Patricia J. Sime, M.D.

Patricia J. Sime, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 692
Rochester, NY 14642

Office: (585) 275-4161
Fax: (585) 273-1171

Journal Articles

Showing all 97 journal articles available.

2015 Aug 21
Croasdell A, Thatcher TH, Kottmann RM, Colas RA, Dalli J, Serhan CN, Sime PJ, Phipps RP. "Resolvins Attenuate Inflammation and Promote Resolution in Cigarette Smoke-Exposed Human Macrophages." American journal of physiology. Lung cellular and molecular physiology. 2015 Aug 21; :ajplung.00125.2015. Epub 2015 Aug 21.
2015 Aug 7
Judge JL, Owens KM, Pollock SJ, Woeller CF, Thatcher TH, Williams JP, Phipps RP, Sime PJ, Kottmann RM. "Ionizing Radiation Induces Myofibroblast Differentiation via Lactate Dehydrogenase." American journal of physiology. Lung cellular and molecular physiology. 2015 Aug 7; :ajplung.00153.2015. Epub 2015 Aug 07.
2015 Jul 2
Jeon KI, Phipps RP, Sime PJ, Huxlin KR. "Inhibitory effects of PPAR? ligands on TGF-?1-induced CTGF expression in cat corneal fibroblasts." Experimental eye research. 2015 Jul 2; 138:52-58. Epub 2015 Jul 02.
2015 Apr 23
Yao H, Sundar IK, Huang Y, Gerloff J, Sellix MT, Sime PJ, Rahman I. "Disruption of SIRT1-mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease." American journal of respiratory cell and molecular biology. 2015 Apr 23; Epub 2015 Apr 23.
2015 Apr
Jones KM, Randtke EA, Howison CM, Cárdenas-Rodríguez J, Sime PJ, Kottmann MR, Pagel MD. "Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI." Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2015 Apr; 17(2):177-84.
Epa AP, Thatcher TH, Pollock SJ, Wahl LA, Lyda E, Kottmann RM, Phipps RP, Sime PJ. "Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-? Induced Myofibroblast Differentiation via Prostaglandin E2." PloS one. 2015 10(8):e0135266. Epub 2015 Aug 06.
2014 Jun 1
Lugade AA, Bogner PN, Thatcher TH, Sime PJ, Phipps RP, Thanavala Y. "Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection." The Journal of immunology : official journal of the American Association of Immunologists. 2014 Jun 1; 192(11):5226-35. Epub 2014 Apr 21.
2014 Jun
Thannickal VJ, Henke CA, Horowitz JC, Noble PW, Roman J, Sime PJ, Zhou Y, Wells RG, White ES, Tschumperlin DJ. "Matrix biology of idiopathic pulmonary fibrosis: a workshop report of the national heart, lung, and blood institute." The American journal of pathology. 2014 Jun; 184(6):1643-51. Epub 2014 Apr 13.
2014 May 1
Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente LP, Rahman I. "SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism." American journal of physiology. Lung cellular and molecular physiology. 2014 May 1; 306(9):L816-28. Epub 2014 Mar 14.
2014 May
Jeon KI, Kulkarni A, Woeller CF, Phipps RP, Sime PJ, Hindman HB, Huxlin KR. "Inhibitory effects of PPAR? ligands on TGF-?1-induced corneal myofibroblast transformation." The American journal of pathology. 2014 May; 184(5):1429-45. Epub 2014 Mar 17.
2014 Jan 15
Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. "Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report." American journal of respiratory and critical care medicine. 2014 Jan 15; 189(2):214-22.
Sundar IK, Yao H, Huang Y, Lyda E, Sime PJ, Sellix MT, Rahman I. "Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis." PloS one. 2014 9(2):e87999. Epub 2014 Feb 10.
2013 Oct 1
Rosas IO, Kottman RM, Sime PJ. "New light is shed on the enigmatic origin of the lung myofibroblast." American journal of respiratory and critical care medicine. 2013 Oct 1; 188(7):765-6.
2013 Jun 1
McMillan DH, Woeller CF, Thatcher TH, Spinelli SL, Maggirwar SB, Sime PJ, Phipps RP. "Attenuation of inflammatory mediator production by the NF-?B member RelB is mediated by microRNA-146a in lung fibroblasts." American journal of physiology. Lung cellular and molecular physiology. 2013 Jun 1; 304(11):L774-81. Epub 2013 Apr 05.
Hsiao HM, Sapinoro RE, Thatcher TH, Croasdell A, Levy EP, Fulton RA, Olsen KC, Pollock SJ, Serhan CN, Phipps RP, Sime PJ. "A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation." PloS one. 2013 8(3):e58258. Epub 2013 Mar 06.
Kulkarni AA, Thatcher TH, Hsiao HM, Olsen KC, Kottmann RM, Morrissette J, Wright TW, Phipps RP, Sime PJ. "The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis." PloS one. 2013 8(5):e63798. Epub 2013 May 31.
Huxlin KR, Hindman HB, Jeon KI, Bühren J, Macrae S, Demagistris M, Ciufo D, Sime PJ, Phipps RP. "Topical rosiglitazone is an effective anti-scarring agent in the cornea." PloS one. 2013 8(8):e70785. Epub 2013 Aug 05.
2012 Nov 15
Ramon S, Bancos S, Thatcher TH, Murant TI, Moshkani S, Sahler JM, Bottaro A, Sime PJ, Phipps RP. "Peroxisome proliferator-activated receptor ? B cell-specific-deficient mice have an impaired antibody response." The Journal of immunology : official journal of the American Association of Immunologists. 2012 Nov 15; 189(10):4740-7. Epub 2012 Oct 05.
2012 Oct 15
Kottmann RM, Kulkarni AA, Smolnycki KA, Lyda E, Dahanayake T, Salibi R, Honnons S, Jones C, Isern NG, Hu JZ, Nathan SD, Grant G, Phipps RP, Sime PJ. "Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-?." American journal of respiratory and critical care medicine. 2012 Oct 15; 186(8):740-51. Epub 2012 Aug 23.
2012 May
Davies ER, Haitchi HM, Thatcher TH, Sime PJ, Kottmann RM, Ganesan A, Packham G, O'Reilly KM, Davies DE. "Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis." American journal of respiratory cell and molecular biology. 2012 May; 46(5):687-94. Epub 2012 Jan 12.
2012 Jan
Kuriyan AE, Lehmann GM, Kulkarni AA, Woeller CF, Feldon SE, Hindman HB, Sime P, Huxlin KR, Phipps RP. "Electrophilic PPAR? ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring." Experimental eye research. 2012 Jan; 94(1):136-45. Epub 2011 Dec 08.
Kulkarni AA, Woeller CF, Thatcher TH, Ramon S, Phipps RP, Sime PJ. "Emerging PPAR?-Independent Role of PPAR? Ligands in Lung Diseases." PPAR research. 2012 2012:705352. Epub 2012 Jun 18.
Reddy RC, Rehan VK, Roman J, Sime PJ. "PPARs: Regulators and Translational Targets in the Lung." PPAR research. 2012 2012:342924. Epub 2012 Nov 04.
2011 Oct
Blumberg N, Sime PJ, Phipps RP. "The mystery of transfusion-related acute lung injury." Transfusion. 2011 Oct; 51(10):2054-7.
2011 Sep 15
Olsen KC, Sapinoro RE, Kottman RM, Kulkarni AA, Iismaa SE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ. "Transglutaminase 2 and its role in pulmonary fibrosis." American journal of respiratory and critical care medicine. 2011 Sep 15; 184(6):699-707. Epub 2011 Jun 23.
2011 Sep
Kottmann RM, Kelly J, Lyda E, Gurell M, Stalica J, Ormsby W, Moon K, Trawick D, Sime PJ. "Bronchoscopy with bronchoalveolar lavage: determinants of yield and impact on management in immunosuppressed patients." Thorax. 2011 Sep; 66(9):823. Epub 2010 Sep 13.
2011 Jul
McMillan DH, Baglole CJ, Thatcher TH, Maggirwar S, Sime PJ, Phipps RP. "Lung-targeted overexpression of the NF-?B member RelB inhibits cigarette smoke-induced inflammation." The American journal of pathology. 2011 Jul; 179(1):125-33. Epub 2011 May 05.
2011 Jun 15
Lin X, Sime PJ, Xu H, Williams MA, Larussa L, Georas SN, Guo J. "Yin yang 1 is a novel regulator of pulmonary fibrosis." American journal of respiratory and critical care medicine. 2011 Jun 15; 183(12):1689-97. Epub 2010 Dec 17.
2011 Jun
Xi X, McMillan DH, Lehmann GM, Sime PJ, Libby RT, Huxlin KR, Feldon SE, Phipps RP. "Ocular fibroblast diversity: implications for inflammation and ocular wound healing." Investigative ophthalmology & visual science. 2011 Jun; 52(7):4859-65. Epub 2011 Jul 01.
Rico de Souza A, Zago M, Pollock SJ, Sime PJ, Phipps RP, Baglole CJ. "Genetic ablation of the aryl hydrocarbon receptor causes cigarette smoke-induced mitochondrial dysfunction and apoptosis." The Journal of biological chemistry. 2011 286(50):43214-28. Epub 2011 Oct 07.
Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, Sime PJ. "PPAR-? ligands repress TGF?-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis." PloS one. 2011 6(1):e15909. Epub 2011 Jan 06.
Hogan CM, Thatcher TH, Sapinoro RE, Gurell MN, Ferguson HE, Pollock SJ, Jones C, Phipps RP, Sime PJ. "Electrophilic PPAR? Ligands Attenuate IL-1? and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPAR?-Independent Mechanism." PPAR research. 2011 2011:318134. Epub 2011 Jun 16.
2010 Nov
Simpson-Haidaris PJ, Seweryniak KE, Spinelli SL, Garcia-Bates TM, Murant TI, Pollock SJ, Sime PJ, Phipps RP. "A putative role for platelet-derived PPAR? in vascular homeostasis demonstrated by anti-PPAR? induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis." Journal of biotechnology. 2010 Nov; 150(3):417-27. Epub 2010 Oct 01.
2010 May 10
Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. "Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells." Virology. 2010 May 10; 400(2):224-32. Epub 2010 Feb 25.
2010 Apr
Hindman HB, Swanton JN, Phipps R, Sime PJ, Huxlin KR. "Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro." Investigative ophthalmology & visual science. 2010 Apr; 51(4):1935-42. Epub 2009 Nov 11.
2010 Feb
Blumberg N, Sime PJ, Phipps RP. "Leukoreduction of blood transfusions--there is such a thing as a free lunch." Critical care medicine. 2010 Feb; 38(2):720-1.
2009 Nov
Ferguson HE, Thatcher TH, Olsen KC, Garcia-Bates TM, Baglole CJ, Kottmann RM, Strong ER, Phipps RP, Sime PJ. "Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism." American journal of physiology. Lung cellular and molecular physiology. 2009 Nov; 297(5):L912-9. Epub 2009 Sep 04.
2009 Sep
Kottmann RM, Hogan CM, Phipps RP, Sime PJ. "Determinants of initiation and progression of idiopathic pulmonary fibrosis." Respirology (Carlton, Vic.). 2009 Sep; 14(7):917-33.
2009 Feb
Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I. "RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke." American journal of respiratory cell and molecular biology. 2009 Feb; 40(2):147-58. Epub 2008 Aug 07.
Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ. "Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts." American journal of respiratory cell and molecular biology. 2009 41(6):722-30. Epub 2009 Mar 13.
2008 Oct 24
Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ. "The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB." The Journal of biological chemistry. 2008 Oct 24; 283(43):28944-57. Epub 2008 Aug 12.
2008 Oct
Baglole CJ, Sime PJ, Phipps RP. "Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione." American journal of physiology. Lung cellular and molecular physiology. 2008 Oct; 295(4):L624-36. Epub 2008 Aug 08.
2008 Sep 2
Gurell MN, Kottmann RM, Xu H, Sime PJ. "Exogenous lipoid pneumonia: an unexpected complication of substance abuse." Annals of internal medicine. 2008 Sep 2; 149(5):364-5.
2008 Sep
Thatcher TH, Benson RP, Phipps RP, Sime PJ. "High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function." American journal of physiology. Lung cellular and molecular physiology. 2008 Sep; 295(3):L412-21. Epub 2008 Jun 20.
2008 Feb
Hart CM, Roman J, Reddy R, Sime PJ. "PPARgamma: a novel molecular target in lung disease." Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2008 Feb; 56(2):515-7.
2008 Feb
Sime PJ. "The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis." Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2008 Feb; 56(2):534-8.
Garcia-Bates TM, Lehmann GM, Simpson-Haidaris PJ, Bernstein SH, Sime PJ, Phipps RP. "Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies." PPAR research. 2008 2008:834612.
Bernard MP, Bancos S, Sime PJ, Phipps RP. "Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise." Current pharmaceutical design. 2008 14(21):2051-60.
Hu JZ, Rommereim DN, Minard KR, Woodstock A, Harrer BJ, Wind RA, Phipps RP, Sime PJ. "Metabolomics in lung inflammation:a high-resolution (1)h NMR study of mice exposedto silica dust." Toxicology mechanisms and methods. 2008 18(5):385-98.
2007 Mar 1
O'Reilly KM, Mclaughlin AM, Beckett WS, Sime PJ. "Asbestos-related lung disease." American family physician. 2007 Mar 1; 75(5):683-8.
2007 Mar
Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ. "Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB." The American journal of pathology. 2007 Mar; 170(3):855-64.
Lakatos HF, Thatcher TH, Kottmann RM, Garcia TM, Phipps RP, Sime PJ. "The Role of PPARs in Lung Fibrosis." PPAR research. 2007 2007:71323.
2006 Aug
Viscardi RM, Atamas SP, Luzina IG, Hasday JD, He JR, Sime PJ, Coalson JJ, Yoder BA. "Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lung." Pediatric research. 2006 Aug; 60(2):141-6.
2006 Jul
Baglole CJ, Bushinsky SM, Garcia TM, Kode A, Rahman I, Sime PJ, Phipps RP. "Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema." American journal of physiology. Lung cellular and molecular physiology. 2006 Jul; 291(1):L19-29. Epub 2006 Jan 27.
2006 May
Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ. "Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation." Experimental lung research. 2006 May; 32(5):181-99.
Baglole CJ, Ray DM, Bernstein SH, Feldon SE, Smith TJ, Sime PJ, Phipps RP. "More than structural cells, fibroblasts create and orchestrate the tumor microenvironment." Immunological investigations. 2006 35(3-4):297-325.
Shah AP, Xu H, Sime PJ, Trawick DR. "Severe airflow obstruction and eosinophilic lung disease after Stevens-Johnson syndrome." The European respiratory journal. 2006 28(6):1276-9.
2005 Sep
Martey CA, Baglole CJ, Gasiewicz TA, Sime PJ, Phipps RP. "The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts." American journal of physiology. Lung cellular and molecular physiology. 2005 Sep; 289(3):L391-9. Epub 2005 Apr 29.
2005 Sep
Thatcher TH, Sime PJ, Barth RK. "Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire." Experimental lung research. 2005 Sep; 31(7):685-700.
2005 Aug
Thatcher TH, McHugh NA, Egan RW, Chapman RW, Hey JA, Turner CK, Redonnet MR, Seweryniak KE, Sime PJ, Phipps RP. "Role of CXCR2 in cigarette smoke-induced lung inflammation." American journal of physiology. Lung cellular and molecular physiology. 2005 Aug; 289(2):L322-8. Epub 2005 Apr 15.
2005 Jul
Vallance BA, Gunawan MI, Hewlett B, Bercik P, Van Kampen C, Galeazzi F, Sime PJ, Gauldie J, Collins SM. "TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis." American journal of physiology. Gastrointestinal and liver physiology. 2005 Jul; 289(1):G116-28. Epub 2005 Mar 18.
2005 Jun
O'Reilly KM, Phipps RP, Thatcher TH, Graf BA, Van Kirk J, Sime PJ. "Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis." American journal of physiology. Lung cellular and molecular physiology. 2005 Jun; 288(6):L1010-6. Epub 2005 Jan 21.
2005 Jun
Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M, Phipps RP, Sime PJ. "PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis." American journal of physiology. Lung cellular and molecular physiology. 2005 Jun; 288(6):L1146-53. Epub 2005 Feb 25.
Baglole CJ, Reddy SY, Pollock SJ, Feldon SE, Sime PJ, Smith TJ, Phipps RP. "Isolation and phenotypic characterization of lung fibroblasts." Methods in molecular medicine. 2005 117:115-27.
2004 Nov
Martey CA, Pollock SJ, Turner CK, O'Reilly KM, Baglole CJ, Phipps RP, Sime PJ. "Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer." American journal of physiology. Lung cellular and molecular physiology. 2004 Nov; 287(5):L981-91. Epub 2004 Jul 02.
2004 Aug
Pociask DA, Sime PJ, Brody AR. "Asbestos-derived reactive oxygen species activate TGF-beta1." Laboratory investigation; a journal of technical methods and pathology. 2004 Aug; 84(8):1013-23.
2004 Aug
Turner CK, Blieden TM, Smith TJ, Feldon SE, Foster DC, Sime PJ, Phipps RP. "A novel ELISpot method for adherent cells." Journal of immunological methods. 2004 Aug; 291(1-2):63-70.
2004 Jun
O'Reilly KM, Boscia JA, Kaplan KL, Sime PJ. "A case of steroid responsive pulmonary hyalinising granuloma: complicated by deep venous thrombosis." The European respiratory journal. 2004 Jun; 23(6):954-6.
2004 Feb 1
Kaufman J, Sime PJ, Phipps RP. "Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis." The Journal of immunology : official journal of the American Association of Immunologists. 2004 Feb 1; 172(3):1862-71.
2002 Aug
Kolb M, Bonniaud P, Galt T, Sime PJ, Kelly MM, Margetts PJ, Gauldie J. "Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains." American journal of respiratory cell and molecular biology. 2002 Aug; 27(2):141-50.
2002 Aug
Warshamana GS, Pociask DA, Fisher KJ, Liu JY, Sime PJ, Brody AR. "Titration of non-replicating adenovirus as a vector for transducing active TGF-beta1 gene expression causing inflammation and fibrogenesis in the lungs of C57BL/6 mice." International journal of experimental pathology. 2002 Aug; 83(4):183-201.
Gauldie J, Kolb M, Sime PJ. "A new direction in the pathogenesis of idiopathic pulmonary fibrosis?" Respiratory research. 2002 3:1. Epub 2001 Sep 26.
2001 Jul
Liu JY, Sime PJ, Wu T, Warshamana GS, Pociask D, Tsai SY, Brody AR. "Transforming growth factor-beta(1) overexpression in tumor necrosis factor-alpha receptor knockout mice induces fibroproliferative lung disease." American journal of respiratory cell and molecular biology. 2001 Jul; 25(1):3-7.
2001 Jun
Kolb M, Margetts PJ, Sime PJ, Gauldie J. "Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung." American journal of physiology. Lung cellular and molecular physiology. 2001 Jun; 280(6):L1327-34.
2001 Jun
Sime PJ, O'Reilly KM. "Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment." Clinical immunology : the official journal of the Clinical Immunology Society. 2001 Jun; 99(3):308-19.
2001 Mar
Kolb M, Margetts PJ, Galt T, Sime PJ, Xing Z, Schmidt M, Gauldie J. "Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin." American journal of respiratory and critical care medicine. 2001 Mar; 163(3 Pt 1):770-7.
1999 Oct
Zhao J, Sime PJ, Bringas P, Tefft JD, Buckley S, Bu D, Gauldie J, Warburton D. "Spatial-specific TGF-beta1 adenoviral expression determines morphogenetic phenotypes in embryonic mouse lung." European journal of cell biology. 1999 Oct; 78(10):715-25.
1999 Aug
Zhao J, Sime PJ, Bringas P, Gauldie J, Warburton D. "Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis." The American journal of physiology. 1999 Aug; 277(2 Pt 1):L412-22.
Lee WC, Wan YH, Li W, Fu F, Sime PJ, Gauldie J, Thomson AW, Fung JJ, Lu L, Qian S. "Enhancement of dendritic cell tolerogenicity by genetic modification using adenoviral vectors encoding cDNA for TGF beta 1." Transplantation proceedings. 1999 31(1-2):1195.
Gauldie J, Sime PJ, Xing Z, Marr B, Tremblay GM. "Transforming growth factor-beta gene transfer to the lung induces myofibroblast presence and pulmonary fibrosis." Current topics in pathology. Ergebnisse der Pathologie. 1999 93:35-45.
1998 Sep
Sime PJ, Marr RA, Gauldie D, Xing Z, Hewlett BR, Graham FL, Gauldie J. "Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts." The American journal of pathology. 1998 Sep; 153(3):825-32.
1998 Mar
Zhao J, Sime PJ, Bringas P, Gauldie J, Warburton D. "Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-beta type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA." Mechanisms of development. 1998 Mar; 72(1-2):89-100.
Stämpfli MR, Ritz SA, Neigh GS, Sime PJ, Lei XF, Xing Z, Croitoru K, Jordana M. "Adenoviral infection inhibits allergic airways inflammation in mice." Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1998 28(12):1581-90.
1997 Aug 15
Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. "Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung." The Journal of clinical investigation. 1997 Aug 15; 100(4):768-76.
1997 Jun
Sime PJ, Xing Z, Foley R, Graham FL, Gauldie J. "Transient gene transfer and expression in the lung." Chest. 1997 Jun; 111(6 Suppl):89S-94S.
1997 Jun
Sime PJ, Sarnstrand B, Xing Z, Graham F, Fisher L, Gauldie J. "Adenovirus-mediated gene transfer of the proteoglycan biglycan induces fibroblastic responses in the lung." Chest. 1997 Jun; 111(6 Suppl):137S.
1997 Jan
Xing Z, Tremblay GM, Sime PJ, Gauldie J. "Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation." The American journal of pathology. 1997 Jan; 150(1):59-66.
1996 Oct 31
Gauldie J, Graham F, Xing Z, Braciak T, Foley R, Sime PJ. "Adenovirus-vector-mediated cytokine gene transfer to lung tissue." Annals of the New York Academy of Sciences. 1996 Oct 31; 796:235-44.
1996 Apr
Xing Z, Braciak T, Ohkawara Y, Sallenave JM, Foley R, Sime PJ, Jordana M, Graham FL, Gauldie J. "Gene transfer for cytokine functional studies in the lung: the multifunctional role of GM-CSF in pulmonary inflammation." Journal of leukocyte biology. 1996 Apr; 59(4):481-8.
1995 Sep
Kingshott RN, Sime PJ, Engleman HM, Douglas NJ. "Self assessment of daytime sleepiness: patient versus partner." Thorax. 1995 Sep; 50(9):994-5.
1994 Sep
Sime PJ, Chilvers ER, Leitch AG. "Miliary tuberculosis in Edinburgh--a comparison between 1984-1992 and 1954-1967." Respiratory medicine. 1994 Sep; 88(8):609-11.
1994 Aug
Rubilar M, Sime PJ, Moudgil H, Chilvers ER, Leitch AG. "Time to extend 'the timetable of tuberculosis'?" Respiratory medicine. 1994 Aug; 88(7):481-2.
1994 Jul
Priestley GC, Aldridge RD, Sime PJ, Wilson D. "Skin fibroblast activity in pretibial myxoedema and the effect of octreotide (Sandostatin) in vitro." The British journal of dermatology. 1994 Jul; 131(1):52-6.
1994 May
Böllert FG, Sime PJ, MacNee W, Crompton GK. "Pulmonary Mycobacterium malmoense and aspergillus infection: a fatal combination?" Thorax. 1994 May; 49(5):521-2.
Jordana M, Särnstrand B, Sime PJ, Ramis I. "Immune-inflammatory functions of fibroblasts." The European respiratory journal. 1994 7(12):2212-22.
1993 Oct
Matusiewicz SP, Williamson IJ, Sime PJ, Brown PH, Wenham PR, Crompton GK, Greening AP. "Plasma lactate dehydrogenase: a marker of disease activity in cryptogenic fibrosing alveolitis and extrinsic allergic alveolitis?" The European respiratory journal. 1993 Oct; 6(9):1282-6.
Sime PJ, Gordon A, Hooper ML, Bell JE. "Differentiation in medulloblastomas and other primitive neuroectodermal tumours." British journal of neurosurgery. 1989 3(1):89-100.