Jing Wang, B.Med., Ph.D.

Jing Wang, B.Med., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Lab: (585) 275-5111

Research Bio

1. Macrophage mediated fungal clearance and lung injury during
Pneumocystis pneumonia
2. Mechanism of immune mediated lung injury during infectious diseases
3. Seeking new strategies to treat inflammatory lung diseases



Pneumocystis is an opportunistic fungal respiratory pathogen that causes life-threatening pneumonia in patients suffering from defects in cell-mediated immunity, including those with acquired immunodeficiency syndrome (AIDS) and immunosuppression secondary to chemotherapy or organ transplantation. Despite dramatic advances in health care and the availability of antibiotics to treat this infection, mortality rates have improved little over the past 25 years. Pneumocystis carinii pneumonia remains a leading cause of death among HIV-infected patients and a significant cause of AIDS-related mortality and morbidity. This highlights the need for better understanding of the pathogenesis of the disease, and underscores the necessity of investigating new therapeutic strategies.

My research uses Pneumocystis pneumonia as one of the models to study the mechanisms of lung injury. I use a variety of immunology, imaging, and cell biolological techniques to study the role of alveolar macrophage phenotype during inflammatory lung diseases.

The specific goals of my research are to: 1) determine the functional changes in alveolar macrophages during inflammatory lung diseases, and 2) evaluate the feasibility of using specific macrophage phenotype subsets as adjunctive treatments to ameliorate inflammatory lung diseases.

Awards & Honors (National)

Junior Faculty Travel Grant | 2010 American Association of Immunologist, 97th AAI Annual Mtg | Baltimore, MD 2010
Travel Award | 2009 American Thoracic Society International Conference | San Diego, CA 2009
Travel Award | X International Workshops on Opportunistic Protists | Boston, MA 2008
New York State Blavatnik Award for Young Scientists (Nominee) | University of Rochester School of Medicine and Dentistry 2008
Travel Award | The 22nd International Congress of Pediatrics | Amsterdam, Holland 1998

Awards & Honors (Local)

Dean's Scholarship for Excellent Academic Achievement(five-time recipient) | Chongqing Medical University 1990 - 1995

Recent Journal Articles

Showing the 5 most recent journal articles. 12 available »

2014
Bello-IrizarrySN; Wang J; Olsen K; Gigliotti F; Wright TW. "MyD88 signaling regulates both host defense and immnopathogenesis during Pneumocystis infection". J Immunol. 2014; : 282-92.
2012 Nov
Bello-Irizarry SN, Wang J, Olsen K, Gigliotti F, Wright TW. "The alveolar epithelial cell chemokine response to pneumocystis requires adaptor molecule MyD88 and interleukin-1 receptor but not toll-like receptor 2 or 4." Infection and immunity.. 2012 Nov; 80(11):3912-20. Epub 2012 Aug 27.
2011
Wang J, Wright TW, Gigliotti F. "Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia." Interdisciplinary perspectives on infectious diseases. 2011 2011:918038. Epub 2011 Aug 29.
2010
Wang J, Gigliotti F, Bhagwat S, Georgoe TC, Wright TW. "Immune Modulation with Sulfasalazine Attenuates Immunopathogenesis but EnhancesMacrophages-Mediated Fungal Clearance during Pneumocystis Pneumonia". PLoS Pathogens. 2010; 6(8): pii:e1001058.
2010
Xiangrong He, Wang J, Messing, EM, Guan Wu,. "Regulation of Receptor for Activated C Kinasse 1 Protein by teh von Hippel-Lindau Tumor Suppressor in IGF-I-induced Renal Carcinoma Cell Invasiveness". Oncogene. 2010; .

Current Appointments

Research Assistant Professor - Department of Pediatrics, Infectious Diseases (SMD) - Primary

Education

PhD | Medical Microbiology and Immunology Graduate Program | School of Medicine and Dentistry, University of Rochester2006
Master | Clinical Immunology | Chongqing Medical University1998
M.D. Equivalency | Chongqing Medical UniversityAttended 1990 - 1995

Post-Doctoral Training & Residency

Internship, Children's Hospital, Chongqing Medical University, Chongqing, Sirchuan, China. 1998
Clerkship, Children's Hospital; The Second Affiliated Hospital; The Third People's Hospital, Chongqing Medical University, Chongqing, China 1995
Research Fellowship, Department of Pediatrics, West China Second University Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China 2001
Residency, Department of Pediatrics, West China Second University Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China 2001