Patient Care Bio
Jane Sottile is an Associate Professor of Medicine in the Aab Cardiovascular Research Institute. My laboratory is interested in understanding how tissues respond to injury, and the mechanisms that regulate the tissue repair process. In broad terms, my laboratory investigates 1) how blood vessels respond to injury, and 2) how abnormal tissue repair leads to fibrosis. One goal of our research is to understand the underlying events associated with vascular diseases, especially the vascular remodeling (the process by which blood vessels enlarge or contract) that occurs during hypertension, atherosclerosis, and following arterial injury.
Our ultimate aim is to understand the response of vascular cells to injury, and to develop therapies based on regulating the activity of certain proteins to restore normal vascular function. Another goal of our research is to better understand the process of fibrosis. Fibrosis is a progressive and often fatal disease that can develop in many organ systems, including the heart, lungs and kidneys. During fibrosis, there is abnormal accumulation of proteins in the tissues, which contributes to impaired organ function. One goal of our research is to better understand the processes that control the development of fibrosis, and to develop reagents to inhibit the progression of fibrosis.