Research Bio
My research focuses primarily on 1) the molecular and cellular events underlying stem cell differentiation that leads to skeletal tissue regeneration, including Notch, Wnt and TGF beta signaling; and 2) an emphasis on challenging clinical problems and translational solutions, including stem cell based cartilage, bone defect and fracture repair.
2010 May
Dong Y, Jesse A, Kohn A, Gunnell L, Honjo T, Zuscik M, O'Keefe R, Hilton M. "RBPJk-dependent Notch signaling maintains and expends mesenchymal stem/progenitor cells during skeletal development". Development. 2010; 137(9): 1461-71. |
2008
Eliseev R, Dong Y, Sampson E, Zuscik M, Schwarz EM, O'Keefe RJ, Rosier R, Drissi H. "Runx2-mediated activation of the Bax gene increase osteosarcoma cell sensitivity to apoptosis". Oncogene. 2008; 27(25): 3605-14. |
2007 Nov
Dong Y, Soung DY, Chang Y, Enomoto M, Paris M, Schwarz EM, O'Keefe RJ, Drissi H. "TGF-b and Wnt signaling stage-specifically regulate chondrocyte differentiation through Twist1". Molecular Endocrinology. 2007; 21(11): 2805-20. |
2007
Soung DY, Dong Y, Wang Y, Schwarz EM, O'Keefe RJ, Drissi H. "Runx3/AML2/Cbfa3 Regulates Early and Late Chondrocyte Differentiation". J Bone Miner Res. 2007; 8: 1260-70. |
2006 May
Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. "Runx2 mediated regulation of the zinc finger osterix/SP7 gene". Gene. 2006; 372: 62-70. |
