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Ollivier Hyrien, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester, NY 14642

Office: (585) 275-5303

Books

Journal Articles

Showing all 42 journal articles available.

2011
Chen, R.; Hyrien, O. "Quasi- and pseudo-likelihood estimation for discretely observed Markov branching processes". Journal of Statistical Planning and Inference. 2011; 141(7): 2209-2227. Link
2011
Chen, Y.; Pandya, K.; Hyrien, O.; Keng, P.; Smudzin, T.; Anderson, J.; Qazi, R.; Smith, B.; Watson, T.; Feins, R.; Johnstone, D. "Preclinical and pilot clinical study of decetaxel chemoradiation for stage III non-small cell lung cancer." International Journal of Radiation Oncology, Biology, Physics. 2011; 80(5): 1358-1364. Link
2011
Chen, R.; Hyrien, O.; Mayer-Proschel, M.; Noble, M. "A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process." Biostatistics. 2011; 12(1): 173-191. Link
2011
Zhang, H.; Travis, L.B.; Chen, R.; Hyrien, O.; Milano, M.T.; Newlands, S.D.; Chen, Y. "Impact of Radiotherapy on Laryngeal Cancer Survival: A Population-Based Study of 13,808 U.S. Patients". Cancer. 2011; Jul 19. doi: 10.1002/cncr.26357.. Link
2011
Kaspler, P.; Chen, R.; Hyrien, O.; Jelveh, S.; Bristow, R.G.; Hill, R.P. "Biodosimetry using Radiation-Induced Micronuclei in Skin Fibroblasts". International Journal of Radiation Biology. 2011; 87(8): 824-838. Link
2010 Jun
Hyrien O, Chen R, Mayer-Pröschel M, Noble M. "Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications." Biometrics.. 2010 Jun; 66(2):567-77. Epub 2009 Jun 09.
2010 Jun
Dertinger SD, Phonethepswath S, Franklin D, Weller P, Torous DK, Bryce SM, Avlasevich S, Bemis JC, Hyrien O, Palis J, Macgregor JT. "Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies." Toxicological sciences : an official journal of the Society of Toxicology.. 2010 Jun; 115(2):401-11. Epub 2010 Mar 04.
2010 May
Biswas, T.; Dhakal, S.; Chen, R.; Hyrien, O.; Bernstein, S.; Friedberg, J.; Fisher, R.; Liesveld, J.; Phillips, G.; Constine, L. "Involved field radiation after autologous stem cell transplant for large B-cell lymphoma in the rituximab era". International Journal of Radiation Oncology, Biology, Physics. 2010; 77(1): 79-85. Link
2010 Feb
Chen Y, Tsai Y, Nowak I, Wang N, Hyrien O, Wilkins R, Ferrarotto C, Sun H, Dertinger SD. "Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model." Health physics.. 2010 Feb; 98(2):218-27.
2010 Feb
Kaspler P, Hyrien O, Hill RP. "Dynamics of micronuclei in mouse skin fibroblasts after gamma irradiation." Health physics.. 2010 Feb; 98(2):228-33.
2010 Jan
Bhogal N, Kaspler P, Jalali F, Hyrien O, Chen R, Hill RP, Bristow RG. "Late residual gamma-H2AX foci in murine skin are dose responsive and predict radiosensitivity in vivo." Radiation research.. 2010 Jan; 173(1):1-9.
2010
Hyrien, O.; Yanev, N.M. "Modeling Cell Kinetics Using Branching Processes with Nonhomogeneous Poisson Immigration". Comptes Rendus de l'Academie des Sciences Bulgares. 2010; 63(10): 1405-1414. Link
2010
Phonethepswath, S.; Franklin, D.; Torous D.K.; Bryce, S.M.; Bemis, J.C.; Avlasevich, S.; Weller, P. Hyrien, O.; Palis, J.; MacGregor, J.T.; Dertinger, S.D. "Pig-A mutation: kinetics of appearance and disappearance of mutant phenotype erythrocytes in rat blood following exposure to five prototypical mutagens". Toxicological Sciences. 2010; 114(1): 59-70. Link
2010
Hyrien, O.; Dietrich, J.; Nobel, M. "Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neurological precursers." Cancer Research. 2010; 70(24): 10051-10059. Link
2010
Hyrien, O.; Chen, R.; Zand, M.S. "An age-dependent branching process model for the analysis of CFSE-labeling experiments". Biology Direct, Mathematical Biology Section. 2010; 5: 41. Link
2009 Nov 15
Hilchey SP, Kobie JJ, Cochran MR, Secor-Socha S, Wang JC, Hyrien O, Burack WR, Mosmann TR, Quataert SA, Bernstein SH. "Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness." The Journal of immunology : official journal of the American Association of Immunologists.. 2009 Nov 15; 183(10):6157-66. Epub 2009 Oct 28.
2009 Jul 8
Hocdé SA, Hyrien O, Waugh RE. "Molecular accessibility in relation to cell surface topography and compression against a flat substrate." Biophysical journal. 2009 Jul 8; 97(1):369-78.
2009 Jul 8
Hocdé SA, Hyrien O, Waugh RE. "Cell adhesion molecule distribution relative to neutrophil surface topography assessed by TIRFM." Biophysical journal. 2009 Jul 8; 97(1):379-87.
2009 Apr 30
Dertinger SD, Bemis JC, Phonethepswath S, Tsai Y, Nowak I, Hyrien O, Palis J, Chen Y. "Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age." Mutation research. 2009 Apr 30; 675(1-2):77-80. Epub 2009 Feb 11.
2009 Apr 16
Hilchey SP, Hyrien O, Mosmann TR, Livingstone AM, Friedberg JW, Young F, Fisher RI, Kelleher RJ, Bankert RB, Bernstein SH. "Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab." Blood.. 2009 Apr 16; 113(16):3809-12. Epub 2009 Feb 04.
2009
Sun, H.; Dertinger, S.D.; Hyrien, O.; Wu, D.; Chen, Y. "Gamma radiation induces micronucleated reticulocytes in ex-vivo 3-D bone marrow bioreactors". Mutation Research. 2009; 680(1-2): 49-55. Link
2009
Henn, A.D.; Rebhahn, J.; Brown, M.A.; Murphy, A.; Coca, M.N.; Hyrien, O.; Pellegrin, T.; Mosmann, T.; Zand, M.S. "Modulation of Single-Cell IgG Secretion Frequency and Rates in Human Memory B Cells by CpG DNA, CD40L, IL-21, and Cell Division". Journal of Immunology. 2009; 183(5): 3177-3187. Link
2008 Nov
Khorana AA, Francis CW, Menzies KE, Wang JG, Hyrien O, Hathcock J, Mackman N, Taubman MB. "Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer." Journal of thrombosis and haemostasis : JTH.. 2008 Nov; 6(11):1983-5. Epub 2008 Sep 15.
2008
Hyrien O. and Zand M.S. "A mixture model with dependent observations for the analysis of CFSE-labeling experiments." Journal of the American Statistical Association. 2008; 103(481): 222-239. Link
2008
Couderc, J.P.; McNitt, S.; Hyrien, O.; Vaglio, M.; Xia, X.; Polonsky, S.; Moss, A.J.; Zareba, W. "Electrocardiographic Abnormalities of Repolarization Induced by Moxifloxacin: Improving the Detection of Subtle IKr-Inhibition". Drug Safety. 2008; 31(3): 249-260. Link
2008
Zhang, H.; Hyrien, O.; Pandya, K.; Keng, P.; and Chen, Y. "Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization,". Journal of Thoracic Oncology. 2008; 3(6): 563-568. Link
2008
Connolly, G.C.; Chen, R.; Hyrien, O.; Mantry, P.; Bozorgzadeh, A.; Abt, P.; Khorana, A.A. "Incidence, Risk Factors and Consequences of Portal vein and systemic thromboses in hepatocellular carcinoma". Thrombosis Research. 2008; 122(3): 299-306. Link
2007
Dertinger SD, Tsai Y, Nowak I, Hyrien O, Sun H, Bemis JC, Torous DK, Keng P, Palis J, Chen Y. "Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry." Mutation research. 2007 634(1-2):119-25. Epub 2007 Jul 05.
2007
Hyrien, O. "A pseudo-maximum likelihood estimator for discretely observed multitype Bellman-Harris branching processes." Journal of Statistical Planning and Inference. 2007; 137(4): 1375-1388. Link
2007
Connolly, G.C.; Khorana, A.; Mantry, P.; Bozorgzadeh, A.; Abt, P.; Chen, R.; Hyrien, O. "Portal vein and systemic thromboses in hepatocellular carcinoma". Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition).. 2007; 25(18S (June 20 Supplement)): 155048. Link
2006 Apr 21
Hanin L, Hyrien O, Bedford J, Yakovlev A. "A comprehensive stochastic model of irradiated cell populations in culture." Journal of theoretical biology.. 2006 Apr 21; 239(4):401-16. Epub 2005 Sep 19.
2006
Hyrien, O.; Mayer-Proschel, M.; Nobel, M.; Yakovlev, A. "The statistical analysis of longitudinal clonal data on oligodendrocytes generation." WSEAS Transactions on Biology and Biomedicine. 2006; : 227-232. Link
2006
Couderc J.P.; Vaglio M.; Xia X.; McNitt S.; Hyrien O. "Electrocardiographic method for identifying moxifloxacin-induced ventricular repolarization abnormalities". Computers in Cardiology. 2006; 33: 705-708. Link
2006
Couderc J.P.; Vaglio M.; Xia X.; McNitt S.; Hyrien O. "Electrocardiographic Method for Identifying Drug-induced Repolarization Abnormalities Associated with a Reduction of the Rapidly Activating Delayed Rectifier Potassium Current." IEEE Engineering in Medicine and Biology Society. 2006; 1: 4010-4015. Link
2006
Hyrien O, Ambeskovic I, Mayer-Proschel M, Noble M, Yakovlev A. "Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data." Theoretical biology & medical modelling. 2006 3:21. Epub 2006 May 17.
2005 May 1
Chen Y, Hyrien O, Williams J, Okunieff P, Smudzin T, Rubin P. "Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis." International journal of radiation oncology, biology, physics.. 2005 May 1; 62(1):260-6.
2005 Mar
Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "A stochastic model to analyze clonal data on multi-type cell populations." Biometrics.. 2005 Mar; 61(1):199-207.
2005 Feb
Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture." Mathematical biosciences. 2005 Feb; 193(2):255-74. Epub 2005 Jan 22.
2003
Baker, L, Hyrien, O and Ratka, A. "Contributions of morphine-3-glucuronide and morphine-6-glucoronide to differences in morphine analgesia in humans." American Journal of Pain Management. 2003; 13: 16-28. Link
2003
Klés V, Hyrien O, Poul JM, Sanders P. "Application of pharmacokinetic/pharmacodynamic and stochastic modelling to 6-mercaptopurine micronucleus induction in mouse bone marrow erythrocytes." Journal of applied toxicology : JAT. 2003 23(1):59-70.
2001 Jan
Hyrien O, Klés V, Concordet D, Bonneu M, Laurentie M, Sanders P. "Stochastic modeling in toxicokinetics. Application to the in vivo micronucleus assay." Mathematical biosciences. 2001 Jan; 169(1):27-51.
1999 Jul 21
Godard T, Fessard V, Huet S, Mourot A, Deslandes E, Pottier D, Hyrien O, Sichel F, Gauduchon P, Poul J. "Comparative in vitro and in vivo assessment of genotoxic effects of etoposide and chlorothalonil by the comet assay." Mutation research. 1999 Jul 21; 444(1):103-16.