Jane M. Sottile, Ph.D.

Jane M. Sottile, Ph.D.

Contact Information

Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta, NY 14586

Office: (585) 276-9780
Fax: (585) 276-9829
Lab: (585) 276-9832
Administrative: (585) 276-9802

Research Bio

Research Overview



A precise balance between the deposition and degradation of extracellular matrix molecules, including collagen type I and fibronectin, is required for normal tissue function, and is a key component of normal tissue repair. The studies in my lab are focused on understanding the mechanisms that control extracellular matrix remodeling. Our data show that the extracellular matrix protein, fibronectin, plays a key role in controlling the deposition and stability of extracellular matrix proteins, including collagen I. Our data also demonstrate that the polymerization of fibronectin into the extracellular matrix regulates adhesion-dependent cell growth, cell contractility and cell migration. Agents that disrupt fibronectin polymerization trigger enhanced fibronectin and collagen I turnover; these agents also induce turnover of fibronectin in tissues. These data indicate that extracellular matrix turnover is regulated by fibronectin polymerization. Hence, agents that regulate fibronectin polymerization are likely to be crucial in controlling cell proliferation, migration, and extracellular matrix remodeling, all of which are key events that occur during vascular remodeling, wound healing, and fibrosis. We are currently studying the mechanisms by which fibronectin polymerization regulates extracellular matrix remodeling, cell growth, and cell migration using in vitro, ex vivo and in vivo approaches. These studies will provide important insights into factors that contribute to the development of fibrosis, and into mechanisms that could prevent the progression of fibrosis. These studies will also provide important insights into the complex interplay between smooth muscle cells and extracellular matrix, which plays a critical role in the development and progression of vascular disease.

Awards & Honors (National)

Postdoctoral Individual National Research Service Award | NIH 1989

Awards & Honors (Local)

Valedictorian | Marist College | Poughkeepsie, NY 1979

Recent Journal Articles

Showing the 5 most recent journal articles. 6 available »

2014 Jun 16
Altrock E, Sens C, Wuerfel C, Vasel M, Kawelke N, Dooley S, Sottile J, Nakchbandi IA. "Inhibition of Fibronectin Deposition Improves Experimental Liver Fibrosis." Journal of hepatology.. 2014 Jun 16; Epub 2014 Jun 16.
2009 Jul
Chiang HY, Korshunov VA, Serour A, Shi F, Sottile J. "Fibronectin is an important regulator of flow-induced vascular remodeling." Arteriosclerosis, thrombosis, and vascular biology.. 2009 Jul; 29(7):1074-9. Epub 2009 Apr 30.
2008 Jul 15
Shi F, Sottile J. "Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover." Journal of cell science.. 2008 Jul 15; 121(Pt 14):2360-71. Epub 2008 Jun 24.
2007
Sottile, J.; Shi, F.; Rublyevska, I.; Chiang, H.-Y.; Lust, J.; Chandler, J. "Fibronectin-dependent collagen I deposition modulates the cell response to fibronectin." J. Cell. Physiol. 293:C1934-46. 2007; .
2005 Feb
Sottile J, Chandler J. "Fibronectin matrix turnover occurs through a caveolin-1-dependent process." Molecular biology of the cell.. 2005 Feb; 16(2):757-68. Epub 2004 Nov 24.

Current Appointments

Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD) - Primary

Education

PhD | Arts & Sciences | St Univ at Albany1987
BA | Biology | Marist College1979

Post-Doctoral Training & Residency

Postdoctoral Fellow, Department of Physiological Chemistry, University of Wisconsin, Madison, WI. 1991