Ming Qi, Ph.D.

Ming Qi, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Office: (585) 276-9995
Lab: (585) 276-9987
Fax: (585) 427-9334

Research Bio

Molecular pathology of genetic diseases seeks to explain why a given genetic change should result in a particular clinical phenotype. With its rapid progress, the knowledge in the field not only forms the cutting edge of biomedical research, but at the same time it has immediate application to the diagnosis of more and more diseases, and has great potential for the management of those diseases. Clinical symptoms are often the end result of a long chain of causation and complicate genetic interaction. The goals of the research in this laboratory, collaborated with multiple laboratories inside and outside the University, are to developing new tests for molecular diagnosis, and identify new genes responsible for bone and cardiovascular genetic diseases. Approaches of gene functional cloning, positional candidate gene cloning, and gene knock-out/in have been used in these studies.

Recent Journal Articles

1998 May 15
Brandon EP, Logue SF, Adams MR, Qi M, Sullivan SP, Matsumoto AM, Dorsa DM, Wehner JM, McKnight GS, Idzerda RL. "Defective motor behavior and neural gene expression in RIIbeta-protein kinase A mutant mice." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1998 May 15; 18(10):3639-49.
1998 Mar
Qi M, Byers PH. "Constitutive skipping of alternatively spliced exon 10 in the ATP7A gene abolishes Golgi localization of the menkes protein and produces the occipital horn syndrome." Human molecular genetics.. 1998 Mar; 7(3):465-9.
1997 Nov 25
Hamilton SE, Loose MD, Qi M, Levey AI, Hille B, McKnight GS, Idzerda RL, Nathanson NM. "Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice." Proceedings of the National Academy of Sciences of the United States of America.. 1997 Nov 25; 94(24):13311-6.
1997 Jul
Li L, Krantz ID, Deng Y, Genin A, Banta AB, Collins CC, Qi M, Trask BJ, Kuo WL, Cochran J, Costa T, Pierpont ME, Rand EB, Piccoli DA, Hood L, Spinner NB. "Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1." Nature genetics.. 1997 Jul; 16(3):243-51.
1996 Feb 20
Qi M, Zhuo M, Skålhegg BS, Brandon EP, Kandel ER, McKnight GS, Idzerda RL. "Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase." Proceedings of the National Academy of Sciences of the United States of America.. 1996 Feb 20; 93(4):1571-6.

Current Appointments

Professor (Part-Time) - Department of Pathology and Laboratory Medicine (SMD) - Primary

Education

PhD | Molecular Biology | Univ of Pittsburgh1991
MS | Genetics | China - Free-Standing Inst1985
BS | Biology | China - Free-Standing Inst1982