Margot Mayer-Proschel, Ph.D.

Margot Mayer-Proschel, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester, NY 14642

Office: (585) 273-1449
Lab: (585) 273-2407
Administrative: (585) 273-1440
Fax: (585) 273-1450


Noble M., Mayer-Proschel M.. "PreGlial restricted Precursors". Stem cells and CNS development. : Rao M. Humana Press Inc, 2001. 123-151
Mayer-Proschel M.. Isolation and purification of oligodendrocytes. Ron McKay. : John Wiley and Sons, 1998.

Journal Articles

Showing all 49 journal articles available.

2012 Apr 4
Lee DL, Strathmann FG, Gelein R, Walton J, Mayer-Pröschel M. "Iron deficiency disrupts axon maturation of the developing auditory nerve." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2012 Apr 4; 32(14):5010-5.
2011 Apr 20
Tanner DC, Cherry JD, Mayer-Pröschel M. "Oligodendrocyte progenitors reversibly exit the cell cycle and give rise to astrocytes in response to interferon-?." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2011 Apr 20; 31(16):6235-46.
Mihaila C, Schramm J, Strathmann FG, Lee DL, Gelein RM, Luebke AE, Mayer-Pröschel M. "Identifying a window of vulnerability during fetal development in a maternal iron restriction model." PloS one. 2011 6(3):e17483. Epub 2011 Mar 15.
Han R.; Yang Yin M.; Dietrich J.; Luebke A.; Mayer-Proschel M.; Noble, M. "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the CNS". J Biol. 2008; 7(4). Link
Davies JE; Proschel C; Zhang N; Noble M; Mayer-Proschel M; Davies SA. "Transplanted astrocytes derived from BMP or CNTF treated glial restricted precursors have opposite effects on recovery and allodynia after spinal cord injury". J Biol.. 2008; 7(24). Link
Strathmann FG, Wang X, Mayer-Pröschel M. "Identification of two novel glial-restricted cell populations in the embryonic telencephalon arising from unique origins." BMC developmental biology. 2007 7:33. Epub 2007 Apr 17.
Hyrien O.; Ambeskovic I.; Mayer-Proschel M.; Noble M.; Andrei Yakovlev. "Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data". Theoretical Biology and Medical Modelling. 2006; 17: 3-21. Link
Mock, D.; Blumberg B.; Strathmann F.; Mayer-Proschel, M. "Infection of murine oligodendrocyte glial precursor cells with human herpesvirus 6 (HHV-6)- Establishment of a murine in vitro model". J. of Clinical Virology. 2006; 37(Supplement 1): 13-23. Link
Mock DJ; Chugh P; Kim B; Proschel C; Dietrich, J.; Strathmann F; Blumberg BM; Mayer-Proschel M. "Characterization of specific HHV-6 and cell cycle genes implicated in virus-mediated G1/S cell-cycle arrest of glial precursors". Retrovirology. 2006; 21(3 Suppl 1): S65. Link
Davies JE, Huang C, Proschel C, Noble M, Mayer-Proschel M, Davies SJ. "Astrocytes derived from glial-restricted precursors promote spinal cord repair." Journal of biology. 2006 5(3):7. Epub 2006 Apr 27.
Dietrich J, Han R, Yang Y, Mayer-Pröschel M, Noble M. "CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo." Journal of biology. 2006 5(7):22.
2005 Mar
Dietrich J, Lacagnina M, Gass D, Richfield E, Mayer-Pröschel M, Noble M, Torres C, Pröschel C. "EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy." Nature medicine.. 2005 Mar; 11(3):277-83. Epub 2005 Feb 20.
2005 Mar
Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "A stochastic model to analyze clonal data on multi-type cell populations." Biometrics.. 2005 Mar; 61(1):199-207.
2005 Feb
Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture." Mathematical biosciences. 2005 Feb; 193(2):255-74. Epub 2005 Jan 22.
2004 May 19
Dietrich J, Blumberg BM, Roshal M, Baker JV, Hurley SD, Mayer-Pröschel M, Mock DJ. "Infection with an endemic human herpesvirus disrupts critical glial precursor cell properties." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2004 May 19; 24(20):4875-83.
Hill C.E.; Proschel C.; Noble M.; Mayer-Proschel M.; Gensel J.; Beattie M.S.; J. C. Bresnahan. "Acute transplantation of glial restricted precursor cells into spinal cord contusion injuries: survival, differentiation and effects on lesion environment and axonal regeneration". Exp. Neurology. 2004; 190: 289-310. Link
Noble M.; Smith J.; Power J.; M. Mayer-Proschel. "Redox state as a central modulator of precursor cell function". Annals of New York Acad. Sci. 2003; 991: 253-272. Link
Noble M.; Proschel, C.; Mayer-Proschel M. "Getting a GR(i)P on oligodendrocyte development". Dev. Biology. 2003; 265: 33-52. Link
N.J. Maragakis; V. Wong; H. Xue; M.S. Rao; J. Dietrich; M. Mayer-Proschel; J.D. Rothstein. "Glutamate transporter expression and function in human glial progenitors". Glia. 2003; 45: 133-143. Link
Noble M, Arhin A, Gass D, Mayer-Pröschel M. "The cortical ancestry of oligodendrocytes: common principles and novel features." Developmental neuroscience.. 2003 25(2-4):217-33.
2002 Oct
Dietrich J, Noble M, Mayer-Proschel M. "Characterization of A2B5+ glial precursor cells from cryopreserved human fetal brain progenitor cells." Glia.. 2002 Oct; 40(1):65-77.
2002 May 15
Power J, Mayer-Pröschel M, Smith J, Noble M. "Oligodendrocyte precursor cells from different brain regions express divergent properties consistent with the differing time courses of myelination in these regions." Developmental biology. 2002 May 15; 245(2):362-75.
Gregori, N.; Proschel, C.; Noble, M.; Mayer-Proschel,M. "The tripotential glial-restricted precursor cell (GRP) cell and glial development in the spinal cord: Generation of bipotential oligodendrocyte-type-2 astrocyte progenitor cells and dorsal-ventral differences in GRP cell function". J. Neuroscience. 2002; 22: 259-265. Link
Mayer-Proschel, M.; Ying, Liu; Haipeng, Xue; Yuan Yuan, Wu; Carpenter, M.; Rao, M. "Human neural precursor cells- an in vitro characterization". Clinical Neurosci. Res. 2002; 2: 58-69. Link
Morath DJ, Mayer-Pröschel M. "Iron deficiency during embryogenesis and consequences for oligodendrocyte generation in vivo." Developmental neuroscience.. 2002 24(2-3):197-207.
2001 Sep 1
Morath DJ, Mayer-Pröschel M. "Iron modulates the differentiation of a distinct population of glial precursor cells into oligodendrocytes." Developmental biology. 2001 Sep 1; 237(1):232-43.
2001 Sep
Herrera J, Yang H, Zhang SC, Proschel C, Tresco P, Duncan ID, Luskin M, Mayer-Proschel M. "Embryonic-derived glial-restricted precursor cells (GRP cells) can differentiate into astrocytes and oligodendrocytes in vivo." Experimental neurology.. 2001 Sep; 171(1):11-21.
Mayer-Pröschel M, Morath D, Noble M. "Are hypothyroidism and iron deficiency precursor cell diseases?" Developmental neuroscience.. 2001 23(4-5):277-86.
2000 Apr
Lee JC, Mayer-Proschel M, Rao MS. "Gliogenesis in the central nervous system." Glia.. 2000 Apr; 30(2):105-21.
Smith, J.; Ladi, E.; Mayer-Proschel, M.; Noble M. "Redox state is a central modulator of the balance between self-renewal and differentiation in oligodendrocyte-type 2 astrocyte progenitor cells." PNAS. 2000; 18: 10032-10037. Link
Zorin, A.; Mayer-Proschel, M.; Noble, M.; Yakovlelv, A. "Estimation problems associated with stochastic modeling of prolferation and differentiation of O-2A progenitor cells in vitro". Mathematical Bioscience. 2000; 167: 109-121. Link
Kaas JH. "The reorganization of somatosensory and motor cortex after peripheral nerve or spinal cord injury in primates." Progress in brain research. 2000 128:173-9.
1999 Jul
von Collani E, Tsodikov A, Yakovlev A, Mayer-Proschel M, Noble M. "A random walk model of oligodendrocyte generation in vitro and associated estimation problems." Mathematical biosciences. 1999 Jul; 159(2):189-204.
Boucher K,; Yakovlev, A.; Mayer-Prosche,M.; Noble,M. "A stochastic model of temporally regulated generation of oligodendrocytes in cell culture". Mathem. Bioscience. 1999; 159: 47-78. Link
Stringer, S.E.; Mayer-Proschel M.; Kalyani A.; Rao, M.; Gallagher J.T. "Heparin is a unique marker of progenitors in the glial cell lineage". J. Biol. Chem. 1999; 36: 25455-25460. Link
1998 Nov 24
Yakovlev AY, Boucher K, Mayer-Proschel M, Noble M. "Quantitative insight into proliferation and differentiation of oligodendrocyte type 2 astrocyte progenitor cells in vitro." Proceedings of the National Academy of Sciences of the United States of America.. 1998 Nov 24; 95(24):14164-7.
1998 Jul
Yakovlev AY, Mayer-Proschel M, Noble M. "A stochastic model of brain cell differentiation in tissue culture." Journal of mathematical biology. 1998 Jul; 37(1):49-60.
1998 Mar 31
Rao MS, Noble M, Mayer-Pröschel M. "A tripotential glial precursor cell is present in the developing spinal cord." Proceedings of the National Academy of Sciences of the United States of America.. 1998 Mar 31; 95(7):3996-4001.
Yakovlev, A.; Mayer-Proschel, M.; Noble, M. "A stochastic model of brain cell differentiation in tissue culture." J. Math. Biol.. 1998; 1: 48-60. Link
Mujtiaba, T.; Mayer-Pröschel, M.; Rao ,M.S. "A common neural progenitor for the CNS and PNS". Dev. Biology. 1998; 200: 1-15. Link
Mayer-Proschel M. "Cell differentiation in the embryonic mammalian spinal cord". J. of Neural Transm. 1998; 55: 1-8. Link
1997 Oct
Mayer-Proschel M, Kalyani AJ, Mujtaba T, Rao MS. "Isolation of lineage-restricted neuronal precursors from multipotent neuroepithelial stem cells." Neuron.. 1997 Oct; 19(4):773-85.
Rao, M.S.; Mayer-Pröschel M. "Glial-restricted precursors are derived from multipotent neuroepithelial stem cells". Dev. Biology. 1997; 188: 48-63. Link
Mayer-Pröschel M.; Rao, M.S.; Noble, M. "Progenitor cells of the central nervous system: A boon for clinical neuroscience". The Journal of NIH Research. 1997; 9: 31-36. Link
Noble M, Mayer-Pröschel M. "Growth factors, glia and gliomas." Journal of neuro-oncology.. 1997 35(3):193-209.
1996 Nov 25
Ibarrola N, Mayer-Pröschel M, Rodriguez-Peña A, Noble M. "Evidence for the existence of at least two timing mechanisms that contribute to oligodendrocyte generation in vitro." Developmental biology. 1996 Nov 25; 180(1):1-21.
1994 Jan
Mayer M, Bhakoo K, Noble M. "Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro." Development.. 1994 Jan; 120(1):143-53.
Mayer, M.; Noble, M. "N-Acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro". Proc. Natl. Acad. Sci. USA. 1994; 91. Link
1993 Apr 1
Groves AK, Barnett SC, Franklin RJ, Crang AJ, Mayer M, Blakemore WF, Noble M. "Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells." Nature. 1993 Apr 1; 362(6419):453-5.