Mark A. Sullivan, Ph.D.

Mark A. Sullivan, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 695
Rochester, NY 14642

Office: (585) 273-1629
Fax: (585) 276-0190
Lab: (585) 273-2718

Lab Information

Phage antibody technology in the development of novel reagents for characterization of protein expression and structures

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Research Bio

The ability to rapidly isolate human antibodies using phage display has opened up new approaches to understanding protein function. Research in my laboratory is focused on the manipulation of immunoglobulin molecules to develop novel reagents for characterization of protein expression and structure. We are using phage antibody technology in several areas of proteomics research to develop improved reagents for protein characterization as well as novel inhibitors of protein function that will aid in defining the roles of the many new proteins discovered through genomic sequencing. Major efforts are aimed at dissecting the saliva proteome and developing panels of antibodies for incorporation into new diagnostic platforms using protein microarrays.

A second initiative is to derive antibodies useful for solving the structure of proteins by X-ray crystallography. Additional studies focus on the therapeutic potential of single-chain antibodies to reduce protein aggregation and misfolding, a process that characterizes a variety of neurodegenerative diseases.

Awards & Honors (Local)

C.E.K. Mees Award for Excellence in Scientific Research and Reporting | Eastman Kodak Company 1990
NIH Predoctoral Fellowship | University of Wisconsin 1976 - 1979
Wisconsin Alumni Research Foundation Fellowship | University of Wisconsin 1975 - 1976

Patents

Protease Activated Cytokines to Enhance Immune Reponses to Tumors

United States Serial NO.: 13/639,006
Filed Date: March 31, 2011
Title: Protease Activated Cytokines
Invented by: John Frelinger, John Puskas, Baek Kim, Mark Sullivan
Antigenic Mimics of Discontinuous HIV-1 Envelope Epitopes Recognized by Broadly Neutralizing Antibodies

United States Serial NO.: 13/577,419
Filed Date: February 14, 2011
Title: Antigenic Mimics of Discontinuous HIV-1 Envelope Epitopes Recognized by Broadly Neutralizing Antibodies
Invented by: Stephen Dewhurst, Mark Sullivan

Recent Journal Articles

Showing the 5 most recent journal articles. 20 available »

2013 Mar 12
Sullivan MA, Brooks LR, Weidenborner P, Domm W, Mattiacio J, Xu Q, Tiberio M, Wentworth T, Kobie J, Bryk P, Zheng B, Murphy M, Sanz I, Dewhurst S. "Anti-idiotypic monobodies derived from a fibronectin scaffold." Biochemistry.. 2013 Mar 12; 52(10):1802-13. Epub 2013 Mar 01.
2013 Feb
Heo KS, Chang E, Takei Y, Le NT, Woo CH, Sullivan MA, Morrell C, Fujiwara K, Abe JI. "Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity." Arteriosclerosis, thrombosis, and vascular biology.. 2013 Feb; 33(2):321-9. Epub 2012 Nov 29.
2013 Jan 29
Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe JI. "A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis." Circulation.. 2013 Jan 29; 127(4):486-99. Epub 2012 Dec 14.
2012 Oct
Boonanantanasarn K, Gill AL, Yap Y, Jayaprakash V, Sullivan MA, Gill SR. "Enterococcus faecalis enhances cell proliferation through hydrogen peroxide-mediated epidermal growth factor receptor activation." Infection and immunity.. 2012 Oct; 80(10):3545-58. Epub 2012 Jul 30.
2010 Aug
Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. "Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice." Molecular therapy : the journal of the American Society of Gene Therapy.. 2010 Aug; 18(8):1471-81. Epub 2010 Jun 15.

Current Appointments

Research Assistant Professor - Department of Microbiology and Immunology (SMD) - Primary

Education

PhD | Biochemistry | Univ Wisconsin-Madison1981
BS | Chemistry | Purdue University1975

Post-Doctoral Training & Residency

Postdoctoral Fellow, Department of Microbiology & Immunology University of Rochester Rochester, NY 1983