Catherine E. Ovitt, Ph.D.

Catherine E. Ovitt, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester, NY 14642

Office: (585) 275-2920
Fax: (585) 276-0190
Lab: (585) 273-3076

Research Bio

Normal function of the salivary glands is critical for the maintenance of oral health. Radiation treatment of patients with head and neck cancers, as well as autoimmune diseases such as Sjögren's syndrome cause cellular damage in the salivary glands that is usually severe, irreversible, and impairs normal function. The long-range goal of this laboratory is to establish therapeutic strategies for repair or regeneration of the salivary glands. Basic research projects in our laboratory include the identification and characterization of progenitor cells involved in salivary gland development and regeneration, and the factors required for differentiation of secretory cells. Applied projects address strategies for protection of the salivary glands from radiation-induced damage, and for promoting regeneration of damaged glands.

Recent Journal Articles

Showing the 5 most recent journal articles. 27 available »

2015 Jun
Shubin AD, Felong T, Graunke D, Ovitt CE, Benoit D. "Development of poly(ethylene glycol) hydrogels for salivary gland tissue engineering applications." Tissue engineering. Part A. 2015 Jun; 21(11-12):1733-51. Epub 2015 Apr 17.
2015 Apr 20
Aure MH, Konieczny SF, Ovitt CE. "Salivary Gland Homeostasis Is Maintained through Acinar Cell Self-Duplication." Developmental cell. 2015 Apr 20; 33(2):231-7. Epub 2015 Apr 02.
2013 Jun
Arany S, Benoit DS, Dewhurst S, Ovitt CE. "Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo." Molecular therapy : the journal of the American Society of Gene Therapy. 2013 Jun; 21(6):1182-94. Epub 2013 Mar 19.
2012 Jun
Arany S, Xu Q, Hernady E, Benoit DS, Dewhurst S, Ovitt CE. "Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures." Journal of cellular biochemistry. 2012 Jun; 113(6):1955-65.
2012 May
Rugel-Stahl A, Elliott ME, Ovitt CE. "Ascl3 marks adult progenitor cells of the mouse salivary gland." Stem cell research. 2012 May; 8(3):379-87. Epub 2012 Jan 31.

Current Appointments

Associate Professor - Department of Biomedical Genetics, Center for Oral Biology (SMD) - Primary

Education

PhD | Molecular Biology | Washington University1987
BS | Arts & Sciences | University of Connecticut1977

Post-Doctoral Training & Residency

Postdoctoral Fellow, European Molecular Biology Laboratory, Heidelberg, Germany 1997