Professional Bio
None.
Research Bio
My research is focused on the regulation of mRNA stability of monocyte chemoattractant protein-1 (MCP-1) by PDGF and Angiotensin II (Ang II) in smooth muscle cells (SMC). MCP-1 promotes atherosclerosis and is a mediator of the response to arterial injury. MCP-1 level tracks its mRNA level under physiological or pathological conditions in animal models. MCP-1 mRNA is markedly elevated in response to PDGF-B or Ang II elevation largely due to increase of mRNA stability. Both PDGF-B and Ang II stabilize MCP-1 mRNA through a PKCd-dependent signaling pathway. Our ongoing research is to fully figure out the signaling pathways mediating the mRNA stabilizing effect, to isolate the MCP-1 mRNA stabilizing factor induced by PDGF-B and Ang II, and to reveal the RNases involved in PDGF-b and Ang II induced MCP-1 mRNA stabilization.
2007 Apr 6
Dhawan L, Liu B, Blaxall BC, Taubman MB. "A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability." The Journal of biological chemistry. 2007 Apr 6; 282(14):10146-52. Epub 2007 Feb 02. |
2006 Apr
Liu B, Jiang S, Zhang W, Ye F, Wang YH, Wu J, Zhang DY. "Novel biodegradable HSAM nanoparticle for drug delivery." Oncology reports. 2006 Apr 0; 15(4):957-61. |
2006
Liu, B.; Poon, M.; Taubman, MB. "PDGF-BB Enhances Monocyte chemoattractant protein-1 mRNA Stability in Smooth Muscle Cells by Downregulating ribonuclease Activity." Journal of Mol Cell Cardio. 2006; 3: 426. |
2004 May 7
Menzies K, Liu B, Kim WJ, Moschella MC, Taubman MB. "Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cells." Biochemical and biophysical research communications. 2004 May 7; 317(3):801-10. |
2003 Mar
Zhang DY, Liu B. "Detection of target nucleic acids and proteins by amplification of circularizable probes." Expert review of molecular diagnostics. 2003 Mar 0; 3(2):237-48. |
