintenance, and the messenger RNA that encodes a chemical "blueprint" for the production of a protein.



Our recent research has demonstrated that all these three types of RNA can be modified in vivo, either naturally or artificially through the RNA-guided RNA modification mechanisms. Importantly, our experimental data indicate that the posttranscriptional nucleotide modifications contribute significantly to RNA functions. We are currently carrying out three projects, aiming to address some of the fundamental questions regarding RNA modifications.

Patents

Targeted Pre-mRNA/mRNA Modification and Gene Regulation

United States Serial NO.: 11/606,995
Filed Date: December 1, 2006
Title: Nonsense Suppression and Genetic Codon Alteration by Targeted Modification
Invented by: Yi-Tao Yu, Xinliang Zhao
Targeted Pre-mRNA/mRNA Modification and Gene Regulation

United States Serial NO.: 14/056,309
Filed Date: October 17, 2013
Title: Targeted Pre-mRNA/mRNA Modification and Gene Silencing
Invented by: Yi-Tao Yu, Xinliang Zhao
RNA Modification to Modulate Telomerase Activity

United States Serial NO.: 13/809,975
Filed Date: July 5, 2011
Title: Targeted 2'-O-Methylation of Telomerase Non-Coding RNA
Invented by: Yi-Tao Yu, Chao Huang

Recent Journal Articles

Showing the 5 most recent journal articles. 54 available »

2014 Nov 26
Adachi H, Yu YT. "Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation." World journal of biological chemistry. 2014 Nov 26; 5(4):398-408.
2014 Oct 31
Jun Lim S, Scott A, Xiong XP, Vahidpour S, Karijolich J, Guo D, Pei S, Yu YT, Zhou R, Li W. "Requirement for CRIF1 in RNA interference and Dicer-2 stability." RNA biology. 2014 Oct 31; :e34381. Epub 2014 Oct 31.
2014 Aug
Karijolich J, Yu YT. "Therapeutic suppression of premature termination codons: mechanisms and clinical considerations (review)." International journal of molecular medicine. 2014 Aug; 34(2):355-62. Epub 2014 Jun 17.
2014
Adachi H, Yu YT. "Purification of radiolabeled RNA products using denaturing gel electrophoresis." Current protocols in molecular biology. 2014 105:Unit 4.20.. Epub 2014 Jan 06.
2013 Aug 1
Fernández IS, Ng CL, Kelley AC, Wu G, Yu YT, Ramakrishnan V. "Unusual base pairing during the decoding of a stop codon by the ribosome." Nature. 2013 Aug 1; 500(7460):107-10. Epub 2013 Jun 30.

Current Appointments

Dean's Professorship - Department of Biochemistry and Biophysics (SMD)
Professor - Department of Biochemistry and Biophysics (SMD) - Primary

Education

PhD | Molecular Biology | Case Western Reserve Univ1994
MS | Neurobiology | Shanghai Institute of Physiology, Chinese Academy of Sciences1988
BS | Chemistry | Fudan University1982