Elena P. Bulgac, Ph.D.

Elena P. Bulgac, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 275-6710
Fax: (585) 271-2683

Research Bio

Chromosomes instability of human fungal pathogen Candida albicans. Survival due to specific chromosome rearrangements.



Candida albicans is a unicellular budding fungus that forms part of normal gut or genitalia microflora. In immunocompromized humans, however, C. albicans becomes an important opportunistic pathogen that can cause mortality. C. albicans is unique among other fungal pathogens by having an ability to infect divers sites of human body, including skin, nails, mucosal surfaces, as well as any other tissues or inner organs. In the laboratory, this fungus demonstrates an impressive ability to flourish under extreme pH and temperatures, as well as in other extreme environments. C. albicans possesses an acute ability to counter act the environmental stresses and to mount adequate phenotypic responses.

Recent Journal Articles

Showing the 5 most recent journal articles. 39 available »

2014 Aug
Kravets A, Yang F, Bethlendy G, Sherman F, Rustchenko E. "Adaptation of Candida albicans to growth on sorbose via monosomy of chromosome 5 accompanied by duplication of another chromosome carrying a gene responsible for sorbose utilization." FEMS yeast research.. 2014 Aug; 14(5):708-13. Epub 2014 May 13.
2013 Oct
Yang F, Kravets A, Bethlendy G, Welle S, Rustchenko E. "Chromosome 5 monosomy of Candida albicans controls susceptibility to various toxic agents, including major antifungals." Antimicrobial agents and chemotherapy.. 2013 Oct; 57(10):5026-36. Epub 2013 Jul 29.
2012 Feb
Ahmad A, Kravets A, Rustchenko E. "Transcriptional regulatory circuitries in the human pathogen Candida albicans involving sense--antisense interactions." Genetics.. 2012 Feb; 190(2):537-47. Epub 2011 Nov 30.
2011
Yang F, Yan TH, Rustchenko E, Gao PH, Wang Y, Yan L, Cao YY, Wang QJ, Ji H, Cao YB, Jiang YY. "High-frequency genetic contents variations in clinical Candida albicans isolates." Biological & pharmaceutical bulletin. 2011 34(5):624-31.
2010
Kravets A, Qin H, Ahmad A, Bethlendy G, Gao Q, Rustchenko E. "Widespread occurrence of dosage compensation in Candida albicans." PloS one. 2010 5(6):e10856. Epub 2010 Jun 11.

Current Appointments

Research Associate Professor (Part-Time) - Department of Biochemistry and Biophysics (SMD) - Primary

Education

PhD | Genetics | USSR - Non-Medical School1974
MS | Genetics | USSR - Non-Medical School1971