Research Bio
Chromosomes instability of human fungal pathogen Candida albicans. Survival due to specific chromosome rearrangements.
Candida albicans is a unicellular budding fungus that forms part of normal gut or genitalia microflora. In immunocompromized humans, however, C. albicans becomes an important opportunistic pathogen that can cause mortality. C. albicans is unique among other fungal pathogens by having an ability to infect divers sites of human body, including skin, nails, mucosal surfaces, as well as any other tissues or inner organs. In the laboratory, this fungus demonstrates an impressive ability to flourish under extreme pH and temperatures, as well as in other extreme environments. C. albicans possesses an acute ability to counter act the environmental stresses and to mount adequate phenotypic responses.
2012 Feb
Ahmad A, Kravets A, Rustchenko E. "Transcriptional regulatory circuitries in the human pathogen Candida albicans involving sense--antisense interactions." Genetics. 2012 Feb 0; 190(2):537-47. Epub 2011 Nov 30. |
2011
Yang F, Yan TH, Rustchenko E, Gao PH, Wang Y, Yan L, Cao YY, Wang QJ, Ji H, Cao YB, Jiang YY. "High-frequency genetic contents variations in clinical Candida albicans isolates." Biological & pharmaceutical bulletin. 2011 34(5):624-31. |
2010
Kravets A, Qin H, Ahmad A, Bethlendy G, Gao Q, Rustchenko E. "Widespread occurrence of dosage compensation in Candida albicans." PloS one. 2010 5(6):e10856. Epub 2010 Jun 11. |
2008
Ahmad, A.; Kabir, M. A.; Kravets, A.; Andaluz, E.; Larriba, G.; Rustchenko, E.;. "Chromosome instability and unusual features of some widely used strains of Candida albicans". Yeast. 2008; 25(36): 433-48. |
2007
Rustchenko, E.;. "Specific chromosome alterations of Candida albicans: mechanisms for adaptation to pathogenicity". Evolutionary biology of bacterial and fungal pathogens. Edited by C. Nombela, G. H. Cassel, F. Baquero and J. A. Gutiérrez-Fuentes. ASM Press. 2007; : (in press). |
