Rashid Deane, B.Sc., Ph.D.

Rashid Deane, B.Sc., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 670
Rochester, NY 14642

Office: (585) 273-5377


Deane, R.; Bradbury, M. W. B.. "Lead and the Brain". Pathophysiology of the blood-brain barrier : long term consequences of barrier d. Johansson, B. B.; Owman, C.; Widner, H.. New York: Elsevier, 1990. 279-291
Deane, R.; Bradbury, M. W. B.. "Is Pulsation Important for the Brain?". Peptide and amino acid transport mechanisms in the central nervous system. Rakic, L.. : Macmillan, 1987. 305-317
Deane, R.; Segal, M. W.. "Why is the Concentration of Glucose in CSF Less Than in Plasma?". Carrier mediated transport of solutes from blood to tissue. Yudilevich, D.L.; Mann, G.E.. New York: Longman, 1985. 303-306

Journal Articles

Showing all 34 journal articles available.

2009 Mar
Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. "Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity." The European journal of neuroscience. 2009 Mar; 29(6):1119-30.
2009 Feb
Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. "SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells." Nature cell biology. 2009 Feb; 11(2):143-53. Epub 2008 Dec 21.
2009 Jan
Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. "Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2009 Jan; 29(1):25-33. Epub 2008 Oct 08.
2008 Apr
Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. "ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration." Nature neuroscience.. 2008 Apr; 11(4):420-2. Epub 2008 Mar 16.
Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. "apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain." The Journal of clinical investigation.. 2008 118(12):4002-13. Epub 2008 Nov 13.
2007 Sep
Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. "Clearance of amyloid-beta by circulating lipoprotein receptors." Nature medicine.. 2007 Sep; 13(9):1029-31. Epub 2007 Aug 12.
2007 Feb
Takano T, Han X, Deane R, Zlokovic B, Nedergaard M. "Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease." Annals of the New York Academy of Sciences.. 2007 Feb; 1097:40-50.
2007 Jan 16
Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV. "Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype." Proceedings of the National Academy of Sciences of the United States of America.. 2007 Jan 16; 104(3):823-8. Epub 2007 Jan 10.
Deane, R.; Zlokovic, B.V. "Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease". Current Alzheimer's Research. 2007; 4: 191-197. Link
Bell, RD; Sagare A; Friedman AE; Bedi G; Holtzman; Deane R; Zlokovic BV. "Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J." J Cerebral Blood flow and Metabolism. 2007; 27: 909-918. Link
Deane, R; Zlokovic, BV. "Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease". Current Alzheimer's Research. 2007; 4: 191-197. Link
2006 Nov
Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. "Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage." Nature medicine.. 2006 Nov; 12(11):1278-85. Epub 2006 Oct 29.
Kassem, N. A.; Deane, R.; Segal, M. B.; Preston, J. E.;. "Role of transthyretin in thyroxine transfer from cerebrospinal fluid to brain and choroid plexus". American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 2006; 291(5): R1310-R1315. Link
2005 Nov
Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. "P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model." The Journal of clinical investigation.. 2005 Nov; 115(11):3285-90. Epub 2005 Oct 20.
2005 Sep
Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease." Nature medicine.. 2005 Sep; 11(9):959-65. Epub 2005 Aug 14.
2005 Jan
Zlokovic BV, Deane R, Sallstrom J, Chow N, Miano JM. "Neurovascular pathways and Alzheimer amyloid beta-peptide." Brain pathology (Zurich, Switzerland). 2005 Jan; 15(1):78-83.
Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. "IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2005 25(50):11495-503.
2004 Nov
Deane R, Wu Z, Zlokovic BV. "RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier." Stroke; a journal of cerebral circulation.. 2004 Nov; 35(11 Suppl 1):2628-31. Epub 2004 Sep 30.
2004 Sep 30
LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV. "Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice." Journal of neuroscience methods.. 2004 Sep 30; 138(1-2):233-42.
2004 Aug 5
Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV. "LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms." Neuron.. 2004 Aug 5; 43(3):333-44.
2004 May 7
Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE. "Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor." The Journal of biological chemistry.. 2004 May 7; 279(19):20296-306. Epub 2004 Feb 25.
2004 Feb
Deane R, Zheng W, Zlokovic BV. "Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain." Journal of neurochemistry. 2004 Feb; 88(4):813-20.
2003 Jul
Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. "RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain." Nature medicine.. 2003 Jul; 9(7):907-13.
Zheng, W.; Deane, R.; Redzic, Z.; Preston, J. E.; Segal, M. B.;. "Transport of L-125Ithyroxine by in situ perfused ovine choroid plexus: inhibition by lead exposure". Journal of Toxicology & Environmental Health Part A. 2003; 66(5): 435-451. Link
Bradbury MW, Deane R. "Permeability of the blood-brain barrier to lead." Neurotoxicology.. 1993 14(2-3):131-6.
1990 Mar
Deane R, Bradbury MW. "Transport of lead-203 at the blood-brain barrier during short cerebrovascular perfusion with saline in the rat." Journal of neurochemistry. 1990 Mar; 54(3):905-14.
Bradbury MW, Deane R. "Brain endothelium and interstitium as sites for effects of lead." Annals of the New York Academy of Sciences.. 1988 529:1-8.
1987 May
Jones HC, Deane R, Bucknall RM. "Developmental changes in cerebrospinal fluid pressure and resistance to absorption in rats." Brain research. 1987 May; 430(1):23-30.
Deane, R.; Park, S. H.; Bradbury, M. W.;. "Effect of intravenous ferric or aluminum chloride on the uptake of 203Pb into brain and other soft tissues of rats". Journal of Pharmacology & Experimental Therapeutics. 1986; 239(2): 548-553. Link
Bradbury MW, Deane R. "Rate of uptake of lead-203 into brain and other soft tissues of the rat at constant radiotracer levels in plasma." Annals of the New York Academy of Sciences.. 1986 481:142-60.
Deane, R.; Segal, M. B.;. "The effect of vascular perfusion of the choroid plexus on the secretion of cerebrospinal fluid proceedings". Journal of Physiology (London). 1979; 293: 18P-19P. Link
Deane, R.; Segal, M. B.;. "The effect of phloridzin, phloretin and theophylline on the transport of sugars by the choroid plexus proceedings". Journal of Physiology (London). 1979; 287: 35P-36P. Link
Deane, R.; Segal, M. B.;. "Effect of vascular perfusion on the transfer of sugars across the choroid plexus of the sheep proceedings". Journal of Physiology (London). 1978; 285: 57P. Link
Deane, R.; Segal, M. B.;. "The sodium-dependent absorption of sugars across the coroid plexus of the sheep proceedings". Journal of Physiology (London). 1976; 263(2): 274P-275P. Link