Hongyu Miao, Ph.D.

Hongyu Miao, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester, NY 14642

Office: (585) 275-0408
Fax: (585) 273-1031

Lab Information

My research group has a cross-disciplinary research environment, involving mathematical modeling, statistics, computational biology and immunology/neurology applications.

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Professional Bio

Quantitative analysis methods, computing techniques and their biological applications have always been of the greatest passion in my work. Currently, a number of biological problems in immunology research interest me, including treatment and vaccination against HIV and influenza infection. To solve these important problems, I have been actively developing a variety of bioinformatics, modeling and data mining methodologies. In the field of computational biology, I specialize in systems immunology, structural bioinformatics and multi-scale complex networks; in the field of statistics, I specialized in parameter estimation of dynamic systems, image analysis, and data mining on manifold; and in the field of mathematical modeling, I specialize in differential equation, stochastic process and probabilistic model.

Research Bio

Quantitative analysis methods, computing techniques and their biological applications have always been of the greatest passion in my work. Currently, a number of biological problems in immunology research interest me, including treatment and vaccination against HIV and influenza infection. To solve these important problems, I have been actively developing a variety of bioinformatics, modeling and data mining methodologies. In the field of computational biology, I specialize in systems immunology, structural bioinformatics and multi-scale complex networks; in the field of statistics, I specialized in parameter estimation of dynamic systems, image analysis, and data mining on manifold; and in the field of mathematical modeling, I specialize in differential equation, stochastic process and probabilistic model.

Awards & Honors (National)

David P. Byar Young Investigator Travel Award | Biometrics, American Statistical Association | Denver, CO

Awards & Honors (Local)

Provost's Multidisciplinary Award | University of Rochester | Rochester, NY

Recent Journal Articles

Showing the 5 most recent journal articles. 24 available »

2014
Sanchez-Lockhart M, Rojas AV, Fettis MM, Bauserman R, Higa TR, Miao H, Waugh RE, Miller J. "T cell receptor signaling can directly enhance the avidity of CD28 ligand binding." PloS one. 2014 9(2):e89263. Epub 2014 Feb 24.
2014
Miao H, Sangster MY, Livingstone AM, Hilchey SP, Zhang L, Topham DJ, Mosmann TR, Holden-Wiltse J, Perelson AS, Wu H, Zand MS. "Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection." PloS one. 2014 9(8):e104781. Epub 2014 Aug 29.
2014
Liu ZP, Wu H, Zhu J, Miao H. "Systematic identification of transcriptional and post-transcriptional regulations in human respiratory epithelial cells during influenza A virus infection." BMC bioinformatics. 2014 15:336. Epub 2014 Oct 04.
2013 Oct
Seckler JM, Leioatts N, Miao H, Grossfield A. "The interplay of structure and dynamics: insights from a survey of HIV-1 reverse transcriptase crystal structures." Proteins. 2013 Oct; 81(10):1792-801. Epub 2013 Aug 16.
2013 Jul 1
Lu N, Silva J, Gu Y, Gerber S, Wu H, Gelbard H, Dewhurst S, Miao H. "Directional Histogram Ratio at Random Probes: A Local Thresholding Criterion for Capillary Images." Pattern recognition. 2013 Jul 1; 46(7):1933-1948. Epub 2013 Jan 18.

Current Appointments

Assistant Professor - Department of Biostatistics and Computational Biology (SMD) - Primary

Education

M.S. | Medical Statistics | University of Rochester2011
PhD | Mechanical Engineering | University of Rochester2007
MS | Mechanical Engineering | University of Rochester2004
MS | Mechanical Engineering | China-Tsinghua University2002
BS | Mechanical Engineering | China-Tsinghua University1999

Post-Doctoral Training & Residency

Postdoctoral Research Associate, Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY 2008