Chen Yan, Ph.D.

Chen Yan, Ph.D.

Contact Information

Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta, NY 14586

Appointment: (585) 275-URMC (8762)

Professional Bio

Dr. Chen Yan received her Bachelor of Science degree in Biochemistry in 1983 and Master's degree in Human/Medical Genetics from the Fudan University in 1983. She received her Ph.D. degree in molecular pharmacology from the University of Washington (UW), Seattle in 1996 and performed her postdoctoral training in molecular cardiology, also at UW. She was recruited to the University of Rochester as a Research Assistant Professor in December 1998. She currently is a assistant professor.

Patient Care Bio

Dr. Yan was born and grew up in Shanghai, China. She received her Bachelors and Masters degrees in the field of Biochemistry and Genetics, respectively, from Fudan University, Shanghai, China. Her PhD research was done in the lab of Dr. Joseph A. Beavo in Department of Pharmacology at the University of Washington in Seattle, WA USA. Her postdoctoral training was done with Dr. Bradford C. Berk in the Cardiology Unit of the University of Washington. Currently Dr. Yan is an associate professor in Aab Cardiovascular Research Institute, University of Rochester, School of Medicine and Dentistry.

Her research focuses on a family of enzymes called phosphodiesterases (PDE) that degrade second messengers, diffusible signaling molecules that are rapidly generated and activate proteins within the cell to exert a cellular response. By inhibiting PDEs one can amplify cellular responses. One successful example is Viagra, which inhibits a specific PDE. Altered second messenger signaling and PDE activity/expression have been implicated in a variety of cardiovascular diseases such as hypertension, atherosclerosis and heart failure. Understanding the role of PDEs in cardiovascular diseases may provide new therapeutic information for the treatment of cardiovascular diseases. To date, Dr. Yan has published over 80 research and review articles and has recently received an American Heart Association Established Investigator Award.

Awards & Honors (Local)

American Heart Association Established Investigator Award 2007 - 2011
NIH Postdoctoral Fellowship 1997 - 1998
Fellowship for Advanced Predoctoral Training in Pharmacology/Toxicology of Pharmaceutical Research & Manufactures of America Foundation 1994 - 1996
Shanghai City Honor (Sanhao) Student (top 0.1% students who display the overall well-roundedness). Received this award for three consecutive years. 1979 - 1982
Honor (Sanhao) Student of Fudan University (top 2% of students who display the best all round development of morality, intelligence, and physique). Received this award for three consecutive years. 1979 - 1982

Patents

A Novel Anti-Inflammatory Agent for the Treatment of Inflammatory Diseases

United States Serial NO.: 12/678,352
Filed Date: September 16, 2008
Title: Method and Compositions For Treatment or Prevention of Inflammatory Conditions
Invented by: Chen Yan, Jian-Dong Li, Kye-Im Jeon, Xiangbin Xu, Bradford Berk
A Novel Anti-Inflammatory Agent for the Treatment of Inflammatory Diseases

United States Serial NO.: 14/191,219
Filed Date: February 26, 2014
Title: Method and Compositions For Treatment or Prevention of Inflammatory Conditions
Invented by: Chen Yan, Jian-Dong Li, Kye-Im Jeon, Xiangbin Xu, Bradford Berk

Current Appointments

Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD) - Primary

Education

Ph.D. | Pharmacology | University of Washington1996
MS | Genetics | Genetic Institute, Fudan University1986
BS | Biochemistry | Department of Biology, Fudan University1983

Post-Doctoral Training & Residency

Division of Cardiology, University of Washington, Seattle, WA, USA Supervisor: Dr. Bradford Berk 1998
Department of Pharmacology, University of Washington, Seattle, WA, USA Supervisor: Dr. Joseph Beavo 1997