Rashid Deane, B.Sc., Ph.D.

Rashid Deane, B.Sc., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 670
Rochester, NY 14642

Office: (585) 273-5377

Research Bio

Research interest includes the following:



1) Control of the brain microenvironment (Blood-brain barrier, choroid plexus and cerebrospinal fluid).

2) Metals in health and disease.

3) Aging and neurodegenerative diseases (e.g. Alzheimer's disease).

Awards & Honors (National)

Science and Engineering Research Council (SERC) Awards | Agency for Science, Technology and Research | Singapore 1990 - 2001

Awards & Honors (Local)

Wellcome Trust Travel Award | Columbia University | New York, NY 2001
1993 Performance Indicator Award | School of Chemical and Life Sciences / | London, England 1993
Medical Research Council (MRC, England) Scholar 1974 - 1977

Patents

Small Molecules which Disrupt RAGE/ Amyloid-Beta Peptide Interaction

United States Serial NO.: 12/223,276
Filed Date: January 26, 2007
Title: Inhibiting Amyloid-Beta Peptide/RAGE Interaction at the Blood-Brain Barrier
Invented by: Berislav Zlokovic, Rashid Deane, Benjamin Miller

Recent Journal Articles

Showing the 5 most recent journal articles. 34 available »

2009 Mar
Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. "Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity." The European journal of neuroscience. 2009 Mar; 29(6):1119-30.
2009 Feb
Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. "SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells." Nature cell biology. 2009 Feb; 11(2):143-53. Epub 2008 Dec 21.
2009 Jan
Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. "Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2009 Jan; 29(1):25-33. Epub 2008 Oct 08.
2008 Apr
Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. "ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration." Nature neuroscience. 2008 Apr; 11(4):420-2. Epub 2008 Mar 16.
2008
Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. "apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain." The Journal of clinical investigation. 2008 118(12):4002-13. Epub 2008 Nov 13.

Current Appointments

Research Professor - Department of Neurosurgery, Center for Translational Neuromedicine (SMD) - Primary

Education

PhD | Medical Physiology | St. Thomas's Hospital Medical School1983
BSc | Physiology | Bedford College, University of London1974

Post-Doctoral Training & Residency

Postdoctoral Research Fellow, King's College London, England 1987
Postdoctoral Research Associate; University of Hull; Hull, UK 1983