Brendan F. Boyce, M.B.Ch.B.

Brendan F. Boyce, M.B.Ch.B.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Office: (585) 275-5837
Fax: (585) 276-2832
Administrative: (585) 275-1959

Research Bio

The major focus of research in my lab is study of the regulation of the formation, activation and survival of osteoclasts, the cells that resorb bone. In recent years, many genes have been identified as regulators of these aspects of osteoclast function, and our studies presently are focused on the roles of NF-kappaB and src tyrosine kinase in osteoclasts. My colleague, Dr. Lianping Xing, and I, along with members of the Center for Musculoskeletal Research at the University, are studying the roles of these gene products in the increased bone resorption and decreased bone formation that characterize a number of bone diseases, including postmenopausal osteoporosis, inflammatory joint disease, metastatic bone disease and loosening of joint prostheses.

We are also studying the effects of a number of potential drug development compounds developed by ARIAD Pharmaceuticals on bone resorption and bone formation, using a number of models of human bone diseases. NF-kappaB also appears to regulate chondrocyte differentiation, and we are studying its role in endochondral ossification. We acknowledge funding from the National Institutes of Health to support our studies.

Awards & Honors (Local)

Treasurer, United States Biological Stain Commission 2010 - Present
Secretary/Treasurer-Elect, American Society for Bone & Mineral Research 2010 - Present
Chair, Gordon Research Conference on Bones and Teeth 2009
Vice Chair, Gordon Research Conference on Bone and Teeth 2007
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab) 2007
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab) 2005
Young Investigator of Year Award from International Society of Bone Morphometry to Dr. Zhenqiang Yao (post-doc fellow in my lab) 2005
Secretary/Treasurer, Association of Osteobiology 2003 - 2006
President International Society of Bone Morphometry 2002 - 2006
Council Member Association of Osteobiology 2001 - 2007
Travel Award From American Society for Bone and Mineral Research to Dr. Lianping Xing from my lab 2000
Member, Board of Directors International Society of Bone Morphometry 1999 - Present
New Investigator Award From Orthopaedic Research Society to Dr. Lianping Xing (post-doctoral fellow in my lab) 1999
Travel Award From American Society for Bone and Mineral Research to Dr. Sheela Rani (post-doctoral fellow in my lab) 1998
Most Outstanding Abstract of Mtg President's Award fr. Amer. Soc Bone & Min Res Drs L Xing, G Franzoso, U Siebenlist & BF Boyce 1997
Young Investigator of Year Award fr Amer. Society for Bone & Mineral Research to Dr. Lianping Xing (post-doc fellow in my lab) 1996
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Hong Chen (post-doc fellow in my lab) 1993
Peel International Research Fellowship (London, England) 1986 - 1987
Pathological Society Travel Award (London, England) 1986 - 1987
McCunn Trust Traveling Fellowship (Glasgow, Scotland) 1986 - 1987
Jean Mackintosh Traveling Research Fellowship (Glasgow, Scotland) 1977

Patents

Neutralizing Rat Monoclonal Antibody Specific for Mouse Vascular Endothelial Growth Factor Receptor (VEGFR)-2 (DC101) Reduces Joint Damage in Chronic Inflammatory Arthritis

United States Serial NO.: 12/389,193
Filed Date: February 19, 2009
Title: Methods and Compositions for Treating Inflammatory Conditions
Invented by: Lianping Xing, Brendan Boyce, Edward Schwarz
Neutralizing Rat Monoclonal Antibody Specific for Mouse Vascular Endothelial Growth Factor Receptor (VEGFR)-2 (DC101) Reduces Joint Damage in Chronic Inflammatory Arthritis

United States Serial NO.: 14/068,823
Filed Date: October 31, 2013
Title: Methods and Compositions for Treating Inflammatory Conditions
Invented by: Lianping Xing, Brendan Boyce, Edward Schwarz

Recent Journal Articles

Showing the 5 most recent journal articles. 177 available »

2014 Jul 1
Zhang H, Hilton MJ, Anolik JH, Welle SL, Zhao C, Yao Z, Li X, Wang Z, Boyce BF, Xing L. "NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-?B." The Journal of clinical investigation. 2014 Jul 1; 124(7):3200-14. Epub 2014 Jun 02.
2014 Apr
Yao Z, Li Y, Yin X, Dong Y, Xing L, Boyce BF. "NF-?B RelB negatively regulates osteoblast differentiation and bone formation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2014 Apr; 29(4):866-77.
2014 Mar
Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS. "Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia." Bone. 2014 Mar; 60:148-61. Epub 2013 Dec 04.
2014 Mar
Shi J, Liang Q, Zuscik M, Shen J, Chen D, Xu H, Wang YJ, Chen Y, Wood RW, Li J, Boyce BF, Xing L. "Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice." Arthritis & rheumatology. 2014 Mar; 66(3):657-66.
2014 Jan 2
Xiu Y, Xu H, Zhao C, Li J, Morita Y, Yao Z, Xing L, Boyce BF. "Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation." The Journal of clinical investigation. 2014 Jan 2; 124(1):297-310. Epub 2013 Dec 09.

Current Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD) - Primary
Professor - Department of Orthopaedics (SMD)

Specialties

Anatomic Pathology - American Board of Pathology

Education

F. R.C. Path | Royal College of Pathologists1991
M.R.C. Path | Royal College of Pathologists1979
MD (M.B., Ch.B.) | Medicine | UK-U Glasgow Fac Med1972

Post-Doctoral Training & Residency

Fellowship in Pathology at Royal Infirmary07/19/1979 - 09/30/1982
Residency in Pathology at Royal Infirmary08/01/1973 - 07/18/1979
Internship in General Surgery at Royal Infirmary02/01/1973 - 07/31/1973
Internship in General Medicine at Western Infirmary07/01/1972 - 01/31/1973