Research Bio
Normal function of the salivary glands is critical for the maintenance of oral health. Radiation treatment of patients with head and neck cancers, as well as autoimmune diseases such as Sjögren's syndrome cause cellular damage in the salivary glands that is usually severe, irreversible, and impairs normal function. The long-range goal of this laboratory is to establish therapeutic strategies for repair or regeneration of the salivary glands. Basic research projects in our laboratory include the identification and characterization of progenitor cells involved in salivary gland development and regeneration, and the factors required for differentiation of secretory cells. Applied projects address strategies for protection of the salivary glands from radiation-induced damage, and for promoting regeneration of damaged glands.
2012 Jun
Arany S, Xu Q, Hernady E, Benoit DS, Dewhurst S, Ovitt CE. "Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures." Journal of cellular biochemistry. 2012 Jun 0; 113(6):1955-65. |
2012 May
Rugel-Stahl A, Elliott ME, Ovitt CE. "Ascl3 marks adult progenitor cells of the mouse salivary gland." Stem cell research. 2012 May 0; 8(3):379-87. Epub 2012 Jan 31. |
2011 May 15
Arany S, Catalán MA, Roztocil E, Ovitt CE. "Ascl3 knockout and cell ablation models reveal complexity of salivary gland maintenance and regeneration." Developmental biology. 2011 May 15; 353(2):186-93. Epub 2011 Mar 04. |
2010 Oct
Liu W, Watson SS, Lan Y, Keene DR, Ovitt CE, Liu H, Schweitzer R, Jiang R. "The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis." Molecular and cellular biology. 2010 Oct 0; 30(20):4797-807. Epub 2010 Aug 09. |
2009 Apr 15
Gao Y, Lan Y, Ovitt CE, Jiang R. "Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development." Developmental biology. 2009 Apr 15; 328(2):200-9. Epub 2009 Jan 14. |
