Bin Liu, B.Med.

Bin Liu, B.Med.

Contact Information

Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta, NY 14586

Fax: (585) 276-9830
Lab: (585) 276-9847
Administrative: (585) 276-9800

Lab Information

Regulation of MCP-1 mRNA stability

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Professional Bio

None.

Research Bio

My research is focused on the regulation of mRNA stability of monocyte chemoattractant protein-1 (MCP-1) by PDGF and Angiotensin II (Ang II) in smooth muscle cells (SMC). MCP-1 promotes atherosclerosis and is a mediator of the response to arterial injury. MCP-1 level tracks its mRNA level under physiological or pathological conditions in animal models. MCP-1 mRNA is markedly elevated in response to PDGF-B or Ang II elevation largely due to increase of mRNA stability. Both PDGF-B and Ang II stabilize MCP-1 mRNA through a PKCd-dependent signaling pathway. Our ongoing research is to fully figure out the signaling pathways mediating the mRNA stabilizing effect, to isolate the MCP-1 mRNA stabilizing factor induced by PDGF-B and Ang II, and to reveal the RNases involved in PDGF-b and Ang II induced MCP-1 mRNA stabilization.

Recent Journal Articles

Showing the 5 most recent journal articles. 9 available »

2007 Apr 6
Dhawan L, Liu B, Blaxall BC, Taubman MB. "A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability." The Journal of biological chemistry.. 2007 Apr 6; 282(14):10146-52. Epub 2007 Feb 02.
2006 Apr
Liu B, Jiang S, Zhang W, Ye F, Wang YH, Wu J, Zhang DY. "Novel biodegradable HSAM nanoparticle for drug delivery." Oncology reports.. 2006 Apr; 15(4):957-61.
2006
Liu, B.; Poon, M.; Taubman, MB. "PDGF-BB Enhances Monocyte chemoattractant protein-1 mRNA Stability in Smooth Muscle Cells by Downregulating ribonuclease Activity." Journal of Mol Cell Cardio. 2006; 3: 426.
2004 May 7
Menzies K, Liu B, Kim WJ, Moschella MC, Taubman MB. "Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cells." Biochemical and biophysical research communications.. 2004 May 7; 317(3):801-10.
2003 Mar
Zhang DY, Liu B. "Detection of target nucleic acids and proteins by amplification of circularizable probes." Expert review of molecular diagnostics. 2003 Mar; 3(2):237-48.

Current Appointments

Research Assistant Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD) - Primary

Education

MD | Medicine | China-Bethune Med Univ, Changchun1982

Post-Doctoral Training & Residency

Senior Scientist Hamilton Thorne Biosciences, Inc., Beverly, MA 2003
Research Fellow in Immunology Institute of Biological Products, Changchun, China 1987
Junior Resident in Oral Surgery 4th Hospital of Bethune Medical School 1985
Intern in Oral Surgery 4th Hospital of Bethune Medical School 1984
Senior Resident in Oral Surgery 4th Hospital of Bethune Medical School 1985